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[PMID]: 28614909 [Au] Autor: Luo G; Zhang Y; Guo P; Wang L; Huang Y; Li K [Ad] Endereço: Department of Public Health, Shantou University Medical College, Shantou, Guangdong, 515041, China. [Ti] Título: Global patterns and trends in stomach cancer incidence: Age, period and birth cohort analysis. [So] Source: Int J Cancer;141(7):1333-1344, 2017 Oct 01. [Is] ISSN: 1097-0215 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The cases of stomach cancer (SC) incidence are increasing per year and the SC burden has remained very high in some countries. We aimed to evaluate the global geographical variation in SC incidence and temporal trends from 1978 to 2007, with an emphasis on the effect of birth cohort. Joinpoint regression and age-period-cohort model were applied. From 2003 to 2007, male rate were 1.5- to 3-fold higher than female in all countries. Rates were highest in Eastern Asian and South American countries. Except for Uganda, all countries showed favorable trends. Pronounced cohort-specific increases in risk for recent birth cohorts were seen in Brazil, Colombia, Iceland, New Zealand, Norway, Uganda and US white people for males and in Australia, Brazil, Colombia, Costa Rica, Czech Republic, Ecuador, Iceland, India, Malta, New Zealand, Norway, Switzerland, United Kingdom, Uganda, US black and white people for females. The cohort-specific ratio for male significantly decreased in Japan, Malta and Spain for cohorts born since 1950 and in Austria, China, Croatia, Ecuador, Russia, Switzerland and Thailand for cohorts born since 1960 and for female in Japan for cohorts born since 1950 and in Canada, China, Croatia, Latvia, Russia and Thailand for cohorts born since 1960. Disparities in incidence and carcinogenic risk persist worldwide. The favorable trends may be due to changes in environmental exposure and lifestyle, including decreased Helicobacter pylori prevalence, increased intake of fresh fruits and vegetables, the availability of refrigeration and decreased intake of salted and preserved food and smoking prevalence. [Mh] Termos MeSH primário: Saúde Global/estatística & dados numéricos Neoplasias Gástricas/epidemiologia [Mh] Termos MeSH secundário: Adulto Grupo com Ancestrais do Continente Africano/estatística & dados numéricos Distribuição por Idade Fatores Etários Idoso Idoso de 80 Anos ou mais Ásia/epidemiologia Canadá/epidemiologia Estudos de Coortes Europa (Continente)/epidemiologia Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos Feminino Seres Humanos Incidência Masculino Malta/epidemiologia Meia-Idade Oceania/epidemiologia Distribuição por Sexo América do Sul/epidemiologia Fatores de Tempo Estados Unidos/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170927 [Lr] Data última revisão: 170927 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170615 [St] Status: MEDLINE [do] DOI: 10.1002/ijc.30835

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[PMID]: 28445448 [Au] Autor: Gould J [Ti] Título: Nutrition: A world of insecurity. [So] Source: Nature;544(7651):S6-S7, 2017 04 26. [Is] ISSN: 1476-4687 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Abastecimento de Alimentos/estatística & dados numéricos [Mh] Termos MeSH secundário: Américas Ásia Região do Caribe Produção Agrícola/estatística & dados numéricos Cucurbitaceae Grãos Comestíveis/provisão & distribuição Europa (Continente) Seres Humanos Desnutrição/epidemiologia Oceania Hipernutrição/epidemiologia Verduras/provisão & distribuição Gerenciamento de Resíduos/estatística & dados numéricos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170829 [Lr] Data última revisão: 170829 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170427 [St] Status: MEDLINE [do] DOI: 10.1038/544S6a

