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[PMID]:28466244
[Au] Autor:Leysens G; Vlaeyen E; Vanaken D; Janssens E; Dejaeger E; Cambier D; Gielen E; Goemaere S; Vandeput O; Milisen K
[Ad] Endereço:Expertisecentrum Val- en fractuurpreventie Vlaanderen, Leuven, België. greet.leysens@kuleuven.be.
[Ti] Título:[The use of fall prevention strategies in home care: a survey in Flanders].
[Ti] Título:Het toepassen van valpreventiemaatregelen bij thuiswonende ouderen: een survey onderzoek in Vlaanderen..
[So] Source:Tijdschr Gerontol Geriatr;48(3):121-133, 2017 Jun.
[Is] ISSN:0167-9228
[Cp] País de publicação:Netherlands
[La] Idioma:dut
[Ab] Resumo:OBJECTIVES: Falls in community-dwelling older persons occur frequently. The consequences emphasize the need to screen systematically for an increased fall risk and a targeted multifactorial and multidisciplinary approach. This study describes the extent to which fall prevention strategies are applied by primary healthcare workers in Flanders. Insight in barriers is provided. METHOD: An online survey was collected by the Centre of Expertise for Falls and fracture Prevention Flanders. RESULTS: 1483 respondents are included. 93% are confronted monthly with falls. 96% believe they can make a positive contribution to fall prevention. At least once a year, respondents inquire about falls (62%) and screen for gait/balance problems (84%). A multifactorial assessment is performed in case of a recent fall (95%) or an increased fall risk (76%). Most frequently respondents give advice on safe environment/behaviour (93%), walking aid (91%), personal alarm system (89%) and footwear (85%). Unmotivated older persons (75%) who ignore their fall risk (85%), insufficient time (60%), financial compensation (54%), staff (50%), communication (31%) and knowledge (23%) are important barriers. CONCLUSIONS: Although respondents are aware of the importance of fall prevention, these results reveal a necessity of sufficient knowledge, structured multidisciplinary cooperation and a clear policy. Raising awareness of older persons remains crucial.
[Mh] Termos MeSH primário: Acidentes por Quedas/prevenção & controle
Serviços de Assistência Domiciliar
Medição de Risco
[Mh] Termos MeSH secundário: Acidentes por Quedas/estatística & dados numéricos
Atividades Cotidianas
Idoso
Idoso de 80 Anos ou mais
Bélgica
Feminino
Seres Humanos
Masculino
Fatores de Risco
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s12439-017-0215-7


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[PMID]:29398044
[Au] Autor:Cinelli G; Tondeur F; Dehandschutter B
[Ad] Endereço:European Commission, Joint Research Centre, Directorate G, Nuclear Safety & Security, Via Enrico Fermi 2749, I-21027 Ispra, VA, Italy. Electronic address: giorgia.cinelli@ec.europa.eu.
[Ti] Título:Mapping potassium and thorium concentrations in Belgian soils.
[So] Source:J Environ Radioact;184-185:127-139, 2018 Apr.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The European Atlas of Natural Radiation developed by the Joint Research Centre (JRC) of the European Commission includes maps of potassium K and thorium Th. With several different databases available, including data (albeit not calibrated) from an airborne survey, Belgium is a favourable case for exploring the methodology of mapping for these natural radionuclides. Harmonized databases of potassium and thorium in soil were built by radiological (not airborne) and geochemical data. Using this harmonized database it was possible to calibrate the data from the airborne survey. Several methods were used to perform spatial interpolation and to smooth the data: moving average (MA) without constraint, or constrained by soil class and by geological unit. Overall, there was a reasonable agreement between the maps on a 1 × 1 km grid obtained with the two datasets (airborne data and harmonized soil data) with all the methods. The agreement was better when the maps are reduced to a 10 km × 10 km grid used for the European Atlas of Natural Radiation. The best agreement was observed with the MA constrained by geological unit.
[Mh] Termos MeSH primário: Radioisótopos de Potássio/análise
Monitoramento de Radiação
Poluentes Radioativos do Solo/análise
Tório/análise
[Mh] Termos MeSH secundário: Bélgica
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Potassium Radioisotopes); 0 (Soil); 0 (Soil Pollutants, Radioactive); 60YU5MIG9W (Thorium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE


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[PMID]:27771245
[Au] Autor:Dols A; Bouckaert F; Sienaert P; Rhebergen D; Vansteelandt K; Ten Kate M; de Winter FL; Comijs HC; Emsell L; Oudega ML; van Exel E; Schouws S; Obbels J; Wattjes M; Barkhof F; Eikelenboom P; Vandenbulcke M; Stek ML
[Ad] Endereço:Department of Old Age Psychiatry, GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands; EMGO+ Institute of Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: a.dols@ggzingeest.nl.
[Ti] Título:Early- and Late-Onset Depression in Late Life: A Prospective Study on Clinical and Structural Brain Characteristics and Response to Electroconvulsive Therapy.
[So] Source:Am J Geriatr Psychiatry;25(2):178-189, 2017 Feb.
[Is] ISSN:1545-7214
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The clinical profile of late-life depression (LLD) is frequently associated with cognitive impairment, aging-related brain changes, and somatic comorbidity. This two-site naturalistic longitudinal study aimed to explore differences in clinical and brain characteristics and response to electroconvulsive therapy (ECT) in early- (EOD) versus late-onset (LOD) late-life depression (respectively onset <55 and ≥55 years). METHODS: Between January 2011 and December 2013, 110 patients aged 55 years and older with ECT-treated unipolar depression were included in The Mood Disorders in Elderly treated with ECT study. Clinical profile and somatic health were assessed. Magnetic resonance imaging (MRI) scans were performed before the first ECT and visually rated. RESULTS: Response rate was 78.2% and similar between the two sites but significantly higher in LOD compared with EOD (86.9 versus 67.3%). Clinical, somatic, and brain characteristics were not different between EOD and LOD. Response to ECT was associated with late age at onset and presence of psychotic symptoms and not with structural MRI characteristics. In EOD only, the odds for a higher response were associated with a shorter index episode. CONCLUSION: The clinical profile, somatic comorbidities, and brain characteristics in LLD were similar in EOD and LOD. Nevertheless, patients with LOD showed a superior response to ECT compared with patients with EOD. Our results indicate that ECT is very effective in LLD, even in vascular burdened patients.
[Mh] Termos MeSH primário: Idade de Início
Encéfalo/patologia
Transtorno Depressivo/diagnóstico por imagem
Transtorno Depressivo/terapia
Eletroconvulsoterapia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Bélgica
Feminino
Seres Humanos
Modelos Logísticos
Estudos Longitudinais
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Análise Multivariada
Países Baixos
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29297218
[Au] Autor:Musajo-Somma A
[Ti] Título:Vesalius, What have you to do with Pontus?
[So] Source:Vesalius;22(2 Suppl):67-75, 2016 Dec.
[Is] ISSN:1373-4857
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:The challenge to dig in the interplayed aspects linking the Pontus area to the innovative Flemish anatomist Andreas Vesalius (1514-1564) is offered by many suggestions and figures language of metaphor, as well as artistic expressions drawn in this "papers" coupled with moments of his personal and professional life.
[Mh] Termos MeSH primário: Anatomistas/história
Colchicum
Livros de Texto como Assunto/história
[Mh] Termos MeSH secundário: Bélgica
República da Geórgia
História do Século XVI
Federação Russa
Ucrânia
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Vesalius A; Pare A
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


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[PMID]:29283523
[Au] Autor:Zanchin G
[Ti] Título:Guest Editorial
[So] Source:Vesalius;22(1):3-5, 2016 Jun.
[Is] ISSN:1373-4857
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Mh] Termos MeSH primário: Anatomia/história
Médicos/história
[Mh] Termos MeSH secundário: Bélgica
História do Século XVI
Seres Humanos
Itália
[Pt] Tipo de publicação:BIOGRAPHY; CONGRESSES; EDITORIAL; HISTORICAL ARTICLE
[Ps] Nome de pessoa como assunto:Vesalius A
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


