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Pesquisa : A02.165.308.410 [Categoria DeCS]
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  1 / 11067 MEDLINE  
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PMID:28471737
Autor:Walter BA; Mageswaran P; Mo X; Boulter DJ; Mashaly H; Nguyen XV; Prevedello LM; Thoman W; Raterman BD; Kalra P; Mendel E; Marras WS; Kolipaka A
Endereço:From the Spine Research Institute (B.A.W., P.M., H.M., W.T., E.M., W.S.M., A.K.), Department of Biomedical Engineering (B.A.W., A.K.), Department of Integrated Systems Engineering (P.M., W.S.M.), and Department of Biomedical Informatics (X.M.), the Ohio State University, 395 W 12th Ave, 4th Floor Ra
Título:MR Elastography-derived Stiffness: A Biomarker for Intervertebral Disc Degeneration.
Fonte:Radiology; 285(1):167-175, 2017 Oct.
ISSN:1527-1315
País de publicação:United States
Idioma:eng
Resumo:Purpose To determine the repeatability of magnetic resonance (MR) elastography-derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and their relationship with IVD degeneration and subject age. Materials and Methods In a cross-sectional study, in vivo lumbar MR elastography was performed once in the morning and once in the afternoon in 47 subjects without current low back pain (IVDs = 230; age range, 20-71 years) after obtaining written consent under approval of the institutional review board. The Pfirrmann degeneration grade and MR elastography-derived shear stiffness of the nucleus pulposus and annulus fibrosus regions of all lumbar IVDs were assessed by means of principal frequency analysis. One-way analysis of variance, paired t tests, concordance and Bland-Altman tests, and Pearson correlations were used to evaluate degeneration, diurnal changes, repeatability, and age effects, respectively. Results There were no significant differences between morning and afternoon shear stiffness across all levels and there was very good technical repeatability between the morning and afternoon imaging results for both nucleus pulposus (R = 0.92) and annulus fibrosus (R = 0.83) regions. There was a significant increase in both nucleus pulposus and annulus fibrosus MR elastography-derived shear stiffness with increasing Pfirrmann degeneration grade (nucleus pulposus grade 1, 12.5 kPa ± 1.3; grade 5, 16.5 kPa ± 2.1; annulus fibrosus grade 1, 90.4 kPa ± 9.3; grade 5, 120.1 kPa ± 15.4), and there were weak correlations between shear stiffness and age across all levels (R ≤ 0.32). Conclusion Our results demonstrate that MR elastography-derived shear stiffness measurements are highly repeatable, weakly correlate with age, and increase with advancing IVD degeneration. These results suggest that MR elastography-derived shear stiffness may provide an objective biomarker of the IVD degeneration process. RSNA, 2017 Online supplemental material is available for this article.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Biomarkers)


  2 / 11067 MEDLINE  
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PMID:29222149
Autor:Annette W; Posporis C
Endereço:Neurology and Neurosurgery Service, Pride Veterinary Centre, Derby, UK.
Título:Compressive hydrated nucleus pulposus extrusion: is surgery necessary?
Fonte:Vet Rec; 181(23):622-624, 2017 12.
ISSN:2042-7670
País de publicação:England
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE; COMMENT


  3 / 11067 MEDLINE  
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PMID:29192043
Autor:Beltran E
Endereço:Department of Clinical Science & Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.
Título:Acute hydrated non-compressive nucleus pulposus extrusion: what do we know so far?
Fonte:Vet Rec; 181(22):591-593, 2017 12.
ISSN:2042-7670
País de publicação:England
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE; COMMENT


