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[PMID]:27117888
[Au] Autor:Pham MK; Chamizo E; Mas Balbuena JL; Miquel JC; Martín J; Osvath I; Povinec PP
[Ad] Endereço:IAEA-Environment Laboratories, Monte Carlo 98000, Monaco. Electronic address: m.pham@iaea.org.
[Ti] Título:Impact of Saharan dust events on radionuclide levels in Monaco air and in the water column of the northwest Mediterranean Sea.
[So] Source:J Environ Radioact;166(Pt 1):2-9, 2017 Jan.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Characterization of atmospheric aerosols collected in Monaco (2004-2008) and in sediment traps at 200 m and 1000 m water depths at the DYFAMED (Dynamics of Atmospheric Fluxes in the Mediterranean Sea) station (2004) was carried out to improve our understanding of the impact of Saharan dust on ground-level air and on the water column. Activity concentrations of natural ( Pb, Po, uranium and radium isotopes) and anthropogenic ( Cs, Pu, Pu, and Pu) radionuclides and their isotopic ratios confirmed a Saharan impact on the investigated samples. In association with a large particulate matter deposition event in Monaco on 20 February 2004, the Cs (∼40 Bq kg ) and Pu (∼1 Bq kg ) activities were almost a factor of two higher than other Saharan deposition dust events. This single-day particle flux represented 72% of the annual atmospheric deposition in Monaco. The annual deposition of Saharan dust on the sea was 232-407 mBq m for Cs and 6.8-9.8 mBq m for Pu and contributed significantly (28-37% for Cs and 34-45% for Pu) to the total annual atmospheric input to the northwest Mediterranean Sea. The Cs/ Pu activity ratios in dust samples collected during different Saharan dust events confirmed their global fallout origin or mixing with local re-suspended soil particles. In the sediment trap samples the Cs activity varied by a factor of two, while the Pu activity was constant, confirming the different behaviors of Cs (dissolved) and Pu (particle reactive) in the water column. The Cs and Pu activities of sinking particles during the period of the highest mass flux collected in 20 February 2004 at the 200 m and 1000 m water depths represented about 10% and 15%, respectively, of annual deposition from Saharan dust events.
[Mh] Termos MeSH primário: Poluentes Radioativos do Ar/análise
Poeira/análise
Monitoramento de Radiação
Poluentes Radioativos da Água/análise
[Mh] Termos MeSH secundário: África do Norte
Mar Mediterrâneo
Mônaco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Radioactive); 0 (Dust); 0 (Water Pollutants, Radioactive)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160428
[St] Status:MEDLINE


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[PMID]:27316707
[Au] Autor:Duan J; Meng X; Liu T; Yin Y
[Ad] Endereço:Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117, China.
[Ti] Título:Capability of leaf interdigitation with different inverse planning strategies in Monaco: an investigation of representative tumour sites.
[So] Source:Radiat Oncol;11:82, 2016 Jun 17.
[Is] ISSN:1748-717X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study was to experimentally assess the dosimetric impact of leaf interdigitation using different inverse treatment strategies for representative tumour sites and to identify the situations in which leaf interdigitation can benefit these tumour sites. MATERIAL AND METHODS: Sixty previously treated patients (15 nasopharyngeal carcinoma (NPC), 15 multiple brain metastasis (MBM), 15 cervical cancer and 15 prostate cancer) were re-planned for volumetric modulated arc therapy (VMAT), sliding window IMRT (dMLC) and step-and-shoot IMRT (ssIMRT) with and without leaf interdigitation. Various dosimetric variables, such as PTV coverage, OARs sparing, delivery efficiency and planning time, were evaluated for each plan. In addition, a protocol developed by our group was applied to identify the situations in which leaf interdigitation can achieve benefits in clinical practice. RESULTS: Leaf interdigitation produced few benefits in PTV homogeneity for the MBM VMAT plans and NPC ssIMRT plans. For OARs, sparing