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[PMID]:28466355
[Au] Autor:Khalaf M; Matar N
[Ad] Endereço:Otolaryngology Head and Neck Surgery Department, Hotel Dieu de France Hospital, Saint-Joseph University, Beirut, Lebanon.
[Ti] Título:Translation and transcultural adaptation of the VHI-10 questionnaire: the VHI-10lb.
[So] Source:Eur Arch Otorhinolaryngol;274(8):3139-3145, 2017 Aug.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Subjective assessment tools are essential in voice disorders evaluation. The Voice Handicap Index-30 (VHI-30) and the Voice Handicap Index-10 (VHI-10) are the most studied and used questionnaires to assess the severity of the handicap caused by hoarseness on the quality of life of dysphonic patients and, therefore, guiding physician's therapeutic decision making. The aim of our study is to validate a Lebanese version of the VHI-10. The Lebanese Arabic version of the VHI-10 (VHI-10lb) was obtained after a forward translation towards Lebanese Arabic then a back-translation towards English and a pilot study. It was then submitted to 154 participants with clinical dysphonia and 100 healthy subjects. The questionnaire's intrinsic parameters such as the reliability, the reproducibility, the validity, the sensitivity, and the study of the correlation between each item and the total score were measured for the validation of the questionnaire. The results show a high internal consistency of the VHI-10lb (Cronbach's α 0.915) and an intra-class correlation coefficient of 0.963 in the reliability analysis (p < 0.001). The VHI-10lb is also found to be clinically valid (p < 0.001) and sensitive to the improvement of the quality of life after treatment of dysphonic patients (p < 0.001). The Lebanese version of the VHI-10, the VHI-10lb, can be used to self-assess the severity of the impact of dysphonia on the quality of life of the affected patients. This study allows to add the VHI-10lb to the voice evaluation tools adapted to the Lebanese population.
[Mh] Termos MeSH primário: Qualidade de Vida
Traduções
Distúrbios da Voz
[Mh] Termos MeSH secundário: Adulto
Idoso
Comparação Transcultural
Avaliação da Deficiência
Feminino
Seres Humanos
Líbano
Masculino
Meia-Idade
Projetos Piloto
Psicometria/métodos
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
Inquéritos e Questionários
Distúrbios da Voz/diagnóstico
Distúrbios da Voz/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-017-4585-9


  2 / 3329 MEDLINE  
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[PMID]:29357391
[Au] Autor:Aoun M; Karam R; Sleilaty G; Antoun L; Ammar W
[Ad] Endereço:Department of Nephrology, Saint-Joseph University, Beirut, Lebanon.
[Ti] Título:Iron deficiency across chronic kidney disease stages: Is there a reverse gender pattern?
[So] Source:PLoS One;13(1):e0191541, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In non-dialysis chronic kidney disease patients, looking for iron deficiency is highly variable in practice and there is a great variability regarding the cutoffs used to treat iron deficiency. The aim of this study is to investigate the degree of iron deficiency in non-dialysis chronic kidney disease patients on erythropoiesis-stimulating agents. We included all non-dialysis chronic kidney disease patients that applied to the Lebanese Ministry of Public Health for erythropoiesis-stimulating agents' coverage during a 5-month period. Iron requirement was assessed based on two guidelines' target-to-treat cutoffs: 1-ferritin <100 ng/ml and/or TSAT < 20% (KDOQI 2006), 2- ferritin ≤500 ng/ml and TSAT ≤30% (KDIGO 2012). A total of 238 CKD patients were included over 5 months. All patients had a ferritin level in their record and 64% had an available TSAT. Median age was 71.0 (59.8-79.3) years and 61.8% were female. All had an eGFR<60 ml/min. The proportion of patients found to require iron therapy ranged between 48 and 78% with a trend towards higher values when using KDIGO-based criteria. Using ANCOVA test, inverse normal transformations of ferritin and TSAT showed a reverse pattern between men and women with women being more iron deficient in the early stage. Iron deficiency is highly prevalent in non-dialysis chronic kidney disease patients on erythropoiesis-stimulating agents' therapy. These findings reflect a lack in effective iron supplementation when managing anemia in pre-dialysis patients, especially in men at advanced stages. Renal societies should spread awareness about iron deficiency screening in those patients.
[Mh] Termos MeSH primário: Ferro/deficiência
Insuficiência Renal Crônica/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Anemia Ferropriva/complicações
Anemia Ferropriva/tratamento farmacológico
Anemia Ferropriva/metabolismo
Feminino
Ferritinas/sangue
Hematínicos/uso terapêutico
Seres Humanos
Ferro/sangue
Ferro/uso terapêutico
Falência Renal Crônica/complicações
Falência Renal Crônica/tratamento farmacológico
Falência Renal Crônica/metabolismo
Líbano
Masculino
Meia-Idade
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/tratamento farmacológico
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Hematinics); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191541