  4 / 11067 MEDLINE  
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PMID:27771937
Autor:Huang YC; Xiao J; Leung WY; Lu WW; Hu Y; Luk KD
Endereço:Department of Orthopaedics and Traumatology, The University of Hong Kong, 5/F Professor Block, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.hrmoldk@hku.hk.
Título:Lumbar intervertebral disc allograft transplantation: healing and remodelling of the bony structure.
Fonte:Eur Cell Mater; 32:216-227, 2016 10 19.
ISSN:1473-2262
País de publicação:Scotland
Idioma:eng
Resumo:Previous human study suggested that fresh-frozen intervertebral disc allograft transplantation can relieve neurological symptoms and restore segmental kinematics. Before wide clinical application, research into the pathophysiology of the postoperative disc allograft is needed. One important question that remains to be answered in disc allografting is the healing process of the host-graft interface and the subsequent change of the endplates. With the goat model for lumbar disc allografting, histology, micro-computed tomography analysis, scanning electron microscopy and energy-dispersive X-ray spectroscopy mapping were applied to evaluate the healing of the host-graft interfaces, the remodelling of subchondral bone, and the changes of the bony and cartilaginous endplates after transplantation. It was found that healing of the host-graft interfaces started at 1.5 months and was completed at 6 months by natural remodelling. This bony remodelling was also noted in the subchondral bone area after 6 months. The bony endplate was well preserved initially, but was gradually replaced by trabecular bone afterwards; on the other hand, the cartilaginous endplate became atrophic at 6 months and nearly disappeared at the final follow-up. Collectively, after intervertebral disc allograft transplantation, bony healing and remodelling were seen which ensured the stability and mobility of the disc-transplanted segment, but the integrity of bony and cartilaginous endplates was gradually lost and nearly disappeared finally.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T


  5 / 11067 MEDLINE  
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PMID:29201301
Autor:Farajpour H; Jamshidi N
Endereço:Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.
Título:Effects of Different Angles of the Traction Table on Lumbar Spine Ligaments: A Finite Element Study.
Fonte:Clin Orthop Surg; 9(4):480-488, 2017 Dec.
ISSN:2005-4408
País de publicação:Korea (South)
Idioma:eng
Resumo:Background: The traction bed is a noninvasive device for treating lower back pain caused by herniated intervertebral discs. In this study, we investigated the impact of the traction bed on the lower back as a means of increasing the disc height and creating a gap between facet joints. Methods: Computed tomography (CT) images were obtained from a female volunteer and a three-dimensional (3D) model was created using software package MIMICs 17.0. Afterwards, the 3D model was analyzed in an analytical software (Abaqus 6.14). The study was conducted under the following traction loads: 25%, 45%, 55%, and 85% of the whole body weight in different angles. Results: Results indicated that the loading angle in the L3-4 area had 36.8%, 57.4%, 55.32%, 49.8%, and 52.15% effect on the anterior longitudinal ligament, posterior longitudinal ligament, intertransverse ligament, interspinous ligament, and supraspinous ligament, respectively. The respective values for the L4-5 area were 32.3%, 10.6%, 53.4%, 56.58%, and 57.35%. Also, the body weight had 63.2%, 42.6%, 44.68%, 50.2%, and 47.85% effect on the anterior longitudinal ligament, posterior longitudinal ligament, intertransverse ligament, interspinous ligament, and supraspinous ligament, respectively. The respective values for the L4-5 area were 67.7%, 89.4%, 46.6%, 43.42% and 42.65%. The authenticity of results was checked by comparing with the experimental data. Conclusions: The results show that traction beds are highly effective for disc movement and lower back pain relief. Also, an optimal angle for traction can be obtained in a 3D model analysis using CT or magnetic resonance imaging images. The optimal angle would be different for different patients and thus should be determined based on the decreased height of the intervertebral disc, weight and height of patients.
Tipo de publicação: JOURNAL ARTICLE


