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  1 / 2323 MEDLINE  
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[PMID]:29215335
[Au] Autor:Djordjevic ZM; Folic MM; Jankovic SM
[Ad] Endereço:Clinic of Control Hospital Infections, Kragujevac Centre Clinical, Kragujevac, Serbia.
[Ti] Título:Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of spp. and aeruginosa Isolated from Patients with Nosocomial Infections.
[So] Source:Balkan Med J;34(6):527-533, 2017 12 01.
[Is] ISSN:2146-3131
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The alarming spread of antibiotic-resistant bacteria causing healthcare-associated infections has been extensively reported in recent medical literature. AIMS: To compare trends in antimicrobial consumption and development of resistance among isolates of spp. and that cause hospital infections. STUDY DESIGN: Cross-sectional study. METHODS: A study was conducted in a tertiary healthcare institution in central Serbia, during the 7-year period between January 2009 and December 2015. The incidence rate of infections caused by or , as well as their resistance density to commonly used antibiotics, were calculated. Utilization of antibiotics was expressed as the number of defined daily doses per 1000 patient-days. RESULTS: A statistically significant increase in resistance density in 2015 compared to the first year of observation was noted for , but not for , to third-generation cephalosporins (p=0.008), aminoglycosides (p=0.005), carbapenems (p=0.003), piperacillin/tazobactam (p=0.025), ampicillin/sulbactam (p=0.009) and tigecycline (p=0.048). CONCLUSION: Our study showed that there is an association between the resistance density of spp. and utilization of carbapenems, tigecycline and aminoglycosides. A multifaceted intervention is needed to decrease the incidence rate of and hospital infections, as well as their resistance density to available antibiotics.
[Mh] Termos MeSH primário: Infecções por Acinetobacter/microbiologia
Acinetobacter/efeitos dos fármacos
Antibacterianos/uso terapêutico
Infecção Hospitalar/tratamento farmacológico
Infecção Hospitalar/microbiologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Infecções por Pseudomonas/microbiologia
Pseudomonas aeruginosa/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acinetobacter/isolamento & purificação
Infecções por Acinetobacter/tratamento farmacológico
Adulto
Estudos Transversais
Seres Humanos
Testes de Sensibilidade Microbiana
Padrões de Prática Médica/estatística & dados numéricos
Infecções por Pseudomonas/tratamento farmacológico
Pseudomonas aeruginosa/isolamento & purificação
Sérvia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.4274/balkanmedj.2016.1844


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[PMID]:29350889
[Au] Autor:Grujic V; Dragnic N; Mijatovic-Jovanovic V; Ukropina S; Harhaji S; Radic I; Kvrgic S
[Ti] Título:Predictors of overweight and obesity among adults aged 50 years and above: Serbian national health survey.
[So] Source:Vojnosanit Pregl;74(1):38-45, 2017 Jan.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Obesity is a complex and multifactorial condition related to morbidity, mortality, poor quality of life and many other problems. The aim of the study was to determine the prevalence of overweight and obesity and factors associated with them (demographic, socioeconomic factors and lifestyle) in adults aged 50 years and above in Serbia. Methods: This cross-sectional study, representative for the population in Serbia, was carried out in one-year period, including 6,932 people aged 50 and over. Individuals were interviewed and anthropometrically examined. The association between overweight and obesity with demographic, socioeconomic and behavioral factors was analyzed using multivariate logistic regression. Results: Age, level of education and smoking were significantly associated with overweight and obesity, regardless of gender. Marital status was significantly associated with obesity, regardless of gender and with overweight only in women. Breakfast consumption habit was significantly associated with obesity only in men. There was no significant association of overweight and obesity with the type of settlement, alcohol consumption and physical activity, regardless of gender. Conclusion: The results of our study indicate the need for more intensive implementation of measures affecting the factors which contribute to overweight and obesity. Emphasis should be put on the population-based policies and programs that support environmental changes.
[Mh] Termos MeSH primário: Obesidade/epidemiologia
Sobrepeso/epidemiologia
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Estudos Transversais
Bases de Dados Factuais
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Meia-Idade
Obesidade/diagnóstico
Prevalência
Fatores de Risco
Sérvia/epidemiologia
Fatores Sexuais
Fatores Socioeconômicos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.2298/VSP140821140G