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[PMID]:29381734
[Au] Autor:Abdulrahim S; Jawad M
[Ad] Endereço:Department of Health Promotion and Community Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.
[Ti] Título:Socioeconomic differences in smoking in Jordan, Lebanon, Syria, and Palestine: A cross-sectional analysis of national surveys.
[So] Source:PLoS One;13(1):e0189829, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The association between education and wealth, as fundamental determinants of health, and smoking is well-established. Yet, social inequalities have received little attention in the expanding field of tobacco research in the Arab region. In this study, we examine inequalities in cigarette smoking by education and wealth in four Arab countries. METHODS: Utilizing the most recently available population-level data sets (Syria 2009 PAPFAM, Jordan 2012 DHS, Palestine 2010 Family Health Survey, and Lebanon 2004 PAPFAM), we tested the association between cigarette smoking and education and wealth-controlling for age, marital status, and region of residence-for each country, and among men and women depending on data availability. RESULTS: Cigarette smoking prevalence among Arab men is high- 51.3% in Syria, 39.7% in Palestine, and 42.1% in Lebanon; among women, prevalence is 8.4% in Syria, 10.9% in Jordan, and 24.3% Lebanon. Cigarette smoking shows the expected patterns inequalities by education among men in Syria, Palestine, and Lebanon, and among women in Jordan and Lebanon. On the other hand, wealth does not show a clear pattern in its association with cigarette smoking and, in some cases (men in Palestine and women in Syria) the behavioral risk is higher among the wealthiest. CONCLUSIONS: Available data from 2004-2012 show that cigarette smoking among men and women in the four Arab countries is predominant among those with limited access to education as a fundamental cause. The weak or absent negative association between wealth and cigarette smoking suggests that access to material resources does not precipitate a reduction in the consumption of tobacco.
[Mh] Termos MeSH primário: Fumar Cigarros/epidemiologia
Fumar
[Mh] Termos MeSH secundário: Adulto
Árabes
Estudos Transversais
Feminino
Seres Humanos
Israel/epidemiologia
Jordânia/epidemiologia
Líbano
Masculino
Meia-Idade
Prevalência
Classe Social
Síria/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189829


  4 / 3329 MEDLINE  
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[PMID]:29381482
[Au] Autor:Saadeh M; Ghafari JG; Haddad RV; Ayoub F
[Ad] Endereço:Department of Orthodontics, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon.
[Ti] Título:Palatal rugae morphology in an adult mediterranean population.
[So] Source:J Forensic Odontostomatol;1(35):21-32, 2017 Jul 01.
[Is] ISSN:2219-6749
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The use of the palatal rugae in forensic odontology is based on their unique and individual characteristics. Few studies have assessed the palatal rugae in Mediterranean populations and none in the Lebanese population. OBJECTIVE: Assess the shape and other morphological features of the palatal rugae in a Lebanese adult population, and compare them with reported similar features in other populations. MATERIALS AND METHODS: Rugae characteristics were assessed on the maxillary dental casts of 217 non-growing subjects (95 males, 122 females, age 25.5 ± 7.6 years) according to guidelines established by Thomas and Kotze (1983) and Lysell (1955). The overall number of rugae and numbers of primary rugae (> 5mm in length), secondary rugae (3-5mm) and fragmentary rugae (2-3mm) on either side were recorded. Rugae were classified according to shape, direction and presence of unification. Z-tests were used to compare the proportions between right and left sides and between genders. The mean numbers of rugae in each category were compared with independent samples t-tests between males and females; paired samples t-tests were employed to compare mean numbers of rugae in each category between right and left sides. The data were compared with published reports on other Mediterranean cohorts. RESULTS: The average number of rugae was 7.7 per individual, 3.81 on the right and 3.89 on the left. Curved, wavy and straight rugae patterns were equally common (one third each). The spatial direction of most rugae (49.3%) was backward. Circular, non-specific and convergent rugae were rare (< 2% each). Rugae numbers (total, primary, secondary, fragmentary) were symmetrical but shape, direction and the occurrence of convergence were asymmetrical (p < 0.05). None of the examined characteristics showed gender dimorphism. Tabulated comparisons disclosed the equality of rugae patterns as major differences with findings from other Mediterranean studies. CONCLUSIONS: The palatal rugae in the Lebanese population display shape distinct from other reported Mediterranean and non-Caucasian populations. Studies in large samples and primary comparisons with other Mediterranean populations are warranted.
[Mh] Termos MeSH primário: Palato Duro/anatomia & histologia
[Mh] Termos MeSH secundário: Adulto
Modelos Dentários
Feminino
Seres Humanos
Líbano
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