  6 / 11067 MEDLINE  
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PMID:29201299
Autor:Lee KY; Kim MW; Seok SY; Kim DR; Im CS
Endereço:Department of Orthopedic Surgery, Dong-A University College of Medicine, Busan, Korea.
Título:The Relationship between Superior Disc-Endplate Complex Injury and Correction Loss in Young Adult Patients with Thoracolumbar Stable Burst Fracture.
Fonte:Clin Orthop Surg; 9(4):465-471, 2017 Dec.
ISSN:2005-4408
País de publicação:Korea (South)
Idioma:eng
Resumo:Background: To determine the relationship between superior disc-endplate complex injury and correction loss after surgery in a group of young adult patients with a stable thoracolumbar burst fracture. Methods: The study group was comprised of young adult patients who had undergone short-segment posterior fixation and bone grafting under the diagnosis of a stable thoracolumbar burst fracture from March 2008 to February 2014. Follow-up was available for more than 1 year. Before surgery, magnetic resonance imaging was performed to determine injury to the anterior longitudinal ligament, posterior longitudinal ligament, and superior and inferior intervertebral discs and endplates. Correction loss was evaluated by the Cobb angle, intervertebral disc height, upper intervertebral disc angle, vertebral wedge angle, and vertebral body height. Results: No significant relation was noted between correction loss and an injury to the anterior longitudinal ligament, posterior longitudinal ligament, inferior intervertebral disc/endplate, and fracture site, whereas an injury to the superior endplate alone and superior disc-endplate complex showed a significant association. Specifically, a superior intervertebral disc-endplate complex injury showed statistically significant relation to postoperative changes in Cobb angle ( = 0.026) and vertebral wedge angle ( = 0.047). Conclusions: A superior intervertebral disc-endplate complex injury may have an influence on the prognosis after short-segment fixation in young adult patients with a stable thoracolumbar burst fracture.
Tipo de publicação: JOURNAL ARTICLE


  7 / 11067 MEDLINE  
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PMID:28451842
Autor:de Rooij JD; Gadjradj PS; Soria van Hoeve JS; Harhangi BS
Endereço:Department of Neurosurgery, Erasmus MC: University Medical Center Rotterdam, S-Gravendijkwal 230 HS-205, 3015 CE, Rotterdam, The Netherlands. j.derooij@erasmusmc.nl.
Título:Anterior cervical discectomy without fusion for a symptomatic cervical disk herniation.
Fonte:Acta Neurochir (Wien); 159(7):1283-1287, 2017 Jul.
ISSN:0942-0940
País de publicação:Austria
Idioma:eng
Resumo:BACKGROUND: Cervical radiculopathy is characterized by dysfunction of the nerve root usually caused by a cervical disk herniation. The most important symptom is pain, radiating from the neck to the arm. When conservative treatment fails, surgical treatment is indicated to relieve symptoms. During the last decades, multiple fusion techniques have been developed, although without clinical evidence for added value of fusion over non-fusion. METHODS: The surgical procedure of anterior cervical discectomy without fusion is performed step by step, leading to removal of the entire intervertebral disk. CONCLUSION: Anterior cervical discectomy without fusion is a safe and effective treatment for cervical disk herniation.
Tipo de publicação: JOURNAL ARTICLE


  8 / 11067 MEDLINE  
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PMID:28468504
Autor:Charron PN; Blatt SE; McKenzie C; Oldinski RA
Endereço:Department of Mechanical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, Vermont 05405.
Título:Dynamic mechanical response of polyvinyl alcohol-gelatin theta-gels for nucleus pulposus tissue replacement.
Fonte:Biointerphases; 12(2):02C409, 2017 05 03.
ISSN:1559-4106
País de publicação:United States
Idioma:eng
Resumo:Intervertebral disk degeneration is one of the most significant contributors to low back pain. Thus, there is significant interest in designing new treatments and nucleus pulposus (NP) tissue replacements. Herein, the authors propose a biosynthetic material, comprised of a polyvinyl alcohol (PVA) and gelatin theta-gel, as an acellular NP tissue replacement. Theta-gels form during the solidification of PVA and gelatin (phase I), and the phase separation of a disklike short-chain polyethylene glycol (PEG, phase II). The PVA concentration and weight ratio of PVA to PEG were optimized, in order to achieve mechanical properties resembling NP tissue. Mechanical and material properties were analyzed for the PVA-gelatin theta-gels under static and dynamic conditions. Cyclic stress-strain testing demonstrated the theta-gels' ability to relax and perform properly under dynamic loading. Altering the molecular weight and concentration of the theta-gel constituents allows for a tunable material that can match a variety of native tissue properties.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Gels); 9002-89-5 (Polyvinyl Alcohol)


