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  1 / 16109 MEDLINE  
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[PMID]:28938223
[Au] Autor:Kim SY; Kim K; Hwang B; Im K; Park SN; Kim JA; Hwang SM; Bang D; Lee DS
[Ad] Endereço:Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Laboratory Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
[Ti] Título:The high frequency of the U2AF1 S34Y mutation and its association with isolated trisomy 8 in myelodysplastic syndrome in Asians, but not in Caucasians.
[So] Source:Leuk Res;61:96-103, 2017 Oct.
[Is] ISSN:1873-5835
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mutational profiles of 153 Korean myelodysplastic syndrome (MDS) patients were investigated. Sequencing of 87 genes presented similar mutational profiles in Korean MDS patients compared with previous reports. The most frequently mutated genes were ASXL1 (22.9%), U2AF1 (16.3%), TP53 (13.7%), RUNX1 (10.5%), TET2 (10.5%), DNMT3A (8.5%), and SRSF2 (8.5%). The U2AF1 mutation frequency was higher, with different frequencies in the mutated sites of U2AF1 (S34Y, 6/25; S34F, 11/25; and Q157P 8/25). The U2AF1 S34Y mutation was strongly associated with isolated trisomy 8 (5/6, 83%) and was characterized by a younger age of MDS onset (median, 39 years). The S34F mutation was associated with trisomy 8 (6/11, 55%) and del(20q) (3/11, 27%). Data from 10 literatures (total 3460 patients) of 229 U2AF1-mutated cases revealed a significant association between the S34Y and trisomy 8 in Asians (P=0.0001), but not in Caucasians (P=0.080). We infer that U2AF1 S34 mutations characterize a distinct subgroup of MDS: younger age of onset and differential associations with particular cytogenetic aberrations depending on specific mutations [S34Y to +8; S34F to +8 and del(20q)]. The impact and causal relationship between U2AF1 S34 and trisomy 8 need to be elucidated, which might contribute to design of tailored treatments.
[Mh] Termos MeSH primário: Síndromes Mielodisplásicas/genética
Fator de Processamento U2AF/genética
Trissomia/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Grupo com Ancestrais do Continente Asiático/genética
Cromossomos Humanos Par 8/genética
Análise Mutacional de DNA
Grupo com Ancestrais do Continente Europeu/genética
Feminino
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Hibridização in Situ Fluorescente
Estimativa de Kaplan-Meier
Coreia (Geográfico)
Masculino
Meia-Idade
Modelos de Riscos Proporcionais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Splicing Factor U2AF); 0 (U2AF1 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE


  2 / 16109 MEDLINE  
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[PMID]:28489802
[Au] Autor:Lee SH; Kim KM; Kim KN
[Ad] Endereço:Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Republic of Korea.
[Ti] Título:Combined effect of serum gamma-glutamyltransferase and uric acid on incidence of diabetes mellitus: A longitudinal study.
[So] Source:Medicine (Baltimore);96(19):e6901, 2017 May.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gamma-glutamyltransferase (GGT) and uric acid (UA) are novel diabetes risk factors. However, little is known about the combined effects of GGT and UA on the development of diabetes. Here, we assessed the combined effects of GGT and UA on the development of diabetes in a Korean population.We evaluated 1983 women and 2687 men without diabetes. From the baseline health screening to the follow-up examination, the development of diabetes, based on changes in GGT and UA quartile levels, was analyzed. Furthermore, the quartile of GGT and quartile of UA were analyzed together to determine any synergistic effect from the 4th quartile of GGT and UA on the development of diabetes.In women, the development of diabetes gradually increased with an increase in the circulating levels of GGT and UA. For the highest quartile of GGT and UA, hazard ratios of diabetes compared with the lowest quartile were 3.88 (95% confidence interval [CI]: 1.12-13.43, P = .032) and 7.58 (95% CI: 2.17-26.42, P = .002) after adjusting for confounders, respectively. Hazard ratios of diabetes after combining both 4th quartiles of GGT and UA were 5.29 (95% CI: 1.87-15.18, P = .002), as compared with the first and second quartiles. In men, however, the development of diabetes was not significantly different among the quartiles of UA.GGT and UA levels can synergize in predicting the development of diabetes in Korean women.
[Mh] Termos MeSH primário: Diabetes Mellitus/sangue
Ácido Úrico/sangue
gama-Glutamiltransferase/sangue
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Análise Química do Sangue
Diabetes Mellitus/epidemiologia
Feminino
Seguimentos
Seres Humanos
Incidência
Coreia (Geográfico)
Estudos Longitudinais
Masculino
Menopausa/sangue
Meia-Idade
Prognóstico
Modelos de Riscos Proporcionais
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 268B43MJ25 (Uric Acid); EC 2.3.2.2 (gamma-Glutamyltransferase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006901


