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Pesquisa : Z01.542.248.764 [Categoria DeCS]
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  1 / 8905 MEDLINE  
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[PMID]:29301523
[Au] Autor:Fierascu I; Ungureanu C; Avramescu SM; Cimpeanu C; Georgescu MI; Fierascu RC; Ortan A; Sutan AN; Anuta V; Zanfirescu A; Dinu-Pirvu CE; Velescu BS
[Ad] Endereço:The National Institute for Research & Development in Chemistry and Petrochemistry, ICECHIM, 202 Spl. Independentei, 060021, Bucharest, Romania.
[Ti] Título:Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills.
[So] Source:BMC Complement Altern Med;18(1):3, 2018 Jan 04.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Juniperus communis L. represents a multi-purpose crop used in the pharmaceutical, food, and cosmetic industry. Several studies present the possible medicinal properties of different Juniperus taxa native to specific geographical area. The present study aims to evaluate the genoprotective, antioxidant, antifungal and anti-inflammatory potential of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills. METHODS: The prepared hydroethanolic extract of Juniperus communis L. was characterized by GC-MS, HPLC, UV-Vis spectrometry and phytochemical assays. The antioxidant potential was evaluated using the DPPH assay, the antifungal effect was studied on Aspergillus niger ATCC 15475 and Penicillium hirsutum ATCC 52323, while the genoprotective effect was evaluated using the Allium cepa assay. The anti-inflammatory effect was evaluated in two inflammation experimental models (dextran and kaolin) by plethysmometry. Male Wistar rats were treated by gavage with distilled water (negative control), the microemulsion (positive control), diclofenac sodium aqueous solution (reference) and microemulsions containing juniper extract (experimental group). The initial paw volume and the paw volumes at 1, 2, 3, 4, 5 and 24 h were measured. RESULTS: Total terpenoids, phenolics and flavonoids were estimated to be 13.44 ± 0.14 mg linalool equivalent, 19.23 ± 1.32 mg gallic acid equivalent, and 5109.6 ± 21.47 mg rutin equivalent per 100 g of extract, respectively. GC-MS characterization of the juniper extract identified 57 volatile compounds in the sample, while the HPLC analysis revealed the presence of the selected compounds (α-pinene, chlorogenic acid, rutin, apigenin, quercitin). The antioxidant potential of the crude extract was found to be 81.63 ± 0.38% (measured by the DPPH method). The results of the antifungal activity assay (for Aspergillus niger and Penicillium hirsutum) were 21.6 mm, respectively 17.2 mm as inhibition zone. Test results demonstrated the genoprotective potential of J. communis undiluted extract, inhibiting the mitodepressive effect of ethanol. The anti-inflammatory action of the juniper extract, administered as microemulsion in acute-dextran model was increased when compared to kaolin subacute inflammation induced model. CONCLUSION: The hydroalcoholic extract obtained from wild-growing Juniperus communis native to Romanian southern sub-Carpathian hills has genoprotective, antioxidant, antifungal and anti-inflammatory properties.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antifúngicos/farmacologia
Juniperus/química
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Antifúngicos/química
Aspergillus niger/efeitos dos fármacos
Compostos de Bifenilo/análise
Compostos de Bifenilo/metabolismo
Flavonoides/química
Flavonoides/farmacologia
Inflamação/metabolismo
Masculino
Penicillium/efeitos dos fármacos
Fenóis/química
Fenóis/farmacologia
Picratos/análise
Picratos/metabolismo
Extratos Vegetais/química
Substâncias Protetoras/química
Ratos
Ratos Wistar
Romênia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antifungal Agents); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 0 (Protective Agents); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2066-8


  2 / 8905 MEDLINE  
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[PMID]:28748526
[Au] Autor:Allen KG; von Cramon-Taubadel N
[Ad] Endereço:Buffalo Human Evolutionary Morphology Lab, Department of Anthropology, University at Buffalo, Buffalo, New York, 14261.
[Ti] Título:A craniometric analysis of early modern Romania and Hungary: The roles of migration and conversion in shaping European Ottoman population history.
