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[PMID]:29484746
[Au] Autor:Hauge SC; Jensen CK; Nielsen LK; Pedersen OB; Sørensen E; Thørner LW; Hjalgrim H; Erikstrup C; Nielsen KR; Kaspersen KA; Didriksen M; Dziegiel M; Ullum H
[Ad] Endereço:Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
[Ti] Título:The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors.
[So] Source:APMIS;126(3):248-256, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA-deficient blood donors and 1770 control blood donors. A subset of the IgA-deficient donors were further characterized by self-reported health (Short Form-12, n = 28) and circulating C-reactive protein (CRP) (n = 10). IgA-deficient individuals had lower self-reported mental health (p = 0.01) and higher CRP (p < 0.05). A strong trend was found regarding prescription of antimicrobial medicine (hazard ratio = 1.19, p = 0.05). No association was found with hospital infections (hazard ratio = 1.02, p = 0.95) or self-reported physical health (p = 0.86). IgA-deficient blood donors have impaired self-reported mental health, enhanced inflammation and possibly an increased risk of infection. Despite these findings, this study does not provide sufficient evidence to warrant specific health precautions for donors with IgA deficiency.
[Mh] Termos MeSH primário: Proteína C-Reativa/metabolismo
Autoavaliação Diagnóstica
Predisposição Genética para Doença
Deficiência de IgA/imunologia
Imunoglobulina A/imunologia
Infecção/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Doadores de Sangue
Dinamarca/epidemiologia
Feminino
Seres Humanos
Deficiência de IgA/genética
Imunoglobulina A/genética
Infecção/imunologia
Masculino
Meia-Idade
Risco
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin A); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180228
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12807


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[PMID]:28749703
[Au] Autor:Di Carlo G; Fernandez Gurani S; Pinholt EM; Cattaneo PM
[Ad] Endereço:1 Department of Oral and Maxillofacial Science, Sapienza University of Rome, Rome, Italy.
[Ti] Título:A new simple three-dimensional method to characterize upper airway in orthognathic surgery patient.
[So] Source:Dentomaxillofac Radiol;46(8):20170042, 2017 Dec.
[Is] ISSN:0250-832X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To develop and validate a new reproducible 3D upper airway analysis based on skeletal structures not involved in the modification, which occur during orthognathic surgery. METHODS: From retrospective cohort of orthognathic surgically treated patients, pre- and postsurgical CBCT-scans of 10 post-pubertal patients were randomly selected. Two operators identified the landmarks, calculated the airway volumes, cross sections and linear measurements on the 10 scans twice at two different time intervals. Statistical analysis included test for normal distribution, technical error measurements, and intra- and inter-observers reliability. RESULTS: Intra- and inter-observer reliability was excellent for volumes and cross sections. The entire data sets exhibited normal distribution. Technical error of measurements showed an error in the range of 1.6 to 10.2% for volume, 1.6 to 12.2% for cross-sectional measurements, and 0.3 to 2.5% for linear measurements. No systematic errors were detected. CONCLUSIONS: This new proposed definition of upper airway boundaries was shown to be technical feasible and tested to be reliable in measuring upper airway in patients undergoing orthognathic surgery.
[Mh] Termos MeSH primário: Tomografia Computadorizada de Feixe Cônico/métodos
Procedimentos Cirúrgicos Ortognáticos
Faringe/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Pontos de Referência Anatômicos
Dinamarca
Feminino
Seres Humanos
Masculino
Reprodutibilidade dos Testes
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1259/dmfr.20170042


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[PMID]:28749335
[Au] Autor:Larsen J; Sunde M; Islam MZ; Urdahl AM; Barstad AS; Larsen AR; Grøntvedt CA; Angen Ø
[Ad] Endereço:Statens Serum Institut, Copenhagen S, Denmark.
[Ti] Título:Evaluation of a widely used culture-based method for detection of livestock-associated meticillin-resistant Staphylococcus aureus (MRSA), Denmark and Norway, 2014 to 2016.
[So] Source:Euro Surveill;22(28), 2017 Jul 13.
[Is] ISSN:1560-7917
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:We evaluated a widely used culture-based method for detection of livestock-associated meticillin-resistant Staphylococcus aureus (LA-MRSA) in samples collected from pigs and the environment inside pig stables in Denmark and Norway. Selective enrichment in tryptic soy broth containing cefoxitin and aztreonam led to a high ratio of false-negative results (26%; 57/221). On this basis, we recommend reconsidering the use of selective enrichment for detection of LA-MRSA in animal and environmental samples.
[Mh] Termos MeSH primário: Técnicas de Cultura/métodos
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Infecções Estafilocócicas/diagnóstico
Doenças dos Suínos/microbiologia
[Mh] Termos MeSH secundário: Animais
Dinamarca
Gado
Noruega
Sensibilidade e Especificidade
Infecções Estafilocócicas/veterinária
Sus scrofa
Suínos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


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[PMID]:29386181
[Au] Autor:Adelborg K; Szépligeti SK; Holland-Bill L; Ehrenstein V; Horváth-Puhó E; Henderson VW; Sørensen HT
[Ad] Endereço:Department of Clinical Epidemiology, Aarhus University Hospital, Denmark kade@clin.au.dk.
[Ti] Título:Migraine and risk of cardiovascular diseases: Danish population based matched cohort study.
[So] Source:BMJ;360:k96, 2018 01 31.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To examine the risks of myocardial infarction, stroke (ischaemic and haemorrhagic), peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter, and heart failure in patients with migraine and in a general population comparison cohort. DESIGN: Nationwide, population based cohort study. SETTING: All Danish hospitals and hospital outpatient clinics from 1995 to 2013. PARTICIPANTS: 51 032 patients with migraine and 510 320 people from the general population matched on age, sex, and calendar year. MAIN OUTCOME MEASURES: Comorbidity adjusted hazard ratios of cardiovascular outcomes based on Cox regression analysis. RESULTS: Higher absolute risks were observed among patients with incident migraine than in the general population across most outcomes and follow-up periods. After 19 years of follow-up, the cumulative incidences per 1000 people for the migraine cohort compared with the general population were 25 17 for myocardial infarction, 45 25 for ischaemic stroke, 11 6 for haemorrhagic stroke, 13 11 for peripheral artery disease, 27 18 for venous thromboembolism, 47 34 for atrial fibrillation or atrial flutter, and 19 18 for heart failure. Correspondingly, migraine was positively associated with myocardial infarction (adjusted hazard ratio 1.49, 95% confidence interval 1.36 to 1.64), ischaemic stroke (2.26, 2.11 to 2.41), and haemorrhagic stroke (1.94, 1.68 to 2.23), as well as venous thromboembolism (1.59, 1.45 to 1.74) and atrial fibrillation or atrial flutter (1.25, 1.16 to 1.36). No meaningful association was found with peripheral artery disease (adjusted hazard ratio 1.12, 0.96 to 1.30) or heart failure (1.04, 0.93 to 1.16). The associations, particularly for stroke outcomes, were stronger during the short term (0-1 years) after diagnosis than the long term (up to 19 years), in patients with aura than in those without aura, and in women than in men. In a subcohort of patients, the associations persisted after additional multivariable adjustment for body mass index and smoking. CONCLUSIONS: Migraine was associated with increased risks of myocardial infarction, ischaemic stroke, haemorrhagic stroke, venous thromboembolism, and atrial fibrillation or atrial flutter. Migraine may be an important risk factor for most cardiovascular diseases.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/etiologia
Transtornos de Enxaqueca/complicações
Infarto do Miocárdio/etiologia
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Adulto
Fibrilação Atrial/epidemiologia
Fibrilação Atrial/etiologia
Índice de Massa Corporal
Doenças Cardiovasculares/epidemiologia
Estudos de Coortes
Comorbidade
Dinamarca/epidemiologia
Feminino
Insuficiência Cardíaca/epidemiologia
Insuficiência Cardíaca/etiologia
Seres Humanos
Incidência
Hemorragias Intracranianas/epidemiologia
Hemorragias Intracranianas/etiologia
Masculino
Meia-Idade
Transtornos de Enxaqueca/diagnóstico
Transtornos de Enxaqueca/epidemiologia
Infarto do Miocárdio/epidemiologia
Avaliação de Resultados (Cuidados de Saúde)
Doença Arterial Periférica/epidemiologia
Doença Arterial Periférica/etiologia
Estudos Prospectivos
Fatores de Risco
Fumar/epidemiologia
Acidente Vascular Cerebral/epidemiologia
Tromboembolia Venosa/epidemiologia
Tromboembolia Venosa/etiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k96


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[PMID]:29179833
[Au] Autor:Aagaard J; Tuszewski B; Kølbæk P
[Ad] Endereço:Aarhus University Hospital, Risskov DK-8240, Denmark; Aalborg University Hospital, Psychiatric Hospital, Center for Psychosis Research, Aalborg DK-9000, Denmark. Electronic address: joaa@rn.dk.
[Ti] Título:Does Assertive Community Treatment Reduce the Use of Compulsory Admissions?
[So] Source:Arch Psychiatr Nurs;31(6):641-646, 2017 12.
[Is] ISSN:1532-8228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The growing number of compulsory admissions in Denmark and other countries is a compelling challenge. We hypothesized that Assertive Community Treatment (ACT) may have the quality to reduce the use of several type of coercion including compulsory admissions. Although ACT is not designed for coercion prevention, it may prove efficient in averting major crisis among the included patients. Studies in Denmark showed that ACT has a major and significant advantage in reducing number and length of admissions. METHODS/DESIGN: We collected service data from National Case Register at three psychiatric hospitals, which constitutes the inpatient and outpatient mental health services in the North Denmark Region. Data included psychiatric and somatic service use among 240 patients starting in ACT. Primary measure concerned the extent to which ACT might reduce compulsory admissions. RESULTS: During a five years period patients allocated to ACT show decreasing admission trends. In comparison with all other psychiatric service users, we found a significant difference in trends concerning voluntary admissions and involuntary admissions according to the dangerous criterion, and decrease in number of contacts to Psychiatric Emergency Room (PER) CONCLUSION: An assertive approach undoubtedly reduces hospitalization including some involuntary admissions. ACT is preferable from both team and patient perspectives, and further caused reduction of PER visits compared to standard treatment. PERSPECTIVES: The criterion of Severe Mental Illness (SMI) may be revised to facilitate ACT to be offered to a larger group of SMI patients. In addition, introduction of Crisis Intervention Teams should be considered and allocated to PER.
[Mh] Termos MeSH primário: Coerção
Internação Compulsória de Doente Mental/estatística & dados numéricos
Serviços Comunitários de Saúde Mental/utilização
Transtornos Mentais/terapia
[Mh] Termos MeSH secundário: Adulto
Serviços Comunitários de Saúde Mental/estatística & dados numéricos
Intervenção na Crise/métodos
Dinamarca
Feminino
Hospitais Psiquiátricos
Seres Humanos
Pacientes Internados/estatística & dados numéricos
Masculino
Transtornos Mentais/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:28466972
[Au] Autor:Madsen T; Sadowa Vedtofte M; Nordentoft M; Ravnborg Nissen L; Bo Andersen S
[Ad] Endereço:Psychiatric Center Copenhagen, Copenhagen University Hospital, Hellerup, Denmark.
[Ti] Título:Comparing post-deployment mental health services utilization in soldiers deployed to Balkan, Iraq and Afghanistan.
[So] Source:Acta Psychiatr Scand;135(6):564-572, 2017 06.
[Is] ISSN:1600-0447
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Insight on how different missions have impacted rates of mental health service (MHS) utilization is unexplored. We compared postdeployment MHS utilization in a national cohort of first-time deployed to missions in Balkan, Iraq, and Afghanistan respectively. METHODS: A prospective national cohort study of 13 246 first-time deployed in the period 1996 through 2012 to missions in Balkan area, Iraq, or Afghanistan respectively. Soldiers 'MHS utilization was also compared with a 5:1 sex-, age-, and calendar year-matched never-deployed background population. Postdeployment utilization of MHS was retrieved from national coverage registers. Using Cox survival analyses, participants were followed and compared with regard to receiving three different types of psychiatric services: (i) admission to psychiatric hospital, (ii) psychiatric outpatient contact, and (iii) prescriptions of psychotropics. RESULTS: Utilizing of psychiatric outpatient services and psychotropics was significantly higher in first-time deployed to Iraq and Afghanistan compared with deployed to Balkan. However, the rate of postdeployment admission to psychiatric hospital did not differ between missions. Postdeployment rates of psychiatric admission and psychiatric outpatient treatment were significantly higher in Afghanistan-deployed personnel compared with the background population. CONCLUSIONS: Utilization of MHS differed significantly between mission areas and was highest after the latest mission to Afghanistan.
[Mh] Termos MeSH primário: Campanha Afegã de 2001-
Guerra do Iraque 2003-2011
Serviços de Saúde Mental/utilização
Militares/psicologia
[Mh] Termos MeSH secundário: Adulto
Península Balcânica
Dinamarca/epidemiologia
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Militares/estatística & dados numéricos
Modelos de Riscos Proporcionais
Estudos Prospectivos
Guerra
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/acps.12736


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[PMID]:28470441
[Au] Autor:Stallknecht SE; Strandberg-Larsen K; Hestbæk L; Andersen AN
[Ad] Endereço:Department of Public Health, Section of Social Medicine, University of Copenhagen, Øster Farimagsgade 5, 1014, Copenhagen, Denmark. stallknecht.se@gmail.com.
[Ti] Título:Spinal pain and co-occurrence with stress and general well-being among young adolescents: a study within the Danish National Birth Cohort.
[So] Source:Eur J Pediatr;176(6):807-814, 2017 Jun.
[Is] ISSN:1432-1076
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study aims to describe the patterns in low back, mid back, and neck pain complaints in young adolescents from the Danish National Birth Cohort (DNBC) and to investigate the co-occurrence of spinal pain and stress and general well-being, respectively. Cross-sectional data from the 11-year follow-up of DNBC were used. As part of a web-based survey, a total of 45,371 young adolescents between 10 and 14 years old completed the Young Spine Questionnaire, the Stress in Children Questionnaire, and a one-item question on general well-being. Associations between spinal pain and, respectively, stress and general well-being were estimated by means of multiple logistic regression models. Almost one fifth of boys and one quarter of girls reported spinal pain. Compared with adolescents who reported no stress, adolescents reporting medium and high values of stress had odds ratios (OR) of 2.19 (95% CI 2.08-2.30) and 4.73 (95% CI 4.28-5.23), respectively, of reporting spinal pain (adjusted for age, gender, and maternal education). Adolescents who reported poor general well-being had an OR of 2.50 (95% CI 2.31-2.72) for reporting spinal pain compared to adolescents with good general well-being. CONCLUSION: Spinal pain is a common complaint among young adolescents and co-occurs with stress and poor general well-being. The mutual dependency between the factors remained to be explained. What is Known: • The prevalence of spinal pain increases rapidly during childhood and adolescence, but different measurement instruments result in great variation in the estimates of spinal pain in children and adolescents. • Some studies have shown that different psychosocial measures are associated with spinal pain in children and adolescents. What is New: • Spinal pain, as measured by the newly developed and validated Young Spine Questionnaire, is a common complaint in young adolescents aged 10-14 years. • Spinal pain in young adolescents co-occurs with stress and poor general well-being.
[Mh] Termos MeSH primário: Saúde do Adolescente/estatística & dados numéricos
Dor nas Costas/epidemiologia
Estresse Psicológico/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Dor nas Costas/complicações
Dor nas Costas/diagnóstico
Dor nas Costas/psicologia
Estudos de Casos e Controles
Criança
Estudos de Coortes
Estudos Transversais
Dinamarca/epidemiologia
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Modelos Logísticos
Masculino
Razão de Chances
Prevalência
Estresse Psicológico/complicações
Estresse Psicológico/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s00431-017-2915-y


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[PMID]:29192620
[Au] Autor:Frederiksen TW; Ramlau-Hansen CH; Stokholm ZA; Grynderup MB; Hansen ÅM; Kristiansen J; Vestergaard JM; Bonde JP; Kolstad HA
[Ad] Endereço:Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus C; Department of Otolaryngology/Head and Neck Surgery, Regionshospitalet Holstebro, Holstebro, Denmark.
[Ti] Título:Noise-Induced Hearing Loss - A Preventable Disease? Results of a 10-Year Longitudinal Study of Workers Exposed to Occupational Noise.
[So] Source:Noise Health;19(87):103-111, 2017 Mar-Apr.
[Is] ISSN:1463-1741
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:AIMS: To survey current, Danish industrial noise levels and the use of hearing protection devices (HPD) over a 10-year period and to characterise the association between occupational noise and hearing threshold shift in the same period. Furthermore, the risk of hearing loss among the baseline and the follow-up populations according to first year of occupational noise exposure is evaluated. MATERIALS AND METHODS: In 2001-2003, we conducted a baseline survey of noise- and hearing-related disorders in 11 industries with suspected high noise levels. In 2009-2010, we were able to follow up on 271 out of the 554 baseline workers (49%). Mean noise levels per industry and self-reported HPD use are described at baseline and follow-up. The association between cumulative occupational noise exposure and hearing threshold shift over the 10-year period was assessed using linear regression, and the risk of hearing loss according to year of first occupational noise exposure was evaluated with logistic regression. RESULTS: Over the 10-year period, mean noise levels declined from 83.9 dB(A) to 82.8 dB(A), and for workers exposed >85 dB(A), the use of HPD increased from 70.1 to 76.1%. We found a weak, statistically insignificant, inverse association between higher ambient cumulative noise exposure and poorer hearing (-0.10 dB hearing threshold shift per dB-year (95% confidence interval (CI): -0.36; 0.16)). The risk of hearing loss seemed to increase with earlier first year of noise exposure, but odds ratios were only statistically significant among baseline participants with first exposure before the 1980s (odds ratio: 1.90, 95% CI: 1.11; 3.22). CONCLUSIONS: We observed declining industrial noise levels, increased use of HPD and no significant impact on hearing thresholds from current ambient industrial noise levels, which indicated a successful implementation of Danish hearing conservation programs.
[Mh] Termos MeSH primário: Perda Auditiva Provocada por Ruído/etiologia
Perda Auditiva Provocada por Ruído/prevenção & controle
Ruído Ocupacional
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Exposição Ocupacional/análise
[Mh] Termos MeSH secundário: Adulto
Audiometria de Tons Puros
Dinamarca
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.4103/nah.NAH_100_16


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[PMID]:29208737
[Au] Autor:Jensen RB; Thankamony A; Holst KK; Janssen JAMJL; Juul A; Dunger D; Poulsen P; Scheike T
[Ad] Endereço:Department of Growth and ReproductionRigshospitalet, University of Copenhagen, Copenhagen, Denmark rikke.beck@dadlnet.dk.
[Ti] Título:Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins.
[So] Source:Eur J Endocrinol;178(2):155-163, 2018 Feb.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: IGF-I may be a marker of later metabolic and cardiovascular disease. The interactions between IGF-I and glucose metabolism are multifactorial, and there is potential confounding from several secondary effects. In this study, we examined the interaction between IGF-I and glucose metabolism in a large cohort of clinically well-characterized elderly twins. DESIGN: A total of 303 twin pairs of the same gender (606 twins) were included in the study; 125 monozygotic and 178 dizygotic twin pairs. METHODS: A clinical examination including a standard oral glucose tolerance test (OGTT) and anthropometric measurements was performed. RESULTS: The heritability estimates were high for IGF-I and IGFBP-3 (h : 0.65 (95% CI: 0.55-0.74) and 0.71 (0.48-0.94), respectively) and for insulin secretion (h = 0.56, < 0.0001), whereas the heritability estimates for insulin sensitivity were low (h = 0.14, = 0.11). In a multiple regression analysis (adjusting for age, gender and twin status), there was a negative association between IGF-I and insulin sensitivity (B: -0.13, SE 0.03, < 0.0001) and IGF-I and disposition index (B: -0.05, SE 0.02, < 0.001) in the entire cohort of 606 twins. The associations between IGF-I and both DI and HOMA-S did not differ between the DZ and MZ twins. Forty-five twin pairs were discordant for T2D, but the discordant twins had similar concentrations of IGF-I or IGFBP-3. CONCLUSIONS: There was a high heritability for IGF-I and IGFBP-3, but a low heritability for insulin secretion and insulin sensitivity in a group of elderly twins. In addition, we found a strong negative relationship between IGF-I and insulin sensitivity, which did not seem to be strongly genetically determined.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Diabetes Mellitus Tipo 2/genética
Resistência à Insulina/genética
Fator de Crescimento Insulin-Like I/metabolismo
Insulina/secreção
[Mh] Termos MeSH secundário: Idoso
Antropometria
Estudos de Coortes
Dinamarca
Diabetes Mellitus Tipo 2/metabolismo
Doenças em Gêmeos/genética
Doenças em Gêmeos/metabolismo
Feminino
Teste de Tolerância a Glucose
Seres Humanos
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina/metabolismo
Modelos Lineares
Masculino
Meia-Idade
Gêmeos Dizigóticos
Gêmeos Monozigóticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; TWIN STUDY
[Nm] Nome de substância:
0 (Blood Glucose); 0 (IGF1 protein, human); 0 (IGFBP3 protein, human); 0 (Insulin); 0 (Insulin-Like Growth Factor Binding Protein 3); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0754


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[PMID]:28454530
[Au] Autor:Nielsen TRH; Lausten-Thomsen U; Fonvig CE; Bøjsøe C; Pedersen L; Bratholm PS; Hansen T; Pedersen O; Holm JC
[Ad] Endereço:The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Smedelundsgade 60, DK 4300, Holbæk, Denmark. ter@regionsjaelland.dk.
[Ti] Título:Dyslipidemia and reference values for fasting plasma lipid concentrations in Danish/North-European White children and adolescents.
[So] Source:BMC Pediatr;17(1):116, 2017 Apr 28.
[Is] ISSN:1471-2431
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dyslipidemia is reported in 27 - 43% of children and adolescents with overweight/obesity and tracks into adulthood, increasing the risk of cardiovascular morbidity. Cut-off values for fasting plasma lipid concentrations are typically set at fixed levels throughout childhood. The objective of this cross-sectional study was to generate fasting plasma lipid references for a Danish/North-European White population-based cohort of children and adolescents, and investigate the prevalence of dyslipidemia in this cohort as well as in a cohort with overweight/obesity. METHODS: A population-based cohort of 2141 (1275 girls) children and adolescents aged 6 - 19 (median 11.5) years was recruited from 11 municipalities in Denmark. Additionally, a cohort of children and adolescents of 1421 (774 girls) with overweight/obesity aged 6 - 19 years (median 11.8) was recruited for the study. Height, weight, and fasting plasma lipid concentrations were measured on all participants. Smoothed reference curves and percentiles were generated using the Generalized Additive Models for Location Scale and Shape package in the statistical software R. RESULTS: In the population-based cohort, plasma concentrations of total cholesterol (TC) (P < 0.05), low-density lipoprotein cholesterol (LDL) (P < 0.005), and high-density lipoprotein cholesterol (HDL) (P < 0.005) were higher in the youngest compared to the oldest tertile. Fasting plasma levels of triglycerides (TG) (P < 0.005) increased with age in both sexes. In boys, non-HDL was lower in the oldest compared to the youngest tertile (P < 0.0005). Concentrations of TC, LDL, non-HDL, and TG were higher (P < 0.05), and HDL lower (P < 0.05) in the cohort with overweight/obesity in both sexes and for all ages except for TC in the youngest girls. The overall prevalence of dyslipidemia was 6.4% in the population-based cohort and 28.0% in the cohort with overweight/obesity. The odds ratio for exhibiting dyslipidemia in the cohort with overweight/obesity compared with the population-based cohort was 6.2 (95% CI: 4.9 - 8.1, P < 2*10 ). CONCLUSION: Fasting plasma lipid concentrations change during childhood and adolescence and differ with sex and age. Children and adolescents with obesity have increased concentrations of circulating lipids and exhibit an increased prevalence of dyslipidemia. TRIAL REGISTRATION: The study is part of The Danish Childhood Obesity Biobank; ClinicalTrials.gov ID-no.: NCT00928473 retrospectively registered on June 25th 2009.
[Mh] Termos MeSH primário: Colesterol/sangue
Dislipidemias/diagnóstico
Triglicerídeos/sangue
[Mh] Termos MeSH secundário: Adolescente
Biomarcadores/sangue
Estudos de Casos e Controles
Criança
Estudos Transversais
Dinamarca/epidemiologia
Dislipidemias/sangue
Dislipidemias/complicações
Dislipidemias/epidemiologia
Europa (Continente)/epidemiologia
Grupo com Ancestrais do Continente Europeu
Jejum
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Obesidade Pediátrica/sangue
Obesidade Pediátrica/complicações
Obesidade Pediátrica/diagnóstico
Obesidade Pediátrica/epidemiologia
Prevalência
Valores de Referência
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12887-017-0868-y



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