was equivalent with and without leaf interdigitation. Leaf interdigitation showed an increase in MUs for dMLC plans and a decrease in MUs for ssIMRT plans. Leaf interdigitation resulted in an increase in segments for dMLC plans and a decrease in segments for NPC and MBM ssIMRT plans. For beam on time, leaf interdigitation showed an increase in MBM dMLC, NPC ssIMRT and prostate ssIMRT plans. In addition, leaf interdigitation saved planning time for VMAT and dMLC plans but increased planning time for ssIMRT plans. CONCLUSION: Leaf interdigitation does not improve plan quality when performing inverse treatment strategies, regardless of whether the target is simple or complex. However, it influences the delivery efficiency and planning time. Based on these observations, our study suggests that leaf interdigitation should be utilized when performing MBM VMAT plans and NPC ssIMRT plans.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/radioterapia
Neoplasias Nasofaríngeas/radioterapia
Aceleradores de Partículas/instrumentação
Neoplasias da Próstata/radioterapia
Planejamento da Radioterapia Assistida por Computador/métodos
Neoplasias do Colo do Útero/radioterapia
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/secundário
Carcinoma
Feminino
Seres Humanos
Masculino
Mônaco
Neoplasias Nasofaríngeas/patologia
Neoplasias da Próstata/patologia
Radiometria
Dosagem Radioterapêutica
Radioterapia de Intensidade Modulada
Neoplasias do Colo do Útero/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160619
[St] Status:MEDLINE
[do] DOI:10.1186/s13014-016-0655-1


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[PMID]:27312784
[Au] Autor:Gasenzer ER
[Ad] Endereço:IFOM - Institut für Forschung in der Operativen Medizin, Lehrstuhl für Chirurgische Forschung, Fakultät für Gesundheit, Department für Humanmedizin, Universität Witten/Herdecke gGmbh, Ostmerheimer Str. 200, Haus 38, 51109, Köln, Deutschland. Elena.Gasenzer@uni-wh.de.
[Ti] Título:[Psychological and psychoanalytical issues in Schreker's opera "Die Gezeichneten"].
[Ti] Título:Psychologische und psychoanalytische Grundlagen in Schrekers Musikdrama "Die Gezeichneten"..
[So] Source:Wien Med Wochenschr;166(15-16):466-478, 2016 Nov.
[Is] ISSN:1563-258X
[Cp] País de publicação:Austria
[La] Idioma:ger
[Ab] Resumo:Franz Schrekers opera "Die Gezeichneten" is the artistically answer to Sigmund Freud's psychoanalysis. The proceedings in this drama discuss some principles of psychoanalyses. The figures show typical psychological mechanisms like repression, sublimation or regression and also the typical symptoms of neurosis. During the date of origin of the opera, Freud's method of psychoanalysis becomes well known and a lot of physicians and psychologists begin with their education in it. Themes like the theory of sexuality by Freud were discussed in the Vienna society. The story contains all mechanisms of psychoanalysis and discloses the psychopathology of the society of "fín de siègle" on the end of the 19th century. Franz Schreker's opera is like a forecasting of the nemesis, which in Europe occurs two decades later. The figures of the opera show the central facts of psychoanalysis and their artificial expression in music and performance.
[Mh] Termos MeSH primário: Drama/história
Teoria Freudiana
Medicina nas Artes
Música/história
Psicanálise/história
Psicologia/história
Canto
[Mh] Termos MeSH secundário: Áustria
História do Século XIX
História do Século XX
Mônaco
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE


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[PMID]:27188795
[Au] Autor:Trojak B; Soudry-Faure A; Abello N; Carpentier M; Jonval L; Allard C; Sabsevari F; Blaise E; Ponavoy E; Bonin B; Meille V; Chauvet-Gelinier JC
[Ad] Endereço:Department of Psychiatry and Addictology, University Hospital of Dijon, 21079, Dijon Cedex, France. benoit.trojak@chu-dijon.fr.
[Ti] Título:Efficacy of transcranial direct current stimulation (tDCS) in reducing consumption in patients with alcohol use disorders: study protocol for a randomized controlled trial.
[So] Source:Trials;17(1):250, 2016 May 17.
[Is] ISSN:1745-6215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Approximately 15 million persons in the European Union and 10 million persons in the USA are alcohol-dependent. The global burden of disease and injury attributable to alcohol is considerable: worldwide, approximately one in 25 deaths in 2004 was caused by alcohol. At the same time, alcohol use disorders remain seriously undertreated. In this context, alternative or adjunctive therapies such as brain stimulation may play a prominent role. The early results of studies using transcranial direct current stimulation found that stimulations delivered to the dorsolateral prefrontal cortex result in a significant reduction of craving and an improvement of the decision-making processes in various additive disorders. We, therefore, hypothesize that transcranial direct current stimulation can lead to a decrease in alcohol consumption in patients suffering from alcohol use disorders. METHODS/DESIGN: We report the protocol of a randomized, double-blind, placebo-controlled, parallel-group trial, to evaluate the efficacy of transcranial direct current stimulation on alcohol reduction in patients with an alcohol use disorder. The study will be conducted in 14 centers in France and Monaco. Altogether, 340 subjects over 18 years of age and diagnosed with an alcohol use disorder will be randomized to receive five consecutive twice-daily sessions of either active or placebo transcranial direct current stimulation. One session consists in delivering a current flow continuously (anode F4; cathode F3) twice for 13 minutes, with treatments separated by a rest interval of 20 min. Efficacy will be evaluated using the change from baseline (alcohol consumption during the 4 weeks before randomization) to 24 weeks in the total alcohol consumption and number of heavy drinking days. Secondary outcome measures will include alcohol craving, clinical and biological improvements, and the effects on mood and quality of life, as well as cognitive and safety assessments, and, for smokers, an assessment of the effects of transcranial direct current stimulation on tobacco consumption. DISCUSSION: Several studies have reported a beneficial effect of transcranial direct current stimulation on substance use disorders by reducing craving, impulsivity, and risk-taking behavior, and suggest that transcranial direct current stimulation may be a promising treatment in addiction. However, to date, no studies have included sufficiently large samples and sufficient follow-up to confirm the hypothesis. Results from this large randomized controlled trial will give a better overview of the therapeutic potential of transcranial direct current stimulation in alcohol use disorders. TRIAL REGISTRATION: Clinical Trials Gov, NCT02505126 (registration date: July 15 2015).
[Mh] Termos MeSH primário: Abstinência de Álcool
Consumo de Bebidas Alcoólicas/prevenção & controle
Transtornos Relacionados ao Uso de Álcool/terapia
Estimulação Transcraniana por Corrente Contínua
[Mh] Termos MeSH secundário: Afeto
Consumo de Bebidas Alcoólicas/fisiopatologia
Consumo de Bebidas Alcoólicas/psicologia
Transtornos Relacionados ao Uso de Álcool/diagnóstico
Transtornos Relacionados ao Uso de Álcool/fisiopatologia
Transtornos Relacionados ao Uso de Álcool/psicologia
Protocolos Clínicos
Cognição
Fissura
Método Duplo-Cego
Feminino
França
Seres Humanos
Masculino
Mônaco
Escalas de Graduação Psiquiátrica
Qualidade de Vida
Projetos de Pesquisa
Fumar/psicologia
Inquéritos e Questionários
Fatores de Tempo
Estimulação Transcraniana por Corrente Contínua/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160519
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s13063-016-1363-8


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[PMID]:27167277
[Au] Autor:Snyder M; Halford R; Knill C; Adams JN; Bossenberger T; Nalichowski A; Hammoud A; Burmeister J
[Ad] Endereço:Wayne State University School of Medicine; Karmanos Cancer Institute. msnyder@med.wayne.edu.
[Ti] Título:Modeling the Agility MLC in the Monaco treatment planning system.
[So] Source:J Appl Clin Med Phys;17(3):190-202, 2016 05 08.
[Is] ISSN:1526-9914
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigate the relationship between the various parameters in the Monaco MLC model and dose calculation accuracy for an Elekta Agility MLC. The vendor-provided MLC modeling procedure - completed first with external vendor participation and then exclusively in-house - was used in combination with our own procedures to investigate several sets of MLC modeling parameters to determine their effect on dose distributions and point-dose measurements. Simple plans provided in the vendor procedure were used to elucidate specific mechanical characteristics of the MLC, while ten complex treatment plans - five IMRT and five VMAT - created using TG-119-based structure sets were used to test clinical dosimetric effects of particular parameter choices. EDR2 film was used for the vendor fields to give high spatial resolution, while a combination of MapCHECK and ion chambers were used for the in-house TG-119-based proced-ures. The vendor-determined parameter set provided a reasonable starting point for the MLC model and largely delivered acceptable gamma pass rates for clinical plans - including a passing external evaluation using the IROC H&N phantom. However, the vendor model did not provide point-dose accuracy consistent with that seen in other treatment systems at our center. Through further internal testing it was found that there existed many sets of MLC parameters, often at opposite ends of their allowable ranges, that provided similar dosimetric characteristics and good agreement with planar and point-dose measurements. In particular, the leaf offset and tip leakage parameters compensated for one another if adjusted in opposite directions, which provided a level curve of acceptable parameter sets across all plans. Interestingly, gamma pass rates of the plans were less dependent upon parameter choices than point-dose measurements, suggesting that MLC modeling using only gamma evaluation may be generally an insufficient approach. It was also found that exploring all parameters of the very robust MLC model to find the best match to the vendor-provided QA fields can reduce the pass rates of the TG-119-based clinical distributions as compared to simpler models. A wide variety of parameter sets produced MLC models capable of meeting RPC passing criteria for their H&N IMRT phantom. The most accurate models were achievable using a combination of vendor-provided and in-house procedures. The potential existed for an over-modeling of the Agility MLC in an effort to obtain the fine structure of certain quality assurance fields, which led to a reduction in agreement between calculation and measurement of more typical clinical dose distributions.
[Mh] Termos MeSH primário: Modelos Teóricos
Imagens de Fantasmas
Planejamento da Radioterapia Assistida por Computador/métodos
Radioterapia Conformacional/métodos
[Mh] Termos MeSH secundário: Simulação por Computador
Seres Humanos
Mônaco
Dosagem Radioterapêutica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE
[do] DOI:10.1120/jacmp.v17i3.6044


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[PMID]:26705567
[Au] Autor:Latcu DG; Squara F; Massaad Y; Bun SS; Saoudi N; Marchlinski FE
[Ad] Endereço:Cardiologie, Centre Hospitalier Princesse Grace, Avenue Pasteur, Monaco 98000, Monaco dglatcu@yahoo.com.
[Ti] Título:Electroanatomic characteristics of the mitral isthmus associated with successful mitral isthmus ablation.
[So] Source:Europace;18(2):274-80, 2016 Feb.
[Is] ISSN:1532-2092
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: The success of mitral isthmus (MI) ablation has been related to CT scan defined MI anatomy. We sought to correlate electroanatomical MI characteristics with MI ablation success in patients with perimitral flutter (PMF). METHODS AND RESULTS: In 53 consecutive patients (46 males, 61 ± 10 years) with PMF, MI was ablated with endocardial ± coronary sinus (CS) linear radiofrequency (RF) ablation lesion. Acute (termination of PMF during ablation) and long-term procedural success were studied. Mitral isthmus characteristics (thickness--minimal endocardial to CS distance, length, maximal MI bipolar voltage), as well as MI ablation line length and width, RF duration, and delivered energy were analysed. In 43 of the 53 patients (81%), acute success was observed. This was more frequently achieved in patients with thinner MI (2.4 ± 3.1 vs. 7 ± 3.2 mm; P = 0.0009). Mitral isthmus thickness predicted ablation failure with a ROC area of 0.84. The best threshold to predict MI ablation failure was 8.3 mm with a sensitivity of 67% and a specificity of 97%. Left atrial size was of greater importance in failed cases (2D echo surface: 24.1 ± 2.5 vs. 32.5 ± 6.9 cm2, P = 0.005; electroanatomic volume: 124 ± 32 vs. 165 ± 23 mL, P = 0.02). None of the other electroanatomical characteristics were associated with outcome. After a mean follow-up of 28 ± 15 months, 21 patients (39%) had atrial fibrillation (AF) or atypical flutter (PMF recurrence in four). CONCLUSION: Smaller MI thickness is associated with acute success in PMF ablation. Mitral isthmus electroanatomical characteristics might be used for decision-making on strategy during persistent AF ablation and for selecting the best location for interrupting PMF.