  9 / 11067 MEDLINE  
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PMID:28455675
Autor:En'Wezoh DC; Leonard DA; Schoenfeld AJ; Harris MB; Zampini JM; Bono CM
Endereço:Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Título:Relationship between size of disc and early postoperative outcomes after lumbar discectomy.
Fonte:Arch Orthop Trauma Surg; 137(6):805-811, 2017 Jun.
ISSN:1434-3916
País de publicação:Germany
Idioma:eng
Resumo:BACKGROUND: Previous studies suggest that patients with larger disc herniations (greater than 6 mm) will have better outcomes following discectomy. This has not been validated in a large series of patients. PURPOSE: We sought to empirically evaluate this relationship in a series of patients who had data collected prospectively as part of a randomized trial. METHODS: This retrospective review included 63 consecutive adult patients who underwent a single-level, primary lumbar discectomy. Outcomes were VAS for leg and back pain and the modified oswestry disability index (MODI). Statistical tests were used to compare patients using different cutoffs of preoperative disc diameters and disc volume removed. Regression analysis was performed to determine if there was a relationship between outcomes and the measured parameters. RESULTS: While patients who achieved substantial clinical benefit (SCB) for MODI had larger disc diameters, this relationship was not found for leg or back pain for any of the measured parameters. Using 5, 6, 7, or 8 mm as a cutoff for disc diameter demonstrated no differences. Regression analysis did not demonstrate a significant relationship between disc volume removed and final MODI scores. CONCLUSION: While patients with larger disc herniations on average might have a greater likelihood of superior clinical outcomes, the previously suggested "6 mm rule" was not supported.
Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL


  10 / 11067 MEDLINE  
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PMID:29284234
Autor:Kubaszewski L; Ziola-Frankowska A; Gasik Z; Frankowski M; Dabrowski M; Molisak B; Kaczmarczyk J; Gasik R
Endereço:Department of Orthopaedic and Traumatology, W. Dega University Hospital, University of Medical Sciences, Poznan, Poland. eklinika@o2.pl.
Título:Chemometric evaluation of concentrations of trace elements in intervertebral disc tissue in patient with degenerative disc disease.
Fonte:Ann Agric Environ Med; 24(4):610-617, 2017 Dec 23.
ISSN:1898-2263
País de publicação:Poland
Idioma:eng
Resumo:BACKGROUND: The work is designed to uncover the pattern of mutual relation among trace elements and epidemiological data in the degenerated intervertebral disk tissue in humans. Hitherto the reason of the degenerative process is not fully understood. Trace elements are the basic components of the biological compound related both its metabolism as well as environmental exposure. The relation pattern among elements occurs gives new perspective in solving the cause of the disease. MATERIAL AND METHODS: We have analysed trace elements content in the 30 intervertebral disc from 22 patients with degenerative disc disease. The concentrations of Al, Cu, Cd, Mo, Ni and Pb were determined with Atomic Absorption Spectrometry. To analyse the multidimentional relation between trace element concentration and epidemiological data the chemometric analysis was applied. RESULTS: The similarity have been shown in occurrence of following pairs: Cd-Mo as well as Mg-Zn. The second pair was correlated with Pb concentration. Pb levels are observed to be competitive to Cu concentration. Cd concentration was related to Zn and Mg deficiency. No single but rather cluster of epidemiological data show observable influence on the TE tissue variance. Zn and Cu was related to the male sex. Operation with orthopedic implants were related to combined Al, Mo and Zn concentration. CONCLUSIONS: This is the first chemometric analysis of trace elements in disk tissue. It shows multidimentional relations that are missed by the classical statistic. The analysis shows significant relation. The nature of the relations is the basis for further metabolic and environmental research.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Trace Elements); 2P299V784P (Lead); 789U1901C5 (Copper); CPD4NFA903 (Aluminum); J41CSQ7QDS (Zinc)



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