  3 / 2323 MEDLINE  
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[PMID]:29341568
[Au] Autor:Kostic M; Kocic B; Tiodorovic B
[Ti] Título:Stigmatization and discrimination of patients with chronic hepatitis C.
[So] Source:Vojnosanit Pregl;73(12):1116-24, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Chronic hepatitis C (CHC) is often associated with injectable drug users and human immunodeficiency virus coinfection for which there is stigmatization in society. The aim of this study was to identify the presence of stigma and discrimination of patients with CHC, as well as the influence of sociodemographic factors on the occurrence of stigmatization. Methods: A cross-sectional study was performed. Patients with CHC and conducted antiviral therapy completed an anonymous structured questionnaire consisting of sociodemographic questions and Hepatitis C stigma scale. Results: Out of 154 patients 61.7% were male and 72.1% from the city; 59.7% have completed secondary school; 61.7% were employed before the disease while 31.8% after the disease; 45.5% were unsatisfactory with financial situation; 54.5% were married; 37.7% lived with a spouse and children; 86.4% in their own house/apartment; 5.2% of the patients were abandoned by their partners, while 35.7% consumed drugs. A statistical significance of the stigma score was found in those who lived in the city (p = 0.018), unmarried (p = 0.005), abandoned by the partners after the diagnosis of CHC (p < 0.001), drug users (p = 0.002) and those living with parents (p = 0.034). Univariate regression analysis singled out as significant: residence (p = 0.018), living with their parents (p = 0.046), abandonment by a partner (p < 0.001) and drug use (p = 0.002). A multivariate regression model of independent variables singled out abandonment by partners (Beta = 5.158, p = 0.007). Men disagree significantly with the two elements inside stigma [not the same as the others (p = 0.035)] and hurt by the reaction of others (p = 0.047)). Conclusion: The presence of stigma in patients with CHC was proven. The results indicate the need to strengthen anti-stigma programs that will reduce their psychological and social problems and reduce stigmatization in society.
[Mh] Termos MeSH primário: Hepatite C Crônica/psicologia
Preconceito
Opinião Pública
Estigma Social
Estereotipagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Distribuição de Qui-Quadrado
Estudos Transversais
Usuários de Drogas/psicologia
Feminino
Hepatite C Crônica/diagnóstico
Hepatite C Crônica/epidemiologia
Seres Humanos
Modelos Lineares
Masculino
Estado Civil
Meia-Idade
Análise Multivariada
Sérvia/epidemiologia
Fatores Socioeconômicos
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/psicologia
Saúde da População Urbana
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150511135K


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[PMID]:29341569
[Au] Autor:Mihailovic N; Trajkovic G; Simic-Vukomanovic I; Ristic S; Kocic S
[Ti] Título:Agreement between admission and discharge diagnoses: Analysis by the groups of international classification of diseases, 10th revision.
[So] Source:Vojnosanit Pregl;73(12):1125-31, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Admission diagnosis represents the diagnosis of an illness, injury or condition due to which a patient is referred to hospital to be admitted. Discharge diagnosis represents the main reason of illness or condition due to which a patient is admitted. The aim of this study was to analyze the agreement between admission diagnostic groups and discharge diagnostic groups of patients in the Clinical Center Kragujevac in the period from January 1, 2006 to December 31, 2013 on the basis of the hospitalization report. Methods: From the basic set of reports, 5% of random samples were singled out and they contained 20,422 reports. Out of the given number of reports, 18,173 hospitalization reports were complete and then further analyzed in the paper. Admission diagnostic groups given by the primary care doctor were compared with discharge diagnostic groups filled out by the practicing physician in the hospital ward from which a patient was discharged. The agreement of these two diagnostic groups was an indication of the high-quality performance of the primary care doctor. Agreement analysis was conducted using Cohen's Kappa statistics. Restuls: Agreement analysis showed that the values of the Kappa coefficient for the five leading admission diagnostic groups were in the range of κ = 0.61 to κ = 0.94. The values of the Kappa coefficient for the five most common discharge diagnostic groups were in the range of κ = 0.55 to κ = 0.81. Conclusion: Hospitalization report is a reliable individual report on inpatient care, so it could be used in determining the degree of agreement between admission diagnostic groups and discharge diagnostic groups.
[Mh] Termos MeSH primário: Classificação Internacional de Doenças
Admissão do Paciente
Alta do Paciente
[Mh] Termos MeSH secundário: Adulto
Idoso
Grupos Diagnósticos Relacionados
Feminino
Seres Humanos
Tempo de Internação
Masculino
Meia-Idade
Variações Dependentes do Observador
Sumários de Alta do Paciente Hospitalar
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Estudos Retrospectivos
Sérvia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150427057M