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[PMID]:29283530
[Au] Autor:Dirix T
[Ti] Título:Andreas Vesalius and his hoaxes, con variazioni.
[So] Source:Vesalius;22(1):103-111, 2016 Jun.
[Is] ISSN:1373-4857
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:Andreas Vesalius's popularity increases with every anniversary. The commemorations in 2014/2015, the quincentenary of his birth, were no exception and may mark the turning point in Vesalius research. Hoaxes surrounding the life and death of this famed anatomist, some of which have survived despite strong counter-evidence published some fifty, and even one hundred, years ago are finally dying out, while new myths are swiftly nipped in the bud thanks to today's speed of publication and communication.
[Mh] Termos MeSH primário: Anatomistas/história
Anatomia/história
Decepção
[Mh] Termos MeSH secundário: Bélgica
História do Século XVI
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Vesalius A
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


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[PMID]:28452061
[Au] Autor:Hens B; Van Den Abeele J; Rubbens J; Keirsebilck M; Roelens J; Schreurs C; Verheyen K; Casteels M; Laekeman G; Augustijns P
[Ad] Endereço:Drug Delivery and Disposition, KU Leuven, O&N2, Leuven, Belgium.
[Ti] Título:Evaluation of real-life dosing of oral medicines with respect to fluid and food intake in a Dutch-speaking population.
[So] Source:J Clin Pharm Ther;42(4):467-474, 2017 Aug.
[Is] ISSN:1365-2710
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:WHAT IS KNOWN AND OBJECTIVE: Oral drug administration is the most preferred route of drug administration. For some specific classes of drugs, recommendations regarding the intake of the drug product are provided by and approved in the summary of product characteristics (SmPC) after testing the oral drug product in clinical trials under strict and predefined conditions. The aim of this study was to investigate how certain classes of medicines are taken in a "real-life" setting in terms of concomitant fluid and food intake by a Dutch-speaking population in Flanders (Belgium). The outcome of this study was comprehensively discussed with literature data to evaluate the positive or negative consequences of their drug intake in daily life. METHODS: A retrospective and non-interventional study was set up by means of questionnaires completed by two different groups: children (ie 0-15 years) and (young) adults (ie 16 years and older). RESULTS AND DISCUSSION: In children, the co-administered volume increases with age because of a gradual switch from liquids to solid dosage forms. In adults, water was the most selected co-administered fluid and the preferred volume of intake was a half glass of liquid. WHAT IS NEW AND CONCLUSION: Results of the surveys clearly indicated that the majority of all participants took their medication with a sip or half glass of water. However, this was not the case for the youngest children, as their preferred formulations were liquids (eg solutions, suspensions) which do not require any extra intake of liquid. In the case of specific classes of drugs, real-life intake can still be improved, suggesting that the pharmacist's advice has an important influence on their administration of medicines.
[Mh] Termos MeSH primário: Ingestão de Líquidos
Ingestão de Alimentos
Preparações Farmacêuticas/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Adolescente
Adulto
Fatores Etários
Bélgica
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Educação de Pacientes como Assunto/métodos
Farmacêuticos/organização & administração
Estudos Retrospectivos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/jcpt.12535