  3 / 16109 MEDLINE  
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[PMID]:28445591
[Au] Autor:Woo Y; Behrendt CE; Trapp G; Hyun JG; Gonda T; Fong Y; Wang T
[Ad] Endereço:Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California.
[Ti] Título:Screening endoscopy finds high prevalence of Helicobacter pylori and intestinal metaplasia in Korean American with limited access to health care.
[So] Source:J Surg Oncol;116(2):172-176, 2017 Aug.
[Is] ISSN:1096-9098
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gastric cancer (GC) is the leading cause of cancer death among Korean Americans. Prevention and early detection is improved by screening. METHODS: Between September 2013 and March 2015, ethnic Koreans age 40 or older without history or symptoms of GC and without upper endoscopy (UE) during previous 3 years were enrolled. Participants were offered screening with GC risk assessment followed by UE with biopsies. RESULTS: Risk assessment was provided to 146 participants (age 55.6 ± 8.3 years; 52.1% female; 92.5% uninsured), of whom 99 (67.8%) returned for UE. Undergoing UE was independently associated with family history of GC (OR 12.33, 95% CI:1.52-100.17), being a former smoker (6.68,1.42-31.32), and Hp-negative status (0.25,0.11-0.57). Among UE recipients, half (49.5%) had intestinal metaplasia (IM) only (n = 24), Hp only (n = 12), or both (n = 13). No case of GC was found. Adjusted for age, IM was independently associated with male sex (2.89,1.12-7.42), current Hp (2.90,0.99-8.51), unmarried status (single or divorced) (4.23,1.23-14.56). CONCLUSIONS: High prevalence of risk factors associated with gastric carcinogenesis including Hp infection and IM exists in Korean Americans who underwent upper endoscopic screening. Acceptance of GC screening is informed by personal risk factors. These findings support the need to improve access to screening UE among KAs.
[Mh] Termos MeSH primário: Americanos Asiáticos
Endoscopia Gastrointestinal
Acesso aos Serviços de Saúde
Infecções por Helicobacter/diagnóstico
Intestinos/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Doença Crônica
Feminino
Gastrite/diagnóstico
Gastrite/epidemiologia
Helicobacter pylori
Seres Humanos
Coreia (Geográfico)/etnologia
Masculino
Metaplasia
Meia-Idade
New Jersey/epidemiologia
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1002/jso.24622


