Base de dados : MEDLINE
Pesquisa : Z01.542.248.700 [Categoria DeCS]
Referências encontradas : 1842 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 185 ir para página                         

  1 / 1842 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29431324
[Au] Autor:Fedorenko EV; Kolomiets ND; Sychik SI
[Ti] Título:[Actual problems of the microbiological safety of food products].
[So] Source:Gig Sanit;95(9):873-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Food-borne infectious diseases remain an actual problem of health care. In the Republic of Belarus the level of food-borne diseases persists to be stable, at the same time these diseases remain to be significant. Despite the insignificant number of nonconforming food samples the prevalence rates of food-borne acute infectious diseases of various etiology with dominantly food transmission pathway remain to be rather high. The mentioned fact determines the need for the development of approaches on the security of microbiological food safety based on the risk analysis. There are determined criteria for a hygienic assessment of the microbiological hazards (associated with the pathogen, food products and a consumer health state), there is presented the classification offood products in dependence on the grade of microbiological risk. There was performed the comparative analysis of requirements for the microbiological safety of food accepted in the Republic of Belarus and European Economic Union, in the European Union and at the international level, which testify to the presence of separate differences. Based on the international approaches there was substantiated the multilevel control system of management of microbiological risks, there is reported the characteristic of separate criteria. There are determined the directions of the improvement of the security of microbiological safety of food.
[Mh] Termos MeSH primário: Contaminação de Alimentos
Manipulação de Alimentos
Microbiologia de Alimentos
Doenças Transmitidas por Alimentos
[Mh] Termos MeSH secundário: Contaminação de Alimentos/análise
Contaminação de Alimentos/prevenção & controle
Manipulação de Alimentos/métodos
Manipulação de Alimentos/normas
Microbiologia de Alimentos/métodos
Microbiologia de Alimentos/normas
Qualidade dos Alimentos
Doenças Transmitidas por Alimentos/epidemiologia
Doenças Transmitidas por Alimentos/microbiologia
Doenças Transmitidas por Alimentos/prevenção & controle
Seres Humanos
Saúde Pública/métodos
Saúde Pública/normas
República da Bielorrússia/epidemiologia
Medição de Risco/métodos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  2 / 1842 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29424206
[Au] Autor:Melnik VA; Kozakevich NV
[Ti] Título:[Changes in morphologic indices of physical development of urban schoolchildren].
[So] Source:Gig Sanit;95(5):460-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The aim of the research was to assess the age variability of anthropometric parameters in schoolchildren of the city of Gomel examined with a 40-year interval. The authors of the article examined schoolchildren of secondary schools in Gomel. Over 2010-2012 the complex cross-sectional morphometrical examination was carried out on schoolchildren aged of 8-16 years without any significant health problems in the city of Gomel (a total of 3105, out of them there were 1452 boys and 1653 girls). The somatometrical program included body length and mass, chest circumference parameters. The absolute and relative parameters of their annual increases were calculated in schoolchildren, which made it possible to determine the periods of their relative acceleration and deceleration indices. The anthropometric data on schoolchildren of the city of Gomel obtained by V.Ya.Leontyev in 1973 and A.I. Kienya, V.A. Melnik over 1994-1996 were used for comparison. The comparative analysis of the gender and age dynamics of morphometric indices in schoolchildren of the city of Gomel aged of 8-16 years in 1973 and over 2010-2012 revealed the processes of acceleration (increase of body length and mass) in boys and asthenization (increase of body length and decrease of body mass) in girls at the beginning of the XXI century. The indices of the chest circumference before and after puberty period in the contemporary school boys and girls were lower, but in the puberty period being higher than in schoolchildren of the same age examined forty years ago. The authors developed, published and put into both practical public health of Belarus and educational process the Tables for the assessment of physical development of schoolchildren of the city of Gomel.
[Mh] Termos MeSH primário: Desenvolvimento do Adolescente
Desenvolvimento Infantil
Serviços de Saúde Escolar/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Saúde do Adolescente/tendências
Antropometria/métodos
Criança
Saúde da Criança/tendências
Feminino
Indicadores Básicos de Saúde
Seres Humanos
Masculino
População
República da Bielorrússia/epidemiologia
População Urbana/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  3 / 1842 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29412546
[Au] Autor:Kolomiets ND; Mokhort TV; Fedorenko EV; Mokhort EG; Petrenko SV
[Ti] Título:[The problem of iodine deficiency and its solution in the republic of Belarus].
[So] Source:Gig Sanit;95(5):417-21, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The problem of iodine deficiency is relevant to the Republic of Belarus. It's confirmed by virtually commonly found geophysical iodine deficiency in soils and waters. Data on iodine deficiency initiated the development of a state strategy for the elimination of iodine deficiency in the population. This strategy determined the mandatory use of iodized salt only in the country in the food industry and catering as the main event for the elimination of iodine deficiency. The aim of this work was a comprehensive evaluation of the results of the implementation of the strategy for elimination of iodine deficiency among the population of the Republic of Belarus. Medical monitoring of the assessment of the efficacy showed the decrease in the incidence of simple non-toxic goiter in adolescents from 1215,23 per 100,000 population in 1998 to 341,25 in 2013 (3.6 times), and indices ofprimary morbidity rate in children fell by 2.9 times. Over the period from 1998 primary morbidity rate of simple nontoxic goiter decreased significantly in adults from 379.9 to 31,71 people per 100,000 of the population in 2013 respectively (almost 12 times). Data of the assessment of ioduria in Belarus indicate that 89.2% of children enrolled in the study have iodine excretion of more than 100 pg/L. Thus, in the Republic of Belarus there was achieved the level of an adequate intake of iodine with foodstuffs. This model ofprevention of iodine deficiency, as well as the traditional approach based on the adoption of the law, is a versatile and cost-effective mode.
[Mh] Termos MeSH primário: Deficiências Nutricionais
Iodo/farmacologia
Cloreto de Sódio na Dieta/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Deficiências Nutricionais/epidemiologia
Deficiências Nutricionais/etiologia
Deficiências Nutricionais/prevenção & controle
Feminino
Seres Humanos
Iodo/análise
Iodo/deficiência
Masculino
Prevalência
Serviços Preventivos de Saúde/métodos
Serviços Preventivos de Saúde/organização & administração
República da Bielorrússia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium Chloride, Dietary); 0 (iodized salt); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


  4 / 1842 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29381023
[Au] Autor:Tutelyan VA; Kiseleva TL; Kochetkova AA; Smirnova EA; Kiseleva MA; Sarkisyan VA
[Ti] Título:[Promising source of micronutrients for specialized foods with modified carbohydrate profile: traditional medicine experience].
[So] Source:Vopr Pitan;85(4):46-60, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Worldwide experience of Traditional medicine (TM) has been successfully applied to the development of modern standardized herbal medicines. Mainly researchers are guided by local sources of medicinal plants and traditional medical systems. TM experience is also used in the search of plants considered as sources of biologically active substances (BAS) and food ingredients. The steady increase in the incidence of type 2 diabetes, makes clear the need for research of domestic plant sources of BAS (with a proven carbohydrate metabolism effect) to create modern specialized foods. This article proves the feasibility of using TM experience of Russia and some neighboring European countries (Belarus, Ukraine) to develop optimized compositions for specialized food products for patients with type 2 diabetes. For reliable identification of the most promising plants, 550 traditional antidiabetic herbal formulations of 66 traditional recipe directories were studied in Russia, Belarus and Ukraine. It revealed 37 species of plants included to more than 20% of all bibliographical sources, and 13 plants included to more than 50% of prescription directories. The 3 most popular are bilberry leaves, leaffruit of common bean, great nettle leaves.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/dietoterapia
Carboidratos da Dieta/uso terapêutico
Medicina Tradicional/métodos
Micronutrientes/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
República da Bielorrússia
Ucrânia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Micronutrients)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


  5 / 1842 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29378105
[Au] Autor:Savenkova TV; Soldatova EA; Kiseleva TL; Glazkova IV; Zhilinskaya NV
[Ti] Título:[The role of the food industry in dietetic therapy of the population. Specialized confectionery diabetic food].
[So] Source:Vopr Pitan;84(6):107-15, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Diabetes mellitus is a serious health and social problem of modernity, which in the future will increase and experts predict that the number of patients in 2030 will exceed 438,4 million. Taking into account the seriousness of the problem, and the fact that diabetes hurts an increasing number of young adults, the problem of creating diabetic food products, the positive effect of which on the organism is confirmed by experimental and clinical studies, is very relevant. The overview briefly covers information about the role of diet and ways to modify the composition and formulations of confectionery products of industrial production. The results of industry work towards the development of diabetic confectionery products in Russian Federation and peculiarities of their production and implementation in the framework of the Customs Union countries are summarized. Monitoring of the information entered in the register of specialized food products has been carried out, the lack of common approaches and tools in regulation imposed on the diabetic products in Russia, Belarus and Kazakhstan has been revealed. The necessity of objective regulatory impact assessment has been established. Its results will form the basis of the development of a unified approach to the production, handling and identification of diabetic confectionery and of the introduction of the General principle in relation to the probative value of the data, confirming their quality and safety. To improve the quality of population life and to reduce losses from socially significant diseases is possible through the development of personalized diets and their filling with products with attractive sensory properties. These data indicate the need for training highly qualified specialists with interdisciplinary knowledge in the field of food technology, nutrition and medicine.
[Mh] Termos MeSH primário: Diabetes Mellitus/dietoterapia
Dieta para Diabéticos
Indústria Alimentícia
[Mh] Termos MeSH secundário: Diabetes Mellitus/epidemiologia
Seres Humanos
Cazaquistão/epidemiologia
República da Bielorrússia/epidemiologia
Federação Russa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


  6 / 1842 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29372974
[Au] Autor:Tsybovskii IS; Veremeichik VM; Kotova SA; Kritskaya SV; Evmenenko SA; Udina IG
[Ti] Título:[Developing forensic reference database by 18 autosomal STR for DNA identification in Republic of Belarus].
[So] Source:Genetika;53(2):249-58, 2017 Feb.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:For the Republic of Belarus, development of a forensic reference database on the basis of 18 autosomal microsatellites (STR) using a population dataset (N = 1040), "familial" genotypic dataset (N = 2550) obtained from expertise performance of paternity testing, and a dataset of genotypes from a criminal registration database (N = 8756) is described. Population samples studied consist of 80% ethnic Belarusians and 20% individuals of other nationality or of mixed origin (by questionnaire data). Genotypes of 12346 inhabitants of the Republic of Belarus from 118 regional samples studied by 18 autosomal microsatellites are included in the sample: 16 tetranucleotide STR (D2S1338, TPOX, D3S1358, CSF1PO, D5S818, D8S1179, D7S820, THO1, vWA, D13S317, D16S539, D18S51, D19S433, D21S11, F13B, and FGA) and two pentanucleotide STR (Penta D and Penta E). The samples studied are in Hardy­Weinberg equilibrium according to distribution of genotypes by 18 STR. Significant differences were not detected between discrete populations or between samples from various historical ethnographic regions of the Republic of Belarus (Western and Eastern Polesie, Podneprovye, Ponemanye, Poozerye, and Center), which indicates the absence of prominent genetic differentiation. Statistically significant differences between the studied genotypic datasets also were not detected, which made it possible to combine the datasets and consider the total sample as a unified forensic reference database for 18 "criminalistic" STR loci. Differences between reference database of the Republic of Belarus and Russians and Ukrainians by the distribution of the range of autosomal STR also were not detected, corresponding to a close genetic relationship of the three Eastern Slavic nations mediated by common origin and intense mutual migrations. Significant differences by separate STR loci between the reference database of Republic of Belarus and populations of Southern and Western Slavs were observed. The necessity of using original reference database for support of forensic expertise practice in the Republic of Belarus was demonstrated.
[Mh] Termos MeSH primário: Bases de Dados de Ácidos Nucleicos
Genética Forense/métodos
Loci Gênicos
Repetições de Microssatélites
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
República da Bielorrússia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE


  7 / 1842 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29372804
[Au] Autor:Shelepova OV; Semenova MV; Enina OL; Schanzer IA
[Ti] Título:[Genetic, phenotypic, and phytochemical polymorphism in Eastern European populations of Mentha arvensis L.]
[So] Source:Genetika;53(1):54-62, 2017 Jan.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Variability of M. arvensis from five geographically distanced populations was examined using morphological traits and phytochemical composition of essential oil and with the help of DNA fingerprinting using ISSR markers. The population differentiation based on morphological traits was weak. Analysis of the essential oil composition provided the subdivision of the sample into three groups and, on the basis of the composition of ISSR amplicons, into four groups of specimens. A high degree of genetic polymorphism of M. arvensis and substantial, though incomplete, population differentiation were identified. It was demonstrated that the population of M. arvensis from the Komi Republic was the most genetically isolated, while the populations from Moscow and Penza provinces were weakly differentiated from each other. The population from the Republic of Belarus (near Grodno) was genetically and phytochemically considerably different from the other studied populations, although morphologically indistinguishable from them. We argue that the differentiation was caused not only by the isolation by distance but also owing to the formation of three different ecotypes adapted to different climatic conditions.
[Mh] Termos MeSH primário: Genótipo
Mentha
Óleos Voláteis/metabolismo
Fenótipo
Polimorfismo Genético
[Mh] Termos MeSH secundário: Mentha/genética
Mentha/metabolismo
República da Bielorrússia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE


  8 / 1842 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28917181
[Au] Autor:Marciulioniene D; Luksiene B; Montvydiene D; Jefanova O; Mazeika J; Taraskevicius R; Stakeniene R; Petrosius R; Maceika E; Tarasiuk N; Zukauskaite Z; Kazakeviciute L; Volkova M
[Ad] Endereço:State Research Institute Nature Research Centre, Akademijos 2, Vilnius, LT 08412, Lithuania. Electronic address: danute.marciulioniene@gamtostyrimai.lt.
[Ti] Título:Cs and plutonium isotopes accumulation/retention in bottom sediments and soil in Lithuania: A case study of the activity concentration of anthropogenic radionuclides and their provenance before the start of operation of the Belarusian Nuclear Power Plant (NPP).
[So] Source:J Environ Radioact;178-179:253-264, 2017 Nov.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Knowledge of the background activity concentrations of anthropogenic radionuclides before the start of operations of the new nuclear facilities in Belarus is of great value worldwide. Inland water bodies in Lithuania (specifically the Neris River, the Nemunas River and the Curonian Lagoon) are near the site of the Belarusian NPP under construction and, for this reason, sediments and flooded soils from these sensitive areas were analysed for radiocesium and plutonium isotopes (macrophytes were analysed only for Cs) in 2011-2012. The Cs and Pu activity concentrations in bottom sediments from the Nemunas River, sampled in 1995-1996 and re-calculated to the year 2016, were compared with those of 2011-2012. The obtained activity of Cs in bottom sediments of the Nemunas River and Curonian Lagoon varied from 1 Bq/kg to 47.0 Bq/kg. The activity of Cs in the tested soils ranged from 5.3 B g/kg to 32.9 Bq/kg. The Pu activity in bottom sediments of the studied sampling sites varied between 0.016 and 0.34 Bq/kg and in flooded soils from 0.064 to 0.55 Bq/kg. The Pu activity values were very low or lower than the detection limit. The activity of Cs in macrophytes varied from values lower than the detection limit to 6 Bq/kg. A strong positive linear correlation for bottom sediments was calculated between: Pu and total organic carbon (TOC), r = 0.86, p-value 0.01; Pu and silt, r = 0.80, p-value 0.029; Cs and silt, r = 0.78, p-value 0.04; and Cs and TOC, r = 0.85, p-value 0.015. The similar peculiarities of Cs and Pu accumulation in bottom sediments and flooded soil allow us to assume that Cs can be used as a tracer for Pu in the initial stage of searching for radionuclide accumulation zones. A remaining impact of the Chernobyl fallout in average comprised: in the Lower Nemunas River and Curonian Lagoon sediments - 51%, in the Middle Nemunas River -90% and in the floodplains of the Nemunas River - 59%, while the provenance of plutonium in studied bottom sediments and flooded soil was the global fallout.
[Mh] Termos MeSH primário: Radioisótopos de Césio/análise
Poluentes Radioativos da Água/análise
[Mh] Termos MeSH secundário: Sedimentos Geológicos/química
Lituânia
Centrais Nucleares
Monitoramento de Radiação
Cinza Radioativa/análise
República da Bielorrússia
Rios
Poluentes Radioativos do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cesium Radioisotopes); 0 (Radioactive Fallout); 0 (Soil Pollutants, Radioactive); 0 (Water Pollutants, Radioactive)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE


  9 / 1842 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28441535
[Au] Autor:Dowdall M; Bondar Y; Skipperud L; Zabrotski V; Pettersen MN; Selnæs ØG; Brown JE
[Ad] Endereço:Norwegian Radiation Protection Authority, Østerås, Norway. Electronic address: mark.dowdall@nrpa.no.
[Ti] Título:Investigation of the vertical distribution and speciation of Cs in soil profiles at burnt and unburnt forest sites in the Belarusian Exclusion Zone.
[So] Source:J Environ Radioact;175-176:60-69, 2017 Sep.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of fire events on contaminant radionuclides within soils of the Belarusian Exclusion Zone were investigated. A number of cores were taken from locations known to have been subject to fire events in the past as well as a series of cores from nearby unburnt locations. Both burnt and unburnt cores were analyzed for contaminant radionuclides as well as a range of relevant soil parameters. The distribution of Cs between various fractions (reversibly bound, irreversibly bound and insoluble) was analyzed. Results indicate no evidence of enhancement or enrichment of radionuclides within the soil column although this does not negate the possibility that such effects were evident at some point in the past, the fire events at two of the sites having occurred almost ten years earlier. Evidence was present of a persistent effect on how Cs was distributed between different fractions of the soil, primarily in relation to the proportions associated with oxides of Fe and Mn and organic matter. The results of the study appear to indicate that the long-term effects of a forest fire on contaminant Cs within the soil column are expressed through changes in the physico-chemical forms of the nuclide to a larger extent than simple redistribution of the contaminant within the soil column.
[Mh] Termos MeSH primário: Radioisótopos de Césio/análise
Florestas
Liberação Nociva de Radioativos
Poluentes Radioativos do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Fogo
Monitoramento de Radiação
República da Bielorrússia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cesium Radioisotopes); 0 (Soil); 0 (Soil Pollutants, Radioactive)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


  10 / 1842 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28368520
[Au] Autor:Cahoon EK; Nadyrov EA; Polyanskaya ON; Yauseyenka VV; Veyalkin IV; Yeudachkova TI; Maskvicheva TI; Minenko VF; Liu W; Drozdovitch V; Mabuchi K; Little MP; Zablotska LB; McConnell RJ; Hatch M; Peters KO; Rozhko AV; Brenner AV
[Ad] Endereço:Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland 20892-9778.
[Ti] Título:Risk of Thyroid Nodules in Residents of Belarus Exposed to Chernobyl Fallout as Children and Adolescents.
[So] Source:J Clin Endocrinol Metab;102(7):2207-2217, 2017 Jul 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Although radiation exposure is an important predictor of thyroid cancer on diagnosis of a thyroid nodule, the relationship between childhood radiation exposure and thyroid nodules has not been comprehensively evaluated. Objective: To examine the association between internal I-131 thyroid dose and thyroid nodules in young adults exposed during childhood. Design, setting, and participants: In this cross-sectional study, we screened residents of Belarus aged ≤18 years at the time of the Chernobyl nuclear accident for thyroid disease (median age, 21 years) with thyroid palpation, ultrasonography, blood/urine analysis, and medical follow-up when appropriate. Eligible participants (N = 11,421) had intact thyroid glands and doses based on direct individual thyroid activity measurements. Main outcome measures: Excess odds ratios per Gray (EOR/Gy, scaled at age 5 years at exposure) for any thyroid nodule and for nodules grouped by cytology/histology, diameter size, and singularity. Results: Risk of any thyroid nodule increased significantly with I-131 dose and, for a given dose, with younger age at exposure. The EOR/Gy (95% confidence intervals) for neoplastic nodules (3.82; 0.87 to 15.52) was significantly higher than for nonneoplastic nodules (0.32; <0.03 to 0.70) and did not vary by size; whereas the EOR/Gy for nonneoplastic nodules did vary by size (P = 0.02) and was 1.55 (0.36 to 5.46) for nodules ≥10 mm and 0.02 (<-0.02 to 0.70) for nodules <10 mm. EORs/Gy for single and multiple nodules were comparable. Conclusions: Childhood exposure to internal I-131 is associated with increased risk of neoplastic thyroid nodules of any size and nonneoplastic nodules ≥10 mm.
[Mh] Termos MeSH primário: Acidente Nuclear de Chernobyl
Neoplasias Induzidas por Radiação/etiologia
Nódulo da Glândula Tireoide/etiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Relação Dose-Resposta à Radiação
Detecção Precoce de Câncer/métodos
Feminino
Seres Humanos
Lactente
Recém-Nascido
Radioisótopos do Iodo/efeitos adversos
Masculino
Neoplasias Induzidas por Radiação/epidemiologia
República da Bielorrússia/epidemiologia
Medição de Risco/métodos
Fatores de Risco
Nódulo da Glândula Tireoide/diagnóstico por imagem
Nódulo da Glândula Tireoide/epidemiologia
Nódulo da Glândula Tireoide/patologia
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Iodine Radioisotopes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-3842



página 1 de 185 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde