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[PMID]: | 27959883 |
[Au] Autor: | Xiong L; Yan H; Shi L; Mo Z |
[Ad] Endereço: | School of Food Science and Technology, South China University of Technology, No. 381, Wushan Road, TianHe District, Guangzhou, Guangdong 510641, China. |
[Ti] Título: | Antibiotic susceptibility of Legionella strains isolated from public water sources in Macau and Guangzhou. |
[So] Source: | J Water Health;14(6):1041-1046, 2016 Dec. | [Is] ISSN: | 1477-8920 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | The purpose of this study was to investigate the susceptibility of waterborne strains of Legionella to eight antimicrobials commonly used in legionellosis therapy. The minimum inhibitory concentrations (MICs) of 66 environmental Legionella strains, isolated from fountains and cooling towers of public facilities (hotels, schools, and shopping malls) in Macau and Guangzhou, were tested using the microdilution method in buffered yeast extract broth. The MIC /MIC values for erythromycin, cefotaxime (CTX), doxycycline (DOC), minocycline (MIN), azithromycin, ciprofloxacin, levofloxacin (LEV), and moxifloxacin were 0.125/0.5 mg/L, 4/8 mg/L, 8/16 mg/L, 4/8 mg/L, 0.125/0.5 mg/L, 0.031/0.031 mg/L, 0.031/0.031 mg/L, and 0.031/0.062 mg/L, respectively. Legionella isolates were inhibited by either low concentrations of macrolides and fluoroquinolones, or high concentrations of CTX and tetracycline drugs. LEV was the most effective drug against different Legionella species and serogroups of L. pneumophila isolates. The latter were inhibited in decreasing order by MIN > CTX >DOC, while non-L. pneumophila isolates were inhibited by CTX> MIN >DOC. In this study, we evaluated drug resistance of pathogenic bacteria from the environment. This may help predict the emergence of drug resistance, improve patient outcomes, and reduce hospitalization costs. |
[Mh] Termos MeSH primário: |
Antibacterianos/farmacologia Água Potável/microbiologia Farmacorresistência Bacteriana Legionella/efeitos dos fármacos
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[Mh] Termos MeSH secundário: |
China Legionella pneumophila/efeitos dos fármacos Macau Testes de Sensibilidade Microbiana
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Anti-Bacterial Agents); 0 (Drinking Water) |
[Em] Mês de entrada: | 1703 |
[Cu] Atualização por classe: | 170323 |
[Lr] Data última revisão:
| 170323 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 161214 |
[St] Status: | MEDLINE |
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