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[PMID]:28452688
[Au] Autor:Singh P; Hayden KA; Ens T; Khan N; Quan H; Plested D; Sinclair S; King-Shier KM
[Ad] Endereço:Faculty of Nursing, University of Calgary, Calgary, AB,Canada.
[Ti] Título:Ethno-cultural Preferences in Receipt of Heart Health Information.
[So] Source:Am J Health Behav;41(2):114-126, 2017 Mar 01.
[Is] ISSN:1945-7359
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We attempted to understand how people of South Asian and Chinese descent prefer to receive health information. METHODS: To achieve this end we conducted a search of academic and grey literature articles published between 1946 and 2016. To be included, articles had to be focused South Asian and Chinese specific ethno-culturally-based preferences of receiving health information. RESULTS: A total of 3478 abstracts were retrieved, of which, 27 articles met the inclusion criteria. We were able to identify South Asian and Chinese people's preferences for and facilitators of receiving health information. South Asians and Chinese preferred health information and programs that were more culturally relevant and appealing, had translations into South Asian and Chinese languages, and used simple terms as opposed to technical jargon. CONCLUSIONS: There is little direction regarding for how to tai- lor health information South Asian and Chinese ethno-cultural groups. Having evidence-based information about how South Asians and Chinese prefer to receive health information has potential to enhance patients' learning and health literacy, improve clinical outcomes, and reduce health disparities.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde/etnologia
Educação de Pacientes como Assunto
[Mh] Termos MeSH secundário: Bangladesh/etnologia
China/etnologia
Seres Humanos
Índia/etnologia
Paquistão/etnologia
Sri Lanka/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.5993/AJHB.41.2.2


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[PMID]:28747202
[Au] Autor:Gamage AU; Jayawardana PL
[Ad] Endereço:Consultant Community Physician, Ministry of Health, 385, Ven. Baddegama Wimalawansa Thero Mawatha, Colombo, 10, Sri Lanka. anujigamage@gmail.com.
[Ti] Título:Knowledge of non-communicable diseases and practices related to healthy lifestyles among adolescents, in state schools of a selected educational division in Sri Lanka.
[So] Source:BMC Public Health;18(1):64, 2017 07 26.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Behaviors established during the adolescence have life-long consequences to the onset of non-communicable diseases (NCDs) in later life. Therefore, it is essential to understand adolescents' knowledge and practices with the intention of developing preventive programs focusing on this age group. The objective of the study was to assess knowledge about selected NCDs, and lifestyle choices among school students aged 17-19 years in state schools of the Maharagama Educational Division, Sri Lanka. METHODS: A descriptive, cross-sectional study was conducted among students aged 17-19 years attending state schools in Maharagama Education Division. A total of 634 students were selected from 9 schools conducting Advance Level classes. Stratified sampling was done based on stream of study and the number needed from each stratum was decided according to probability proportionate to size which was followed by cluster sampling within the strata to select the classes included. Data were collected using a self-administered-questionnaire on socio-demographic characteristics and economic status; lifestyle-related practices; knowledge on Non-Communicable -Diseases. Logistic regression was used to assess the associations. RESULTS: Proportion students with good overall knowledge was 43%(n = 272). Forty-three percent (n = 275) consumed a healthy diet, and 20%(n = 129) engaged in adequate physical activity 3%(n = 18) of students were current smokers and 12%(n = 73) current alcohol users 12%(n = 73). Overall "good" knowledge about NCDs was associated with being a science stream student(OR = 3.3; 95%CI:2.1-5.2). Healthy diet was associated with female sex (OR = 2.1; 95%CI: 1.5-3.0), and adequate physical activity with male sex (OR = 2.1; 95% CI:1.4-3.2), non-science-stream (OR = 2.1; 95%CI:1.2-3.7) and upper socio economic status (OR = 2.0; 95%CI:1.3-3.0). Non-smoking was associated with overall good knowledge (OR = 4.1; 95%CI:1.2-13.7) and female sex (OR = 0;95%CI:1.5-infinity). Abstinence from alcohol was associated with being a female (OR = 6.9; 95%CI:3.4-13.9), and with mother and fathers' education level of > General-Certificate of Examinations Ordinary Level (GCE O/L) (OR = 2.9; 95%CI:1.1-8.4 and OR = 3.5; 95%CI:1.1-11.2 respectively). CONCLUSION: Knowledge about NCDs and healthy lifestyle-practices were poor among school students aged 17-19 years. Lack of knowledge about healthy and unhealthy behaviors highlights the importance of carrying out regular surveillance for NCD risk factors, and initiating programs for the prevention of NCDs amongst adolescents.
[Mh] Termos MeSH primário: Comportamentos Relacionados com a Saúde
Estilo de Vida
Doenças não Transmissíveis/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Consumo de Bebidas Alcoólicas/epidemiologia
Estudos Transversais
Exercício
Feminino
Conhecimentos, Atitudes e Prática em Saúde
Estilo de Vida Saudável
Seres Humanos
Masculino
Fatores de Risco
Fatores Socioeconômicos
Sri Lanka
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180304
[Lr] Data última revisão:
180304
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4622-z


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[PMID]:29205009
[Au] Autor:Huang JP; Yang F; Liu YN; Zou KN; Cao Y; Wu D; Chen RH; Ping Y; Zhou HG
[Ad] Endereço:Shanghai Key Laboratory of Crime Scene Evidence, Key Laboratory of Forensic Evidence and Science Technology, Ministry of Public Security, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China.
[Ti] Título:[Research Progress on Gene Alterations of Locus in Gender Identification].
[So] Source:Fa Yi Xue Za Zhi;32(5):371-377, 2016 Oct.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:There are two kinds of gene mutation, including mutation in primer-binding region of gene and micro deletion of Y chromosome encompassing gene, and the latter is more common. The mechanisms of mutation in primer-binding region of gene is nucleotide point mutation and the mechanism of micro deletion of Y chromosome encompassing gene maybe non-allelic homologous recombination or non-homologous end-joining. Among the population worldwide, there is a notably higher frequency of gene mutations in Indian population, Sri Lanka population and Nepalese population which reside within the Indian subcontinent. Though gene mutations have little impact on fertility and phenotype, they might cause incorrect result in gender identification. Using composite-amplification kit which including autosomal STR locus, gene locus and multiple Y-STR locus, could avoid wrong gender identification caused by gene mutation.
[Mh] Termos MeSH primário: Amelogenina/genética
Aberrações Cromossômicas
Cromossomos Humanos Y/genética
[Mh] Termos MeSH secundário: Alelos
Grupo com Ancestrais do Continente Asiático/genética
Seres Humanos
Índia
Masculino
Repetições de Microssatélites
Nepal
Reação em Cadeia da Polimerase
Deleção de Sequência
Sri Lanka
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amelogenin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.05.013


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[PMID]:29320520
[Au] Autor:Arasumani M; Khan D; Das A; Lockwood I; Stewart R; Kiran RA; Muthukumar M; Bunyan M; Robin VV
[Ad] Endereço:INTACH-Kodaikanal, Melati, Wilbet house, Kodaikanal, India.
[Ti] Título:Not seeing the grass for the trees: Timber plantations and agriculture shrink tropical montane grassland by two-thirds over four decades in the Palani Hills, a Western Ghats Sky Island.
