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  1 / 22509 MEDLINE  
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[PMID]:28466547
[Au] Autor:Inch J; Notman F; Watson M; Green D; Baird R; Ferguson J; Hind C; McKinstry B; Strath A; Bond C; Telepharmacy Research Team
[Ad] Endereço:Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK.
[Ti] Título:Tele-pharmacy in rural Scotland: a proof of concept study.
[So] Source:Int J Pharm Pract;25(3):210-219, 2017 Jun.
[Is] ISSN:2042-7174
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Technology enables medical services to be provided to rural communities. This proof of concept study assessed the feasibility and acceptability of delivering community pharmacy services (CPS; including advice, sale of over-the-counter products and dispensing of prescriptions) by tele-technology (the Telepharmacy Robotic Supply Service (TPRSS)) to a rural population in Scotland. METHODS: Data collection included the following: postal surveys to local residents; focus groups/ interviews with pharmacists, other healthcare professionals (HCPs) and service users, at baseline and follow-up; TPRSS logs. Interviews/focus groups were audio-recorded, transcribed and thematically analysed. Descriptive statistics were reported for survey data. RESULTS: Qualitative results: Pre-installation: residents expressed satisfaction with current pharmacy access. HCPs believed the TPRSS would improve pharmacy access and reduce pressure on GPs. Concerns included costs, confidentiality, patient safety and 'fear' of technology. Post-installation: residents and pharmacy staff were positive, finding the service easy to use. Quantitative results: Pre-installation: almost half the respondents received regular prescription medicines and a third used an over-the-counter (OTC) medicine at least monthly. More than 80% (124/156) reported they would use the TPRSS. There was low awareness of the minor ailment service (MAS; 38%; 59/156). Post-installation: prescription ordering and OTC medicine purchase were used most frequently; the video link was used infrequently. Reasons for non-use were lack of need (36%; 40/112) and linkage to only one pharmacy (31%; 35/112). DISCUSSION: Community pharmacy services delivered remotely using tele-technology are feasible and acceptable. A larger study should be undertaken to confirm the potential of the TPRSS to reduce health inequalities in rural areas.
[Mh] Termos MeSH primário: Farmácia/tendências
Serviços de Saúde Rural/tendências
Telemedicina/tendências
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Serviços Comunitários de Farmácia
Prescrições de Medicamentos/estatística & dados numéricos
Estudos de Viabilidade
Feminino
Acesso aos Serviços de Saúde
Seres Humanos
Masculino
Meia-Idade
Medicamentos sem Prescrição
Farmacêuticos
População Rural
Escócia
Fatores Socioeconômicos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nonprescription Drugs)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/ijpp.12376


  2 / 22509 MEDLINE  
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[PMID]:29440602
[Ti] Título:Counting mountain hares in Scotland.
[So] Source:Vet Rec;182(6):158-159, 2018 02 10.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The mountain hare ( ) is Britain's only native hare, but counting them is challenging. Here, explains how new research is helping to finally discover the numbers of this elusive species.
[Mh] Termos MeSH primário: Lebres
[Mh] Termos MeSH secundário: Animais
Densidade Demográfica
Escócia
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE


  3 / 22509 MEDLINE  
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[PMID]:29246990
[Ti] Título:Mortality due to pulpy kidney in beef calves and goats.
[So] Source:Vet Rec;181(24):646-650, 2017 12 16.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças dos Animais/epidemiologia
Surtos de Doenças/veterinária
Vigilância de Evento Sentinela/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças das Aves/epidemiologia
Aves
Bovinos
Doenças dos Bovinos/epidemiologia
Doenças dos Bovinos/mortalidade
Feminino
Doenças das Cabras/epidemiologia
Doenças das Cabras/mortalidade
Cabras
Nefropatias/mortalidade
Nefropatias/veterinária
Aves Domésticas
Gravidez
Escócia/epidemiologia
Ovinos
Doenças dos Ovinos/epidemiologia
Suínos
Doenças dos Suínos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1136/vr.j5822


  4 / 22509 MEDLINE  
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[PMID]:29330157
[Au] Autor:Caan W
[Ad] Endereço:Duxford, UK.
[Ti] Título:Measuring the prevention of harm due to minimum alcohol pricing.
[So] Source:BMJ;360:k130, 2018 01 12.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/prevenção & controle
Bebidas Alcoólicas/economia
Redução do Dano
Suicídio/prevenção & controle
[Mh] Termos MeSH secundário: Consumo de Bebidas Alcoólicas/efeitos adversos
Consumo de Bebidas Alcoólicas/economia
Consumo de Bebidas Alcoólicas/mortalidade
Política de Saúde/legislação & jurisprudência
Promoção da Saúde/legislação & jurisprudência
Seres Humanos
Formulação de Políticas
Escócia/epidemiologia
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180114
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k130


  5 / 22509 MEDLINE  
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[PMID]:28470928
[Au] Autor:Ganzola R; Nickson T; Bastin ME; Giles S; Macdonald A; Sussmann J; McIntosh AM; Whalley HC; Duchesne S
[Ad] Endereço:Institut universitaire en santé mentale de Québec, Québec City, Québec, Canada.
[Ti] Título:Longitudinal differences in white matter integrity in youth at high familial risk for bipolar disorder.
[So] Source:Bipolar Disord;19(3):158-167, 2017 May.
[Is] ISSN:1399-5618
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Previous neuroimaging studies have reported abnormalities in white matter (WM) pathways in subjects at high familial risk of mood disorders. In the current study, we examined the trajectory of these abnormalities during the early stages of illness development using longitudinal diffusion tensor imaging (DTI) data. METHODS: Subjects (16-28 years old) were recruited in the Scottish Bipolar Family Study, a prospective longitudinal study that has examined individuals at familial risk of mood disorder on three occasions, 2 years apart. The current study concerns imaging data from the first and second assessments. We analysed DTI data for 43 controls and 69 high-risk individuals who were further subdivided into a group of 53 high-risk subjects who remained well (high-risk well) and 16 who met diagnostic criteria for major depressive disorder (high-risk MDD) at follow-up. Longitudinal differences in fractional anisotropy (FA) between groups based on diagnostic status were investigated using the tract-based spatial statistics technique (TBSS). RESULTS: We found a significant reduction in FA (P <.05) across widespread brain regions over 2 years in all three groups. The trajectory of FA reduction did not differ significantly between groups. CONCLUSIONS: These results suggest that there are similar trajectories of FA reductions for controls and high-risk young adults, despite high-risk individuals being at a disadvantaged starting point considering their reduced WM integrity detected at baseline in previous studies. Difference in WM integrity between high-risk individuals and controls could therefore occur in earlier childhood and be a necessary but not sufficient condition to develop future mood disorders.
[Mh] Termos MeSH primário: Transtorno Bipolar
Substância Branca/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anisotropia
Transtorno Bipolar/diagnóstico
Transtorno Bipolar/epidemiologia
Transtorno Depressivo Maior/diagnóstico
Transtorno Depressivo Maior/epidemiologia
Imagem de Tensor de Difusão/métodos
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Anamnese/métodos
Neuroimagem/métodos
Estudos Prospectivos
Medição de Risco
Fatores de Risco
Escócia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1111/bdi.12489


  6 / 22509 MEDLINE  
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[PMID]:29253440
[Au] Autor:Ellis DA; McQueenie R; McConnachie A; Wilson P; Williamson AE
[Ad] Endereço:Department of Psychology, Lancaster University, Lancaster, UK.
[Ti] Título:Demographic and practice factors predicting repeated non-attendance in primary care: a national retrospective cohort analysis.
[So] Source:Lancet Public Health;2(12):e551-e559, 2017 Dec.
[Is] ISSN:2468-2667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Addressing the causes of low engagement in health care is a prerequisite for reducing health inequalities. People who miss multiple appointments are an under-researched group who might have substantial unmet health needs. Individual-level patterns of missed general practice appointments might thus provide a risk marker for vulnerability and poor health outcomes. We sought to ascertain the contributions of patient and practice factors to the likelihood of missing general practice appointments. METHODS: For this national retrospective cohort analysis, we extracted UK National Health Service general practice data that were routinely collected across Scotland between Sept 5, 2013, and Sept 5, 2016. We calculated the per-patient number of missed appointments from individual appointments and investigated the risk of missing a general practice appointment using a negative binomial model offset by number of appointments made. We then analysed the effect of patient-level factors (including age, sex, and socioeconomic status) and practice-level factors (including appointment availability and geographical location) on the risk of missing appointments. FINDINGS: The full dataset included information from 909 073 patients, of whom 550 083 were included in the analysis after processing. We observed that 104 461 (19·0%) patients missed more than two appointments in the 3 year study period. After controlling for the number of appointments made, patterns of non-attendance could be differentiated, with patients who were aged 16-30 years (relative risk ratio [RRR] 1·21, 95% CI 1·19-1·23) or older than 90 years (2·20, 2·09-2·29), and of low socioeconomic status (Scottish Index of Multiple Deprivation decile 1: RRR 2·27, 2·22-2·31) significantly more likely to miss multiple appointments. Men missed fewer appointments overall than women, but were somewhat more likely to miss appointments in the adjusted model (1·05, 1·04-1·06). Practice factors also substantially affected attendance patterns, with urban practices in affluent areas that typically have appointment waiting times of 2-3 days the most likely to have patients who serially miss appointments. The combination of both patient and practice factors to predict appointments missed gave a higher pseudo R value (0·66) than models using either group of factors separately (patients only R =0·54; practice only R =0·63). INTERPRETATION: The findings that both patient and practice characteristics contribute to non-attendance of general practice appointments raise important questions for both the management of patients who miss multiple appointments and the effectiveness of existing strategies that aim to increase attendance. Addressing these issues should lead to improvements in provision of services and public health. FUNDING: Scottish Government Chief Scientist Office and Data Sharing and Linkage Service of the Scottish Government.
[Mh] Termos MeSH primário: Agendamento de Consultas
Medicina Geral
Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos
Atenção Primária à Saúde/utilização
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Estudos Retrospectivos
Escócia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  7 / 22509 MEDLINE  
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[PMID]:29374722
[Au] Autor:Kalampokas E; Young H; Bednarek A; Habib M; Parkin DE; Gurumurthy M; Cairns M
[Ad] Endereço:Department of Gynecologic Oncology, Aberdeen Royal Infirmary, Aberdeen, U.K. m.kalampokas@gmail.com.
[Ti] Título:Surgical Outcomes and Morbidity After Radical Surgery for Ovarian Cancer in Aberdeen Royal Infirmary, the Northeast of Scotland Gynaecologic Oncology Centre.
[So] Source:Anticancer Res;38(2):923-928, 2018 02.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Ovarian cancer (OC) has a high mortality rate and usually presents late in advanced stage, which poses challenges to management. Better understanding of the disease biology and application of radical surgery (RS) to achieve no visible residual tumor, alongside with chemotherapy, may lead to longer survival amongst these patients. Our purpose was to examine the demographic characteristics, surgical morbidity and outcomes of patients undergoing RS for OC. MATERIALS AND METHODS: A retrospective cohort study of women undertaking surgery for OC between February 2014 and September 2016 in Aberdeen Royal Infirmary. RESULTS: A total of 121 women had surgery for OC of whom 78 (64.5%) were stage II and above. Of these, 40 (51.3%) women had primary and 38 (48.7%) had interval debulking surgery with 42 (53.8%) having radical surgery. The most common procedures that were performed as part of RS included rectosigmoid resection (n=20, 47.6%), small bowel resection (n=10, 23.8%), splenectomy (n=9, 21.4%). Morbidity outcomes included blood loss >1.5 lt. (n=14, 33.3%), hospitalization >7days (n=31, 73.8%), sepsis (n=8, 19%). There was no short-term mortality. Debulking outcomes were: no macroscopic residual disease (n=36, 85.7%), ≤10 mm disease (n=2, 4.8%), and ≥10 mm disease (n=3, 7.1%). CONCLUSION: Our findings support the practise where RS for OC can be offered to selected patients, with good surgery outcomes and low morbidity rates.
[Mh] Termos MeSH primário: Adenocarcinoma de Células Claras/cirurgia
Adenocarcinoma Mucinoso/cirurgia
Cistadenocarcinoma Seroso/cirurgia
Neoplasias do Endométrio/cirurgia
Neoplasias Ovarianas/cirurgia
[Mh] Termos MeSH secundário: Adenocarcinoma de Células Claras/patologia
Adenocarcinoma Mucinoso/patologia
Idoso
Cistadenocarcinoma Seroso/patologia
Procedimentos Cirúrgicos de Citorredução
Neoplasias do Endométrio/patologia
Feminino
Seguimentos
Seres Humanos
Meia-Idade
Morbidade
Neoplasias Ovarianas/patologia
Estudos Retrospectivos
Escócia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE


  8 / 22509 MEDLINE  
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[PMID]:29236828
[Au] Autor:Carvalho VM; Nogueira EAG; Rosa GR; Fragoso YD
[Ad] Endereço:Universidade Metropolitana de Santos, Departamento de Neurologia, Santos SP, Brasil.
[Ti] Título:Mary Broadfoot Walker: 83 years since a historical discovery.
[So] Source:Arq Neuropsiquiatr;75(11):825-826, 2017 Nov.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis. An original five-minutes movie is available online and the skepticism of her contemporary British medical doctors is understandable when the drastic effect of the treatment is shown in this movie. What Mary Walker taught us, more than eight decades ago, about myasthenia gravis continues to be the basis of a pharmacological diagnostic test and treatment of this disease.
[Mh] Termos MeSH primário: Inibidores da Colinesterase/história
Miastenia Gravis/história
Fisostigmina/história
[Mh] Termos MeSH secundário: Inibidores da Colinesterase/uso terapêutico
História do Século XX
Miastenia Gravis/tratamento farmacológico
Fisostigmina/uso terapêutico
Escócia
Gravação em Vídeo
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Walker MB
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 9U1VM840SP (Physostigmine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  9 / 22509 MEDLINE  
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[PMID]:29240791
[Au] Autor:Sawyer ADM; Jones R; Ucci M; Smith L; Kearns A; Fisher A
[Ad] Endereço:Department of Behavioural Science and Health, University College London, London, United Kingdom.
[Ti] Título:Cross-sectional interactions between quality of the physical and social environment and self-reported physical activity in adults living in income-deprived communities.
[So] Source:PLoS One;12(12):e0188962, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Understanding the environmental determinants of physical activity in populations at high risk of inactivity could contribute to the development of effective interventions. Socioecological models of activity propose that environmental factors have independent and interactive effects of physical activity but there is a lack of research into interactive effects. OBJECTIVES: This study aimed to explore independent and interactive effects of social and physical environmental factors on self-reported physical activity in income-deprived communities. METHODS: Participants were 5,923 adults in Glasgow, United Kingdom. Features of the social environment were self-reported. Quality of the physical environment was objectively-measured. Neighbourhood walking and participation in moderate physical activity [MPA] on ≥5 days/week was self-reported. Multilevel multivariate logistic regression models tested independent and interactive effects of environmental factors on activity. RESULTS: 'Social support' (walking: OR:1.22,95%CI = 1.06-1.41,p<0.01; MPA: OR:0.79,95%CI = 0.67-0.94,p<0.01), 'social interaction' (walking: OR:1.25,95%CI = 1.10-1.42,p<0.01; MPA: OR:6.16,95%CI = 5.14-7.37,p<0.001) and 'cohesion and safety' (walking: OR:1.78,95%CI = 1.56-2.03,p<0.001; MPA: OR:1.93,95%CI = 1.65-2.27,p<0.001), but not 'trust and empowerment', had independent effects on physical activity. 'Aesthetics of built form' (OR:1.47,95%CI = 1.22-1.77,p<0.001) and 'aesthetics and maintenance of open space' (OR:1.32, 95%CI = 1.13-1.54,p<0.01) were related to walking. 'Physical disorder' (OR:1.63,95%CI = 1.31-2.03,p<0.001) had an independent effect on MPA. Interactive effects of social and physical factors on walking and MPA were revealed. CONCLUSIONS: Findings suggest that intervening to create activity-supportive environments in deprived communities may be most effective when simultaneously targeting the social and physical neighbourhood environment.
[Mh] Termos MeSH primário: Exercício
Pobreza
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Escócia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188962


  10 / 22509 MEDLINE  
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[PMID]:28748773
[Au] Autor:Jin L; Xu S; Maple PAC; Xu W; Brown KE
[Ad] Endereço:Virus Reference Department,National Infections Service,Public Health England,London,UK.
[Ti] Título:Differentiation between wild-type and vaccines strains of varicella zoster virus (VZV) based on four single nucleotide polymorphisms.
[So] Source:Epidemiol Infect;145(12):2618-2625, 2017 09.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Varicella-zoster virus (VZV) infection (chickenpox) results in latency and subsequent reactivation manifests as shingles. Effective attenuated vaccines (vOka) are available for prevention of both illnesses. In this study, an amplicon-based sequencing method capable of differentiating between VZV wild-type (wt) strains and vOka vaccine is described. A total of 44 vesicular fluid specimens collected from 43 patients (16 from China and 27 from the UK) with either chickenpox or shingles were investigated, of which 10 had received previous vaccination. Four sets of polymerase chain reactions were set up simultaneously with primers amplifying regions encompassing four single nucleotide polymorphisms (SNPs), '69349-106262-107252-108111'. Nucleotide sequences were generated by Sanger sequencing. All samples except one had a wt SNP profile of 'A-T-T-T'. The sample collected from a patient who received vaccine 7-10 days ago, along with VZV vaccine preparations, Zostavax and Baike-varicella gave a SNP profile 'G-C-C-C'. The results show that this method can distinguish vaccine-derived virus from wt viruses from main four clades, (clades 1-4) and should be of utility worldwide.
[Mh] Termos MeSH primário: Vacina contra Varicela/genética
Herpesvirus Humano 3/genética
Reação em Cadeia da Polimerase
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Varicela/virologia
Vacina contra Varicela/classificação
Criança
Pré-Escolar
China
Inglaterra
Feminino
Herpes Zoster/virologia
Herpesvirus Humano 3/classificação
Seres Humanos
Lactente
Masculino
Meia-Idade
Escócia
Análise de Sequência de DNA
Vacinas Atenuadas/classificação
Vacinas Atenuadas/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chickenpox Vaccine); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001509



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