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[PMID]:28468665
[Au] Autor:Baynam G; Broley S; Bauskis A; Pachter N; McKenzie F; Townshend S; Slee J; Kiraly-Borri C; Vasudevan A; Hawkins A; Schofield L; Helmholz P; Palmer R; Kung S; Walker CE; Molster C; Lewis B; Mina K; Beilby J; Pathak G; Poulton C; Groza T; Zankl A; Roscioli T; Dinger ME; Mattick JS; Gahl W; Groft S; Tifft C; Taruscio D; Lasko P; Kosaki K; Wilhelm H; Melegh B; Carapetis J; Jana S; Chaney G; Johns A; Owen PW; Daly F; Weeramanthri T; Dawkins H; Goldblatt J
[Ad] Endereço:Genetic Services of Western Australia, Department of Health, Government of Western Australia, Perth, WA, Australia. Gareth.baynam@health.wa.gov.au.
[Ti] Título:Initiating an undiagnosed diseases program in the Western Australian public health system.
[So] Source:Orphanet J Rare Dis;12(1):83, 2017 May 03.
[Is] ISSN:1750-1172
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: New approaches are required to address the needs of complex undiagnosed diseases patients. These approaches include clinical genomic diagnostic pipelines, utilizing intra- and multi-disciplinary platforms, as well as specialty-specific genomic clinics. Both are advancing diagnostic rates. However, complementary cross-disciplinary approaches are also critical to address those patients with multisystem disorders who traverse the bounds of multiple specialties and remain undiagnosed despite existing intra-specialty and genomic-focused approaches. The diagnostic possibilities of undiagnosed diseases include genetic and non-genetic conditions. The focus on genetic diseases addresses some of these disorders, however a cross-disciplinary approach is needed that also simultaneously addresses other disorder types. Herein, we describe the initiation and summary outcomes of a public health system approach for complex undiagnosed patients - the Undiagnosed Diseases Program-Western Australia (UDP-WA). RESULTS: Briefly the UDP-WA is: i) one of a complementary suite of approaches that is being delivered within health service, and with community engagement, to address the needs of those with severe undiagnosed diseases; ii) delivered within a public health system to support equitable access to health care, including for those from remote and regional areas; iii) providing diagnoses and improved patient care; iv) delivering a platform for in-service and real time genomic and phenomic education for clinicians that traverses a diverse range of specialties; v) retaining and recapturing clinical expertise; vi) supporting the education of junior and more senior medical staff; vii) designed to integrate with clinical translational research; and viii) is supporting greater connectedness for patients, families and medical staff. CONCLUSION: The UDP-WA has been initiated in the public health system to complement existing clinical genomic approaches; it has been targeted to those with a specific diagnostic need, and initiated by redirecting existing clinical and financial resources. The UDP-WA supports the provision of equitable and sustainable diagnostics and simultaneously supports capacity building in clinical care and translational research, for those with undiagnosed, typically rare, conditions.
[Mh] Termos MeSH primário: Planejamento em Saúde/organização & administração
Saúde Pública/métodos
[Mh] Termos MeSH secundário: Genômica
Seres Humanos
Proteômica
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s13023-017-0619-z


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[PMID]:27777376
[Au] Autor:Brameld K; Spilsbury K; Rosenwax L; Murray K; Semmens J
[Ad] Endereço:1 Centre for Population Health Research, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
[Ti] Título:Issues using linkage of hospital records and death certificate data to determine the size of a potential palliative care population.
[So] Source:Palliat Med;31(6):537-543, 2017 Jun.
[Is] ISSN:1477-030X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Studies aiming to identify palliative care populations have used data from death certificates and in some cases hospital records. The size and characteristics of the identified populations can show considerable variation depending on the data sources used. It is important that service planners and researchers are aware of this. AIM: To illustrate the differences in the size and characteristics of a potential palliative care population depending on the differential use of linked hospital records and death certificate data. DESIGN: Retrospective cohort study. SETTING/PARTICIPANTS: The cohort consisted of 23,852 people aged 20 years and over who died in Western Australia between 1 January 2009 and 31 December 2010 after excluding deaths related to pregnancy or trauma. Within this cohort, the number, proportion and characteristics of people who died from one or more of 10 medical conditions considered amenable to palliative care were identified using linked hospital records and death certificate data. RESULTS: Depending on the information source(s) used, between 43% and 73% of the 23,852 people who died had a condition potentially amenable to palliative care identified. The median age at death and the sex distribution of the decedents by condition also varied with the information source. CONCLUSION: Health service planners and researchers need to be aware of the limitations when using hospital records and death certificate data to determine a potential palliative care population. The use of Emergency Department and other administrative data sources could further exacerbate this variation.
[Mh] Termos MeSH primário: Atestado de Óbito
Registros Hospitalares/estatística & dados numéricos
Registro Médico Coordenado/normas
Determinação de Necessidades de Cuidados de Saúde/normas
Cuidados Paliativos/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Austrália Ocidental
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1177/0269216316673550


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[PMID]:29251460
[Au] Autor:Keast K
[Ti] Título:NURSE PRACTITIONERS TAKING URGENT CARE OF PERTH.
[So] Source:Aust Nurs Midwifery J;24(5):22, 2016 11.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:From chronic disease management to emergency care, Nurse Practitioners (NPs) have been redefining the face of health care in Australia since 2000. While the role continues to remain a largely untapped health solution, two endorsed nurse practitioners are treading their own career path with an innovative venture.
[Mh] Termos MeSH primário: Plantão Médico/organização & administração
Instituições de Assistência Ambulatorial/recursos humanos
Mobilidade Ocupacional
Profissionais de Enfermagem
Papel do Profissional de Enfermagem
[Mh] Termos MeSH secundário: Seres Humanos
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29220140
[Au] Autor:Avery M
[Ti] Título:The fast lane: Nursing in WA's busiest emergency department.
[So] Source:Aust Nurs Midwifery J;22(4):34, 2014 10.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Mh] Termos MeSH primário: Enfermagem em Emergência/estatística & dados numéricos
Serviço Hospitalar de Emergência/estatística & dados numéricos
Recursos Humanos de Enfermagem no Hospital/psicologia
[Mh] Termos MeSH secundário: Adulto
Atitude do Pessoal de Saúde
Feminino
Seres Humanos
Masculino
Meia-Idade
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29210237
[Au] Autor:Helmstedt KJ; Possingham HP; Brennan KEC; Rhodes JR; Bode M
[Ti] Título:Cost-efficient fenced reserves for conservation: single large or two small?
[So] Source:Ecol Appl;24(7):1780-92, 2014.
[Is] ISSN:1051-0761
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fences that exclude alien invasive species are used to reduce predation pressure on reintroduced threatened wildlife. Planning these continuously managed systems of reserves raises an important extension of the Single Large or Several Small (SLOSS) reserve planning framework: the added complexity of ongoing management. We investigate the long-term cost-efficiency of a single large or two small predator exclusion fences in the arid Australian context of reintroducing bilbies Macrotis lagotis, and we highlight the broader significance of our results with sensitivity analysis. A single fence more frequently results in a much larger net cost than two smaller fences. We find that the cost-efficiency of two fences is robust to strong demographic and environmental uncertainty, which can help managers to mitigate the risk of incurring high costs over the entire life of the project.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais/métodos
[Mh] Termos MeSH secundário: Animais
Análise Custo-Benefício
Monitoramento Ambiental
Espécies Introduzidas
Marsupiais/fisiologia
Modelos Biológicos
Dinâmica Populacional
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:29190667
[Au] Autor:Abdalla T; Hendrickx D; Fathima P; Walker R; Blyth CC; Carapetis JR; Bowen AC; Moore HC
[Ad] Endereço:Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
[Ti] Título:Hospital admissions for skin infections among Western Australian children and adolescents from 1996 to 2012.
[So] Source:PLoS One;12(11):e0188803, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to describe the occurrence of skin infection associated hospitalizations in children born in Western Australia (WA). We conducted a retrospective cohort study of all children born in WA between 1996 and 2012 (n = 469,589). Of these, 31,348 (6.7%) were Aboriginal and 240,237 (51.2%) were boys. We report the annual age-specific hospital admission rates by geographical location and diagnostic category. We applied log-linear regression modelling to analyse changes in temporal trends of hospitalizations. Hospitalization rates for skin infections in Aboriginal children (31.7/1000 child-years; 95% confidence interval [CI] 31.0-32.4) were 15.0 times higher (95% CI 14.5-15.5; P<0.001) than those of non-Aboriginal children (2.1/1000 child-years; 95% CI 2.0-2.1). Most admissions in Aboriginal children were due to abscess, cellulitis and scabies (84.3%), while impetigo and pyoderma were the predominant causes in non-Aboriginal children (97.7%). Admissions declined with age, with the highest rates for all skin infections observed in infants. Admissions increased with remoteness. Multiple admissions were more common in Aboriginal children. Excess admissions in Aboriginal children were observed during the wet season in the Kimberley and during summer in metropolitan areas. Our study findings show that skin infections are a significant cause of severe disease, requiring hospitalization in Western Australian children, with Aboriginal children at a particularly high risk. Improved community-level prevention of skin infections and the provision of effective primary care are crucial in reducing the burden of skin infection associated hospitalizations. The contribution of sociodemographic and environmental risk factors warrant further investigation.
[Mh] Termos MeSH primário: Hospitalização
Admissão do Paciente
Dermatopatias Infecciosas/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
História do Século XX
História do Século XXI
Seres Humanos
Lactente
Recém-Nascido
Masculino
Grupo com Ancestrais Oceânicos
Estações do Ano
Austrália Ocidental/epidemiologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188803


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[PMID]:27776985
[Au] Autor:Almeida OP; Hankey GJ; Yeap BB; Golledge J; Hill KD; Flicker L
[Ad] Endereço:School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia; WA Center for Health and Aging of Center for Medical Research, Harry Perkins Institute of Medical Research, Perth, Australia; Department of Psychiatry, Royal Perth Hospital, Perth, Australia.
[Ti] Título:Depression Among Nonfrail Old Men Is Associated With Reduced Physical Function and Functional Capacity After 9 Years Follow-up: The Health in Men Cohort Study.
[So] Source:J Am Med Dir Assoc;18(1):65-69, 2017 Jan.
[Is] ISSN:1538-9375
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Older adults with depression have increased risk of frailty and death. OBJECTIVE: To determine if history of depression hinders future physical and functional capacity. DESIGN, SETTING, AND PARTICIPANTS: Prospective longitudinal cohort study of 1148 men aged 70-87 years who were living in the Perth metropolitan community in 2001-2004 and completed a follow-up assessment of physical and functional capacity in 2011-2012. MAIN OUTCOME AND MEASURES: Outcomes were collected in 2011-2012 and included 4 measures of physical function (timed up-and-go, timed sit-to-stand, functional reach, and step test) and the assessment of basic (activities of daily living) and instrumental activities of daily living. We also collected information on depression and frailty [using the FRAIL (fatigue resistance ambulation illness, and loss of weight) scale] in 2001-2004 and 2011-2012. Frail men at the 2001-2004 were excluded from the analyses. RESULTS: Men with history of depression at the 2001-2004 assessment showed significantly worse performance than their counterparts in the timed sit-to-stand and step tests 9 years later. They also had approximately twice the risk of attaining the lowest decile of performance in both tests (analyses adjusted for age, education, and prevalent depressive symptoms). In addition, the adjusted risk ratio of impaired instrumental activities of daily living was 58% (95% confidence interval 15%, 116%) greater for men with than without history of past depression. These associations were particularly robust for men with current depression at the 2001-2004 assessment. CONCLUSIONS: Nonfrail older men with history of current or past depression showed greater impairment of physical and functional capacity 9 years later. Older men with history of depression may benefit from regular monitoring of physical and occupational function and should be targeted by preventive trials designed to improve function and decrease frailty.
[Mh] Termos MeSH primário: Depressão/epidemiologia
Limitação da Mobilidade
Aptidão Física/psicologia
[Mh] Termos MeSH secundário: Atividades Cotidianas
Idoso
Idoso de 80 Anos ou mais
Estudos de Coortes
Seres Humanos
Masculino
Estudos Prospectivos
Austrália Ocidental/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28846031
[Au] Autor:Clarke T; Pluske JR; Miller DW; Collins T; Fleming PA
[Ad] Endereço:a School of Veterinary and Life Sciences , Murdoch University , Perth , Western Australia , Australia.
[Ti] Título:Parity Influences the Demeanor of Sows in Group Housing.
[So] Source:J Appl Anim Welf Sci;21(1):17-26, 2018 Jan-Mar.
[Is] ISSN:1532-7604
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Across the globe, producers are moving from individual housing to group housing for sows during gestation. Producers typically group sows of a range of parities together, although the impacts are largely unknown. This study examined the behavioral expression at mixing for young, midparity, and older sows. Ten mixed-parity groups were filmed at mixing on a commercial piggery. One-minute clips were edited from continuous footage where focal sows of known parity could be identified, and scored for qualitative behavioral expression. Parity 2 and 6 sows were more calm/tired than Parity 4 sows, who were more active/energetic. Parity 2 sows were more curious/inquisitive than Parity 4 and 6 sows, who were more anxious/frustrated. Correlations between qualitative behavioral expression and activity indicated sows scored as more calm/tired spent a greater proportion of time standing, while sows scored as more active/energetic spent more time performing avoidance behavior. Different body language is likely to reflect physical or affective differences in how sows cope with mixing.
[Mh] Termos MeSH primário: Comportamento Animal
Paridade
Comportamento Social
Suínos/psicologia
[Mh] Termos MeSH secundário: Criação de Animais Domésticos
Bem-Estar do Animal
Animais
Ansiedade/psicologia
Fadiga/veterinária
Feminino
Abrigo para Animais
Movimento
Gravidez
Análise de Componente Principal
Distribuição Aleatória
Gravação em Vídeo
Austrália Ocidental
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1080/10888705.2017.1363651


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[PMID]:29065137
[Au] Autor:Mowlaboccus S; Mullally CA; Richmond PC; Howden BP; Stevens K; Speers DJ; Keil AD; Bjørnstad ON; Perkins TT; Kahler CM
[Ad] Endereço:Marshall Center for Infectious Disease Research and Training, School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
[Ti] Título:Differences in the population structure of Neisseria meningitidis in two Australian states: Victoria and Western Australia.
[So] Source:PLoS One;12(10):e0186839, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neisseria meningitidis is the causative agent of invasive meningococcal disease (IMD). A recombinant vaccine called Bexsero® incorporates four subcapsular antigens (fHbp, NHBA, NadA and PorA) which are used to assign a Bexsero® antigen sequence type (BAST) to each meningococcal strain. The vaccine elicits an immune response against combinations of variants of these antigens which have been grouped into specific BAST profiles that have been shown to have different distributions within geographical locations thus potentially affecting the efficacy of the vaccine. In this study, invasive meningococcal disease isolates from the western seaboard of Australia (Western Australia; WA) were compared to those from the south-eastern seaboard (Victoria; VIC) from 2008 to 2012. Whole-genome sequencing (WGS) of 131 meningococci from VIC and 70 meningococci from WA were analysed for MLST, FetA and BAST profiling. Serogroup B predominated in both jurisdictions and a total of 10 MLST clonal complexes (cc) were shared by both states. Isolates belonging to cc22, cc103 and cc1157 were unique to VIC whilst isolates from cc60 and cc212 were unique to WA. Clonal complex 41/44 represented one-third of the meningococcal population in each state but the predominant ST was locally different: ST-6058 in VIC and ST-146 in WA. Of the 108 BAST profiles identified in this collection, only 9 BASTs were simultaneously observed in both states. A significantly larger proportion of isolates in VIC harboured alleles for the NHBA-2 peptide and fHbp-1, antigenic variants predicted to be covered by the Bexsero® vaccine. The estimate for vaccine coverage in WA (47.1% [95% CI: 41.1-53.1%]) was significantly lower than that in VIC (66.4% [95% CI: 62.3-70.5%]). In conclusion, the antigenic structure of meningococci causing invasive disease in two geographically distinct states of Australia differed significantly during the study period which may affect vaccine effectiveness and highlights the need for representative surveillance when predicting potential impact of meningococcal B vaccines.
[Mh] Termos MeSH primário: Neisseria meningitidis/classificação
[Mh] Termos MeSH secundário: Antígenos de Bactérias/imunologia
Genes Bacterianos
Seres Humanos
Neisseria meningitidis/genética
Neisseria meningitidis/imunologia
Vitória
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Bacterial)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186839


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[PMID]:29020906
[Au] Autor:Davis TM; Makepeace AE; Ellard S; Colclough K; Peters K; Hattersley A; Davis WA
[Ad] Endereço:University of Western Australia, Perth, WA tim.davis@uwa.edu.au.
[Ti] Título:The prevalence of monogenic diabetes in Australia: the Fremantle Diabetes Study Phase II.
[So] Source:Med J Aust;207(8):344-347, 2017 Oct 16.
[Is] ISSN:1326-5377
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the prevalence of monogenic diabetes in an Australian community. DESIGN: Longitudinal observational study of a cohort recruited between 2008 and 2011. SETTING: Urban population of 157 000 people (Fremantle, Western Australia). PARTICIPANTS: 1668 (of 4639 people with diabetes) who consented to participation (36.0% participation). MAIN OUTCOME MEASURES: Prevalence of maturity-onset diabetes of the young (MODY) and permanent neonatal diabetes in patients under 35 years of age, from European and non-European ethnic backgrounds, who were at risk of MODY according to United Kingdom risk prediction models, and who were then genotyped for relevant mutations. RESULTS: Twelve of 148 young participants with European ethnic backgrounds (8%) were identified by the risk prediction model as likely to have MODY; four had a glucokinase gene mutation. Thirteen of 45 with non-European ethnic backgrounds (28%) were identified as likely to have MODY, but none had a relevant mutation (DNA unavailable for one patient). Two patients with European ethnic backgrounds (one likely to have MODY) had neonatal diabetes. The estimated MODY prevalence among participants with diagnosed diabetes was 0.24% (95% confidence interval [CI], 0.08-0.66%), an overall population prevalence of 89 cases per million; the prevalence of permanent neonatal diabetes was 0.12% (95% CI, 0.02-0.48%) and the population prevalence 45 cases per million. CONCLUSIONS: One in 280 Australians diagnosed with diabetes have a monogenic form; most are of European ethnicity. Diagnosing MODY and neonatal diabetes is important because their management (including family screening) and prognosis can differ significantly from those for types 1 and 2 diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/epidemiologia
Diabetes Mellitus Tipo 2/genética
Diabetes Mellitus/epidemiologia
Diabetes Mellitus/genética
[Mh] Termos MeSH secundário: Diabetes Mellitus/etnologia
Diabetes Mellitus Tipo 2/etnologia
Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos
Feminino
Glucoquinase/genética
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Mutação
Prevalência
Medição de Risco
Austrália Ocidental/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
EC 2.7.1.2 (Glucokinase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE



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