Base de dados : MEDLINE
Pesquisa : A02.165.308.538 [Categoria DeCS]
Referências encontradas : 66 [refinar]
Mostrando: 1 .. 10   no formato [Longo]

página 1 de 7 ir para página                  

  1 / 66 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28857908
Autor:Grelsamer R
Endereço:New York, NY.
Título:Physical Examination of the Knee: Meniscus, Cartilage, and Patellofemoral Conditions.
Fonte:J Am Acad Orthop Surg; 25(10):e243, 2017 10.
ISSN:1940-5480
País de publicação:United States
Idioma:eng
Tipo de publicação: LETTER; COMMENT


  2 / 66 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28797093
Autor:Touraine S; Bouhadoun H; Engelke K; Laredo JD; Chappard C
Endereço:B2OA, UMR CNRS 7052, University Paris Diderot, Paris, France.
Título:Influence of meniscus on cartilage and subchondral bone features of knees from older individuals: A cadaver study.
Fonte:PLoS One; 12(8):e0181956, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:OBJECTIVE: Cartilage and subchondral bone form a functional unit. Here, we aimed to examine the effect of meniscus coverage on the characteristics of this unit in knees of older individuals. METHODS: We assessed the hyaline cartilage, subchondral cortical plate (SCP), and subchondral trabecular bone in areas covered or uncovered by the meniscus from normal cadaver knees (without degeneration). Bone cores harvested from the medial tibial plateau at locations uncovered (central), partially covered (posterior), and completely covered (peripheral) by the meniscus were imaged by micro-CT. The following were measured on images: cartilage volume (Cart.Vol, mm3) and thickness (Cart.Th, mm); SCP thickness (SCP.Th, µm) and porosity (SCP.Por, %); bone volume to total volume fraction (BV/TV, %); trabecular thickness (Tb.Th, µm), spacing (Tb.Sp, µm), and number (Tb.N, 1/mm); structure model index (SMI); trabecular pattern factor (Tb.Pf); and degree of anisotropy (DA). RESULTS: Among the 28 specimens studied (18 females) from individuals with mean age 82.8±10.2 years, cartilage and SCP were thicker at the central site uncovered by the meniscus than the posterior and peripheral sites, and Cart.Vol was greater. SCP.Por was highest in posterior samples. In the upper 1-5 mm of subchondral bone, central samples were characterized by higher values for BV/TV, Tb.N, Tb.Th, and connectivity (Tb.Pf), a more plate-like trabecular structure and lower anisotropy than with other samples. Deeper down, at 6-10 mm, the differences were slightly higher for Tb.Th centrally, DA peripherally and SMI posteriorly. CONCLUSIONS: The coverage or not by meniscus in the knee of older individuals is significantly associated with Cart.Th, SCP.Th, SCP.Por and trabecular microarchitectural parameters in the most superficial 5 mm and to a lesser extent the deepest area of subchondral trabecular bone. These results suggest an effect of differences in local loading conditions. In subchondral bone uncovered by the meniscus, the trabecular architecture resembles that of highly loaded areas.
Tipo de publicação: JOURNAL ARTICLE


  3 / 66 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28791820
Autor:Pihut ME; Margielewicz J; Kijak E; Wisniewska G
Endereço:Department of Prosthodontics, Jagiellonian University Medical College, Kraków, Poland.
Título:Evaluation of articular disc loading in the temporomandibular joints after prosthetic and pharmacological treatment in model studies.
Fonte:Adv Clin Exp Med; 26(3):455-460, 2017 May-Jun.
ISSN:1899-5276
País de publicação:Poland
Idioma:eng
Resumo:BACKGROUND: Temporomandibular joint dysfunction is often related to excessive load in the stomatognathic system. OBJECTIVES: The objective of the model tests, using numeric calculations, was to assess the articular disc loads in the temporomandibular joints after prosthetic and pharmacological treatment of functional disorders of the masticatory organ. MATERIAL AND METHODS: The study involved 10 patients, aged 21-48 years, of both sexes, randomly selected from a group of 120 patients treated with relaxation occlusal splints (60 patients, group I) and intramuscular injection of botulinum toxin type A (60 patients, group II), suffering from temporomandibular joint dysfunction with the dominant muscle component. In all subjects, a specialized functional examination was carried out. Treatment groups: occlusal splint therapy (group I) and intramuscular injection of botulinum toxin type A (group II). An assessment of the loads of 4 disc zones of the temporomandibular joints was carried out based on the results of clinical studies (phase I of the study), and numeric model tests (phase II). In the representatives of the study groups (5 patients in each group), measurements of occlusal forces and an evaluation of tension of the masseter and temporalis muscle were performed. RESULTS: The results of the average load values for all evaluated zones of the right and left articular disc differ in a statistically significant way in favor of group II, with the exception of the external mid part of the discs. In the case of the anterior of the right disc, the load was lower in patients belonging to group I than in those obtained in group II. CONCLUSIONS: Botulinum toxin type A significantly reduces the loads within the temporomandibular joints, generated by masseter muscle hypertonia.
Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
Nome de substância:EC 3.4.24.69 (Botulinum Toxins, Type A)