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[PMID]: 28410997 [Au] Autor: Steliarova-Foucher E; Colombet M; Ries LAG; Moreno F; Dolya A; Bray F; Hesseling P; Shin HY; Stiller CA; IICC-3 contributors [Ad] Endereço: Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France. Electronic address: steliarova@iarc.fr. [Ti] Título: International incidence of childhood cancer, 2001-10: a population-based registry study. [So] Source: Lancet Oncol;18(6):719-731, 2017 Jun. [Is] ISSN: 1474-5488 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. METHODS: This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001-10. Incidence rates per million person-years for the 0-14 years and 0-19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0-4 years, 5-9 years, 10-14 years, and 15-19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0-14 years were compared with comparable data obtained in the 1980s. FINDINGS: Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001-10. 385 509 incident cases in children aged 0-19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0-14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15-19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0-14 years has increased from 124·0 (95% CI 123·3-124·7) to 140·6 (140·1-141·1) per million person-years. INTERPRETATION: This unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research. FUNDING: International Agency for Research on Cancer and the Union for International Cancer Control. [Mh] Termos MeSH primário: Neoplasias/epidemiologia [Mh] Termos MeSH secundário: Adolescente África/epidemiologia Distribuição por Idade Ásia/epidemiologia Região do Caribe/epidemiologia Criança Pré-Escolar Europa (Continente)/epidemiologia Feminino Seres Humanos Incidência Lactente Masculino Neoplasias/etnologia América do Norte/epidemiologia Oceania/epidemiologia Sistema de Registros América do Sul/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170824 [Lr] Data última revisão: 170824 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170416 [St] Status: MEDLINE

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[PMID]: 28336671 [Au] Autor: Tomasetti C; Li L; Vogelstein B [Ad] Endereço: Division of Biostatistics and Bioinformatics, Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA. ctomasetti@jhu.edu vogelbe@jhmi.edu. [Ti] Título: Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. [So] Source: Science;355(6331):1330-1334, 2017 03 24. [Is] ISSN: 1095-9203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cell divisions in all countries, regardless of their environment. The major role of R mutations in cancer etiology was supported by an independent approach, based solely on cancer genome sequencing and epidemiological data, which suggested that R mutations are responsible for two-thirds of the mutations in human cancers. All of these results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment. Moreover, they accentuate the importance of early detection and intervention to reduce deaths from the many cancers arising from unavoidable R mutations. [Mh] Termos MeSH primário: Divisão Celular Replicação do DNA/genética Neoplasias/genética Neoplasias/prevenção & controle Células-Tronco/citologia [Mh] Termos MeSH secundário: África/epidemiologia Ásia/epidemiologia Região do Caribe/epidemiologia Feminino Interação Gene-Ambiente Seres Humanos Incidência América Latina/epidemiologia Masculino Mutação Neoplasias/epidemiologia América do Norte/epidemiologia Oceania/epidemiologia Prevenção Primária [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171103 [Lr] Data última revisão: 171103 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170325 [St] Status: MEDLINE [do] DOI: 10.1126/science.aaf9011

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[PMID]: 28288060 [Au] Autor: Ferris M; Quan S; Kaplan BS; Molodecky N; Ball CG; Chernoff GW; Bhala N; Ghosh S; Dixon E; Ng S; Kaplan GG [Ad] Endereço: *Department of Medicine, University of Calgary, Calgary, AB, Canada †Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada ‡Department of Surgery, University of Calgary, Calgary, AB, Canada §Miistakis Institute, University of Calgary, Calgary, AB, Canada ¶Queen Elizabeth Hospital, Birmingham, UK ||Chinese University of Hong Kong, Sha Tin, Hong Kong. [Ti] Título: The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies. [So] Source: Ann Surg;266(2):237-241, 2017 Aug. [Is] ISSN: 1528-1140 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: We compared the incidence of appendicitis or appendectomy across the world and evaluated temporal trends. SUMMARY BACKGROUND DATA: Population-based studies reported the incidence of appendicitis. METHODS: We searched MEDLINE and EMBASE databases for population-based studies reporting the incidence of appendicitis or appendectomy. Time trends were explored using Poisson regression and reported as annual percent change (APC) with 95% confidence intervals (CI). APC were stratified by time periods and pooled using random effects models. Incidence since 2000 was pooled for regions in the Western world. RESULTS: The search retrieved 10,247 citations with 120 studies reporting on the incidence of appendicitis or appendectomy. During the 21st century the pooled incidence of appendicitis or appendectomy (in per 100,000 person-years) was 100 (95% CI: 91, 110) in Northern America, and the estimated number of cases in 2015 was 378,614. The pooled incidence ranged from 105 in Eastern Europe to 151 in Western Europe. In Western countries, the incidence of appendectomy steadily decreased since 1990 (APC after 1989=-1.54; 95% CI: -2.22, -0.86), whereas the incidence of appendicitis stabilized (APC=-0.36; 95% CI: -0.97, 0.26) for both perforated (APC=0.95; 95% CI: -0.25, 2.17) and nonperforated appendicitis (APC=0.44; 95% CI: -0.84, 1.73). In the 21st century, the incidence of appendicitis or appendectomy is high in newly industrialized countries in Asia (South Korea pooled: 206), the Middle East (Turkey pooled: 160), and Southern America (Chile: 202). CONCLUSIONS: Appendicitis is a global disease. The incidence of appendicitis is stable in most Western countries. Data from newly industrialized countries is sparse, but suggests that appendicitis is rising rapidly. [Mh] Termos MeSH primário: Apendicite/epidemiologia Saúde Global/estatística & dados numéricos [Mh] Termos MeSH secundário: África/epidemiologia Apendicectomia/estatística & dados numéricos Apendicite/cirurgia Ásia/epidemiologia Austrália/epidemiologia Europa (Continente)/epidemiologia Seres Humanos Incidência Oriente Médio/epidemiologia América do Norte/epidemiologia Oceania/epidemiologia América do Sul/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170823 [Lr] Data última revisão: 170823 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170314 [St] Status: MEDLINE [do] DOI: 10.1097/SLA.0000000000002188

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[PMID]: 28178973 [Au] Autor: Kyu HH; Mumford JE; Stanaway JD; Barber RM; Hancock JR; Vos T; Murray CJ; Naghavi M [Ad] Endereço: Institute for Health Metrics and Evaluation, University of Washington, 2301 5th Ave. Suite 600, Seattle, WA, 98121, USA. hmwekyu@uw.edu. [Ti] Título: Mortality from tetanus between 1990 and 2015: findings from the global burden of disease study 2015. [So] Source: BMC Public Health;17(1):179, 2017 Feb 08. [Is] ISSN: 1471-2458 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Although preventable, tetanus still claims tens of thousands of deaths each year. The patterns and distribution of mortality from tetanus have not been well characterized. We identified the global, regional, and national levels and trends of mortality from neonatal and non-neonatal tetanus based on the results from the Global Burden of Disease Study 2015. METHODS: Data from vital registration, verbal autopsy studies and mortality surveillance data covering 12,534 site-years from 1980 to 2014 were used. Mortality from tetanus was estimated using the Cause of Death Ensemble modeling strategy. RESULTS: There were 56,743 (95% uncertainty interval (UI): 48,199 to 80,042) deaths due to tetanus in 2015; 19,937 (UI: 17,021 to 23,467) deaths occurred in neonates; and 36,806 (UI: 29,452 to 61,481) deaths occurred in older children and adults. Of the 19,937 neonatal tetanus deaths, 45% of deaths occurred in South Asia, and 44% in Sub-Saharan Africa. Of the 36,806 deaths after the neonatal period, 47% of deaths occurred in South Asia, 36% in sub-Saharan Africa, and 12% in Southeast Asia. Between 1990 and 2015, the global mortality rate due to neonatal tetanus dropped by 90% and that due to non-neonatal tetanus dropped by 81%. However, tetanus mortality rates were still high in a number of countries in 2015. The highest rates of neonatal tetanus mortality (more than 1,000 deaths per 100,000 population) were observed in Somalia, South Sudan, Afghanistan, and Kenya. The highest rates of mortality from tetanus after the neonatal period (more than 5 deaths per 100,000 population) were observed in Somalia, South Sudan, and Kenya. CONCLUSIONS: Though there have been tremendous strides globally in reducing the burden of tetanus, tens of thousands of unnecessary deaths from tetanus could be prevented each year by an already available inexpensive and effective vaccine. Availability of more high quality data could help narrow the uncertainty of tetanus mortality estimates. [Mh] Termos MeSH primário: Carga Global da Doença/estatística & dados numéricos Internacionalidade Tétano/mortalidade [Mh] Termos MeSH secundário: Adolescente Adulto África/epidemiologia Fatores Etários Idoso Idoso de 80 Anos ou mais Ásia/epidemiologia Australásia/epidemiologia Região do Caribe/epidemiologia Criança Pré-Escolar Europa (Continente)/epidemiologia Feminino Seres Humanos Lactente Recém-Nascido América Latina/epidemiologia Masculino Meia-Idade Oriente Médio/epidemiologia América do Norte/epidemiologia Oceania/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170901 [Lr] Data última revisão: 170901 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170210 [St] Status: MEDLINE [do] DOI: 10.1186/s12889-017-4111-4

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[PMID]: 27904152 [Au] Autor: Nagle N; Ballantyne KN; van Oven M; Tyler-Smith C; Xue Y; Wilcox S; Wilcox L; Turkalov R; van Oorschot RA; van Holst Pellekaan S; Schurr TG; McAllister P; Williams L; Kayser M; Mitchell RJ; Genographic Consortium [Ad] Endereço: Department of Biochemistry and Genetics, La Trobe University, Melbourne, VIC, Australia. [Ti] Título: Mitochondrial DNA diversity of present-day Aboriginal Australians and implications for human evolution in Oceania. [So] Source: J Hum Genet;62(3):343-353, 2017 Mar. [Is] ISSN: 1435-232X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Aboriginal Australians are one of the more poorly studied populations from the standpoint of human evolution and genetic diversity. Thus, to investigate their genetic diversity, the possible date of their ancestors' arrival and their relationships with neighboring populations, we analyzed mitochondrial DNA (mtDNA) diversity in a large sample of Aboriginal Australians. Selected mtDNA single-nucleotide polymorphisms and the hypervariable segment haplotypes were analyzed in 594 Aboriginal Australians drawn from locations across the continent, chiefly from regions not previously sampled. Most (~78%) samples could be assigned to mtDNA haplogroups indigenous to Australia. The indigenous haplogroups were all ancient (with estimated ages >40 000 years) and geographically widespread across the continent. The most common haplogroup was P (44%) followed by S (23%) and M42a (9%). There was some geographic structure at the haplotype level. The estimated ages of the indigenous haplogroups range from 39 000 to 55 000 years, dates that fit well with the estimated date of colonization of Australia based on archeological evidence (~47 000 years ago). The distribution of mtDNA haplogroups in Australia and New Guinea supports the hypothesis that the ancestors of Aboriginal Australians entered Sahul through at least two entry points. The mtDNA data give no support to the hypothesis of secondary gene flow into Australia during the Holocene, but instead suggest long-term isolation of the continent. [Mh] Termos MeSH primário: DNA Mitocondrial/genética Variação Genética Grupo com Ancestrais Oceânicos/genética Filogenia [Mh] Termos MeSH secundário: Evolução Biológica DNA Mitocondrial/história Feminino Fluxo Gênico Haplótipos História do Século XXI História Antiga Seres Humanos Masculino Oceania Grupo com Ancestrais Oceânicos/história Paleontologia Filogeografia Polimorfismo de Nucleotídeo Único Isolamento Reprodutivo [Pt] Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA, Mitochondrial) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170727 [Lr] Data última revisão: 170727 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161202 [St] Status: MEDLINE [do] DOI: 10.1038/jhg.2016.147

