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[PMID]:29458550
[Au] Autor:Petridou E; Jensen CB; Arvanitidis A; Giannaki-Psinaki M; Michos A; Krogfelt KA; Petersen RF
[Ad] Endereço:1​Department of Clinical Microbiology, 'Aghia Sophia' Children's Hospital, Athens, Greece.
[Ti] Título:Molecular epidemiology of Bordetella pertussis in Greece, 2010-2015.
[So] Source:J Med Microbiol;67(3):400-407, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine the predominant strains of Bordetella pertussis in Greece during 2010-2015. METHODOLOGY: Infants and children (n=1150) (15 days to 14 years) of Greek, Roma and immigrant origin with different vaccination statuses were hospitalized in Athens, Greece with suspected pertussis infection. IS481/IS1001 real-time PCR confirmed Bordetella spp./B. pertussis infection in 300 samples. A subset of samples (n=153) were analysed by multi-locus variable number tandem repeat analysis (MLVA) and (n=25) by sequence-based typing of the toxin promotor region (ptxP) on DNA extracted from clinical specimens.Results/Key findings. A complete MLVA profile was determined in 66 out of 153 samples; the B. pertussis MLVA type 27 (n=55) was the dominant genotype and all tested samples (n=25) expressed the ptxP3 genotype. The vaccine coverage in the Greek population was 90 %; however, the study population expressed complete coverage in 2 out of 264 infants (0-11 months) and in 20 out of 36 children (1-14 years). Roma and immigrant minorities represent 7 % of the Greek population, but make up 50 % of the study population, indicating a low vaccine coverage among these groups. CONCLUSIONS: The B. pertussis MT27 and ptxP3 genotype is dominant in Greek, Roma and immigrant infants and children hospitalized in Greece. Thus, the predominant MLVA genotype in Greece is similar to other countries using acellular vaccines.
[Mh] Termos MeSH primário: Bordetella pertussis/genética
Coqueluche/epidemiologia
Coqueluche/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Bordetella pertussis/isolamento & purificação
Criança
Pré-Escolar
DNA Bacteriano/genética
Feminino
Variação Genética
Genótipo
Grécia/epidemiologia
Hospitais Pediátricos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Repetições Minissatélites
Epidemiologia Molecular
Tipagem de Sequências Multilocus
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de DNA
Coqueluche/diagnóstico
Coqueluche/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000688


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[PMID]:29177261
[Au] Autor:Koutsikos J; Angelidis G; Zafeirakis A; Mamarelis I; Vogiatzis M; Ilia E; Lazaridis K; Demakopoulos N
[Ad] Endereço:Department of Nuclear Medicine Army Share Fund Hospital (417 NIMTS) Athens, Greece. jtkoutsik@yahoo.gr.
[Ti] Título:Performance and safety profile of regadenoson myocardial perfusion imaging: first experience in Greece.
[So] Source:Hell J Nucl Med;20(3):232-236, 2017 Sep-Dec.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: MPI can provide valuable information in the investigation of patients with known or suspected coronary artery disease. The stress component of the studies can be conducted with regadenoson, which was approved for clinical use in Greece in 2016. We investigated the performance and safety profile of regadenoson MPI based on our 7 months institutional experience. PATIENTS AND METHODS: We studied 96 consecutive patients (59 males, 37 females, mean age 70.35y.o, range: 46-87y.o.) referred to our department for a clinically indicated MPI study with pharmacological stress. Eleven patients suffered from chronic obstructive pulmonary disease. Patients underwent regadenoson stress test, combined with both stress and rest imaging. Data on the symptoms and electrocardiographic changes due to regadenoson administration were recorded. Symptoms were graded as 1-mild: a symptom that did not distress the patient, 2-moderate: a symptom that distressed the patient but it was self-limiting, or 3-severe: a symptom that distressed the patient requiring medical intervention. RESULTS: Regadenoson-related symptoms were reported in 56 patients and were: dyspnea, discomfort, dizziness, chest pain, epigastric pain, neck pain, headache, flushing, nausea, heartburn, weakness, and upper limbs numbness. The severity of symptoms was recorded as grade 1 in 30 patients, grade 2 in 25 patients, and grade 3 in 1 patient. Two or more different symptoms were reported in 28 patients. Ischemic electrocardiographic changes and arrhythmias were observed in 8 patients. CONCLUSION: Our findings support previously published data indicating the optimal safety profile of regadenoson MPI, even in the group of patients suffering from chronic obstructive pulmonary disease.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/diagnóstico por imagem
Doença da Artéria Coronariana/epidemiologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Teste de Esforço/estatística & dados numéricos
Imagem de Perfusão do Miocárdio/métodos
Purinas
Pirazóis
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Causalidade
Comorbidade
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico
Feminino
Grécia/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Imagem de Perfusão do Miocárdio/estatística & dados numéricos
Projetos Piloto
Tomografia por Emissão de Pósitrons/métodos
Tomografia por Emissão de Pósitrons/estatística & dados numéricos
Prevalência
Reprodutibilidade dos Testes
Fatores de Risco
Sensibilidade e Especificidade
Resultado do Tratamento
Vasodilatadores
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Purines); 0 (Pyrazoles); 0 (Vasodilator Agents); 2XLN4Y044H (regadenoson)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1967/s002449910607


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[PMID]:29363527
[Au] Autor:Vasileiou V; Kyratzoglou E; Paschou SA; Kyprianou M; Anastasiou E
[Ad] Endereço:Department of Endocrinology and Diabetes'Alexandra' Hospital, Athens, Greece.
[Ti] Título:The impact of environmental temperature on the diagnosis of gestational diabetes mellitus.
[So] Source:Eur J Endocrinol;178(3):209-214, 2018 Mar.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate a probable impact of seasons on the diagnosis of GDM, as well as the specific effect of the environmental temperature on the diagnosis of this clinical entity. PATIENTS AND METHODS: Two observational studies, one retrospective and one prospective, were conducted in a referral center. Study A included retrospectively 7618 pregnant women who underwent a 3-h 100 g OGTT during the 3rd trimester of gestation. Study B prospectively included 768 pregnant women tested in the 3rd trimester of gestation with a 75 g OGTT. Temperature was recorded every day at 09:00 h. RESULTS: Retrospective Study A: GDM prevalence differed significantly by season: winter = 28.1%, summer = 39.2%, spring = 32.4% and autumn = 32.4% ( < 0.0001). The odds ratio for being diagnosed with GDM was much higher during summer 1.65 (95% CI: 1.43-1.90), with spring and autumn following with 1.23 (95% CI: 1.08-1.39) compared to winter. Glucose levels during OGTT were measured: significantly increased blood glucose values were observed at 60, 120 and 180 min in summer, which remained significant after adjustment for age, gestational age, BMI, weight gain during pregnancy and blood pressure. Prospective Study B: At temperatures above 25°C, the average glucose 60-min and 120-min levels were increased. The relative risk for abnormal glucose values at 60 min, when the environmental temperature increased over 25°C, was 2.2 (1.5-3.3). CONCLUSIONS: GDM prevalence in Greece presents seasonal variation, with higher risk during summer due to post glucose load level variations. These variations could be attributed to differences in environmental temperature.
[Mh] Termos MeSH primário: Diabetes Gestacional/epidemiologia
Estações do Ano
Temperatura Ambiente
[Mh] Termos MeSH secundário: Adulto
Glicemia/metabolismo
Diabetes Gestacional/diagnóstico
Diabetes Gestacional/metabolismo
Feminino
Teste de Tolerância a Glucose
Grécia/epidemiologia
Seres Humanos
Razão de Chances
Gravidez
Terceiro Trimestre da Gravidez
Prevalência
Estudos Prospectivos
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0730


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[PMID]:29283532
[Au] Autor:Pollier P
[Ti] Título:The Art of Vesalius: The continuing influence of "De Humani Corporis Fabrica" on Art.
[So] Source:Vesalius;22(1):125-32, 2016 Jun.
[Is] ISSN:1373-4857
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:A search for the intimate relationship between art and science in the study of the human body inevitably leads to the beautiful pictures of Vesalius' Fabrica. Medical artists and scientific researchers alike discover the enhanced power of text and iconography in transmitting knowledge as well as beauty of expression. Pursuing this goal, a facial reconstruction was made of Vesalius' portrait in the Fabrica. Final proof of the correctness of this reconstruction will be given when Vesalius' s grave and remains may be found on the island of Zakynthos where Vesalius died and was buried. Meanwhile medical artists continue to give their vision on anatomy, the human body and its intangible soul.
[Mh] Termos MeSH primário: Anatomia/história
Corpo Humano
Ilustração Médica/história
[Mh] Termos MeSH secundário: Grécia
História do Século XVI
Itália
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Vesalius A
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


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[PMID]:28749779
[Au] Autor:Karakatsani A; Samoli E; Rodopoulou S; Dimakopoulou K; Papakosta D; Spyratos D; Grivas G; Tasi S; Angelis N; Thirios A; Tsiotsios A; Katsouyanni K
[Ad] Endereço:2nd Pulmonary Department, ATTIKON University Hospital, School of Medicine, National and Kapodistrian University of Athens , Athens, Greece
[Ti] Título:Weekly Personal Ozone Exposure and Respiratory Health in a Panel of Greek Schoolchildren.
[So] Source:Environ Health Perspect;125(7):077017, 2017 07 21.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The association of ozone exposure with respiratory outcomes has been investigated in epidemiologic studies mainly including asthmatic children. The findings reported had methodological gaps and inconsistencies. OBJECTIVES: We aimed to investigate effects of personal ozone exposure on various respiratory outcomes in school-age children generally representative of the population during their normal activities. METHODS: We conducted a panel study in a representative sample of school-age children in the two major cities of Greece, Athens and Thessaloniki. We followed 188, 10- to 11-y-old, elementary school students for 5 wk spread throughout the 2013­2014 academic year, during which ozone was measured using personal samplers. At the end of each study week, spirometry was performed by trained physicians, and the fractional concentration of nitric oxide in exhaled air ( ) was measured. Students kept a daily time­activity­symptom diary and measured PEF (peak expiratory flow) using peak flow meters. Mixed models accounting for repeated measurements were applied. RESULTS: An increase of 10 µg/m in weekly ozone concentration was associated with a decrease in FVC (forced vital capacity) and FEV (forced expiratory volume in 1 s) of 0.03 L [95% confidence interval (CI): −0.05, −0.01] and 0.01 L (95% CI: −0.03, 0.003) respectively. The same increase in exposure was associated with a 11.10% (95% CI: 4.23, 18.43) increase in and 19% (95% CI: −0.53, 42.75) increase in days with any symptom. The effect estimates were robust to PM adjustment. No inverse association was found between ozone exposure and PEF. CONCLUSIONS: The study provides evidence that airway inflammation and the frequency of respiratory symptoms increase, whereas lung function decreases with increased ozone exposure in schoolchildren. https://doi.org/10.1289/EHP635.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Exposição Ambiental
Inflamação/epidemiologia
Ozônio/toxicidade
Doenças Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Criança
Monitoramento Ambiental
Feminino
Grécia/epidemiologia
Seres Humanos
Inflamação/induzido quimicamente
Masculino
Testes de Função Respiratória
Doenças Respiratórias/induzido quimicamente
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants); 66H7ZZK23N (Ozone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1289/EHP635


  6 / 14513 MEDLINE  
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[PMID]:29253418
[Au] Autor:Laliotis I; Ioannidis JPA; Stavropoulou C
[Ad] Endereço:School of Economics, Faculty of Arts and Social Sciences, University of Surrey, Guildford, UK.
[Ti] Título:Total and cause-specific mortality before and after the onset of the Greek economic crisis: an interrupted time-series analysis.
[So] Source:Lancet Public Health;1(2):e56-e65, 2016 Dec.
[Is] ISSN:2468-2667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Greece was one of the countries hit the hardest by the 2008 financial crisis in Europe. Yet, evidence on the effect of the crisis on total and cause-specific mortality remains unclear. We explored whether the economic crisis affected the trend of overall and cause-specific mortality rates. METHODS: We used regional panel data from the Hellenic Statistical Authority to assess mortality trends by age, sex, region, and cause in Greece between January, 2001, and December, 2013. We used Eurostat data to calculate monthly age-standardised mortality rates per 100 000 inhabitants for each region. Data were divided into two subperiods: before the crisis (January, 2001, to August, 2008) and after the onset of the crisis (September, 2008, to December, 2013). We tested for changes in the slope of mortality by doing an interrupted time-series analysis. FINDINGS: Overall mortality continued to decline after the onset of the financial crisis (-0·065, 95% CI -0·080 to -0·049), but at a slower pace than before the crisis (-0·13, -0·15 to -0·10; trend difference 0·062, 95% CI 0·041 to 0·083; p<0·0001). The trend difference was more evident for females (0·087, 95% CI 0·064-0·11; p<0·0001) than for males (0·040, 0·013-0·066; p=0·007). Those aged at least 75 years experienced more negative effects (trend difference 0·056, 95% CI 0·042 to 0·071; p<0·0001) than did those aged 20-34 years, in whom mortality trends improved (-0·0074, -0·0089 to -0·0059; p<0·0001). Deaths by diseases of the circulatory system declined more slowly after the onset of compared with before the crisis (trend difference 0·043, 95% CI 0·024 to 0·063; p<0·0001), whereas deaths from vehicular accidents declined faster (-0·0062, -0·0090 to -0·0033; p<0·0001), most prominently among men aged 20-34 years (-0·0065, -0·0085 to -0·0044; p<0·0001). Conversely, deaths from suicides (trend difference 0·0021, 95% CI 0·00092-0·0033; p=0·002), diseases of the nervous system (0·0036, 0·0016-0·0056; p=0·002), and mental health problems (0·00073, 0·000047-0·0014 p=0·038) increased after the onset of the crisis. Also, deaths due to adverse events during medical treatment increased significantly after the onset of the crisis (trend difference 0·0020, 95% CI 0·0012-0·0028; p<0·0001). By comparing the expected values of the period after the onset of the crisis with extrapolated values based on the period before the crisis, we estimate that an extra 242 deaths per month occurred after the onset of the crisis. INTERPRETATION: Mortality trends have been interrupted after the onset of compared with before the crisis, but changes vary by age, sex, and cause of death. The increase in deaths due to adverse events during medical treatment might reflect the effects of deterioration in quality of care during economic recessions. FUNDING: None.
[Mh] Termos MeSH primário: Recessão Econômica/estatística & dados numéricos
Mortalidade
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Causas de Morte
Feminino
Grécia/epidemiologia
Seres Humanos
Análise de Séries Temporais Interrompida
Masculino
Meia-Idade
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  7 / 14513 MEDLINE  
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[PMID]:29281669
[Au] Autor:Finné M; Holmgren K; Shen CC; Hu HM; Boyd M; Stocker S
[Ad] Endereço:Department of Archaeology and Ancient History, Uppsala University, Uppsala, Sweden.
[Ti] Título:Late Bronze Age climate change and the destruction of the Mycenaean Palace of Nestor at Pylos.
[So] Source:PLoS One;12(12):e0189447, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper offers new high-resolution oxygen and carbon isotope data from Stalagmite S1 from Mavri Trypa Cave, SW Peloponnese. Our data provide the climate background to the destruction of the nearby Mycenaean Palace of Nestor at Pylos at the transition from Late Helladic (LH) IIIB to LH IIIC, ~3150-3130 years before present (before AD 1950, hereafter yrs BP) and the subsequent period. S1 is dated by 24 U-Th dates with an averaged precision of ±26 yrs (2σ), providing one of the most robust paleoclimate records from the eastern Mediterranean for the end of the Late Bronze Age (LBA). The δ18O record shows generally wetter conditions at the time when the Palace of Nestor at Pylos was destroyed, but a brief period of drier conditions around 3200 yrs BP may have disrupted the Mycenaean agricultural system that at the time was likely operating close to its limit. Gradually developing aridity after 3150 yrs BP, i.e. subsequent to the destruction, probably reduced crop yields and helped to erode the basis for the reinstitution of a central authority and the Palace itself.
[Mh] Termos MeSH primário: Arqueologia
Mudança Climática
[Mh] Termos MeSH secundário: Fósseis
Grécia
Datação Radiométrica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189447


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[PMID]:29190454
[Au] Autor:Mathioudaki A; Berzesta A; Kypriotakis Z; Skaltsa H; Heilmann J
[Ad] Endereço:Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71, Athens, Greece; Universität Regensburg, Pharmaceutical Biology, Universitätsstr. 31, D-93053, Regensburg, Germany.
[Ti] Título:Phenolic metabolites from Hypericum kelleri Bald., an endemic species of Crete (Greece).
[So] Source:Phytochemistry;146:1-7, 2018 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thirteen compounds were isolated from the aerial parts of Hypericum kelleri Bald., growing as an endemic on the island of Crete (Greece). These compounds comprise four previously unknown prenylated xanthones 1,2-dihydro-3,8-dihydroxy-6-methoxy-1,1,5-tri(3-methylbut-2-enyl)xanthen-2,9-dione (kellerine A), 1,2-dihydro-3,6,8-trihydroxy-1,1,5-tri(3-methylbut-2-enyl)xanthen-2,9-dione (kellerine B), 1,2-dihydro-3,8-dihydroxy-6-methoxy-1,1-bi(3-methylbut-2-enyl)xanthen-2,9-dione (6-methylpatulone), (R/S)-1,3,5-trihydroxy-2-(3-methyl-2-buten-1-yl)-4-[2-(3-methylbut-2-enyl)-3-methylbut-3-enyl]-6-methoxy-9H-xanthen-9-one ((2″R/S)-kellerine C) and the hitherto undescribed depsidone (R/S)-1,3,6-trihydroxy-5-methoxy-2-(3-methyl-2-buten-1-yl)-4-[2-(3-methylbut-2-enyl)-3-methylbut-3-enyl]-11Η-dibenzo[b,e] [1,4]dioxepin-9-one ((2″R/S)-creticine). As known compounds, brevipsidone D, 4-geranyl-2-(2'-isobutyryl)-phloroglucinol, 4-geranyl-2-(2'-methylbutyryl)-phloroglucinol, I3, II8-biapigenin, quercetin, avicularin, pseudohypericin and neochlorogenic acid have been isolated. The structures were elucidated on the basis of their 1D, 2D NMR, CD and MS data. The study confirms the typical occurrence of xanthones in Hypericum section Oligostema (Boiss.) Stef., and is also the first report on the simultaneous isolation of acylphloroglucinols in this section. Furthermore the first evidence of depsidones in the genus Hypericum L. is reported. Cytotoxicity was investigated in HeLa cells for prenylated xanthones and the depsidones. Both triprenylated 1,2-dihydroxanthones (kellerine A and B) showed significant in vitro cytotoxicity with IC values of 2.5 ± 0.1 (kellerine A) and 5.9 ± 0.9 (kellerine B) µM, whereas other compounds were less cytotoxic (IC > 20 µM).
[Mh] Termos MeSH primário: Hypericum/química
Fenóis/farmacologia
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Grécia
Células HeLa
Seres Humanos
Estrutura Molecular
Fenóis/química
Fenóis/isolamento & purificação
Componentes Aéreos da Planta/química
Relação Estrutura-Atividade
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  9 / 14513 MEDLINE  
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[PMID]:28966025
[Au] Autor:Honda M; Kannan K
[Ad] Endereço:Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509, USA.
[Ti] Título:Biomonitoring of chlorophenols in human urine from several Asian countries, Greece and the United States.
[So] Source:Environ Pollut;232:487-493, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chlorophenols (CPs) are used in the production of pesticides and preservatives. Although human exposure to CPs has been known for years, current exposure levels to these chemicals in Asian countries are not known. In this study, we analyzed concentrations of eight CPs in 300 human urine samples collected from nine countries. Of these CPs, 2,5-dichlorophenol and 2,4-dichlorophenol were found at the highest median concentrations (median for all nine countries: 1.78 and 0.34 ng/mL, respectively). Pentachlorophenol was found in 59% of the samples analyzed at a median concentration of 0.07 ng/mL. Urine samples from Japan had the highest concentration of total CPs (median: 16.7 ng/mL) with 2,5-dichlorophenol accounting for 93.1% of the total concentration. The estimated daily intake (DI) for precursors of dichlorophenols varied widely, but several samples showed values higher than the acceptable DI recommended by the United States Environmental Protection Agency (EPA). These results suggest that CP exposure, especially to dichlorophenols, is prevalent in several countries, particularly in Asia, suggesting a pressing need for further assessment of the global sources and potential health effects of these chemicals.
[Mh] Termos MeSH primário: Clorofenóis/urina
Exposição Ambiental/análise
Poluentes Ambientais/urina
[Mh] Termos MeSH secundário: Ásia
Meio Ambiente
Exposição Ambiental/estatística & dados numéricos
Monitoramento Ambiental
Grécia
Seres Humanos
Japão
Nível de Efeito Adverso não Observado
Pentaclorofenol
Praguicidas
Fenóis/urina
Estados Unidos
United States Environmental Protection Agency
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorophenols); 0 (Environmental Pollutants); 0 (Pesticides); 0 (Phenols); 3B11G9AKBA (2,5-dichlorophenol); D9BSU0SE4T (Pentachlorophenol); R669TG1950 (2,4-dichlorophenol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE


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[PMID]:29242334
[Au] Autor:Nowotny H
[Ad] Endereço:Helga Nowotny is the former president of the European Research Council. helga.nowotny@wwtf.at.
[Ti] Título:Fotis Kafatos (1940-2017).
[So] Source:Science;358(6369):1387, 2017 Dec 15.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alergia e Imunologia/história
Doenças Transmissíveis/história
[Mh] Termos MeSH secundário: Grécia
História do Século XX
História do Século XXI
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Kafatos F
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1126/science.aar6095



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