  5 / 2323 MEDLINE  
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[PMID]:29341567
[Au] Autor:Dordevic Z; Folic M; Jankovic S
[Ti] Título:Community-acquired urinary tract infections: Causative agents and their resistance to antimicrobial drugs.
[So] Source:Vojnosanit Pregl;73(12):1109-15, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Urinary tract infections (UTIs) are among the most common infections in outpatients. The aim of this study was to define the causative agents of urinary tract infections and their resistance to antimicrobial drugs in the urban area of central Serbia, as well as to evaluate eventual differences associated with age and gender of the patients. Methods: This retrospective study analysed data taken from routine, consecutively collected urine cultures of outpatients with symptomatic UTIs, collected from the Department of Microbiology, Institute of Public Health in Kragujevac, Serbia, from January 2009 to December 2013. Results: There were 71,905 urine cultures, and 24,713 (34.37%) of them were positive for bacterial pathogens. The most common pathogen was Escherichia coli (E. coli) (56.56%), followed by Klebsiella spp. (16.20%), Proteus spp. (14.68%), Enterococcus spp. (5.29%) and Pseudomonas aeruginosa (3.74%). E. coli and Enterococcus spp. isolation rates were lower in males ≥ 60 years old (23.71% and 4.87%, respectively), while Klebsiella spp. was more prevalent in this group (32.06%). The most common causative agents isolated from 15­29 years old male patients were Enterococcus spp. and Pseudomonas aeruginosa (13.28% each). Among women, the isolation rate of E.coli was high in all age groups (around 70%). Proteus spp. was frequently isolated from females ≤ 14 years old (13.27%), while Klebsiella spp. was the most frequent in the oldest age female group (10.99%). Conclusion: Choice of antibiotics for treatment of UTIs should be governed not only by the local resistance patterns, but also by gender and age of patients.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Bactérias/efeitos dos fármacos
Infecções Comunitárias Adquiridas/tratamento farmacológico
Infecções Comunitárias Adquiridas/microbiologia
Farmacorresistência Bacteriana
Infecções Urinárias/tratamento farmacológico
Infecções Urinárias/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Bactérias/isolamento & purificação
Criança
Pré-Escolar
Tomada de Decisão Clínica
Infecções Comunitárias Adquiridas/diagnóstico
Infecções Comunitárias Adquiridas/epidemiologia
Feminino
Seres Humanos
Lactente
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Seleção de Pacientes
Estudos Retrospectivos
Sérvia/epidemiologia
Fatores Sexuais
Infecções Urinárias/diagnóstico
Infecções Urinárias/epidemiologia
Urina/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150122218D


  6 / 2323 MEDLINE  
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[PMID]:29341566
[Au] Autor:Dordevic V; Jovanovic M; Milicic B; Stefanovic V; Dukic-Dejanovic S
[Ti] Título:Prevalence of dental caries in hospitalized patients with schizophrenia.
[So] Source:Vojnosanit Pregl;73(12):1102-8, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: It is considered that over 450 million people worldwide suffer from some form of mental disorder. Previous studies in other countries have shown that schizophrenia is among the most frequent. Oral health is significant for general health and should not be separated from mental health. Studies in other countries have shown an increased incidence of carious and extracted teeth, and less incidence of filled teeth in this group of psychiatric patients. The aim of this study was to establish condition of the existing teeth, to determine the prevalence of caries and to consider possible risk factors that contribute to the current oral health status of hospitalized patients with schizophrenia. Methods: The study comprised 190 patients with schizophrenia, hospitalized at the Clinic for Psychiatric Disorders "Dr. Laza Lazarevic" in Belgrade, and 190 mentally healthy patients at the Clinic for Periodontology and Oral Medicine, Faculty of Dental Medicine in Belgrade. The decayed, missing, filled (DMF) index, sociodemographic and economic characteristics were registered in both groups, as well as characteristics of the primary disease of hospitalized patients with schizophrenia. Results: The value of DMF index (representing the sum of carious, extracted and filled teeth), in the hospitalized patients with schizophrenia was 18.57 ± 7.07 and 12.47 ± 5.64 in the healthy group (p = 0.000). The structure of the DMF index in the study group showed that caries and extracted teeth dominated with 88.1%; in the control group, filled teeth dominated with 55.6%, which was a statistically significant difference for all the three observed variables Conclusion: Hospitalized patients with schizophrenia had twice as many caries and extracted teeth, and five time less filled teeth than healthy people. The patient's age and taking antiparkinsonics were established as predictors of the increased DMF index in hospitalized patients with schizophrenia.
[Mh] Termos MeSH primário: Cárie Dentária/epidemiologia
Pacientes Internados
Esquizofrenia/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Estudos Transversais
Índice CPO
Cárie Dentária/diagnóstico
Restauração Dentária Permanente
Feminino
Hospitalização
Seres Humanos
Masculino
Meia-Idade
Saúde Bucal
Prevalência
Fatores de Risco
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
Sérvia/epidemiologia
Extração Dentária
Perda de Dente/diagnóstico
Perda de Dente/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150917111D


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[PMID]:29341565
[Au] Autor:Dinic M; Zecevic RD; Hajdukovic Z; Mijuskovic M; Duric P; Jovic Z; Grdinic A; Petrovic M; Terzic B; Pejovic J; Kandolf-Sekulovic L
[Ti] Título:Psoriasis is the independent factor for early atherosclerosis: A prospective study of cardiometabolic risk profile.
[So] Source:Vojnosanit Pregl;73(12):1094-1101, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Psoriasis as multisystemic inflammatory dis-ease is related with an increased cardiometabolic risk. The aim of the study was to analyze risk biomarkers, peripheral and renal arteries ultrasonography and echocardiography for subclinical atherosclerosis and metabolic disease in 106 subjects (66 psoriasis patients and 40 controls, 20 eczema patients and 20 healthy volunteers). Methods: In all exameenes following parameters were analyzed: body mass index (BMI), C-reactive protein, D-dimer, serum amyloid A (SAA), apolipoprotein (Apo) A1, ApoB, ApoB/Apo A1 index, fasting glucose, C-peptide, fasting insulinemia, homeostatic model assessment-insulin resistance (HOMA-IR), HOMA-ß-cell, lipid profile, serum uric acid concentration (SUAC), 24-h proteinuria and microalbuminuria. Carotid, brachial, femoral and renal arteries ultrasonography, as well as echocardiography was also performed. Results: Five of 66 (7.6%) psoriasis patients had metabolic syndrome (not present in both control groups). The following variables were increased in patients with psoriasis compared to both control groups: BMI (p = 0.012), insulinemia (p < 0.001), HOMA-IR (p = 0.003), HOMA-ß cell (p < 0.001), SUAC (p = 0.006), ApoB/ApoA1 ra-tio (p = 0.006) and microalbuminuria (p < 0.001). Also, increased C-peptide (p = 0.034), D-dimer (p = 0.029), triglycerides (p = 0.044), SAA (p = 0.005) and decreased ApoA1 (p = 0.014) were found in the psoriasis patients compared to healthy controls. HDL cholesterol was decreased in the psoriasis patients compared to the control group of eczema patients (p = 0.004). Common carotid (CIMT) and femoral artery intima-media thickness (FIMT) was significantly greater (p < 0.001) and the maximal flow speed (cm/s) in brachial artery significantly de-creased (p = 0.017) in the patients with psoriasis in comparison to both control groups. In multivariate logistic regression analysis, after the adjustment for confounding variables, the most important predictor of CIMT and FIMT was the diagnosis of psoriasis (p < 0.001).. Conclusion: Cardiometabolic risk biomarkers and ultrasonographic signs of early atherosclerosis are correlated with the diagnosis of psoriasis, and not to generalized eczema. Psoriasis was found to be an independent risk factor for subclinical atherosclerosis
[Mh] Termos MeSH primário: Aterosclerose/epidemiologia
Eczema/epidemiologia
Síndrome Metabólica/epidemiologia
Psoríase/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Aterosclerose/sangue
Aterosclerose/diagnóstico por imagem
Biomarcadores/sangue
Índice de Massa Corporal
Espessura Intima-Media Carotídea
Estudos de Casos e Controles
Distribuição de Qui-Quadrado
Comorbidade
Ecocardiografia
Eczema/sangue
Eczema/diagnóstico por imagem
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Síndrome Metabólica/sangue
Síndrome Metabólica/diagnóstico por imagem
Meia-Idade
Análise Multivariada
Razão de Chances
Prognóstico
Estudos Prospectivos
Psoríase/sangue
Psoríase/diagnóstico por imagem
Medição de Risco
Fatores de Risco
Sérvia/epidemiologia
Ultrassonografia Doppler em Cores
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150510134D


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[PMID]:29341564
[Au] Autor:Budimirovic DB; Protic D
[Ti] Título:FMR1 gene mutations cause neurodevelopmental-degenerative disorders: Importance of fragile X testing in Serbia
[So] Source:Vojnosanit Pregl;73(12):1089-93, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Mh] Termos MeSH primário: Análise Mutacional de DNA
Proteína do X Frágil de Retardo Mental/genética
Síndrome do Cromossomo X Frágil/genética
Testes Genéticos/métodos
Mutação
[Mh] Termos MeSH secundário: Comportamento Cooperativo
Síndrome do Cromossomo X Frágil/diagnóstico
Síndrome do Cromossomo X Frágil/epidemiologia
Predisposição Genética para Doença
Seres Humanos
Comunicação Interdisciplinar
Cooperação Internacional
Fenótipo
Valor Preditivo dos Testes
Sérvia/epidemiologia
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (FMR1 protein, human); 139135-51-6 (Fragile X Mental Retardation Protein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP161006315B


  9 / 2323 MEDLINE  
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[PMID]:29341563
[Au] Autor:Radonjic V; Jovic I; Kalaba M; Godman B; Kosutic J
[Ti] Título:Consumption of antihistamines in Serbia in the period 2011-2015 and the correlation with adverse drug reaction reports.
[So] Source:Vojnosanit Pregl;73(11):1076-7, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Mh] Termos MeSH primário: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Antagonistas dos Receptores Histamínicos/efeitos adversos
[Mh] Termos MeSH secundário: Sistemas de Notificação de Reações Adversas a Medicamentos
Revisão de Uso de Medicamentos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico
Seres Humanos
Fatores de Risco
Sérvia/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Histamine Antagonists)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP160909242R


  10 / 2323 MEDLINE  
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[PMID]:29328644
[Au] Autor:Grgov S; Tasic T; Radovanovic-Dinic B; Benedeto-Stojanov D
[Ti] Título:Can probiotics improve efficiency and safety profile of triple Helicobacter pylori eradication therapy? A prospective randomized study.
[So] Source:Vojnosanit Pregl;73(11):1044-9, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Some studies suggest the benefit of applying different probiotic strains in combination with antibiotics in the eradication of Helicobacter pylori (H. pylori) infection. The aim of this study was to evaluate the effect of co-administration of multiple probiotic strains with triple H. pylori eradication therapy.This prospective study included 167 patients with dyspeptic symptoms and chronic gastritis who were diagnosed with H. pylori infection and randomized into two groups. The group I of 77 patients underwent triple eradication therapy, for 7 days, with lansoprazole, 2 × 30 mg half an hour before the meal, amoxicillin 2 × 1.000 mg per 12 hours and clarithromycin 2 × 500 mg per 12 hours. After the 7th day of the therapy, lansoprazole continued at a dose of 30 mg for half an hour before breakfast for 4 weeks. The group II of 90 patients received the same treatment as the patients of the group I, with the addition of the probiotic cultures in the form of a capsule comprising Lactobacillus Rosell-52, Lactobacillus Rosell-11, Bifidobacterium Rosell-1755 and Saccharomyces boulardii, since the beginning of eradication for 4 weeks. Eradication of H. pylori infection control was performed 8 weeks after the therapy by rapid urease test and histopathologic evaluation of endoscopic biopsies or by stool antigen test for H. pylori.Eradication of H. pylori infection was achieved in 93.3% of the patients who received probiotics with eradication therapy and in 81.8% of patients who were only on eradication therapy without probiotics. The difference in eradication success was statistically significant, (p < 0.05). The incidence of adverse effects of eradication therapy was higher in the group of patients who were not on probiotic (28.6%) than in the group that received probiotic (17.7%), but the difference was not statistically significant.Multiple probiotic strains addition to triple eradication therapy of H. pylori achieves a significantly better eradication success, with fewer side effects of antibiotics.
[Mh] Termos MeSH primário: Amoxicilina/uso terapêutico
Antibacterianos/uso terapêutico
Claritromicina/uso terapêutico
Gastrite/tratamento farmacológico
Infecções por Helicobacter/tratamento farmacológico
Helicobacter pylori/efeitos dos fármacos
Lansoprazol/uso terapêutico
Probióticos/uso terapêutico
Inibidores da Bomba de Prótons/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Amoxicilina/efeitos adversos
Antibacterianos/efeitos adversos
Biópsia
Doença Crônica
Claritromicina/efeitos adversos
Quimioterapia Combinada
Feminino
Gastrite/diagnóstico
Gastrite/microbiologia
Gastroscopia
Infecções por Helicobacter/diagnóstico
Infecções por Helicobacter/microbiologia
Helicobacter pylori/patogenicidade
Seres Humanos
Lansoprazol/efeitos adversos
Masculino
Meia-Idade
Probióticos/efeitos adversos
Estudos Prospectivos
Inibidores da Bomba de Prótons/efeitos adversos
Sérvia
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Proton Pump Inhibitors); 0K5C5T2QPG (Lansoprazole); 804826J2HU (Amoxicillin); H1250JIK0A (Clarithromycin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150415127G



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