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[PMID]: 27664696 [Au] Autor: Spiteri M; Rogers KM; Jamin E; Thomas F; Guyader S; Lees M; Rutledge DN [Ad] Endereço: Eurofins Analytics France, Rue Pierre Adolphe Bobierre, B.P. 42301, F-44323 NANTES Cedex 3, France. [Ti] Título: Combination of 1H NMR and chemometrics to discriminate manuka honey from other floral honey types from Oceania. [So] Source: Food Chem;217:766-772, 2017 Feb 15. [Is] ISSN: 0308-8146 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Manuka honey is a product produced essentially in New Zealand, and has been widely recognised for its antibacterial properties and specific taste. In this study, 264 honeys from New Zealand and Australia were analysed using proton NMR spectroscopy coupled with chemometrics. Known manuka markers, methylglyoxal and dihydroxyacetone, have been characterised and quantified, together with a new NMR marker, identified as being leptosperin. Manuka honey profiling using 1H NMR is shown to be a possible alternative to chromatography with the added advantage that it can measure methylglyoxal (MGO), dihydroxyacetone (DHA) and leptosperin simultaneously. By combining the information from these three markers, we established a model to estimate the proportion of manuka in a given honey. Markers of other botanical origins were also identified, which makes 1H NMR a convenient and efficient tool, complementary to pollen analysis, to control the botanical origin of Oceania honeys. [Mh] Termos MeSH primário: Flores/química Mel/análise Espectroscopia de Prótons por Ressonância Magnética/métodos [Mh] Termos MeSH secundário: Austrália Di-Hidroxiacetona/química Análise Discriminante Flores/classificação Modelos Teóricos Nova Zelândia Oceania Aldeído Pirúvico/química [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 722KLD7415 (Pyruvaldehyde); O10DDW6JOO (Dihydroxyacetone) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170902 [Lr] Data última revisão: 170902 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160925 [St] Status: MEDLINE

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[PMID]: 27571887 [Au] Autor: Miranda-Filho A; Piñeros M; Soerjomataram I; Deltour I; Bray F [Ad] Endereço: National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. [Ti] Título: Cancers of the brain and CNS: global patterns and trends in incidence. [So] Source: Neuro Oncol;19(2):270-280, 2017 02 01. [Is] ISSN: 1523-5866 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Background: Cancers of the brain and CNS constitute a group of rare and heterogeneous tumors. Increasing incidence in Western populations has been linked to improvements in diagnostic technology, although interpretation is hampered by changes in diagnosis and reporting. The present study examines geographic and temporal variations in incidence rates of brain and CNS cancers worldwide. Methods: Data from successive volumes of Cancer Incidence in Five Continents were used, including 96 registries in 39 countries. We used Joinpoint regression to estimate the average annual percentage change and its 95% CI. Results: Globally, a large variability in the magnitude of the diagnosis of new cases of brain and CNS cancer was found, with a 5-fold difference between the highest rates (mainly in Europe) and the lowest (mainly in Asia). Increasing rates of brain and CNS cancer were found in South America, namely in Ecuador, Brazil, and Colombia; in eastern Europe (Czech Republic and Russia), in southern Europe (Slovenia), and in the 3 Baltic countries. Trends were similar between sexes, although decreasing trends in men and women were seen in Japan