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  1 / 1105 MEDLINE  
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PMID:29017853
Autor:Danderson CA; Downie SR; Hermann M
Endereço:Department of Plant Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: cdanders@aum.edu.
Título:Rampant polyphyly in the Arracacia clade (Apiaceae) and an assessment of the phylogenetic utility of 20 noncoding plastid loci.
Fonte:Mol Phylogenet Evol; 118:286-305, 2018 Jan.
ISSN:1095-9513
País de publicação:United States
Idioma:eng
Resumo:The Arracacia clade (Apiaceae, Apioideae) is a heterogeneous assemblage of 12 genera, comprising 111 known species distributed in high montane temperate and sub-alpine habitats of meso- and South America. Previous studies have indicated that the genera Arracacia, Coulterophytum, and Prionosciadium are polyphyletic, but for the most part relationships among the members of the clade are largely unknown. Initially, cladistic analyses of nrDNA ITS sequences were carried out on 212 accessions (122 taxa), representing 92 species of the Arracacia clade and outgroups from the closely-related páramo genera Cotopaxia, Niphogeton, and Perissocoeleum and members of the Perennial Endemic North American clade and its allies. Using the ITS results to inform sampling of a small subset of taxa, a pilot study examining the phylogenetic utility of 20 noncoding chloroplast loci was subsequently performed to identify those regions most useful at resolving relationships. A cost-benefit analysis determined that five loci (trnQ-5'rps16, trnD-trnT, rpl32-trnL, psbD-trnT, ndhA intron) would maximize resolution and branch support in the clade. Cladistic analyses of four of these loci (trnQ-5'rps16, trnD-trnT, rpl32-trnL, ndhA intron) and the ITS region, separately and combined, revealed that Arracacia, Coaxana, Coulterophytum, Prionosciadium, and Rhodosciadium are each polyphyletic and that Donnellsmithia and Myrrhidendron are each monophyletic. Although most relationships in the Arracacia clade and among the closely-related genera Cotopaxia, Niphogeton, and Perissocoeleum are poorly resolved and supported, ten groups are recognized for future revisionary studies. Polyploidy and rapid species radiation have likely confounded generic circumscriptions and interpretation of relationships.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (DNA, Chloroplast)


  2 / 1105 MEDLINE  
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PMID:28853883
Autor:Genovese S; Taddeo VA; Epifano F; Fiorito S; Bize C; Rives A; de Medina P
Endereço:Department of Pharmacy, University "G. D'Annunzio" of Chieti-Pescara , Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy.
Título:Characterization of the Degradation Profile of Umbelliprenin, a Bioactive Prenylated Coumarin of a Ferulago Species.
Fonte:J Nat Prod; 80(9):2424-2431, 2017 Sep 22.
ISSN:1520-6025
País de publicação:United States
Idioma:eng
Resumo:Umbelliprenin is a secondary plant metabolite that displays promising chemopreventive, anti-inflammatory, and antigenotoxic properties. It possesses potential for applications to human welfare notably to prevent the emergence of cancer. For this purpose, stability studies are needed to define proper storage conditions and adapted formulations for this drug candidate. The identification of degradative products is a major concern for the preclinical development of umbelliprenin, providing also interesting information related to potential original phytochemicals formed in plants exposed to stressors. The stability profile of umbelliprenin under various stress conditions including exposure to heat, light, oxidation, and hydrolytic medium was assessed via HPLC/UV data. The data support that umbelliprenin undergoes inter- and intramolecular [2+2] cycloaddition under light exposure, leading respectively to a cyclobutane-umbelliprenin dimer and a 16-membered macrocycle. Their structures were characterized via MS and NMR data. It was shown that UV-A filters prevent this process, whereas UV-B filters and antioxidants are not or weakly effective. The study provides useful information for the preclinical development of umbelliprenin as an original chemopreventive agent.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Coumarins); 0 (Umbelliferones); A4VZ22K1WT (coumarin); MSD8N8A1LQ (umbelliprenin)