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[PMID]:29187511
[Au] Autor:Veltri F; Kleynen P; Grabczan L; Salajan A; Rozenberg S; Pepersack T; Poppe K
[Ad] Endereço:Endocrine UnitCentre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium.
[Ti] Título:Pregnancy outcomes are not altered by variation in thyroid function within the normal range in women free of thyroid disease.
[So] Source:Eur J Endocrinol;178(2):191-199, 2018 Feb.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: In the recently revised guidelines on the management of thyroid dysfunction during pregnancy, treatment with thyroid hormone (LT4) is not recommended in women without thyroid autoimmunity (TAI) and TSH levels in the range 2.5-4.0 mIU/L, and in a recent study in that particular group of pregnant women, more complications were observed when a treatment with LT4 was given. The objective of the study was therefore to investigate whether variation in thyroid function within the normal (non-pregnant) range in women free of thyroid disease was associated with altered pregnancy outcomes? DESIGN: Cross-sectional data analysis of 1321 pregnant women nested within an ongoing prospective collection of pregnant women's data in a single centre in Brussels, Belgium. METHODS: Thyroid peroxidase antibodies (TPO-abs), thyroid-stimulating hormone (TSH), free T4 (FT4) and ferritin levels were measured and baseline characteristics were recorded. Women taking LT4, with TAI and thyroid function outside the normal non-pregnant range were excluded. Pregnancy outcomes and baseline characteristics were correlated with all TSH and FT4 levels within the normal range and compared between two groups (TSH cut-off < and ≥2.5 mIU/L). RESULTS: Tobacco use was associated with higher serum TSH levels (OR: 1.38; CI 95%: 1.08-1.74); = 0.009. FT4 levels were inversely correlated with age and BMI (rho = -0.096 and -0.089; < 0.001 and 0.001 respectively) and positively correlated with ferritin levels (rho = 0.097; < 0.001). Postpartum haemorrhage (>500 mL) was inversely associated with serum FT4 levels (OR: 0.35; CI 95%: 0.13-0.96); = 0.040. Also 10% of women free of thyroid disease had serum TSH levels ≥2.5 mIU/L. CONCLUSIONS: Variation in thyroid function during the first trimester within the normal (non-pregnant) range in women free of thyroid disease was not associated with altered pregnancy outcomes. These results add evidence to the recommendation against LT4 treatment in pregnant women with high normal TSH levels and without TPO antibodies.
[Mh] Termos MeSH primário: Resultado da Gravidez
Glândula Tireoide/fisiologia
[Mh] Termos MeSH secundário: Fatores Etários
Bélgica
Índice de Massa Corporal
Estudos Transversais
Feminino
Seres Humanos
Hemorragia Pós-Parto/sangue
Guias de Prática Clínica como Assunto
Gravidez
Primeiro Trimestre da Gravidez
Estudos Prospectivos
Valores de Referência
Tireotropina/sangue
Tiroxina/administração & dosagem
Tiroxina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9002-71-5 (Thyrotropin); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0628


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[PMID]:29216206
[Au] Autor:De Bruyn S; Wouters E; Ponnet K; Van Damme J; Van Hal G; Task Force substance use in Flemish universities and colleges
[Ad] Endereço:Department of Sociology, University of Antwerp, Antwerp, Belgium.
[Ti] Título:The psychometric properties of a shortened Dutch version of the consequences scale used in the Core Alcohol and Drug Survey.
[So] Source:PLoS One;12(12):e0187876, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Alcohol and drug misuse among college students has been studied extensively and has been clearly identified as a public health problem. Within more general populations alcohol misuse remains one of the leading causes of disease, disability and death worldwide. Conducting research on alcohol misuse requires valid and reliable instruments to measure its consequences. One scale that is often used is the consequences scale in the Core Alcohol and Drug Survey (CADS). However, psychometric studies on the CADS are rare and the ones that do exist report varying results. This article aims to address this imbalance by examining the psychometric properties of a Dutch version of the CADS in a large sample of Flemish university and college students. METHODS: The analyses are based on data collected by the inter-university project 'Head in the clouds', measuring alcohol use among students. In total, 19,253 students participated (22.1% response rate). The CADS scale was measured using 19 consequences, and participants were asked how often they had experienced these on a 6-point scale. Firstly, the factor structure of the CADS was examined. Two models from literature were compared by performing confirmatory factor analyses (CFA) and were adapted if necessary. Secondly, we assessed the composite reliability as well as the convergent, discriminant and concurrent validity. RESULTS: The two-factor model, identifying personal consequences (had a hangover; got nauseated or vomited; missed a class) and social consequences (got into an argument or fight; been criticized by someone I know; done something I later regretted; been hurt or injured) was indicated to be the best model, having both a good model fit and an acceptable composite reliability. In addition, construct validity was evaluated to be acceptable, with good discriminant validity, although the convergent validity of the factor measuring 'social consequences' could be improved. Concurrent validity was evaluated as good. CONCLUSIONS: In deciding which model best represents the data, it is crucial that not only the model fit is evaluated, but the importance of factor reliability and validity issues is also taken into account. The two-factor model, identifying personal consequences and social consequences, was concluded to be the best model. This shortened Dutch version of the CADS (CADS_D) is a useful tool to screen alcohol-related consequences among college students.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas
Psicometria
Transtornos Relacionados ao Uso de Substâncias
[Mh] Termos MeSH secundário: Adolescente
Adulto
Bélgica
Análise Fatorial
Feminino
Seres Humanos
Masculino
Reprodutibilidade dos Testes
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187876