  4 / 16109 MEDLINE  
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[PMID]:28437658
[Au] Autor:Kim SY; Liu L; Cao F
[Ad] Endereço:Department of Psychology, National University of Singapore, Singapore; Department of English Language and Literature, Sejong University, Seoul, Korea.
[Ti] Título:How does first language (L1) influence second language (L2) reading in the brain? Evidence from Korean-English and Chinese-English bilinguals.
[So] Source:Brain Lang;171:1-13, 2017 Aug.
[Is] ISSN:1090-2155
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To examine how L1 influences L2 reading in the brain, two late bilingual groups, Korean-English (KE) and Chinese-English (CE), performed a visual word rhyming judgment task in their L2 (English) and were compared to L1 control groups (i.e., KK and CC). The results indicated that the L2 activation is similar to the L1 activation for both KE and CE language groups. In addition, conjunction analyses revealed that the right inferior frontal gyrus and medial frontal gyrus were more activated in KK and KE than CC and CE, suggesting that these regions are more involved in Korean speakers than Chinese speakers for both L1 and L2. Finally, an ROI analysis at the left middle frontal gyrus revealed greater activation for CE than for KE and a positive correlation with accuracy in CE, but a negative correlation in KE. Taken together, we found evidence that important brain regions for L1 are carried over to L2 reading, maybe more so in highly proficient bilinguals.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Multilinguismo
Leitura
[Mh] Termos MeSH secundário: Fatores Etários
Mapeamento Encefálico
China/etnologia
Inglaterra
Feminino
Lobo Frontal/fisiologia
Seres Humanos
Coreia (Geográfico)/etnologia
Imagem por Ressonância Magnética
Masculino
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  5 / 16109 MEDLINE  
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[PMID]:28432484
[Au] Autor:Yoon SH; Kim J; Shin D; Cho S; Kwak W; Lee HK; Park KD; Kim H
[Ad] Endereço:Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-742, Republic of Korea.
[Ti] Título:Complete mitochondrial genome sequences of Korean native horse from Jeju Island: uncovering the spatio-temporal dynamics.
[So] Source:Mol Biol Rep;44(2):233-242, 2017 Apr.
[Is] ISSN:1573-4978
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The Korean native horse (Jeju horse) is one of the most important animals in Korean historical, cultural, and economical viewpoints. In the early 1980s, the Jeju horse was close to extinction. The aim of this study is to explore the phylogenomics of Korean native horse focusing on spatio-temporal dynamics. We determined complete mitochondrial genome sequences for the first Korean native (n = 6) and additional Mongolian (n = 2) horses. Those sequences were analyzed together with 143 published ones using Bayesian coalescent approach as well as three different phylogenetic analysis methods, Bayesian inference, maximum likelihood, and neighbor-joining methods. The phylogenomic trees revealed that the Korean native horses had multiple origins and clustered together with some horses from four European and one Middle Eastern breeds. Our phylogenomic analyses also supported that there was no apparent association between breed or geographic location and the evolution of global horses. Time of the most recent common ancestor of the Korean native horse was approximately 13,200-63,200 years, which was much younger than 0.696 My of modern horses. Additionally, our results showed that all global horse lineages including Korean native horse existed prior to their domestication events occurred in about 6000-10,000 years ago. This is the first study on phylogenomics of the Korean native horse focusing on spatio-temporal dynamics. Our findings increase our understanding of the domestication history of the Korean native horses, and could provide useful information for horse conservation projects as well as for horse genomics, emergence, and the geographical distribution.
[Mh] Termos MeSH primário: Cavalos/genética
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Evolução Biológica
Cruzamento
DNA Mitocondrial/genética
Genoma Mitocondrial/genética
Coreia (Geográfico)
Mitocôndrias/genética
Filogenia
Filogeografia/métodos
Análise de Sequência de DNA/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE
[do] DOI:10.1007/s11033-017-4101-8


  6 / 16109 MEDLINE  
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[PMID]:28423504
[Au] Autor:Choi JH; Lee J; Oh JH; Chang HJ; Sohn DK; Shin A; Kim J
[Ad] Endereço:Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Korea.
[Ti] Título:Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans.
[So] Source:Oncotarget;8(13):21253-21265, 2017 Mar 28.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bitterness perception is known to be an important factor in individuals' dietary behaviors and is also associated with the sensing of nutritious/noxious molecules for subsequent metabolic responses in multiple organs. Therefore, the genetic variation in bitterness sensing may be associated with diet-related diseases, including colorectal cancer (CRC). We investigated the influence of variations in the bitterness-sensing genes taste receptor type 2 member 38 (TAS2R38) and carbonic anhydrase 6 (CA6) on the consumption of food, tobacco and alcohol and the risk of CRC in Koreans. The study population consisted of 681 cases and 1361 controls, and their intake of vegetables, fruits, fiber, fat-food and sweets was analyzed. The genotypes for TAS2R38 A49P, V262A and I296V and CA6 rs2274333 A/G were assessed using the MassArray technique. Our findings suggested that the TAS2R38 diplotype, CA6 rs2274333 and their combined genotype had a negligible influence on dietary and alcohol intake. The combined TAS2R38-CA6 AVI/AVI-AA genotype was associated with higher tobacco consumption than the other genotypes in CRC cases only. However, the genetic variations were a significant risk factor for CRC. The TAS2R38 AVI/AVI diplotype and CA6 G allele were associated with a reduced risk of CRC. Moreover, when the combined genotypes of the subjects were analyzed, possessing both the variant diplotype/variant allele (AVI/AVI+G*) was associated with a greater reduction in the risk of CRC (adjusted OR = 0.49; 95%CI: 0.34-0.74). In summary, variations in the bitterness perception genes TAS2R38 and CA6 did not influence the examined food intake in Koreans. However, those genetic variants were a decisive modifying factor of CRC susceptibility.
[Mh] Termos MeSH primário: Anidrases Carbônicas/genética
Neoplasias Colorretais/genética
Predisposição Genética para Doença/genética
Receptores Acoplados a Proteínas-G/genética
Paladar/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Grupo com Ancestrais do Continente Asiático/genética
Dieta
Feminino
Genótipo
Seres Humanos
Coreia (Geográfico)
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, G-Protein-Coupled); 0 (taste receptors, type 2); EC 4.2.1.1 (Carbonic Anhydrases); EC 4.2.1.1 (carbonic anhydrase VI)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15512