  3 / 1105 MEDLINE  
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PMID:28843162
Autor:Snene A; Sirignano C; Rigano D; Formisano C; El Mokni R; Ercolano G; Dhaouadi H; Ianaro A; Hammami S; Taglialatela-Scafati O
Endereço:Research Unit Applied Chemistry and Environment 13ES63, Monastir University, Faculty of Sciences of Monastir, 5000 Monastir, Tunisia.
Título:Antiproliferative metabolites from the Northern African endemic plant Daucus virgatus (Apiaceae).
Fonte:Phytochemistry; 143:194-198, 2017 Nov.
ISSN:1873-3700
País de publicação:England
Idioma:eng
Resumo:Chemical analysis of the dichloromethane fraction obtained from aerial parts of the Northern African endemic plant Daucus virgatus led to the isolation of three previously undescribed sesquiterpenoids, namely the daucane vaginatin B, a eudesmane and the elemane elemavirgolide, along with five known metabolites. The structures of these compounds were determined by a detailed MS and NMR analysis and they were evaluated for antiproliferative activity against three human cell lines, A375 (melanoma), MCF-7 (breast adenocarcinoma), and HACAT (keratinocyte). The phytoalexin 6-methoxymellein revealed a previously unreported antiproliferative activity, while the eudesmane and the elemane derivatives exhibited a selective activity (SI = 11.1 and 3.3, respectively) against melanoma tumor cell lines.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents, Phytogenic); 0 (Isocoumarins); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Eudesmane); 37297-20-4 (phytoalexins); 473-11-0 (eudesmane); 6803-02-7 (6-methoxy-8-hydroxy-3-methyl-3,4-dihydroisocoumarin)


  4 / 1105 MEDLINE  
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PMID:28806731
Autor:Konowalik K; Procków M; Procków J
Endereço:Department of Plant Biology, Institute of Biology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
Título:Climatic niche of Selinum alatum (Apiaceae, Selineae), a new invasive plant species in Central Europe and its alterations according to the climate change scenarios: Are the European mountains threatened by invasion?
Fonte:PLoS One; 12(8):e0182793, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:In recent years, a few established populations of Selinum alatum have been found in the Eastern Carpathians outside its native range that is the Caucasus and the Armenian Highlands. The species is spreading predominantly in Poland where it can outcompete native plants in certain cases. This study addresses a potential climatic niche of the plant with the special aims to illuminate future spreading and indicate areas suitable for invasion. Our results show that the extent of the favourable habitat of the species is broader than currently known. This suggests that the plant has the ability to become a potential new element in some semi-natural or disturbed ecosystems associated with mountainous areas, especially in Central and Southern Europe. Future (2070) models mostly rendered similar suitability maps, but showed slight differences over particular areas and a contraction of suitable habitats, mainly in the northern part of the non-native range.
Tipo de publicação: JOURNAL ARTICLE


  5 / 1105 MEDLINE  
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PMID:28762091
Autor:Sarker SD; Nahar L
Endereço:Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK. S.Sarker@ljmu.ac.uk.
Título:Progress in the Chemistry of Naturally Occurring Coumarins.
Fonte:Prog Chem Org Nat Prod; 106:241-304, 2017.
ISSN:2191-7043
País de publicação:Austria
Idioma:eng
Resumo:Coumarins are the largest group of 1-benzopyran derivatives found in plants. The initial member of this group of compounds, coumarin (2H-1-benzopyran-2-one), a fragrant colorless compound, was first isolated from the Tonka bean (Dipteryx odorata, family Fabaceae) in 1820. The name coumarin comes from a French term for the tonka bean, coumarou. Since the discovery of coumarin, several of its derivatives, with umbelliferone (7-hydroxycoumarin) being the most common one, have been reported from various natural sources. The families Apiaceae, Asteraceae, and Rutaceae are the three major plant sources of coumarins.Generally, these plant secondary metabolites may be classified into simple, simple prenylated, simple geranylated, furano, pyrano, sesquiterpenyl and oligomeric coumarins. Using this standard classification, this chapter aims to present an account on the advances of the chemistry of naturally occurring coumarins, as reported in the literature during the period 2013-2015.In Sect. 1, the coumarins are introduced and their generic biosynthetic route discussed briefly. In Sect. 2, the largest of the three sections, various classes of natural coumarins are detailed, with their relevant structures and the citation of appropriate references. In a concluding section, it is highlighted that during the last 3 years, more than 400 coumarins have been reported in the literature. Many of these coumarins have been re-isolations of known compounds from known or new sources, most often associated with various biological activities. However, a substantial number of coumarins bearing new skeletons, especially dimers, prenylated furanocoumarins, sesquiterpenyl, and some unusual coumarins were also reported during the period of 2013-2015.Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. Despite significant advancements in the extraction, isolation, structure elucidation and bioactivity testing of naturally occurring coumarins, only a marginal advancement has been observed recently in relation to the study of their biosynthesis.
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Coumarins); 0 (Plant Extracts)


  6 / 1105 MEDLINE  
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PMID:28712477
Autor:Momtazi AA; Askari-Khorasgani O; Abdollahi E; Sadeghi-Aliabadi H; Mortazaeinezhad F; Sahebkar A
Endereço:Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: abbasmomtazi@yahoo.com.
Título:Phytochemical Analysis and Cytotoxicity Evaluation of Kelussia odoratissima Mozaff.
Fonte:J Acupunct Meridian Stud; 10(3):180-186, 2017 Jun.
ISSN:2093-8152
País de publicação:Korea (South)
Idioma:eng
Resumo:BACKGROUND: Kelussia odoratissima Mozaff. (Apiaceae) is an edible, indigenous, and ethnomedicinal plant that grows only in Iran. Although antioxidant and anti-inflammatory properties of K. odoratissima have been reported, cytotoxic activity of this plant has not been investigated previously. OBJECTIVE: This study aims to evaluate the cytotoxicity of K. odoratissima leaf extract against a panel of human cancer cell lines. A secondary aim was to perform a phytochemical analysis of the plant's leaf oil. METHODS: To extract the plant oil, dried leaves were subjected to hydrodistillation using a Clevenger-type apparatus for up to 3 hours. For the phytochemical analysis, essential oil was subjected to gas chromatography/mass spectrometry. Plant extraction was performed by macerating leaf powder of K. odoratissima (50 g) in 70% methanol (500 mL) at room temperature (25-28°C) for 24 hours. To perform cytotoxicity assays, methanolic extract of K. odoratissima was tested against a panel of cell lines including MDA-MB468 (human breast cancer cell line), K562 (human leukemia cell line), SKOV3 (human ovarian cancer cell line), Y79 (human eye cancer cell line), A549 (lung cancer cell line), and HEK 293 (normal human embryonic kidney cell line). RESULTS: Gas chromatography/mass spectrometry analysis revealed that sesquiterpens are dominant volatile components of the plant, followed by phthalides comprising 3-butyldine phthalide and 3-n-butyl phthalide, the latter compound being the major component of the leaf oil (25.1%). The leaf extract showed selective and dose-dependent cytotoxicity against MDA-MB468, K562, SKOV3, Y79, and A549 cancer cell lines with IC values (concentration that inhibits cell growth by 50%) of 85 µg/mL, 70 µg/mL, 120 µg/mL, 82 µg/mL, and145 µg/mL, respectively. CONCLUSIONS: The present results suggest a direct cytotoxic activity of K. odoratissima leaf extract against human cancer cell lines. This activity of K. odoratissima may find application in combination with traditional herbal medicines to develop a new anticancer pharmacopuncture therapy.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents); 0 (Plant Extracts)


  7 / 1105 MEDLINE  
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PMID:28587222
Autor:Wu XW; Wei W; Yang XW; Zhang YB; Xu W; Yang YF; Zhong GY; Liu HN; Yang SL
Endereço:State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing 100191, China. wuxiuwen0725@126.com.
Título:Anti-Inflammatory Phenolic Acid Esters from the Roots and Rhizomes of Notopterygium incisium and Their Permeability in the Human Caco-2 Monolayer Cell Model.
Fonte:Molecules; 22(6), 2017 Jun 04.
ISSN:1420-3049
País de publicação:Switzerland
Idioma:eng
Resumo:A new ferulic acid ester named 4-methyl-3- -hexenylferulate ( ), together with eight known phenolic acid esters ( - ), was isolated from the methanolic extract of the roots and rhizomes of . Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. 4-Methoxyphenethyl ferulate ( ) NMR data is reported here for the first time. The uptake and transepithelial transport of the isolated compounds - were investigated in the human intestinal Caco-2 cell monolayer model. Compounds and were assigned for the well-absorbed compounds, compound was assigned for the moderately absorbed compound, and compounds , , , , , and were assigned for the poorly absorbed compounds. Moreover, all of the isolated compounds were assayed for the inhibitory effects against nitric oxide (NO) production in the lipopolysaccharide-activated RAW264.7 macrophages model and 6-(1-iminoethyl)-lysine (L-NIL) was used as a positive control. Compounds , , , and exhibited potent inhibitory activity on NO production with the half maximal inhibitory concentration (IC ) values of 1.01, 4.63, 2.47, and 2.73 µM, respectively, which were more effective than L-NIL with IC values of 9.37 µM. These findings not only enriched the types of anti-inflammatory compounds in but also provided some useful information for predicting their oral bioavailability and their suitability as drug leads or promising anti-inflammatory agents.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (4-methyl-3-trans-hexenylferulate); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Coumaric Acids); 0 (Esters); 0 (Hydroxybenzoates); 0 (Lipopolysaccharides); 0 (Plant Extracts); 29656-58-4 (phenolic acid); 31C4KY9ESH (Nitric Oxide)


  8 / 1105 MEDLINE  
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PMID:28489375
Autor:Popovic V; Goeman JL; Bougarne N; Eyckerman S; Heyerick A; De Bosscher K; Van der Eycken J
Endereço:Laboratory for Organic and Bio-Organic Synthesis, Department of Organic and Macromolecular Chemistry, Ghent University , Krijgslaan 281 (S.4), B-9000 Ghent, Belgium.
Título:Involvement of the Glucocorticoid Receptor in Pro-inflammatory Transcription Factor Inhibition by Daucane Esters from Laserpitium zernyi.
Fonte:J Nat Prod; 80(5):1505-1513, 2017 May 26.
ISSN:1520-6025
País de publicação:United States
Idioma:eng
Resumo:Species of the genus Laserpitium have been used traditionally to treat inflammation and infection. From the herb of Laserpitium zernyi, six new compounds were isolated and their structures elucidated (using IR, NMR, HRMS data) as derivatives of 8-daucene-2,4,10-triol (1, 2, and 4), 7-daucene-2,4,10-triol (3), a lapiferin derivative featuring a C-2 ester moiety (5), and a daucane featuring an exomethylene group at C-8 (6). Also isolated were the rare daucanes vaginatin (7) and laserpitin (8). In a search for selective glucocorticoid receptor (GR) modulators, the compounds were tested for their capacity to inhibit NF-κB and AP-1 pro-inflammatory factors and for a potential competitive effect on a dexamethasone (Dex)-induced GR-driven glucocorticoid response element (GRE) reporter gene. The new 2ß-angeloyloxy-10α-acetoxy-8-daucene-2,4,10-triol (2) significantly inhibited transactivation of both NF-κB and AP-1, while vaginatin (7) was the most active of the compounds tested in blocking AP-1. Both compounds competitively repressed Dex-induced GRE-driven promoter activities, indicative of a potential role for GR. In addition, a decreased potential to inhibit NF-κB was apparent in GR knockout A549 cells. In line with the transcriptional assays, compounds 2 and 7 also significantly lowered CCL-2 chemokine production, albeit to a lesser extent than Dex. The results suggest that daucanes may be interesting candidates in the search for compounds with GR-modulating activities.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (8-daucene-2,4,10-triol); 0 (Anti-Inflammatory Agents); 0 (Bridged Bicyclo Compounds); 0 (Esters); 0 (NF-kappa B); 0 (Receptors, Glucocorticoid); 0 (Sesquiterpenes); 0 (Transcription Factor AP-1); 0 (daucene); 0 (lapiferin); 7S5I7G3JQL (Dexamethasone)


  9 / 1105 MEDLINE  
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PMID:28480390
Autor:Sanli A; Karadogan T
Endereço:süleyman Demirel University, Faculty of Agriculture, Field Crops Department, Isparta, Turkey.
Título:GEOGRAPHICAL IMPACT ON ESSENTIAL OIL COMPOSITION OF ENDEMIC HUB.-MOR. (APIACEAE).
Fonte:Afr J Tradit Complement Altern Med; 14(1):131-137, 2017.
ISSN:2505-0044
País de publicação:Nigeria
Idioma:eng
Resumo:BACKGROUND: Hub.-Mor. is an endemic specie of Apiaceae diversified in Turkey. Several parts of the plant may contain essential oils in different quantity which can be influenced by environmental factors, mainly altitude. The aim of this study was to test whether there is any altitude effect on volatile chemical constituents of essential oil obtained from the fruits of growing spontaneously in different altitudes of Lakes Region in Turkey. MATERIALS AND METHODS: was collected in 2015 at different altitudes (400, 820, 1002 and 1560 m) of Lakes Region Turkey. The fruits of the plants were distilled for 3 h using a Clevenger type apparatus according to the British Pharmacopiea (1980). Essential oils of the fruits were collected using hydro distillation method and analyzed by GC-MS/FID. RESULTS: Essential oil contents of fruits increased by corresponding increase in altitude level. Predominant compounds were a-Pinene (27.87-61.94%) and ß-Pinene (24.92-36.46%) of the total oil of . Other important compounds were α-Thujene (2.66-8.15%), l-Limonene (1.83-8.23%), α-Phellandrene (1.85-5.01%) and these compounds were higher in low altitudes. CONCLUSION: Altitude change affected the terpenoid biosynthesis and oxygenated monoterpenes generally and were greatest when low; while sesquiterpene constituents were greatest at high altitudes. The influence of altitude seems to be an important factor for yielding the chemical profile of essential oils. Thus, the location of the plant must be taken into account depending on the intended use.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Oils, Volatile); 0 (Plant Extracts)


  10 / 1105 MEDLINE  
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PMID:28441407
Autor:Boestfleisch C; Papenbrock J
Endereço:Institute of Botany, Leibniz University Hannover, Hannover, Germany.
Título:Changes in secondary metabolites in the halophytic putative crop species Crithmum maritimum L., Triglochin maritima L. and Halimione portulacoides (L.) Aellen as reaction to mild salinity.
Fonte:PLoS One; 12(4):e0176303, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:It is assumed that salinity enhances the concentration of valuable metabolites in halophytes. The objective was to find a salt concentration and a point in time at which the yield for the valuable metabolites was maximal. Therefore, three different halophyte species were grown under different salinities and harvested over a period from shortly after stress induction up to three weeks. Various reaction patterns were found in the metabolite composition of the analyzed plant material. Halimione portulacoides showed a "short term response", indicated by an increase in all metabolites analyzed after a few hours, whereas Crithmum maritimum showed a "long term response" through accumulation of proline starting after days. Triglochin maritima did not change in metabolite concentration, but like the other plant species the biomass was reduced by salinity. Generally, a higher production in secondary metabolites by higher salinity was outbalanced by a reduction in biomass production. Concentrations of analyzed antioxidants showed a similar reaction and correlated with each other.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:451W47IQ8X (Sodium Chloride)



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