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[PMID]:28449647
[Au] Autor:Yang WY; Petit T; Cauwenberghs N; Zhang ZY; Sheng CS; Thijs L; Salvi E; Izzi B; Vandenbriele C; Wei FF; Gu YM; Jacobs L; Citterio L; Delli Carpini S; Barlassina C; Cusi D; Hoylaerts MF; Verhamme P; Kuznetsova T; Staessen JA
[Ad] Endereço:Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences,, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Box 7001, BE-3000, Leuven, Belgium.
[Ti] Título:PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.
[So] Source:BMC Med Genet;18(1):45, 2017 04 27.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Platelet Endothelial Aggregation Receptor 1 (PEAR1), a membrane protein highly expressed in platelets and endothelial cells, plays a role in platelet contact-induced activation, sustained platelet aggregation and endothelial function. Previous reports implicate PEAR1 rs12041331 as a variant influencing risk in patients with coronary heart disease. We investigated whether genetic variation in PEAR1 predicts cardiovascular outcome in a white population. METHODS: In 1938 participants enrolled in the Flemish Study on Environment, Genes and Health Outcomes (51.3% women; mean age 43.6 years), we genotyped 9 tagging SNPs in PEAR1, measured baseline cardiovascular risk factors, and recorded Cardiovascular disease incidence. For SNPs, we contrasted cardiovascular disease incidence of minor-allele heterozygotes and homozygotes (variant) vs. major-allele homozygotes (reference) and for haplotypes carriers vs. non-carriers. In adjusted analyses, we accounted for family clusters and baseline covariables, including sex, age, body mass index, mean arterial pressure, the total-to-HDL cholesterol ratio, smoking and drinking, antihypertensive drug treatment, and history of cardiovascular disease and diabetes mellitus. RESULTS: Over a median follow-up of 15.3 years, 238 died and 181 experienced a major cardiovascular endpoint. The multivariable-adjusted hazard ratios of eight PEAR1 SNPs, including rs12566888, ranged from 0.87 to 1.07 (P ≥0.35) and from 0.78 to 1.30 (P ≥0.15), respectively. The hazard ratios of three haplotypes with frequency ≥10% ranged from 0.93 to 1.11 (P ≥0.49) for mortality and from 0.84 to 1.03 (P ≥0.29) for a cardiovascular complications. These results were not influenced by intake of antiplatelet drugs, nonsteroidal anti-inflammatory drugs, or both (P-values for interaction ≥ 0.056). CONCLUSIONS: In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that PEAR1 might be a susceptibility gene for cardiovascular complications.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/genética
Predisposição Genética para Doença
Receptores de Superfície Celular/genética
[Mh] Termos MeSH secundário: Adulto
Bélgica
Feminino
Haplótipos
Seres Humanos
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (PEAR1 protein, human); 0 (Receptors, Cell Surface)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171231
[Lr] Data última revisão:
171231
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0411-x



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