[So] Source:Am J Phys Anthropol;164(3):477-487, 2017 11.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Debate persists regarding the biological makeup of European Ottoman communities settled during the expansion of the Ottoman Empire during the 16th and 17th centuries, and the roles of conversion and migration in shaping demography and population history. The aim of this study was to perform an assessment of the biological affinities of three European Ottoman series based on craniometric data. MATERIALS AND METHODS: Craniometric data collected from three Ottoman series from Hungary and Romania were compared to European and Anatolian comparative series, selected to represent biological affinity representative of historically recorded migration and conversion influences. Sex-separated samples were analyzed using D -matrices, along with principal coordinates and PERMANOVA analyses to investigate biological affinities. Discriminant function analysis was employed to assign Ottoman individuals to two potential classes: European or Anatolian. RESULTS: Affinity analyses show larger than expected biological differences between males and females within each of the Ottoman communities. Discriminant function analyses show that the majority of Ottoman individuals could be classified as either European or Anatolian with a high probability. Moreover, location within Europe proved influential, as the Ottomans from a location of more geopolitical importance (Budapest) diverged from more hinterland communities in terms of biological affinity patterns. DISCUSSION: The results suggest that male and female Ottomans may possess distinct population histories, with males and females divergent from each other in terms of their biological affinities. The Ottoman communities appear diverse in terms of constituting a mix of peoples from different biological backgrounds. The greater distances between sexes from the same community, and the differences between communities, may be evidence that the processes of migration and conversion impacted individual people and groups diversely.
[Mh] Termos MeSH primário: Cefalometria/métodos
Grupo com Ancestrais do Continente Europeu/etnologia
Migração Humana/história
Crânio/anatomia & histologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antropologia Física
Feminino
História do Século XVI
História do Século XVII
História do Século XX
Seres Humanos
Hungria/etnologia
Masculino
Império Otomano/etnologia
Romênia/etnologia
Adulto Jovem
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23287


  3 / 8905 MEDLINE  
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[PMID]:29284255
[Au] Autor:Danciu C; Pavel IZ; Babuta R; Ersilia A; Pop G; Soica C; Dehelean C; Radulov I; Oana S
[Ad] Endereço:University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania. corina.danciu@umft.ro.
[Ti] Título:Total phenolic content, FTIR analysis, and antiproliferative evaluation of lupin seeds harvest from western Romania.
[So] Source:Ann Agric Environ Med;24(4):726-731, 2017 Dec 23.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Lupinus spp. are herbaceous perennial flowering plants included in the Fabaceae family. Among the approximately 200 species belonging to this genre, Lupinus albus L., also known as white lupin, Lupinus angustifolius L., and narrow-leafed lupin or blue lupin, represent two of the most studied species due to their intense culinary use and potential biological activity. The intention of the study was to characterize total phenolic content, perform FTIR analysis, and antiproliferative effects against A375 human melanoma cells extracts obtained from germinated and ungerminated seeds from Lupinus albus L. and Lupinus angustifolius L. MATERIAL AND METHODS: Total phenolic content was assessed using the Folin-Ciocalteu colorimetric method. FTIR spectra were carried out by a Shimadzu Prestige-21 spectrometer in the range 400-4000 cm-1, using KBr pellets and resolution of 4 cm-1. Antiproliferative capacity was screened by employing the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and scratch assay methods. RESULTS: The study showed increased values corresponding to total phenolic content for the germinated extracts. FTIR spectra confirmed the presence of genistein and main cinnamic acids derivatives (ferulic, caffeic, rosmarinic, and coumaric acids). All tested extracts showed weak antiproliferative potential against A375 human melanoma cells. CONCLUSIONS: Germination increased the amount of bioactive compounds in the seeds of the two studied species of lupin. FTIR analyses provided an important fingerprint of the chemical composition.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Lupinus/química
Fenóis/química
Fenóis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Germinação
Seres Humanos
Lupinus/crescimento & desenvolvimento
Romênia
Sementes/química
Sementes/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE


  4 / 8905 MEDLINE  
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[PMID]:28873594
[Au] Autor:Perini M; Giongo L; Grisenti M; Bontempo L; Camin F
[Ad] Endereço:Experiment and Technological Services Department, Technology Transfer Centre, Fondazione Edmund Mach (FEM), Via E. Mach 1, 38010 San Michele all'Adige, Italy. Electronic address: matteo.perini@fmach.it.
[Ti] Título:Stable isotope ratio analysis of different European raspberries, blackberries, blueberries, currants and strawberries.
[So] Source:Food Chem;239:48-55, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To date the stable isotope ratios of berries have never been extensively explored. In this work the H, C, N and O isotopic ratios of 190 samples of different soft fruits (strawberries, raspberries, blueberries, blackberries and currants) produced in a northern Italian region and at two sites in Romania and Poland collected over three harvest years are presented and discussed. The different soft fruits showed a typical range for one or more isotopic parameters that can be used to verify the authenticity of the fruit composition declared on the label. The δ C and δ N of pulp and the δ O of juice can be considered effective tools for identifying the different geographical origin of fruit. A significant effect of crop cover on juice δ O and fertilisation practices on pulp δ N was demonstrated and must be considered with attention when evaluating data.
[Mh] Termos MeSH primário: Fragaria
Ribes
Rubus
[Mh] Termos MeSH secundário: Isótopos
Polônia
Romênia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isotopes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  5 / 8905 MEDLINE  
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[PMID]:28857155
[Au] Autor:Fountzilas G; Psyrri A; Giannoulatou E; Tikas I; Manousou K; Rontogianni D; Ciuleanu E; Ciuleanu T; Resiga L; Zaramboukas T; Papadopoulou K; Bobos M; Chrisafi S; Tsolaki E; Markou K; Giotakis E; Koutras A; Psoma E; Kalogera-Fountzila A; Skondra M; Bamia C; Pectasides D; Kotoula V
[Ad] Endereço:Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.
[Ti] Título:Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe.
[So] Source:Int J Cancer;142(1):66-80, 2018 Jan 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genomic patterns of nasopharyngeal carcinomas (NPCs) have as yet been studied in Southeast Asian (SEA) patients. Here, we investigated genomic patterns of locally advanced NPC Southeast European (SEE) patients treated with chemoradiotherapy. We examined 126 tumors (89% EBV positive) from Greek and Romanian NPC patients with massively parallel sequencing. Paired tumor-cell-rich (TC) and infiltrating-lymphocyte-rich (TILs) samples were available in 19 and paired tumor-germline samples in 68 cases. Top mutated genes were BRCA1 (54% of all tumors); BRCA2 (29%); TP53 (22%); KRAS (18%). Based on the presence and number of mutations and mutated genes, NPC were classified as stable (no mutations, n = 27); unstable (>7 genes with multiple mutations, all BRCA1 positive, n = 21); and of intermediate stability (1-7 singly mutated genes, n = 78). BRCA1 p.Q563* was present in 59 tumors (48%), more frequently from Romanian patients (p < 0.001). No pathogenic germline mutations were identified. NPC exhibited APOBEC3A/B and nucleotide-excision-repair-related mutational signatures. As compared to TC, TILs demonstrated few shared and a higher number of low frequency private mutations (p < 0.001). In multivariate analysis models for progression-free survival, EBV positivity was a favorable prognosticator in stable tumors; BRCA1 mutations were unfavorable only in tumors of intermediate stability. In conclusion, other than described for SEA NPC, somatic BRCA1 mutations were common in SEE NPC; these were shared between TC and TILs, and appeared to affect patient outcome according to tumor genomic stability status. Along with the identified mutational signatures, these novel data may be helpful for designing new treatments for locally advanced NPC.
[Mh] Termos MeSH primário: Proteína BRCA1/genética
Carcinoma/genética
Neoplasias Nasofaríngeas/genética
[Mh] Termos MeSH secundário: Carcinoma/mortalidade
Carcinoma/patologia
Análise Mutacional de DNA
Intervalo Livre de Doença
Genótipo
Grécia
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Estimativa de Kaplan-Meier
Mutação
Neoplasias Nasofaríngeas/mortalidade
Neoplasias Nasofaríngeas/patologia
Romênia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BRCA1 Protein); 0 (BRCA1 protein, human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.31023


  6 / 8905 MEDLINE  
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[PMID]:29069036
[Au] Autor:Marginean CO; Melit LE; Chincesan M; Muresan S; Georgescu AM; Suciu N; Pop A; Azamfirei L
[Ad] Endereço:aDepartment of Pediatrics bDepartment of Physiology cDepartment of Infectious Disease dDepartment of International Projects eDepartment of Langueges fDepartment of Anesthesiology, University of Medicine and Pharmacy Tîrgu Mures, Tirgu Mure, Romania.
[Ti] Título:Communication skills in pediatrics - the relationship between pediatrician and child.
[So] Source:Medicine (Baltimore);96(43):e8399, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Interpersonal and communication skills are 2 essential qualities of every physician. These are separate and distinct parts of the professional character of every physician. In pediatrics these abilities present even a higher impact.We performed a survey-type prospective study based on questionnaires on 100 subjects, equally divided into 4 groups: 25 children, 25 pediatricians, 25 care-givers (parents, tutors, and relatives), and 25 health care staff, in a Tertiary Pediatric Clinic from Romania, between January 2017 and April 2017.We included 100 participants in our study, equally divided into 4 groups: pediatric patients, pediatricians, care-givers, and health care staff. The 1st group comprised 25 children diagnosed with different chronic conditions, presenting the age between 5 and 14 years. The male gender predominated among the children (57%). The lowest general average score for "Communication" section was encountered among pediatricians group, 3.8, while the other 3 groups presented the same average score for this section, that is, 4.6. The children and the health care staff offered the same average score for "Transparency," that is, 4.6, while the pediatricians offered a score of 4.5, and the care-givers of 4.7. The lowest average score for the item "Hospital environment" was given by the doctors, that is, 3.3, followed by care-givers with a score of 3.6, health care staff 3.7, and children with an average score of 3.8. All the 4 groups included in the study offered a general average of 4.9 out of 5 for the "Intercultural issues" section. The lowest average score for "Time management" section was offered by both children and pediatricians, that is, 4.1, while care-givers and health care staff had a slightly better perception regarding this item, offering 4.2 and 4.3, respectively.The opinion among the 4 groups included in the study was generally similar regarding the 5 items assessed by our questionnaires. Therefore, the main aspects that need to be improved in the health care system in downward order are the following: hospital environment, time management, communication, transparency, and intercultural issues.
[Mh] Termos MeSH primário: Cuidadores/psicologia
Comunicação
Pessoal de Saúde/psicologia
Pediatras/psicologia
Relações Médico-Paciente
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Romênia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008399


  7 / 8905 MEDLINE  
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[PMID]:29016621
[Au] Autor:Paraschiv S; Banica L; Nicolae I; Niculescu I; Abagiu A; Jipa R; Pineda-Peña AC; Pingarilho M; Neaga E; Theys K; Libin P; Otelea D; Abecasis A
[Ad] Endereço:Molecular Diagnostics Laboratory, National Institute for Infectious Diseases 'Matei Bals', Bucharest, Romania.
[Ti] Título:Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users.
[So] Source:PLoS One;12(10):e0185866, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to characterize and compare transmission dynamics of the two viruses. Three large HIV clusters (2 subtype F1 and one CRF14_BG) and thirteen smaller HCV transmission networks (genotypes 1a, 1b, 3a, 4a and 4d) were identified. Eighty (65%) patients were both in HIV and HCV transmission chains and 70 of those shared the same HIV and HCV cluster with at least one other patient. Molecular clock analysis indicated that all identified HIV clusters originated around 2006, while the origin of the different HCV clusters ranged between 1980 (genotype 1b) and 2011 (genotypes 3a and 4d). HCV infection preceded HIV infection in 80.3% of cases. Coincidental transmission of HIV and HCV was estimated to be rather low (19.65%) and associated with an outbreak among PWID during detention in the same penitentiary. This study has reconstructed and compared the dispersion of these two viruses in a PWID population.
[Mh] Termos MeSH primário: Coinfecção/transmissão
Infecções por HIV/transmissão
HIV/genética
Hepacivirus/genética
Hepatite C/transmissão
[Mh] Termos MeSH secundário: Adulto
Coinfecção/epidemiologia
Coinfecção/genética
Coinfecção/virologia
Surtos de Doenças
Usuários de Drogas
Feminino
Genótipo
HIV/patogenicidade
Infecções por HIV/epidemiologia
Infecções por HIV/genética
Infecções por HIV/virologia
Hepacivirus/patogenicidade
Hepatite C/epidemiologia
Hepatite C/genética
Hepatite C/virologia
Seres Humanos
Masculino
Filogenia
Romênia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185866


  8 / 8905 MEDLINE  
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[PMID]:28832257
[Au] Autor:Imre K; Morar A; Ilie MS; Plutzer J; Imre M; Emil T; Herbei MV; DarabuÈ™ G
[Ad] Endereço:1 Department of Animal Production and Veterinary Public Health, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" Timisoara , Romania .
[Ti] Título:Survey of the Occurrence and Human Infective Potential of Giardia duodenalis and Cryptosporidium spp. in Wastewater and Different Surface Water Sources of Western Romania.
[So] Source:Vector Borne Zoonotic Dis;17(10):685-691, 2017 Oct.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:From the group of parasitic protozoa, Giardia and Cryptosporidium are the most common pathogens spread in surface water sources, representing a continuous threat to public health and water authorities. The aim of this survey was to assess the occurrence and human infective potential of these pathogens in treated wastewaters and different surface water sources. A total of 76 western Romanian water bodies in four counties (Arad, Bihor, CaraÈ™-Severin and TimiÈ™) were investigated, including the effluents of wastewater treatment plants (n = 11) and brooks (n = 19), irrigation channels (n = 8), lakes (n = 16), and ponds (n = 22). Water samples were collected through polyester microfiber filtration. Giardia cysts and Cryptosporidium oocysts were isolated using immunomagnetic separation, according to the US EPA 1623 method, followed by their identification and counting by immunofluorescence (IF) microscopy. All samples were screened through PCR-based techniques targeting the gdh gene for Giardia spp. and the 18S rRNA gene for Cryptosporidium spp., followed by sequencing of the positive results. Cryptosporidium-positive samples were subtyped based on sequence analysis of the GP60 gene. Giardia spp. was found in all tested water types with a cumulative detection rate of 90.1% in wastewaters, 26.3% in brooks, 37.5% in irrigation channels, 31.2% in lakes, and 36.4% in ponds. Except for ponds, all monitored water bodies harbored the Giardia duodenalis AII subassemblage with human infective potential. In addition, the ruminant origin assemblage E was widely distributed, and the domestic/wild canid-specific assemblage D was also recorded in a pond. Three (27.3%) wastewater samples were Cryptosporidium positive, and the identified species was the zoonotic Cryptosporidium parvum, with IIaA15G2R1 (n = 2) and IIdA18G1 subtypes. The results highlight that this threat to the public health must be brought to the attention of epidemiologists, health officials, and water authorities.
[Mh] Termos MeSH primário: Cryptosporidium/isolamento & purificação
Giardia lamblia/isolamento & purificação
Águas Residuais/parasitologia
Água/parasitologia
[Mh] Termos MeSH secundário: Animais
Cryptosporidium/classificação
Seres Humanos
Lagos/parasitologia
Tanques/parasitologia
Rios/parasitologia
Romênia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Waste Water); 059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2017.2155


  9 / 8905 MEDLINE  
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[PMID]:28727796
[Au] Autor:Herghelegiu AM; Moser A; Prada GI; Born S; Wilhelm M; Stuck AE
[Ad] Endereço:National Institute of Gerontology and Geriatrics "Ana Aslan", Bucharest, Romania.
[Ti] Título:Effects of health risk assessment and counselling on physical activity in older people: A pragmatic randomised trial.
[So] Source:PLoS One;12(7):e0181371, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Interventions to increase physical activity (PA) among older community-dwelling adults may be enhanced by using multidimensional health risk assessment (HRA) as a basis for PA counselling. METHODS: The study was conducted among nondisabled but mostly frail persons 65 years of age and older at an ambulatory geriatric clinic in Bucharest, Romania. From May to July 2014, 200 participants were randomly allocated to intervention and control groups. Intervention group participants completed an initial HRA questionnaire and then had monthly counselling sessions with a geriatrician over a period of six months that were aimed at increasing low or maintaining higher PA. Counselling also addressed the older persons' concomitant health risks and problems. The primary outcome was PA at six months (November 2014 to February 2015) evaluated with the International Physical Activity Questionnaire. RESULTS: At baseline, PA levels were similar in intervention and control groups (median 1089.0, and 1053.0 MET [metabolic equivalent of task] minutes per week, interquartile ranges 606.0-1401.7, and 544.5-1512.7 MET minutes per week, respectively). Persons in the intervention group had an average of 11.2 concomitant health problems and risks (e.g., pain, depressive mood, hypertension). At six months, PA increased in the intervention group by a median of 180.0 MET minutes per week (95% confidence interval (CI) 43.4-316.6, p = 0.01) to 1248.8 MET minutes per week. In the control group, PA decreased by a median of 346.5 MET minutes per week (95% CI 178.4-514.6, p<0.001) to 693.0 MET minutes per week due to a seasonal effect, resulting in a difference of 420.0 MET minutes per week (95% CI 212.7-627.3, p< 0.001) between groups. CONCLUSION: The use of HRA to inform individualized PA counselling is a promising method for achieving improvements in PA, and ultimately health and longevity among large groups of community-dwelling older persons. TRIAL REGISTRATION: International Standard Randomized Controlled Trial Number: ISRCTN11166046.
[Mh] Termos MeSH primário: Aconselhamento
Exercício
Medição de Risco
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Idoso Fragilizado
Comportamentos Relacionados com a Saúde
Seres Humanos
Masculino
Medicina de Precisão
Prevalência
Comportamento de Redução do Risco
Romênia
Autorrelato
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRAGMATIC CLINICAL TRIAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181371


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[PMID]:28723764
[Au] Autor:Socolov D; Socolov R; Gorduza VE; Butureanu T; Stanculescu R; Carauleanu A; Pavaleanu I
[Ad] Endereço:aDepartment of Mother and Child Medicine, University of Medicine and Pharmacy Gr. T. Popa Iasi bHospital of Obstetrics and Gynecology Elena Doamna-Iasi cHuman Genetics Department, University of Medicine and Pharmacy Gr. T. Popa Iasi dUniversity of Medicine and Pharmacy Carol Davila-Bucharest, Romania.
[Ti] Título:Increased nuchal translucency in fetuses with a normal karyotype-diagnosis and management: An observational study.
[So] Source:Medicine (Baltimore);96(29):e7521, 2017 Jul.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of nuchal translucency (NT) in 1992 by Nicolaides et al was a major breakthrough in screening for chromosomal aneuploidies at the end of the first trimester. However, pathological conditions other than chromosomal aneuploidies are also associated with increased NT, which can also be detected in normal fetuses. This study sought to evaluate the causes of this ultrasound sign in a group of patients from Iasi, Romania.During the decade-long study period, there were 71 certified cases involving increased NT; the patients in these cases underwent diagnostic amniocentesis and karyotyping.In most of the examined cases (55 cases, 78%), there was no aneuploidy. The remaining cases involved trisomy 21 (T21) (18%), trisomy 18 (T18) (2%), or triploidy (2%). In most cases, the indication for amniocentesis was increased NT alone (81%), whereas the remaining cases also involved advanced maternal age (5.5%), abnormal serologic markers (10%), or other ultrasound signs (3.5%) (2 cases-cardiac anomalies and fetal hydrops). A favorable pregnancy outcome at term was achieved in 40 cases (56% from total, 72% from euploid pregnancies); kidney anomalies or nonlethal cardiac conditions were observed in 12 cases (17%), 6 of which involved complications associated with premature onset of labor, and miscarriages occurred in 6 cases. Three cases were lost at follow-up.Although it is common practice to assume that increased NT is an indication for amniocentesis, both literature results and our study findings indicate that the majority of cases with increased NT involve no aneuploidy and result in a favorable outcome if no other anomaly is present. Better evidence-based management of such cases could be promoted by conducting larger, multicenter studies, and following cases for longer periods.
[Mh] Termos MeSH primário: Aneuploidia
Doenças Fetais/diagnóstico por imagem
Doenças Fetais/terapia
Cariotipagem
Medição da Translucência Nucal
[Mh] Termos MeSH secundário: Adulto
Amniocentese
Feminino
Doenças Fetais/genética
Seguimentos
Seres Humanos
Gravidez
Resultado da Gravidez
Estudos Retrospectivos
Romênia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007521



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