and New Zealand. Conclusions: Important regional variations in brain and CNS cancers exist, and given an increasing burden and risk worldwide, there is a need for further etiological research that focuses on the elucidation of environmental risk. The trends are sufficiently complex and diffuse, however, to warrant a cautious approach to interpretation. [Mh] Termos MeSH primário: Neoplasias Encefálicas/epidemiologia Neoplasias do Sistema Nervoso Central/epidemiologia Saúde Global Sistema de Registros/estatística & dados numéricos [Mh] Termos MeSH secundário: Adulto África/epidemiologia Fatores Etários Idoso Idoso de 80 Anos ou mais Américas/epidemiologia Ásia/epidemiologia Europa (Continente)/epidemiologia Feminino Seres Humanos Incidência Agências Internacionais Masculino Meia-Idade Gradação de Tumores Estadiamento de Neoplasias Oceania/epidemiologia Prognóstico Fatores Sexuais Taxa de Sobrevida Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170913 [Lr] Data última revisão: 170913 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160831 [St] Status: MEDLINE [do] DOI: 10.1093/neuonc/now166

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[PMID]: 27425184 [Au] Autor: Biswas S; Better N; Pascual TN; Mercuri M; Vitola JV; Karthikeyan G; Westcott J; Alexánderson E; Allam AH; Al-Mallah MH; Bom HH; Bouyoucef SE; Flotats A; Jerome S; Kaufman PA; Lele V; Luxenburg O; Mahmarian JJ; Shaw LJ; Underwood SR; Rehani M; Kashyap R; Dondi M; Paez D; Einstein AJ; INCAPS Investigators Group [Ad] Endereço: Department of Cardiology and Department of Nuclear Medicine, Royal Melbourne Hospital, Melbourne, Vic., Australia. Electronic address: sinjini@gmail.com. [Ti] Título: Nuclear Cardiology Practices and Radiation Exposure in the Oceania Region: Results From the IAEA Nuclear Cardiology Protocols Study (INCAPS). [So] Source: Heart Lung Circ;26(1):25-34, 2017 Jan. [Is] ISSN: 1444-2892 [Cp] País de publicação: Australia [La] Idioma: eng [Ab] Resumo: BACKGROUND: There is concern about radiation exposure with radionuclide myocardial perfusion imaging (MPI). This sub-study of the International Atomic Energy Agency (IAEA) Nuclear Cardiology Protocols Study reports radiation doses from MPI, and use of dose-optimisation protocols in Australia and New Zealand (ANZ), and compares them with data from the rest of the world. METHODS: Data were collected from 7911 MPI studies performed in 308 laboratories worldwide in one week in 2013, including 439 MPI studies from 34 ANZ laboratories. For each laboratory, effective radiation dose (ED) and a quality index (QI) score (out of 8) based on pre-specified "best practices" was determined. RESULTS: In ANZ patients, ED ranged from 0.9-17.9 milliSievert (mSv). Median ED was similar in ANZ compared with the rest of the world (10.0 (IQR: 6.5-11.7) vs. 10.0 (IQR 6.4-12.6, P=0.15), as were mean QI scores (5.5±0.7 vs. 5.4±1.3, P=0.84). Use of stress-only imaging (17.6% vs. 31.8% of labs, P=0.09) and weight-based dosing of technetium-99m (14.7% vs. 30.3%, P=0.07) was lower in ANZ compared with the rest of the world but this difference was not statistically significant. Median ED was significantly lower in metropolitan versus non-metropolitan laboratories (10.1 mSv vs. 11.6 mSv, P<0.01), although mean QI scores were similar (5.4±0.8 vs. 5.5±0.7, P=0.75). CONCLUSION: Across ANZ, there is variability in ED from MPI, and use of radiation safety practices, particularly between metropolitan and non-metropolitan laboratories. Overall, ANZ laboratories have a similar median ED to laboratories in the rest of the world. [Mh] Termos MeSH primário: Imagem de Perfusão do Miocárdio/efeitos adversos Dose de Radiação Exposição à Radiação [Mh] Termos MeSH secundário: Idoso Feminino Seres Humanos Masculino Meia-Idade Oceania [Pt] Tipo de publicação: CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170406 [Lr] Data última revisão: 170406 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160719 [St] Status: MEDLINE

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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