[So] Source:PLoS One;13(1):e0190003, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tropical montane habitats, grasslands, in particular, merit urgent conservation attention owing to the disproportionate levels of endemic biodiversity they harbour, the ecosystem services they provide, and the fact that they are among the most threatened habitats globally. The Shola Sky Islands in the Western Ghats host a matrix of native forest-grassland matrix that has been planted over the last century, with exotic timber plantations. The popular discourse on the landscape change is that mainly forests have been lost to the timber plantations and recent court directives are to restore Shola forest trees. In this study, we examine spatiotemporal patterns of landscape change over the last 40 years in the Palani Hills, a significant part of the montane habitat in the Western Ghats. Using satellite imagery and field surveys, we find that 66% of native grasslands and 31% of native forests have been lost over the last 40 years. Grasslands have gone from being the dominant, most contiguous land cover to one of the rarest and most fragmented. They have been replaced by timber plantations and, to a lesser extent, expanding agriculture. We find that the spatial pattern of grassland loss to plantations differs from the loss to agriculture, likely driven by the invasion of plantation species into grasslands. We identify remnant grasslands that should be prioritised for conservation and make specific recommendations for conservation and restoration of grasslands in light of current management policy in the Palani Hills, which favours large-scale removal of plantations and emphasises the restoration of native forests.
[Mh] Termos MeSH primário: Agricultura
Conservação dos Recursos Naturais
Agricultura Florestal
Pradaria
[Mh] Termos MeSH secundário: Agricultura/tendências
Área Sob a Curva
Ecossistema
Agricultura Florestal/tendências
Atividades Humanas
Lagos
Modelos Teóricos
Curva ROC
Imagens de Satélites
Sri Lanka
Árvores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190003


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[PMID]:27773472
[Au] Autor:Wijesinghe PR; Abeysinghe MRN; Yoksan S; Yao Y; Zhou B; Zhang L; Fleming JA; Marfin AA; Victor JC
[Ad] Endereço:Epidemiological Unit, Ministry of Healthcare and Nutrition, Colombo, Sri Lanka.
[Ti] Título:Immunogenicity of live attenuated Japanese encephalitis SA 14-14-2 vaccine among Sri Lankan children with previous receipt of inactivated JE vaccine.
[So] Source:Vaccine;34(48):5923-5928, 2016 11 21.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The performance of live attenuated Japanese Encephalitis SA 14-14-2 vaccine (CD-JEV) among children previously given inactivated mouse brain-derived JE vaccine (IMBV) is unknown. We evaluated the safety and immunogenicity of CD-JEV administered to 2- and 5-year-old children in Sri Lanka. METHODS: In this open-label, single arm trial in the Colombo District of Sri Lanka, generally healthy children 2 and 5years of age who had previously received two and three doses of IMBV, respectively, were administered one dose of CD-JEV subcutaneously. Participants were monitored for adverse events for one year post-vaccination. Serum neutralizing antibody responses were evaluated pre and 28 and 365days post-vaccination using JE plaque reduction neutralization test and characterized as the proportion of participants seroconverting. Seroconversion was defined as either reaching a titer considered seroprotective (⩾1:10) among participants with a baseline titer <1:10 or achieving at least a 4-fold rise in titer among participants with a baseline titer ⩾1:10. RESULTS: Of 305 children given CD-JEV, 294 were included in the primary analysis of immunogenicity. Prior to vaccination, 144/147 (98.0%) 2-year-olds and 146/147 (99.3%) 5-year-olds had seroprotective levels. 28days post-vaccination, 79/147 [53.7% (95% CI, 45.3-62.0)] 2-year olds and of 60/147 [40.8% (95% CI, 32.8-49.2)] 5-year olds achieved seroconversion. Among 2-year-olds, geometric mean titers (GMTs) rose from 697 to 3175 28days post-vaccination. Among 5-year-olds, GMTs rose from 926 to 2776. Most adverse reactions were mild, and no serious adverse events were related to study vaccination. CONCLUSION: Administration of CD-JEV to these children with pre-existing neutralizing JE antibody titers was safe and resulted in substantial boosting of antibody levels. These results may inform other countries in Asia considering switching from IMBV to now WHO-prequalified CD-JEV vaccine to combat this disease of public health importance.