  7 / 16109 MEDLINE  
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[PMID]:28395568
[Au] Autor:Shin DH; Kim YS; Yoo DS; Kim MJ; Oh CS; Hong JH; Lee E; Chai JY; Seo M
[Ad] Endereço:Bioanthropology and Paleopathology Lab, Institute of Forensic Science, Seoul National University College of Medicine, 103 Daehak-ro (Yongon-dong), Jongno-gu, Seoul 03080, South Korea. Correspondence should be sent to M. Seo at: bbbenji@naver.com.
[Ti] Título:A Case of Ectopic Paragonimiasis in a 17th Century Korean Mummy.
[So] Source:J Parasitol;103(4):399-403, 2017 Aug.
[Is] ISSN:1937-2345
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Archaeoparasitological studies on fossilized feces obtained from Joseon Dynasty (1392-1910 CE) mummies have provided invaluable data on the patterns of parasitic infection in pre-modern Korean societies. In our recent radiological investigation of a 17th century Joseon mummy discovered in Cheongdo (South Korea), we located a liver mass just below the diaphragm. Anatomical dissection confirmed the presence of a mass of unknown etiology. A subsequent parasitological examination of a sample of the mass revealed a large number of ancient Paragonimus sp. eggs, making the current report the first archaeoparasitological case of liver abscess caused by ectopic paragonimiasis.
[Mh] Termos MeSH primário: Múmias/parasitologia
Paragonimíase/história
[Mh] Termos MeSH secundário: Animais
Autopsia
História do Século XVII
Seres Humanos
Coreia (Geográfico)
Fígado/diagnóstico por imagem
Fígado/parasitologia
Fígado/patologia
Masculino
Meia-Idade
Paragonimíase/diagnóstico por imagem
Paragonimíase/patologia
Paragonimus/isolamento & purificação
República da Coreia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1645/16-63


  8 / 16109 MEDLINE  
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[PMID]:28380021
[Au] Autor:Wei LH; Yan S; Teo YY; Huang YZ; Wang LX; Yu G; Saw WY; Ong RT; Lu Y; Zhang C; Xu SH; Jin L; Li H
[Ad] Endereço:MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
[Ti] Título:Phylogeography of Y-chromosome haplogroup O3a2b2-N6 reveals patrilineal traces of Austronesian populations on the eastern coastal regions of Asia.
[So] Source:PLoS One;12(4):e0175080, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Austronesian diffusion is considered one of the greatest dispersals in human history; it led to the peopling of an extremely vast region, ranging from Madagascar in the Indian Ocean to Easter Island in Remote Oceania. The Y-chromosome haplogroup O3a2b*-P164(xM134), a predominant paternal lineage of Austronesian populations, is found at high frequencies in Polynesian populations. However, the internal phylogeny of this haplogroup remains poorly investigated. In this study, we analyzed -seventeen Y-chromosome sequences of haplogroup O3a2b*-P164(xM134) and generated a revised phylogenetic tree of this lineage based on 310 non-private Y-chromosome polymorphisms. We discovered that all available O3a2b*-P164(xM134) samples belong to the newly defined haplogroup O3a2b2-N6 and samples from Austronesian populations belong to the sublineage O3a2b2a2-F706. Additionally, we genotyped a series of Y-chromosome polymorphisms in a large collection of samples from China. We confirmed that the sublineage O3a2b2a2b-B451 is unique to Austronesian populations. We found that O3a2b2-N6 samples are widely distributed on the eastern coastal regions of Asia, from Korea to Vietnam. Furthermore, we propose- that the O3a2b2a2b-B451 lineage represents a genetic connection between ancestors of Austronesian populations and ancient populations in North China, where foxtail millet was domesticated about 11,000 years ago. The large number of newly defined Y-chromosome polymorphisms and the revised phylogenetic tree of O3a2b2-N6 will be helpful to explore the origin of proto-Austronesians and the early diffusion process of Austronesian populations.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Cromossomos Humanos Y/genética
Grupo com Ancestrais Oceânicos/genética
[Mh] Termos MeSH secundário: China
Técnicas de Genotipagem
Haplótipos/genética
História Antiga
Migração Humana/história
Seres Humanos
Coreia (Geográfico)
Masculino
Filogeografia
Polimorfismo Genético/genética
Vietnã
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175080


  9 / 16109 MEDLINE  
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[PMID]:28336134
[Au] Autor:Park JH; Shin JH; Choi MJ; Choi JU; Park YJ; Jang SJ; Won EJ; Kim SH; Kee SJ; Shin MG; Suh SP
[Ad] Endereço:Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
[Ti] Título:Evaluation of matrix-assisted laser desorption/ionization time-of-fight mass spectrometry for identification of 345 clinical isolates of Aspergillus species from 11 Korean hospitals: comparison with molecular identification.
[So] Source:Diagn Microbiol Infect Dis;87(1):28-31, 2017 Jan.
[Is] ISSN:1879-0070
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We evaluated the ability of the Filamentous Fungi Library 1.0 of the MALDI-TOF MS Biotyper system to identify 345 clinical Aspergillus isolates from 11 Korean hospitals. Compared with results of the internal transcribed spacer region sequencing, the frequencies of correct identification at the species-complex level were 94.5% and 98.8% with cutoff values of 2.0 and 1.7, respectively. Compared with results of ß-tubulin gene sequencing, the frequencies of correct identification at the species level were 96.0% (cutoff 2.0) and 100% (cutoff 1.7) for 303 Aspergillus isolates of five common, non-cryptic species, but only 4.8% (cutoff 1.7) and 0% (cutoff 2.0) for 42 Aspergillus isolates of six cryptic species (identifiable by ß-tubulin or calmodulin sequencing). These results show that the MALDI Biotyper using the Filamentous Fungi Library version 1.0 enables reliable identification of the majority of common clinical Aspergillus isolates, although the database should be expanded to facilitate identification of cryptic species.
[Mh] Termos MeSH primário: Aspergilose/diagnóstico
Aspergillus/isolamento & purificação
Técnicas de Diagnóstico Molecular/métodos
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Aspergillus/química
Aspergillus/genética
DNA Espaçador Ribossômico/química
DNA Espaçador Ribossômico/genética
Hospitais
Seres Humanos
Coreia (Geográfico)
Sensibilidade e Especificidade
Análise de Sequência de DNA
Tubulina (Proteína)/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal Spacer); 0 (Tubulin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


  10 / 16109 MEDLINE  
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[PMID]:28329071
[Au] Autor:Kim H; Thomas RJ; Yun CH; Au R; Lee SK; Lee S; Shin C
[Ad] Endereço:Department of Psychological and Brain Sciences, Boston University.
[Ti] Título:Association of Mild Obstructive Sleep Apnea With Cognitive Performance, Excessive Daytime Sleepiness, and Quality of Life in the General Population: The Korean Genome and Epidemiology Study (KoGES).
[So] Source:Sleep;40(5), 2017 May 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study Objectives: Research points to impaired cognitive performance in sleep clinic patients with obstructive sleep apnea (OSA). However, inconsistent findings from various epidemiologic studies make this relationship less generalizable. The current study investigated the association between OSA and functional outcome measures, such as cognition, daytime sleepiness, and quality of life, in a Korean general population sample. Methods: A total of 1492 participants from the Korean Genome and Epidemiology Study (KoGES) were included in the analyses. The presence of OSA measured by overnight polysomnography (PSG) was defined by apnea-hypopnea index (AHI) >5. Cognitive performance was determined with scores from a comprehensive neuropsychological battery. Excessive daytime sleepiness and quality of life were additionally measured through subjective reports. Results: After adjusting for various demographic and medical characteristics, OSA was independently associated with lower performance in the Digit Symbol Test (52.73 ± 17.08 vs. 58.72 ± 18.03, OSA vs. not, p = .02). Hypoxia measures were not related to cognitive performance. OSA was associated with higher odds of displaying excessive daytime sleepiness (odds ratio = 1.72, 95% CI: 1.05-2.80), but there was no significant relationship between OSA and quality of life. Conclusions: Cognition was unexpectedly unaffected overall. However, OSA was associated with impairment in a multidomain test that taps skills generally associated with frontal lobe function. The results suggest that research on protective and adaptive brain mechanisms to OSA stress can provide unique insights into the brain-sleep interface. As the study runs longitudinally, it will enable future studies on the impact of OSA on cognitive decline.
[Mh] Termos MeSH primário: Cognição/fisiologia
Genoma Humano
Qualidade de Vida
Apneia Obstrutiva do Sono/fisiopatologia
Apneia Obstrutiva do Sono/psicologia
Fases do Sono/fisiologia
[Mh] Termos MeSH secundário: Feminino
Lobo Frontal/fisiologia
Seres Humanos
Coreia (Geográfico)/epidemiologia
Masculino
Meia-Idade
Razão de Chances
Polissonografia
Apneia Obstrutiva do Sono/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsx012



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