  5 / 3329 MEDLINE  
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[PMID]:29320542
[Au] Autor:Matisoo-Smith E; Gosling AL; Platt D; Kardailsky O; Prost S; Cameron-Christie S; Collins CJ; Boocock J; Kurumilian Y; Guirguis M; Pla Orquín R; Khalil W; Genz H; Abou Diwan G; Nassar J; Zalloua P
[Ad] Endereço:Department of Anatomy, University of Otago, Dunedin, New Zealand.
[Ti] Título:Ancient mitogenomes of Phoenicians from Sardinia and Lebanon: A story of settlement, integration, and female mobility.
[So] Source:PLoS One;13(1):e0190169, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Phoenicians emerged in the Northern Levant around 1800 BCE and by the 9th century BCE had spread their culture across the Mediterranean Basin, establishing trading posts, and settlements in various European Mediterranean and North African locations. Despite their widespread influence, what is known of the Phoenicians comes from what was written about them by the Greeks and Egyptians. In this study, we investigate the extent of Phoenician integration with the Sardinian communities they settled. We present 14 new ancient mitogenome sequences from pre-Phoenician (~1800 BCE) and Phoenician (~700-400 BCE) samples from Lebanon (n = 4) and Sardinia (n = 10) and compare these with 87 new complete mitogenomes from modern Lebanese and 21 recently published pre-Phoenician ancient mitogenomes from Sardinia to investigate the population dynamics of the Phoenician (Punic) site of Monte Sirai, in southern Sardinia. Our results indicate evidence of continuity of some lineages from pre-Phoenician populations suggesting integration of indigenous Sardinians in the Monte Sirai Phoenician community. We also find evidence of the arrival of new, unique mitochondrial lineages, indicating the movement of women from sites in the Near East or North Africa to Sardinia, but also possibly from non-Mediterranean populations and the likely movement of women from Europe to Phoenician sites in Lebanon. Combined, this evidence suggests female mobility and genetic diversity in Phoenician communities, reflecting the inclusive and multicultural nature of Phoenician society.
[Mh] Termos MeSH primário: Demografia
Grupos Étnicos/história
Genoma Mitocondrial
Migração Humana/história
Mulheres
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Cultura
DNA Mitocondrial/análise
DNA Mitocondrial/isolamento & purificação
Grupos Étnicos/genética
Feminino
Variação Genética
Haplótipos
História Antiga
Seres Humanos
Itália
Líbano/etnologia
Região do Mediterrâneo
Filogenia
Dinâmica Populacional
Dente
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190169


  6 / 3329 MEDLINE  
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[PMID]:29324827
[Au] Autor:Sukkarieh-Haraty O; Egede LE; Abi Kharma J; Bassil M
[Ad] Endereço:Alice Ramez Chagoury School of Nursing, Lebanese American University, Byblos, Lebanon.
[Ti] Título:Psychometric properties of the Arabic version of the 12-item diabetes fatalism scale.
[So] Source:PLoS One;13(1):e0190719, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There are widespread fatalistic beliefs in Arab countries, especially among individuals with diabetes. However, there is no tool to assess diabetes fatalism in this population. This study describes the processes used to create an Arabic version of the Diabetes Fatalism Scale (DFS) and examine its psychometric properties. METHODS: A descriptive correlational design was used with a convenience sample of Lebanese adults (N = 274) with type 2 diabetes recruited from a major hospital in Beirut, Lebanon and by snowball sampling. The 12- item Diabetes Fatalism Scale- Arabic (12-item DFS-Ar) was back-translated from the original version, pilot tested on 22 adults with type 2 diabetes and then administered to 274 patients to assess the validity and reliability of the scale. Confirmatory factor analysis (CFA) was used to test the hypothesized factor structure. Cronbach's alpha was used to test for reliability. RESULTS: CFA supported the existence of the three factor hypothesis of the original DFS scale. The five items measuring "emotional distress" loaded under Factor 1, the four items measuring "spiritual coping" loaded under factor 2 and the last three items measuring "perceived self-efficacy" of the original scale loaded under Factor 3 (p <0.001 for all three subscales). Goodness of fit indices confirmed adequateness of the CFA model (CFI = 0.97, TLI = 0.96, RMSEA = 0.067 and pclose = 0.05). The 12-item DFS-Ar showed good reliability (Cronbach's alpha of 0.86) and significantly predicted HbA1c (ß = 0.20, p < 0.01). After adjusting for the demographic characteristics and the number of diabetes comorbid conditions, the 12-item DFS-Ar score was independently associated with HbA1c in a multivariable model (ß = 0.16, p < 0.05). CONCLUSIONS: The 12-item DFS-Ar demonstrated good psychometric properties that are comparable to the original scale. It is a valid and reliable measure of diabetes fatalism. Further testing with larger and non-Lebanese Arabic population is needed.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/psicologia
Psicometria
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Líbano
Masculino
Meia-Idade
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190719


  7 / 3329 MEDLINE  
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[PMID]:28452150
[Au] Autor:Rességuier A
[Ad] Endereço:PhD Candidate, Sciences Po, France, and Research Assistant, University of Oxford, United Kingdom.
[Ti] Título:The moral sense of humanitarian actors: an empirical exploration.
[So] Source:Disasters;42(1):62-80, 2018 Jan.
[Is] ISSN:1467-7717
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper examines humanitarianism's moral positioning above private and political interests to save lives and alleviate suffering. It does not aim to assess the legitimacy of this stance, but rather to probe the way in which humanitarian actors relate to this moral dimension in their everyday work. It investigates empirically humanitarian ethics from the perspective of humanitarian actors, drawing on interviews conducted in Beirut, Lebanon, in 2014. As it is exploratory, three key conceptual innovations were required. The first of these is the introduction of the tools developed to consider a neglected reality: humanitarian actors' 'moral sense' vis-à-vis the humanitarian sector's 'moral culture'. Second, the study shows how the sector's moral culture is structured around the notion of 'concern for persons in need'. Third, it analyses the way in which the sector and its actors handle the asymmetrical relationships encountered daily. Ultimately this paper seeks to valorise humanitarian actors' creativity in their common practices and explore potential challenges to it.
[Mh] Termos MeSH primário: Altruísmo
Princípios Morais
[Mh] Termos MeSH secundário: Pesquisa Empírica
Seres Humanos
Líbano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/disa.12234


  8 / 3329 MEDLINE  
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[PMID]:29261714
[Au] Autor:Osman M; Benamrouz S; Guyot K; Baydoun M; Frealle E; Chabe M; Gantois N; Delaire B; Goffard A; Aoun A; Jurdi N; Dabboussi F; Even G; Slomianny C; Gosset P; Hamze M; Creusy C; Viscogliosi E; Certad G
[Ad] Endereço:Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille (CIIL), UMR CNRS 8204, INSERM U1019, Université de Lille, CHU de Lille, Biologie et Diversité des Pathogènes Eucaryotes Emergents (BDPEE), Lille, France.
[Ti] Título:High association of Cryptosporidium spp. infection with colon adenocarcinoma in Lebanese patients.
[So] Source:PLoS One;12(12):e0189422, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The association between Cryptosporidium and human colon cancer has been reported in different populations. However, this association has not been well studied. In order to add new strong arguments for a probable link between cryptosporidiosis and colon human cancer, the aim of this study was to determine prevalence and to identify species of Cryptosporidium among Lebanese patients. METHODOLOGY AND PRINCIPAL FINDINGS: Overall, 218 digestive biopsies were collected in Tripoli, Lebanon, from three groups of patients: (i) patients with recently diagnosed colon intraepithelial neoplasia/adenocarcinoma before any treatment (n = 72); (ii) patients with recently diagnosed stomach intraepithelial neoplasia/adenocarcinoma before any treatment (n = 21); and (iii) patients without digestive intraepithelial neoplasia/adenocarcinoma but with persistent digestive symptoms (n = 125). DNA extraction was performed from paraffin-embedded tissue. The presence of the parasite in tissues was confirmed by PCR, microscopic observation and immunofluorescence analysis. We identified a high rate (21%) of Cryptosporidium presence in biopsies from Lebanese patients with recently diagnosed colonic neoplasia/adenocarcinoma before any treatment. This prevalence was significantly higher compared to 7% of Cryptosporidium prevalence among patients without colon neoplasia but with persistent gastrointestinal symptoms (OR: 4, CI: 1.65-9.6, P = 0.001). When the comparison was done against normal biopsies, the risk of infection increased 11-fold in the group of patients with colon adenocarcinoma (OR: 11.315, CI: 1.44-89.02, P = 0.003). CONCLUSIONS: This is the first study performed in Lebanon reporting the prevalence of Cryptosporidium among patients with digestive cancer. These results show that Cryptosporidium is strongly associated with human colon cancer being maybe a potential etiological agent of this disease.
[Mh] Termos MeSH primário: Adenocarcinoma/epidemiologia
Adenocarcinoma/parasitologia
Neoplasias do Colo/epidemiologia
Neoplasias do Colo/parasitologia
Criptosporidiose/complicações
Cryptosporidium/fisiologia
[Mh] Termos MeSH secundário: Adenocarcinoma/complicações
Adenocarcinoma/patologia
Adolescente
Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Biópsia
Estudos de Casos e Controles
Neoplasias do Colo/complicações
Neoplasias do Colo/patologia
Feminino
Seres Humanos
Líbano/epidemiologia
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189422