[Mh] Termos MeSH primário: Vírus da Encefalite Japonesa (Espécie)/imunologia
Imunização Secundária
Imunogenicidade da Vacina
Vacinas contra Encefalite Japonesa/imunologia
[Mh] Termos MeSH secundário: Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Pré-Escolar
Encefalite Japonesa/epidemiologia
Encefalite Japonesa/prevenção & controle
Feminino
Seres Humanos
Vacinas contra Encefalite Japonesa/administração & dosagem
Vacinas contra Encefalite Japonesa/efeitos adversos
Masculino
Sri Lanka/epidemiologia
Absorção Subcutânea
Vacinação
Vacinas Atenuadas/administração & dosagem
Vacinas Atenuadas/efeitos adversos
Vacinas Atenuadas/imunologia
Vacinas de Produtos Inativados/administração & dosagem
Vacinas de Produtos Inativados/efeitos adversos
Vacinas de Produtos Inativados/imunologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Japanese Encephalitis Vaccines); 0 (Vaccines, Attenuated); 0 (Vaccines, Inactivated)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28467188
[Au] Autor:Tatavarthy A; Ali L; Gill V; Hu L; Deng X; Adachi Y; Rand H; Hammack T; Zhang G
[Ad] Endereço:U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5001 Campus Drive, College Park, Maryland 20740, USA.
[Ti] Título:Evaluation of Three Real-Time PCR Methods for Detection of Salmonella from Cloves.
[So] Source:J Food Prot;80(6):982-989, 2017 06.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of the study was to evaluate three real-time PCR platforms for rapid detection of Salmonella from cloves and to compare three different DNA extraction methods. Six trials were conducted with two clove cultivars, Ceylon and Madagascar, and three Salmonella serotypes, Montevideo, Typhimurium, and Weltevreden. Each trial consisted of 20 test portions. The preenrichment cultures were used to perform PCR for comparison of the effectiveness of U.S. Food and Drug Administration, Pacific Regional Laboratory Southwest (FDA-PRLSW), Applied Biosystems Inc. (ABI) MicroSEQ, and GeneDisc platforms for detection of Salmonella. Three DNA extraction methods were used: standard extraction method for each PCR platform, boil preparation, and LyseNow food pathogen DNA extraction cards. The results from real-time PCR correlated well with FDA Bacteriological Analytical Manual culture assay results, with a wide range of cycle threshold (C ) values among the three PCR platforms for intended positive samples. The mean C values for MicroSEQ (16.36 ± 2.78) were significantly lower than for PRLSW (20.37 ± 3.45) and GeneDisc (23.88 ± 2.90) (P < 0.0001). Pairwise comparisons between PCR platforms using different DNA extraction methods indicate that the C values are inversely proportional to the relative DNA quantity (RDQ) yields by different platform-extraction combinations. The pairing of MicroSEQ and boil preparation generated the highest RDQ of 120 and the lowest average C value of 14.48, whereas the pairing of GeneDisc and LyseNow generated the lowest RDQ of 0.18 and the highest average C of 25.97. Boil preparation yielded higher RDQ than the other extraction methods for all three PCR platforms. Although the MicroSEQ platform generated the lowest C values, its sensitivity was compromised by narrow separations between the positive and negative samples. The PRLSW platform generated the best segregation between positive and negative groups and is less likely to produce false results. In conclusion, FDA-PRLSW was the most efficient PCR assay for Salmonella detection, and boil preparation was the best method for DNA extraction.
[Mh] Termos MeSH primário: Reação em Cadeia da Polimerase em Tempo Real
Syzygium
[Mh] Termos MeSH secundário: DNA Bacteriano
Microbiologia de Alimentos
Reação em Cadeia da Polimerase
Salmonella/genética
Sensibilidade e Especificidade
Sri Lanka
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-498


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[PMID]:29282046
[Au] Autor:Ranasinghe P; Jayawardena R; Pigera S; Wathurapatha WS; Weeratunga HD; Premakumara GAS; Katulanda P; Constantine GR; Galappaththy P
[Ad] Endereço:Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. priyanga.ranasinghe@gmail.com.
[Ti] Título:Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial.
[So] Source:BMC Complement Altern Med;17(1):550, 2017 Dec 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The present study aims to evaluate Pharmacodynamic properties and safety of CZ in healthy adults using a Phase I Clinical Trial. METHODS: This phase I clinical trial was conducted at the Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka. Thirty healthy adults were recruited for the study, conducted for a period of 3 months, with the dose of CZ (water extract) increased at monthly intervals (85 mg, 250 mg and 500 mg). Data collection was carried out at baseline and during each monthly follow up visit. Anthropometric, clinical and biochemical assessments were done at baseline and during follow up. Adverse effects and drug compliance was also evaluated. RESULTS: Twenty eight subjects completed the three months follow up. Mean age was 38.8 ± 10.4 years and 50% were males. There were no significant changes in the anthropometric parameters during the three months follow up. Both systolic and diastolic blood pressure reduced significant during the 1st month and this reduction was sustained throughout follow up. Full blood count, renal function tests, liver function tests, fasting blood glucose, HDL-c, VLDL-d and triglycerides remained within the normal range without any significant alteration during the 3 months. A significant reduction in the TC (p < 0.05) and LDL-c (p < 0.001) was noted at the end of the 3 months follow up period. There were no serious adverse effects (including hypersensitivity) noted. In two participants dyspepsia necessitated the discontinuation of study participation. Drug compliance was between 85 and 95% during the study period. CONCLUSIONS: This is the first phase I clinical trial in health adults evaluating efficacy and safety of CZ. Our results demonstrate no significant side effects and toxicity of CZ, including hepatotoxicity and anti-coagulation properties. CZ demonstrated beneficial anti-hyperlipidaemic and blood pressure lowering effects among healthy adults. Further studies with larger samples and longer durations may be able to elucidate other side effects and better describe the pharmacodynamic properties. TRIAL REGISTRATION: SLCTR/2013/001 (Sri Lanka Clinical Trials Registry: http://www.slctr.lk/trials/106 ) (Date of Registration: 01/01/2013).
[Mh] Termos MeSH primário: Cinnamomum zeylanicum
Extratos Vegetais/efeitos adversos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Adulto
Pressão Sanguínea/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Feminino
Seres Humanos
Masculino
Meia-Idade
Pulso Arterial
Sri Lanka
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2067-7


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[PMID]:28464868
[Au] Autor:Galgamuwa LS; Iddawela D; Dharmaratne SD; Galgamuwa GLS
[Ad] Endereço:Department of Parasitology, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka.
[Ti] Título:Nutritional status and correlated socio-economic factors among preschool and school children in plantation communities, Sri Lanka.
[So] Source:BMC Public Health;17(1):377, 2017 05 02.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Child malnutrition is a major public health concern worldwide, leading to higher morbidity and mortality. It is mostly preventable through public health and economic development. The aim of the present study was to determine socio-economic factors associated with nutritional status among children in plantation communities, Sri Lanka. METHODS: A cross-sectional study was performed among preschool and school going children in three rural communities of Sri Lanka from January to August 2014. Demographic and household characteristics were documented and anthropometric measurements were collected to calculate weight-for-age (WAZ), height-for-age (HAZ) and BMI-for-age (BAZ). Anthroplus, epiinfo and SPSS versions were used for the analysis of data. RESULTS: A total of 547 children (aged 1-15 years, mean 7.0 ± 3.6 years, 53% female) participated in the study. 35.6%, 26.9% and 32.9% of children were underweight, stunting and wasting respectively. Undernutrition was more common in primary school children. Maternal employment, high number of siblings, high birth orders and female children were significantly associated with undernutrition among preschool children. Living in small houses, large number of family members, low monthly income and maternal employment were significantly associated with undernutrition among school children. CONCLUSIONS: Child undernutrition is a major public health concern in the plantation sector, Sri Lanka. Health education programs among the study population could be effective for solving the problem.
[Mh] Termos MeSH primário: Transtornos da Nutrição Infantil/epidemiologia
População Rural
Magreza/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Ordem de Nascimento
Pesos e Medidas Corporais
Criança
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Masculino
Estado Nutricional
Fatores Socioeconômicos
Sri Lanka/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4311-y


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[PMID]:29182619
[Au] Autor:Dharmawardena P; Rodrigo C; Mendis K; de A W Gunasekera WMKT; Premaratne R; Ringwald P; Fernando D
[Ad] Endereço:Anti Malaria Campaign, Sri Lanka, Narahenpita, Colombo, Sri Lanka.
[Ti] Título:Response of imported malaria patients to antimalarial medicines in Sri Lanka following malaria elimination.
[So] Source:PLoS One;12(11):e0188613, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:After eliminating local malaria transmission and being certified as a malaria-free country, Sri Lanka is facing the challenge of imported malaria. At the same time, the country has the unique opportunity to be a case study for other countries in a similar situation by approaching this issue systematically, guided by evidence. This study demonstrates the importance of developing a mechanism to detect imported malaria and adopting an evidence-based approach to study the resistance of imported malaria to anti-malarial medicines. This is a prospective study of patients diagnosed with imported malaria in Sri Lanka and treated according to the national treatment guidelines, over 24 months (2015/2016). The clinical features, time to diagnosis, origin of the infection, infecting species, parasite density and the treatment given were recorded. All patients were followed up for 28 days, and in the case of Plasmodium vivax and P. ovale infections, the follow up period was extended to 12 months to establish treatment failures and relapses. Fifty nine uncomplicated and 15 severe imported malaria cases were reported in Sri Lanka during the study period. Most of these infections originated in either Sub-Saharan Africa or South and Southeast Asia. Having a P. vivax infection and low parasitic counts were significantly associated with relative diagnostic delay. One of the 14 uncomplicated P. falciparum patients and two of the 12 severe P. falciparum malaria patients who were followed up till day 28 had a late clinical failure. The others responded adequately to treatment both clinically and parasitologically. There was no treatment failure reported amongst any other species. This study, which is the first to assess the therapeutic response of imported malaria in Sri Lanka after elimination, demonstrates that the current antimalarial treatment policies and strategies in Sri Lanka have been effective against infections acquired overseas up until the end of year 2016.
[Mh] Termos MeSH primário: Antimaláricos/uso terapêutico
Malária/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Malária/prevenção & controle
Malária/transmissão
Masculino
Sri Lanka
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188613


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[PMID]:28867094
[Au] Autor:Silva KDRR; Sirasa MSF
[Ad] Endereço:Department of Applied Nutrition, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila 60170, Sri Lanka. Electronic address: renukasilva@gmail.com.
[Ti] Título:Antioxidant properties of selected fruit cultivars grown in Sri Lanka.
[So] Source:Food Chem;238:203-208, 2018 Jan 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Extracts of twenty locally available Sri Lankan fruits were analysed for 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferrous reducing antioxidant power (FRAP), total phenolic content (TPC), total flavonoid content (TFC) and vitamin C content. The results showed that gooseberry (Phyllanthus emblica 'local') exhibited the highest DPPH scavenging activity (111.25mg ascorbic acid equivalent antioxidant capacity (AEAC)/g), FRAP (1022.05µmol FeSO /g), TPC (915.7mg gallic acid equivalents (GAE)/100g), TFC (873.2mg catechin equivalents (CE)/100g) and vitamin C (136.8mg ascorbic acid equivalents (AAE)/100g), respectively. Sugar apple (Annona squamosa 'local') and star fruit (Averrhoa carambola 'Honey Sweet') obtained the second and third highest antioxidant activities in terms of rankings of FRAP, DPPH activities, TPC, TFC and vitamin C content. Strong correlation between vitamin C, TPC and TFC with FRAP and DPPH showed their contribution to antioxidant capacity. Among the selected fruits, underutilized fruit cultivar gooseberry showed the highest overall antioxidant potential.
[Mh] Termos MeSH primário: Frutas
[Mh] Termos MeSH secundário: Antioxidantes
Compostos de Bifenilo
Fenóis
Picratos
Extratos Vegetais
Sri Lanka
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE



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