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Pesquisa : Z01.639.760.680 [Categoria DeCS]
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  1 / 1032 MEDLINE  
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[PMID]:29243474
[Au] Autor:Barker S
[Ti] Título:REFUGEES IN NAURU.
[So] Source:Aust Nurs Midwifery J;24(3):30, 2016 Sep.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:A report alleging appalling abuse and neglect of refugees and asylum seekers living in detention on Nauru has recently been released based on Amnesty International and Human Rights Watch's investigations. The report detailed inhumane conditions, abuse and assault of detainees including neglect by locals and healthcare providers. The Department of Immigration has lashed out strongly refuting many of the claims in the report. Registered Nurse and citizen of Nauru Sue Barker also says the treatment of refugees and asylum seekers is very different to the one painted by the media. Sue has written to the ANMJ asking to give her account about the humane support refugees and asylum seekers are given by the locals on Nauru.
[Mh] Termos MeSH primário: Acesso aos Serviços de Saúde
Direitos Humanos
Refugiados
[Mh] Termos MeSH secundário: Austrália
Seres Humanos
Meios de Comunicação de Massa
Micronésia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  2 / 1032 MEDLINE  
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[PMID]:28898240
[Au] Autor:Cama A; Müller A; Taoaba R; Butcher RMR; Itibita I; Migchelsen SJ; Kiauea T; Pickering H; Willis R; Roberts CH; Bakhtiari A; Le Mesurier RT; Alexander NDE; Martin DL; Tekeraoi R; Solomon AW; Global Trachoma Mapping Project
[Ad] Endereço:International Agency for the Prevention of Blindness, Western Pacific Region, Suva, Fiji.
[Ti] Título:Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati.
[So] Source:PLoS Negl Trop Dis;11(9):e0005863, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: In some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most populous Kiribati island, both the active trachoma sign "trachomatous inflammation-follicular" (TF) and TT are present at prevalences warranting intervention. We sought to estimate prevalences of TF, TT, ocular Ct infection, and anti-Ct antibodies on Kiritimati Island, Kiribati, to assess local relationships between these parameters, and to help determine the need for interventions against trachoma on Kiribati islands other than Tarawa. METHODS: As part of the Global Trachoma Mapping Project (GTMP), on Kiritimati, we examined 406 children aged 1-9 years for active trachoma. We collected conjunctival swabs (for droplet digital PCR against Ct plasmid targets) from 1-9-year-olds with active trachoma, and a systematic selection of 1-9-year-olds without active trachoma. We collected dried blood spots (for anti-Pgp3 ELISA) from all 1-9-year-old children. We also examined 416 adults aged ≥15 years for TT. Prevalence of TF and TT was adjusted for age (TF) or age and gender (TT) in five-year age bands. RESULTS: The age-adjusted prevalence of TF in 1-9-year-olds was 28% (95% confidence interval [CI]: 24-35). The age- and gender-adjusted prevalence of TT in those aged ≥15 years was 0.2% (95% CI: 0.1-0.3%). Twenty-six (13.5%) of 193 swabs from children without active trachoma, and 58 (49.2%) of 118 swabs from children with active trachoma were positive for Ct DNA. Two hundred and ten (53%) of 397 children had anti-Pgp3 antibodies. Both infection (p<0.0001) and seropositivity (p<0.0001) were strongly associated with active trachoma. In 1-9-year-olds, the prevalence of anti-Pgp3 antibodies rose steeply with age. CONCLUSION: Trachoma presents a public health problem on Kiritimati, where the high prevalence of ocular Ct infection and rapid increase in seropositivity with age suggest intense Ct transmission amongst young children. Interventions are required here to prevent future blindness.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/imunologia
Proteínas de Bactérias/imunologia
Chlamydia trachomatis
Tracoma/epidemiologia
Tracoma/microbiologia
Triquíase/etiologia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Lactente
Micronésia/epidemiologia
Prevalência
Tracoma/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Antigens, Bacterial); 0 (Bacterial Proteins); 0 (pgp3 protein, Chlamydia)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005863


  3 / 1032 MEDLINE  
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[PMID]:28641326
[Au] Autor:Sharp FC; Sayer MD
[Ad] Endereço:Fiona Stanley Hospital, 11 Robin Warren Dr, Murdoch, WA 6150, Australia, sharpief@doctors.org.uk.
[Ti] Título:A technical diving-related burns case: treatment in a remote location.
[So] Source:Diving Hyperb Med;47(2):127-130, 2017 Jun.
[Is] ISSN:1833-3516
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Injuries suffered as a result of a rebreather oxygen explosion and fire occurred to a diver on vacation in the island state of Chuuk, Micronesia. The medical and logistical management of the diver in a remote location are described. The mechanism of both the fire and the subsequent blast and burn injuries are discussed. Prevention of and preparation for such incidents are discussed in the context of the increasing frequency of dive and adventure travel to remote areas.
[Mh] Termos MeSH primário: Traumatismos por Explosões/complicações
Queimaduras/terapia
Mergulho/lesões
Fogo
Oxigênio
[Mh] Termos MeSH secundário: Adulto
Queimaduras/etiologia
Crioterapia/métodos
Desbridamento
Seres Humanos
Masculino
Micronésia
Manejo da Dor/métodos
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE


  4 / 1032 MEDLINE  
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[PMID]:28610179
[Au] Autor:Anderson WDJ; Johnson GD
[Ad] Endereço:Grice Marine Biological Laboratory, College of Charleston, 205 Fort Johnson, Charleston, South Carolina 29412-9110, U.S.A.. andersonwd@cofc.edu.
[Ti] Título:Two new species of callanthiid fishes of the genus Grammatonotus (Percoidei: Callanthiidae) from Pohnpei, western Pacific.
[So] Source:Zootaxa;4243(1):187-194, 2017 Mar 13.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:In late July/early August 2015, ichthyologists from the Bishop Museum collecting fishes off Pohnpei in the Caroline Islands group, western Pacific Ocean, obtained specimens of two undescribed species of Grammatonotus. One of the new species, G. xanthostigma, closely resembles the recently described G. brianne, differing most strikingly in the shape of the caudal fin. The other, G. pelipel, is distinctive in having the following combination of characters: disjunct lateral line, barred pattern of coloration (most distinctive in small individuals), and caudal fin truncate to slightly emarginate in small specimens, but with upper and lower lobes produced in largest example known. Herein we provide characters that distinguish callanthiids from other percoids and that distinguish Grammatonotus from Callanthias, the other genus in the family Callanthiidae, along with descriptions of the new species.
[Mh] Termos MeSH primário: Perciformes
[Mh] Termos MeSH secundário: Animais
Peixes
Micronésia
Oceano Pacífico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4243.1.10


  5 / 1032 MEDLINE  
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[PMID]:28489903
[Au] Autor:Crane NL; Nelson P; Abelson A; Precoda K; Rulmal J; Bernardi G; Paddack M
[Ad] Endereço:Department of Biology, Cabrillo College, Aptos, California, United States of America.
[Ti] Título:Atoll-scale patterns in coral reef community structure: Human signatures on Ulithi Atoll, Micronesia.
[So] Source:PLoS One;12(5):e0177083, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The dynamic relationship between reefs and the people who utilize them at a subsistence level is poorly understood. This paper characterizes atoll-scale patterns in shallow coral reef habitat and fish community structure, and correlates these with environmental characteristics and anthropogenic factors, critical to conservation efforts for the reefs and the people who depend on them. Hierarchical clustering analyses by site for benthic composition and fish community resulted in the same 3 major clusters: cluster 1-oceanic (close proximity to deep water) and uninhabited (low human impact); cluster 2-oceanic and inhabited (high human impact); and cluster 3-lagoonal (facing the inside of the lagoon) and inhabited (highest human impact). Distance from village, reef exposure to deep water and human population size had the greatest effect in predicting the fish and benthic community structure. Our study demonstrates a strong association between benthic and fish community structure and human use across the Ulithi Atoll (Yap State, Federated States of Micronesia) and confirms a pattern observed by local people that an 'opportunistic' scleractinian coral (Montipora sp.) is associated with more highly impacted reefs. Our findings suggest that small human populations (subsistence fishing) can nevertheless have considerable ecological impacts on reefs due, in part, to changes in fishing practices rather than overfishing per se, as well as larger global trends. Findings from this work can assist in building local capacity to manage reef resources across an atoll-wide scale, and illustrates the importance of anthropogenic impact even in small communities.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais
Recifes de Corais
Peixes
[Mh] Termos MeSH secundário: Animais
Biodiversidade
Biomassa
Pesqueiros
Peixes/fisiologia
Seres Humanos
Micronésia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177083


  6 / 1032 MEDLINE  
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[PMID]:28434247
[Au] Autor:Gopalani SV; Samo M; Soaz S; David WJ; Mori S; Luther XN; Carter KL
[Ad] Endereço:1 Department of Health and Social Affairs, Government of the Federated States of Micronesia, Palikir, Pohnpei, Federated States of Micronesia.
[Ti] Título:Premature Mortality From Noncommunicable Diseases in the Federated States of Micronesia, 2003-2012.
[So] Source:Asia Pac J Public Health;29(3):171-179, 2017 Apr.
[Is] ISSN:1941-2479
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:This study was conducted to assess status, and understand burden, of premature and leading causes of deaths from noncommunicable diseases (NCDs) in the Federated States of Micronesia (FSM). From 2003 to 2012, ICD-10 coded mortality data from the national Health Information System were analyzed. Proportional mortality was calculated and a ranking list of the leading causes of premature death was produced. Of the 2349 premature deaths reported, 1970 (83.9%) were due to NCDs, and 1680 (71.5%) were from 4 main NCD groups-cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases. Diabetes (19.5%), ischemic heart diseases (13.2%), and cerebrovascular diseases (7.1%) were the leading causes of premature deaths. The findings indicate that the burden of premature NCD deaths in FSM is higher than global levels, and existing efforts need to be strengthened to alter their course.
[Mh] Termos MeSH primário: Doença Crônica/mortalidade
Efeitos Psicossociais da Doença
Mortalidade Prematura
[Mh] Termos MeSH secundário: Adulto
Idoso
Causas de Morte
Feminino
Seres Humanos
Classificação Internacional de Doenças
Masculino
Micronésia/epidemiologia
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1177/1010539517696555


  7 / 1032 MEDLINE  
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[PMID]:28415942
[Au] Autor:Li CT; Chu KH; Reiher B; Kienene T; Chien LY
[Ad] Endereço:1 Practice Teacher, Department of Nursing, Ching Kuo Institute of Management and Health, Keelung, Taiwan.
[Ti] Título:Evaluation of health-related quality of life in patients with tuberculosis who completed treatment in Kiribati.
[So] Source:J Int Med Res;45(2):610-620, 2017 Apr.
[Is] ISSN:1473-2300
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective To examine the health-related quality of life (HRQoL) and related factors among patients with smear-positive and smear-negative pulmonary tuberculosis (TB) within 2 years after completion of directly observed treatment, short course (DOTS), and to compare their HRQoL with a comparison group of community-dwelling individuals without TB in South Tarawa, Kiribati. Methods A cross-sectional questionnaire survey was conducted among 206 pulmonary TB patients who had completed DOTS and 214 individuals without TB, from July to September 2012. HRQoL was measured using the Short Form (36) Health Survey (SF-36). Results The patients with TB had a statistically significantly higher physical component summary (PCS) score and mental component summary (MCS) score on the SF-36 than the comparison group after adjustment for background characteristics. However, the differences did not exceed the 3-point threshold for clinically significant differences. Multiple liner regression showed that older age and presence of persistent symptoms after completion of DOTS were related to a lower PCS score in TB patients. Patients who were smear-positive before DOTS treatment had higher MCS scores than those who were smear-negative. Conclusions Our results suggest the effectiveness of DOTS treatment. Health professionals can enhance HRQoL among posttreatment TB patients by managing their symptoms.
[Mh] Termos MeSH primário: Indicadores Básicos de Saúde
Qualidade de Vida/psicologia
Tuberculose Pulmonar/tratamento farmacológico
Tuberculose Pulmonar/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antituberculosos/uso terapêutico
Estudos Transversais
Esquema de Medicação
Grupos Étnicos
Feminino
Seres Humanos
Vida Independente/psicologia
Masculino
Micronésia
Meia-Idade
Análise Multivariada
Inquéritos e Questionários
Tuberculose Pulmonar/etnologia
Tuberculose Pulmonar/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1177/0300060517694491


  8 / 1032 MEDLINE  
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[PMID]:28409861
[Au] Autor:Duke MR
[Ad] Endereço:Department of Anthropology, University of Memphis.
[Ti] Título:Neocolonialism and Health Care Access among Marshall Islanders in the United States.
[So] Source:Med Anthropol Q;31(3):422-439, 2017 Sep.
[Is] ISSN:0745-5194
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the Marshall Islands, a history of extensive nuclear weapons testing and covert biomedical research, coupled with the U.S.'s ongoing military presence in the country, has severely compromised the health of the local population. Despite the U.S.'s culpability in producing ill health along with high rates of emigration from the islands to the mainland United States, the large portion of Marshallese who reside in the United States face substantial barriers to accessing health care. Drawing from ongoing field research with a Marshallese community in Arkansas, this article explores the multifaceted impediments that U.S.-based Marshall Islanders face in receiving medical treatment. Calling on an expansive and inclusive notion of neocolonialism, I argue that Marshallese structural vulnerability with regard to health and health care treatment derives from their status as neocolonial subjects and from their limited claims to health-related deservingness associated with this status. [Marshall Islanders, health care access, neocolonialism, radiation exposure, immigrant health] L̗omn̗ak ko rottin̗o: Ilo M̗ajel̗, juon bwebwenato kon kommalmel im nuclear baam̗ ko im ekkatak ko rottin̗o̗ kon wawein an baijin ko jelot armej, barainwot an to an ri tarinae ro an Amedka pad ilo aelon̄ kein, em̗oj an jelot ajmour an armej ro ilo aelon̄ kein. Men̄e alikkar bwe Amedka in ear jino nan̄inmej kein im ej un eo armej rein rej em̗m̗akut jan ane kein ane er n̄an ioon Amedka, elon̄ iaan ri M̗ajel̗ rein rej jelm̗ae elon̄ apan̄ ko n̄an aer del̗o̗n̄e jikin ajmour ko. Jan ekkatak eo ej bok jikin kio, jerbal in ej etali kabojrak rak kein rolon̄ im armej in M̗ajel̗ ro ioon Amedka in rej jelm̗ae ilo aer jibadok lo̗k jikin takto. Ilo an kar Amedka jibadok juon jea eo eutiej imejan lal̗ in, ij kwal̗ok juon ao akweelel bwe apan̄ ko an armej in M̗ajel̗ ikijjeen ajmour im jikin takto ej itok jan aer kar ri kom̗akoko ilo an kar Amedka lelon̄ l̗o̗k etan ilo mejan lal̗ im jan aer jab pukot jipan kein ej aer bwe kon jokjok in.
[Mh] Termos MeSH primário: Colonialismo/história
Acesso aos Serviços de Saúde
Exposição à Radiação
[Mh] Termos MeSH secundário: Antropologia Médica
Emigrantes e Imigrantes
História do Século XX
História do Século XXI
Seres Humanos
Micronésia/etnologia
Armas Nucleares
Estados Unidos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1111/maq.12376


  9 / 1032 MEDLINE  
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[PMID]:28394899
[Au] Autor:Wan X; Koster K; Qian L; Desmond E; Brostrom R; Hou S; Douglas JT
[Ad] Endereço:Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii, United States of America.
[Ti] Título:Genomic analyses of the ancestral Manila family of Mycobacterium tuberculosis.
[So] Source:PLoS One;12(4):e0175330, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With its airborne transmission and prolonged latency period, Mycobacterium tuberculosis spreads worldwide as one of the most successful bacterial pathogens and continues to kill millions of people every year. M. tuberculosis lineage 1 is inferred to originate ancestrally based on the presence of the 52-bp TbD1 sequence and analysis of single nucleotide polymorphisms. Previously, we briefly reported the complete genome sequencing of M. tuberculosis strains 96121 and 96075, which belong to the ancient Manila family and modern Beijing family respectively. Here we present the comprehensive genomic analyses of the Manila family in lineage 1 compared to complete genomes in lineages 2-4. Principal component analysis of the presence and absence of CRISPR spacers suggests that Manila isolate 96121 is distinctly distant from lineages 2-4. We further identify a truncated whiB5 gene and a putative operon consisting of genes encoding a putative serine/threonine kinase PknH and a putative ABC transporter, which are only found in the genomes of Manila family isolates. Six single nucleotide polymorphisms are uniquely conserved in 38 Manila strains. Moreover, when compared to M. tuberculosis H37Rv, 59 proteins are under positive selection in Manila family isolate 96121 but not in Beijing family isolate 96075. The unique features further serve as biomarkers for Manila strains and may shed light on the limited transmission of this ancestral lineage outside of its Filipino host population.
[Mh] Termos MeSH primário: Genoma
Mycobacterium tuberculosis/genética
[Mh] Termos MeSH secundário: Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas
Evolução Molecular
Feminino
Genes Bacterianos
Seres Humanos
Micronésia
Mycobacterium tuberculosis/isolamento & purificação
Filipinas
Polimorfismo de Nucleotídeo Único
Análise de Componente Principal
Análise de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175330


  10 / 1032 MEDLINE  
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[PMID]:28248978
[Au] Autor:Pastula DM; Hancock WT; Bel M; Biggs H; Marfel M; Lanciotti R; Laven J; Chen TH; Staples JE; Fischer M; Hills SL
[Ad] Endereço:Epidemic Intelligence Service Program Office, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America.
[Ti] Título:Chikungunya virus disease outbreak in Yap State, Federated States of Micronesia.
[So] Source:PLoS Negl Trop Dis;11(3):e0005410, 2017 Mar.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chikungunya virus is a mosquito-borne alphavirus which causes an acute febrile illness associated with polyarthralgia. Beginning in August 2013, clinicians from the Yap State Department of Health in the Federated States of Micronesia (FSM) identified an unusual cluster of illness which was subsequently confirmed to be chikungunya virus disease. Chikungunya virus disease previously had not been recognized in FSM. METHODOLOGY/PRINCIPAL FINDINGS: Information from patients presenting to healthcare facilities was collected and analyzed. During August 11, 2013, to August 10, 2014, a total of 1,761 clinical cases were reported for an attack rate of 155 clinical cases per 1,000 population. Among residents of Yap Main Island, 3% were hospitalized. There were no deaths. The outbreak began on Yap Main Island and rapidly spread throughout Yap Main Island and to three neighboring islands. CONCLUSIONS/SIGNIFICANCE: Chikungunya virus can cause explosive outbreaks with substantial morbidity. Given the increasing globalization of chikungunya virus, strong surveillance systems and access to laboratory testing are essential to detect outbreaks.
[Mh] Termos MeSH primário: Febre de Chikungunya/epidemiologia
Surtos de Doenças
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Hospitalização
Seres Humanos
Lactente
Recém-Nascido
Masculino
Micronésia/epidemiologia
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005410



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