  4 / 66 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28735822
Autor:Feehan J; Macfarlane C; Vaughan B
Endereço:College of Health & Biomedicine, Victoria University, Melbourne, Australia.
Título:Conservative management of a traumatic meniscal injury utilising osteopathy and exercise rehabilitation: A case report.
Fonte:Complement Ther Med; 33:27-31, 2017 Aug.
ISSN:1873-6963
País de publicação:Scotland
Idioma:eng
Resumo:Meniscal injury is one of the most common knee soft tissue injuries, commonly affecting young athletes and an older, degenerative population. Treatment largely depends on the type and extent of the injury with arthroscopic repair or meniscectomy being mainstays. Although non-surgical approaches have been described, there is no published literature regarding a combination of indirect osteopathic techniques and rehabilitation in the management of these injuries. The current case report follows a 20-year-old male presenting with a 5-day history of acute knee pain, following trauma during an Australian Rules Football (AFL) match. An 8-week management plan of indirect osteopathic techniques and a tailored rehabilitation program was implemented. The Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Lower Extremity Functional Scale (LEFS) questionnaires were utilised to measure outcomes. After the 8-week treatment and rehabilitation program, the patient had exceeded the minimum detectable change score for all outcome measures. This case report suggests that osteopathic manipulative treatment and rehabilitation may be an alternative, non-surgical approach in the management of post-traumatic meniscal injuries.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE


  5 / 66 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28514414
Autor:Drew L; Scott A; Morgan B; Gruber K
Título:Clinical devices and services: Repair shops.
Fonte:Nature; 545(7654):S21-S24, 2017 05 17.
ISSN:1476-4687
País de publicação:England
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Tropoelastin)


  6 / 66 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28420447
Autor:Akkiraju H; Srinivasan PP; Xu X; Jia X; Safran CBK; Nohe A
Endereço:Quantitative Proteomics and Metabolomics Center, Columbia University, New York, NY, 10027, USA.
Título:CK2.1, a bone morphogenetic protein receptor type Ia mimetic peptide, repairs cartilage in mice with destabilized medial meniscus.
Fonte:Stem Cell Res Ther; 8(1):82, 2017 Apr 18.
ISSN:1757-6512
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We recently designed a novel bone morphogenetic protein receptor type I (BMPRI) mimetic peptide, CK2.1, that activates BMPRIa signaling in the absence of bone morphogenetic protein (BMP). Our previous research demonstrated that CK2.1 induced chondrogenesis in vitro and in vivo; however, it is unknown if CK2.1 restores damaged articular cartilage in vivo. In this study, we demonstrate that CK2.1 induced articular cartilage (AC) repair in an OA mouse model. METHODS: We designed hyaluronic acid (HA)-based hydrogel particles (HGPs) that slowly release CK2.1. HGP-CK2.1 particles were tested for chondrogenic potency on pluripotent mesenchymal stem cells (C3H10T1/2 cells) and locally injected into the intra-articular capsule in mice with cartilage defects. C57BL/6J mice were operated on to destabilize the medial meniscus and these mice were kept for 6 weeks after surgery to sustain OA-like damage. Mice were then injected via the intra-articular capsule with HGP-CK2.1; 4 weeks after injection the mice were sacrificed and their femurs were analyzed for cartilage defects. RESULTS: Immunohistochemical analysis of the cartilage demonstrated complete repair of the AC compared to sham-operated mice. Immunofluorescence analysis revealed collagen type IX production along with collagen type II in the AC of mice injected with HGP-CK2.1. Mice injected with phosphate-buffered saline (PBS) and HGP alone had greater collagen type X and osteocalcin production, in sharp contrast to those injected with HGP-CK2.1, indicating increased chondrocyte hypertrophy. CONCLUSIONS: Our results demonstrate that the slow release HGP-CK2.1 drives cartilage repair without the induction of chondrocyte hypertrophy. The peptide CK2.1 could be a powerful tool in understanding the signaling pathways contributing to the repair process, and also may be used as a potential therapeutic for treating degenerative cartilage diseases such as OA.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (CK2.1 peptide); 0 (Peptides); 104982-03-8 (Osteocalcin); 9007-34-5 (Collagen); EC 2.7.11.30 (Bmpr1a protein, mouse); EC 2.7.11.30 (Bone Morphogenetic Protein Receptors, Type I)


  7 / 66 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PMID:28375398
Autor:Jarrett JB; Sauereisen S
Endereço:University of Illinois at Chicago, USA.
Título:PURLs: When can exercise supplant surgery for degenerative meniscal tears?
Fonte:J Fam Pract; 66(4):250-252, 2017 Apr.
ISSN:1533-7294
País de publicação:United States
Idioma:eng
Resumo:Patients with a medial, degenerative meniscal tear and a minimal history of osteoarthritis make good candidates for physical therapy-- and there is an added benefit, too.
Tipo de publicação: CASE REPORTS; COMPARATIVE STUDY; JOURNAL ARTICLE