[Mh] Termos MeSH primário: Fibrilação Atrial/cirurgia
Flutter Atrial/cirurgia
Ablação por Cateter
Valva Mitral/cirurgia
[Mh] Termos MeSH secundário: Idoso
Fibrilação Atrial/diagnóstico por imagem
Fibrilação Atrial/fisiopatologia
Flutter Atrial/diagnóstico por imagem
Flutter Atrial/fisiopatologia
Eletrocardiografia
Técnicas Eletrofisiológicas Cardíacas
Feminino
Seres Humanos
Masculino
Meia-Idade
Valva Mitral/diagnóstico por imagem
Valva Mitral/fisiopatologia
Mônaco
Pennsylvania
Valor Preditivo dos Testes
Recidiva
Estudos Retrospectivos
Fatores de Risco
Fatores de Tempo
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151226
[St] Status:MEDLINE
[do] DOI:10.1093/europace/euv097


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[PMID]:26698005
[Au] Autor:Chrcanovic BR
[Ad] Endereço:Department of Prosthodontics, Faculty of Odontology, Malmö University, Carl Gustafs väg 34, Malmö SE-205 06, Sweden, Tel.: +46 725541545; fax: +46 406658503. Electronic address: bruno.chrcanovic@mah.se.
[Ti] Título:A History of Periodontitis Suggests a Higher Risk for Implant Loss.
[So] Source:J Evid Based Dent Pract;15(4):185-6, 2015 Dec.
[Is] ISSN:1532-3390
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Periodontitis, implant loss and peri-implantitis. A meta-analysis. Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A.Clin Oral Implants Res 2015;26(4):e8-16. REVIEWER: Bruno Ramos Chrcanovic, DDS, MSc, PhD student PURPOSE/QUESTION: To compare the risks of implant loss, implant bone loss, and peri-implantitis between subjects with and without a history of periodontal disease. SOURCE OF FUNDING: The authors reported that no external funding sources directly supported this study TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidence STRENGTH OF RECOMMENDATION GRADE: Grade B: Inconsistent or limited-quality patient-oriented evidence.
[Mh] Termos MeSH primário: Peri-Implantite
Periodontite
[Mh] Termos MeSH secundário: Seres Humanos
Mônaco
Próteses e Implantes
Fatores de Risco
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151224
[Lr] Data última revisão:
151224
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:151225
[St] Status:MEDLINE


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[PMID]:26158175
[Au] Autor:De Carlis LG; Sguinzi R; Ferla F; Di Sandro S; Dorobantu BM; De Carlis R; Cusumano C; Giacomoni A; Ferrari C
[Ti] Título:Pancreatoduodenectomy: Risk Factors of Postoperative Pancreatic Fistula.
[So] Source:Hepatogastroenterology;61(132):1124-32, 2014 Jun.
[Is] ISSN:0172-6390
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: The aim of the present study is the analysis of risk factors of postoperative pancreatic fistula (POPF) and of clinical outcome after pancreatoduodenectomy (PD) in a retrospective multicentric review of the patient cohort. METHODOLOGY: From January 2003 to July 2013 143 patients underwent PD: 138 cases were included and 3 groups were identified according to the different types of anastomosis: Group 1 invaginating end-to-end pancreatojejunostomy, Group 2 end-to-side pancreatojejunostomy with duct-to-mucosa anastomosis, Group 3 end-to-side pancreatogastrostomy. RESULTS: Twenty-one % of patients developed POPF, 16% in Group 1, 27% in Group 2, 12% in Group 3. Forty % grade A, 13% grade B and 47% grade C total POPF. It results that POPF occurred in 16% of hard and in 40% of soft pancreatic texture; in 11.4% of dilated Wirsung versus 30.8% of non dilated (p = 0.007). Overall actuarial 1 and 3 year survival after PD is 69% and 48% respectively. Perioperative mortality is 5.8% overall, 17.85% for grade C. CONCLUSIONS: No differences have been found among surgical anastomosis techniques. Soft tissues seem to increase, while dilated Wirsung seems to decrease POPF rate. The development of POPF increase morbidity but it doesn't affect overall survival, more strictly related to tumour histopathology.
[Mh] Termos MeSH primário: Pancreatopatias/cirurgia
Fístula Pancreática/etiologia
Pancreaticoduodenectomia/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Itália
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Mônaco
Pancreatopatias/diagnóstico
Pancreatopatias/mortalidade
Fístula Pancreática/diagnóstico
Fístula Pancreática/mortalidade
Pancreaticoduodenectomia/mortalidade
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150709
[Lr] Data última revisão:
150709
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150710
[St] Status:MEDLINE


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[PMID]:25668959
[Au] Autor:Toumnier R
[Ti] Título:[A short history of the hospital of Menton].
[Ti] Título:Petite histoire de I'ancien hôpital de Menton..
[So] Source:Rev Soc Fr Hist Hop;(152):66, 2014 Nov.
[Is] ISSN:1255-250X
[Cp] País de publicação:France
[La] Idioma:fre
[Mh] Termos MeSH primário: Hospitais/história
[Mh] Termos MeSH secundário: França
História do Século XVII
História do Século XVIII
História do Século XIX
História do Século XX
História do Século XXI
História Medieval
Seres Humanos
Mônaco
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150211
[Lr] Data última revisão:
150211
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:150212
[St] Status:MEDLINE


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[PMID]:25240554
[Au] Autor:Tchetche D; Farah B; Misuraca L; Pierri A; Vahdat O; Lereun C; Dumonteil N; Modine T; Laskar M; Eltchaninoff H; Himbert D; Iung B; Teiger E; Chevreul K; Lievre M; Lefevre T; Donzeau-Gouge P; Gilard M; Fajadet J
[Ad] Endereço:Clinique Pasteur, Toulouse, France. Electronic address: d.tchetche@clinique-pasteur.com.
[Ti] Título:Cerebrovascular events post-transcatheter aortic valve replacement in a large cohort of patients: a FRANCE-2 registry substudy.
[So] Source:JACC Cardiovasc Interv;7(10):1138-45, 2014 Oct.
[Is] ISSN:1876-7605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to analyze the incidence, impact, and predictors of cerebrovascular events (CVEs) in patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: Several issues remain unresolved post-TAVR, including CVEs. METHODS: The FRANCE-2 (French Aortic Nation CoreValve and Edwards-2) registry prospectively included all patients who underwent TAVR in France and Monaco from January 2010 to October 2011. A total of 3,191 patients were analyzed. Six-month follow-up data were obtained. Events were adjudicated according to Valve Academic Research Consortium (VARC)-1 definition. RESULTS: Of the cohort, 3.98% experienced a CVE: 55% were major strokes, 14.5% minor strokes, and 30.5% transient ischemic attacks. The mean delay for CVE occurrence was 2 days (interquartile range: 0 to 7 days) with 48.5% of CVEs occurring within 2 days. There was no statistically significant difference in CVE rate with regard to the type of valve (p = 0.899) and the access route (p = 0.128). Patients with a CVE more frequently had new-onset paroxysmal atrial fibrillation (13.6% vs. 7.6%; p = 0.015). During follow-up, the unadjusted mortality rate was higher in patients with a CVE (26% vs. 16.5%; p = 0.002). By multivariate analysis, only advanced age (odds ratio: 1.05; 95% confidence interval: 1.02 to 1.08; p = 0.02) and having 2 valves implanted (odds ratio: 3.13; 95 confidence interval: 1.40 to 7.05; p = 0.006) were associated with a significant risk of CVEs. CONCLUSIONS: CVEs occur frequently after TAVR and are associated with an increased mortality rate. No difference exists in the CVE rate when exploring the type of valve or the access route. Advanced age and multiple valves implanted during the same procedure are predictors of CVE.
[Mh] Termos MeSH primário: Estenose da Valva Aórtica/terapia
Cateterismo Cardíaco/efeitos adversos
Implante de Prótese de Valva Cardíaca/efeitos adversos
Ataque Isquêmico Transitório/epidemiologia
Acidente Vascular Cerebral/epidemiologia
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Estenose da Valva Aórtica/diagnóstico
Estenose da Valva Aórtica/mortalidade
Fibrilação Atrial/epidemiologia
Cateterismo Cardíaco/métodos
Cateterismo Cardíaco/mortalidade
Feminino
França/epidemiologia
Implante de Prótese de Valva Cardíaca/métodos
Implante de Prótese de Valva Cardíaca/mortalidade
Seres Humanos
Incidência
Ataque Isquêmico Transitório/diagnóstico
Ataque Isquêmico Transitório/mortalidade
Estimativa de Kaplan-Meier
Modelos Logísticos
Masculino
Mônaco/epidemiologia
Análise Multivariada
Razão de Chances
Sistema de Registros
Fatores de Risco
Índice de Gravidade de Doença
Acidente Vascular Cerebral/diagnóstico
Acidente Vascular Cerebral/mortalidade
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1511
[Cu] Atualização por classe:141024
[Lr] Data última revisão:
141024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140922
[St] Status:MEDLINE



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