  9 / 3329 MEDLINE  
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[PMID]:28727257
[Au] Autor:Lakkis F; Alaiwi SA; Naffaa L; Atweh L; Khoury N; Abboud M; Muwakkit S; Tarek N; El Solh H; Saab R
[Ad] Endereço:Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
[Ti] Título:Routine surveillance imaging after end of therapy for pediatric extracranial tumors: A retrospective analysis.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Frequent surveillance imaging is routine practice for pediatric patients after cancer therapy. This retrospective study evaluated the follow-up of 301 children with extracranial tumors diagnosed between 2002 and 2012, at a tertiary pediatric cancer center in Beirut, Lebanon. Recurrence occurred in 15% of patients, at a median of 12 months after end of primary therapy. Outcome was not different comparing patients with recurrence detected via imaging surveillance versus clinically. False positive findings in 55 patients led to further interventions. These results raise important questions regarding benefit of current surveillance practices as standard care, especially in countries with limited resources.
[Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/terapia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Lactente
Líbano
Masculino
Estudos Retrospectivos
Centros de Atenção Terciária
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26723


  10 / 3329 MEDLINE  
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[PMID]:28675683
[Au] Autor:Merabi Z; Boulos F; Santiago T; Jenkins J; Abboud M; Muwakkit S; Tarek N; Zaatari G; Jeha S; El-Solh H; Saab R
[Ad] Endereço:Department of Pediatric and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
[Ti] Título:Pediatric cancer pathology review from a single institution: Neuropathology expert opinion is essential for accurate diagnosis of pediatric brain tumors.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Second pathology review has been reported to improve accuracy in oncologic diagnoses, including pediatric malignancies. We assessed the impact of second review on the diagnosis of pediatric malignancies at a tertiary care referral center in Beirut, Lebanon. METHODS: Pathology reports of patients treated at the Children's Cancer Institute in Lebanon were retrospectively reviewed for the period 2008-2016 and compared with same samples' diagnoses at St. Jude Children's Research Hospital. Diagnostic disagreements were divided into major, minor, and none based on their effect on diagnosis and/or patient management. RESULTS: Second review was requested for 171 cases, accounting for 19% of all cases during that period. Second opinion was mostly requested for brain tumors (62% of all brain tumor cases) and neuroblastoma for NMYC testing (65% of all neuroblastoma), while hematologic malignancies had the fewest referrals (3% of all hematologic cases). Major disagreements in second review occurred in 20 cases (12% of total), and minor disagreements in 21 cases (12% of total). The largest proportion of major disagreements (71%) occurred in pediatric brain tumors, and novel molecular tests contributed to the diagnosis in 55% of these cases. CONCLUSIONS: The availability of a specialized pediatric neuropathologist and a basic panel of relevant molecular testing are essential for appropriate diagnosis of pediatric brain tumors. Centers that do not have the available infrastructure in place can benefit greatly from second review referrals for this challenging subset of tumors.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/patologia
Neoplasias Hematológicas/patologia
Neuroblastoma/patologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Líbano
Masculino
Estudos Retrospectivos
Centros de Atenção Terciária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26709



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