  8 / 66 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28355670
Autor:Ariyachaipanich A; Bae WC; Statum S; Chung CB
Endereço:Department of Radiology, University of California-San Diego, La Jolla, California.
Título:Update on MRI Pulse Sequences for the Knee: Imaging of Cartilage, Meniscus, Tendon, and Hardware.
Fonte:Semin Musculoskelet Radiol; 21(2):45-62, 2017 Apr.
ISSN:1098-898X
País de publicação:United States
Idioma:eng
Resumo:Magnetic resonance imaging (MRI) is widely used in the clinical setting as well as for research applications. Since its inception, technical development has broadly progressed as a response to challenges in both the clinical and research settings. Higher magnetic field strength and advances in hardware and software have revolutionized the diagnostic potential of MRI and moved well beyond diagnosis to characterization of tissue metabolism, biochemistry, disease pathogenesis, and material property, to name a few. This article focuses on state-of-the-art clinical and cutting-edge novel pulse sequences applied to knee MRI.
Tipo de publicação: JOURNAL ARTICLE; REVIEW


  9 / 66 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28241715
Autor:Liu X; Feng H; Hong L; Zhang H
Endereço:Department of Sports Medicine Service, Beijing Jishuitan Hospital, Beijing 100035, China.
Título:[A prospective randomized control trial of arthroscopic surgery for stable ramp lesion of the medial meniscus].
Fonte:Zhonghua Wai Ke Za Zhi; 55(3):161-165, 2017 Mar 01.
ISSN:0529-5815
País de publicação:China
Idioma:chi
Resumo:To evaluate the necessity of arthroscopic suture repair for the stable ramp lesion. From August 2008 to April 2012, 91 patients of consecutive cases were diagnosed as anterior cruciate ligament (ACL) injury associated with stable ramp lesion in Department of Sports Medicine Service of Beijing Jishuitan Hospital. All of the diagnosis was confirmed during arthroscopic surgeries. The patients were randomized into suture repair group and control group. The ACL was reconstructed using auto grafts of hamstring. MRI was used for evaluation of the healing of the ramp lesion during the follow-up period. The stability of the knee joint was evaluated using KT-1000 device. The clinical functional outcomes were analyzed with Lysholm and International Knee Documentation Committee(IKDC) score. test and χ(2) test were used to analyze the data, respectively. There were 73 patients (80%) were available for final follow-up. The follow-up period was 24 to 72 months (mean (38.9±16.1) months). The suture repair group included 40 patients, while the control group included 33 patients. There were no statistically difference in age( =0.458, >0.05), gender(χ(2)=0.222, >0.05), time interval from injury( =0.643, >0.05) and associated injuries(χ(2)=0.658, >0.05). At the final follow-up, the healing rate of ramp lesion in suture repair group was 97.5% (95% of complete healed, 2.5% of partial healed, and 2.5% of non-healed), in control group the healing rate was 93.9% (87.8% of complete healed, 6.1% of partial healed, and 6.1% of non healed), there were no significant differences between the two groups (χ(2)=0.446, >0.05). There was no statistically significant difference of postoperative knee stability ( =-0.510, >0.05). The healing status of ramp area from MRI evaluation had statistically significant correlation with the ACL stability (χ(2)=11.919, <0.01). For the analysis of postoperative Lysholm scores and IKDC scores, there was no significant difference between the two groups ( =-0.166, >0.05; =0.032, >0.05). Stable ramp lesion could be well healed after arthroscopic treatment of all-inside suture repair as well as refreshment only. For patients with ACL injury and stable ramp lesion, there was no significant difference between the results of MRI evaluation in the early postoperative stage.The postoperative healing status of ramp area had statistically significant correlation with the stability of knee joint.
Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL


  10 / 66 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PMID:28214459
Autor:Cuellar V; Strauss E
Título:Molecular Biomarkers of Knee Pathology.
Fonte:Bull Hosp Jt Dis (2013); 75(1):30-36, 2017 Jan.
ISSN:2328-5273
País de publicação:United States
Idioma:eng
Resumo:The identification of biomarkers has become increasingly important in our fundamental understanding of the molecular basis for disease and subsequently in the advancement of modern medicine. Biomarkers have been identified in a plethora of normal and pathologic conditions and are most often found in blood, tissue, or synovial fluid. Orthopaedic research has more recently focused on biomarkers of cartilage and joint diseases, with an emphasis on understanding the molecular underpinnings of their pathophysiology. This article focuses on the biomarkers identified to date in several select knee pathologies and how further research can contribute to new diagnostic tools and targeted therapeutics.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Biomarkers); 0 (Cytokines); 0 (Inflammation Mediators)



página 1 de 7 ir para página                  
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde