Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.075.039 [Categoria DeCS]
Referências encontradas : 30 [refinar]
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  1 / 30 MEDLINE  
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PMID:27686420
Autor:Mohammed MM; El-Sharkawy ER
Endereço:a Nucleic Acid Center, Institute of Physics, Chemistry and Pharmacy , University of Southern Denmark , Odense , Denmark.
Título:Cytotoxic new furoquinoline alkaloid isolated from Ammi majus L. growing in Egypt.
Fonte:Nat Prod Res; 31(6):645-652, 2017 Mar.
ISSN:1478-6427
País de publicação:England
Idioma:eng
Resumo:Two alkaloids of the furoquinoline-type were isolated from Ammi majus L.; a new one and was identified as 4-hydro-7-hydroxy-8-methoxyfuroquinoline (1), and the other was isolated for the second time from nature and was identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline (2). The structures of the isolated compounds were established and confirmed by 1D and 2D NMR spectroscopy including H, C NMR, COSY, HSQC and HMBC, while the exact masses were confirmed by HRESI/MS. The cytotoxic activity of the isolated compounds (1 and 2) was evaluated against HepG-2, PC-3, A-549 and MCF-7 and the obtained results suggested selective antiproliferative and cytotoxic effects, with IC = 230.2 and 326.5 µM against HepG-2 and MCF-7, respectively, for compound (1). While, compound (2) recorded IC = 234.2 µM against MCF-7.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Alkaloids); 0 (Plant Extracts); 0 (Quinolines)


  2 / 30 MEDLINE  
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PMID:27936681
Autor:Travaini ML; Sosa GM; Ceccarelli EA; Walter H; Cantrell CL; Carrillo NJ; Dayan FE; Meepagala KM; Duke SO
Endereço:Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , Suipacha 531, 2000 Rosario, Argentina.
Título:Khellin and Visnagin, Furanochromones from Ammi visnaga (L.) Lam., as Potential Bioherbicides.
Fonte:J Agric Food Chem; 64(50):9475-9487, 2016 Dec 21.
ISSN:1520-5118
País de publicação:United States
Idioma:eng
Resumo:Plants constitute a source of novel phytotoxic compounds to be explored in searching for effective and environmentally safe herbicides. From a previous screening of plant extracts for their phytotoxicity, a dichloromethane extract of Ammi visnaga (L.) Lam. was selected for further study. Phytotoxicity-guided fractionation of this extract yielded two furanochromones, khellin and visnagin, for which herbicidal activity had not been described before. Khellin and visnagin were phytotoxic to model species lettuce (Lactuca sativa) and duckweed (Lemna paucicostata), with IC values ranging from 110 to 175 µM. These compounds also inhibited the growth and germination of a diverse group of weeds at 0.5 and 1 mM. These weeds included five grasses [ryegrass (Lolium multiflorum), barnyardgrass (Echinocloa crus-galli), crabgrass (Digitaria sanguinalis), foxtail (Setaria italica), and millet (Panicum sp.)] and two broadleaf species [morningglory (Ipomea sp.) and velvetleaf (Abutilon theophrasti)]. During greenhouse studies visnagin was the most active and showed significant contact postemergence herbicidal activity on velvetleaf and crabgrass at 2 kg active ingredient (ai) ha . Moreover, its effect at 4 kg ai ha was comparable to the bioherbicide pelargonic acid at the same rate. The mode of action of khellin and visnagin was not a light-dependent process. Both compounds caused membrane destabilization, photosynthetic efficiency reduction, inhibition of cell division, and cell death. These results support the potential of visnagin and, possibly, khellin as bioherbicides or lead molecules for the development of new herbicides.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Chromones); 0 (Furans); 0 (Herbicides); 0 (Plant Extracts); 0 (furanochromone); 5G117T0TJZ (Khellin); P64438MLBW (visnagin)


  3 / 30 MEDLINE  
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PMID:27166709
Autor:Petramfar P; Moein M; Samani SM; Tabatabaei SH; Zarshenas MM
Endereço:Clinical Neurology Research Center, Neurology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Título:Trachyspermum ammi 10 % topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial.
Fonte:Neurol Sci; 37(9):1449-55, 2016 Sep.
ISSN:1590-3478
País de publicação:Italy
Idioma:eng
Resumo:A four-week, double-blind, randomized, placebo-controlled trial was conducted to assay the effectiveness of Ajwain 10 % (Trachyspermum ammi Sprague) topical cream on neuropathic pain. Intervention encompassed Ajwain 10 % and placebo creams. Ninety-two patients who specifically mentioned daily and nocturnal burning feet were randomly assigned to receive one of those interventions. Presence and decline in patients' numbness, tingling and allodynia were also evaluated. Major outcome measure was alteration in feet burning intensity (final week versus baseline week) regarding to a visual analog scale on a 0-10 cm scale (0 being "no pain", 10 being "worst pain"). Significant reduction in feet burning scores as well as numbness, tingling and allodynia were found in Ajwain group compared to placebo. This trial examining a cream of Ajwain essential oil versus placebo revealed the significance difference between two groups. This medicament can be a good candidate for the alleviation of feet burning, a neuropathic complication.
Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL


  4 / 30 MEDLINE  
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PMID:26995534
Autor:Pavela R; Vrchotová N; Tríska J
Endereço:Crop Research Institute, Drnovska 507, 161 06 Prague 6, Ruzyne, Czech Republic. Electronic address: pavela@vurv.cz.
Título:Larvicidal activity of extracts from Ammi visnaga Linn. (Apiaceae) seeds against Culex quinquefasciatus Say. (Diptera: Culicidae).
Fonte:Exp Parasitol; 165:51-7, 2016 Jun.
ISSN:1090-2449
País de publicação:United States
Idioma:eng
Resumo:Efficacies of the Ammi visnaga seeds extract and a majority of substances on larval Culex quinquefasciatus mortality in various development stages including pupae were studied. The effect of exposure time on larval mortality was also studied. The effect of sublethal concentrations or short exposure times on further larval development and subsequent fecundity in adults were studied as well. Lethal doses of the extract were estimated for the 2nd, 3rd and 4th instar of C. quinquefasciatus (LC50 for 18, 23 and 180 mg L(-1), respectively). The majority of furanochromenes, khellin and visnagin, were identified by analysing the extract. Khellin was significantly more effective compared to visnagin, whose LC50 was estimated at 8, 10 and 41 mg L(-1) for the 2nd, 3rd and 4th instar larvae. Khellin showed very fast efficacy on mortality for the 3rd instar larvae in a concentration of 100 mg L(-1). Fifty percent mortality was determined 30 min after application, a time which was considerably shorter compared to the extract (113 min) or visnagin (169 min). The effect of the application of lethal concentrations on C. quinquefasciatus larval mortality was studied. The least number of adults were hatched after application of the extract and khellin (41.8% and 37.9%, respectively), less than after visnagin application (46.7%) or in the control (94.2%). LC50 application caused lower fecundity in the hatched adults, lower hatchability of the eggs, and also very low natality, more than 77% lower for khellin compared to the control. A short exposure, corresponding to our estimated LT30, caused no significant acute toxicity in the larvae (until 24 h) for the extract or visnagin (4.3% and 11.5%, respectively); however, 18 min of action from khellin caused a 54.3% mortality rate of the larvae within 24 h.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Insecticides); 0 (Plant Extracts); 5G117T0TJZ (Khellin); P64438MLBW (visnagin)


  5 / 30 MEDLINE  
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PMID:26209576
Autor:Bartnik M; Mazurek AK
Endereço:Chair and Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Chodzki 1 Str., Lublin 20-093, Poland mbartnik@pharmacognosy.org.
Título:Isolation of Methoxyfuranocoumarins From Ammi majus by Centrifugal Partition Chromatography.
Fonte:J Chromatogr Sci; 54(1):10-6, 2016 Jan.
ISSN:1945-239X
País de publicação:United States
Idioma:eng
Resumo:Pure methoxyfuranocoumarins were isolated from Ammi majus L. by use of low-pressure column chromatography (LPCC) followed by centrifugal partition chromatography (CPC). The concentrated petroleum ether extract from fruits of A. majus was fractionated on a silica gel column using a gradient of ethyl acetate in dichloromethane (0-80%, v/v). Coumarin-rich fractions were analyzed by thin-layer chromatography (TLC) and high-performance liquid chromatography with diode array detection (HPLC/DAD). Xanthotoxin (8-MOP) and isopimpinellin (isoP), structurally similar compounds, were isolated in one fraction (FR6). To avoid multistep and long-lasting TLC preparation, optimization of CPC conditions has been performed. In one run, an effective separation of 8-MOP and isoP was achieved. The two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (10 : 8 : 10 : 9; v/v) in an ascending mode (the aqueous phase was a stationary phase, and the organic phase was a mobile phase), with flow rate 3 mL/min and rotation speed 1,600 r.p.m., was used. The identification and high purities of isolated 8-MOP (98.7%) and isoP (100%) were confirmed by HPLC/DAD assay, when compared with standards. The developed CPC method could be applied to the effective isolation of 8-MOP and isoP from plant extracts. The high purity of obtained compounds makes possible further exploitation of these components in biological studies.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Coumarins)


  6 / 30 MEDLINE  
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PMID:26188304
Autor:Nouri L; Bendjama Z; Hamitouche AE; Boumaza S; Kaouah F; Trari M; Riad L
Endereço:Laboratory of Industrial Processes Engineering Sciences, Faculty of Mechanical and Engineering Processes, (USTHB), BP 32, 16111 Algiers, Algeria; Research Centre in Analytical Chemistry and Physics, (CRAPC), BP 248, RP 16004 Algiers, Algeria.
Título:Optimization of a novel biocomposite synthesis (Ammi Visnaga extraction waste/alginate) for Cd(2+) biosorption.
Fonte:Int J Biol Macromol; 80:588-95, 2015 Sep.
ISSN:1879-0003
País de publicação:Netherlands
Idioma:eng
Resumo:A novel environmentally friendly biocomposite namely calcium alginate immobilized Ammi Visnaga (Khella) extraction waste was prepared by electrostatic extrusion method. A full factorial design 2(3) was used to optimize the beads preparation conditions. The effect of sodium alginate concentration (X1), biomass concentration (X2) and cross-linker concentration (X3) on the Cd(2+) removal efficiency was examined in a batch system with a fixed biocomposite dose of 1g/L. Using the experimental results, a linear mathematical model representing the influence of different variables and their interactions was obtained. The optimized values of X1, X2 and X3 were found to be 4.35%, 2.5% and 1.99% respectively. The biocomposite beads were characterized by ATR spectroscopy, scanning electron microscopy for the surface morphology and optical microscopic for the particles size measurements.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Alginates); 0 (Hexuronic Acids); 0 (Plant Extracts); 00BH33GNGH (Cadmium); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid)


  7 / 30 MEDLINE  
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PMID:25111086
Autor:Badr JM; Hadad GM; Nahriry K; Hassanean HA
Endereço:a Department of Natural Products and Alternative Medicine , Faculty of Pharmacy, King Abdulaziz University , Jeddah 21589 , Kingdom of Saudi Arabia.
Título:Validated HPLC method for simultaneous estimation of khellol glucoside, khellin and visnagin in Ammi visnaga L. fruits and pharmaceutical preparations.
Fonte:Nat Prod Res; 29(7):593-601, 2015.
ISSN:1478-6427
País de publicação:England
Idioma:eng
Resumo:Tea bags including fruits of Ammi visnaga L. are used in Egypt as remedy for the treatment of kidney stones. Our study focuses on developing simple and rapid method utilising HPLC for quantitative estimation of khellol glucoside (KG), khellin (KH) and visnagin (VS) simultaneously. Their concentrations were determined in A. visnaga L. fruits at different developmental stages and in pharmaceutical formulations together with following up them during shelf life. Separation was accomplished using HPLC. Perfect resolution between KG, KH and VS was possible through using a mobile phase consisting of water:methanol:tetrahydrofuran (50:45:5, v/v/v). Peaks were detected at 245 nm. The suggested method for the determination of KG, KH and VS was successful in determining the analytes of interest without any interference of other compounds and matrix. All validation parameters were satisfactory and the procedure was relatively easy and fast as extracts are evaluated without previous steps of purification.
Tipo de publicação: JOURNAL ARTICLE; VALIDATION STUDIES
Nome de substância:0 (Plant Extracts); 5G117T0TJZ (Khellin); P64438MLBW (visnagin); ZX4FRZ5WJP (khelloside)


  8 / 30 MEDLINE  
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PMID:24925412
Autor:Edwards AM
Endereço:The David Hide Asthma and Allergy Research Centre, St. Mary's Hospital, Newport, UK.
Título:Chromones.
Fonte:Chem Immunol Allergy; 100:317-22, 2014.
ISSN:1662-2898
País de publicação:Switzerland
Idioma:eng
Resumo:The chromones are a class of chemical compounds characterised by the presence of the structure 5:6 benz-1:4-pyrone in their chemical make-up. The first chromone in clinical use, khellin, was extracted from the seeds of the plant Ammi visnaga, and had been used for centuries as a diuretic and as a smooth muscle relaxant. Its use in bronchial asthma was reported in 1947. In the 1950s, Benger's Laboratories embarked on a research programme to synthesise and develop modifications of khellin for the treatment of asthma. New compounds were screened using animal models to test the ability of the compound to prevent the anaphylactic release of histamine and SRS-A (leukotrienes) from sensitised guinea pig lung, and a human model to check the ability to reduce the bronchoconstriction induced by inhaled antigen bronchial challenge. For initial screening the human work was undertaken by Dr. R.E.C. Altounyan, who suffered from allergic bronchial asthma and was employed by Benger's Laboratories. After 8 years and more than 600 challenges using over 200 compounds, in 1965 Altounyan arrived at disodium cromoglycate (DSCG), the chromone that met the criteria of providing more than 6 h of protection. DSCG is still used today as a mast cell stabiliser.
Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE
Nome de substância:0 (Anti-Allergic Agents); 0 (Chromones); 0 (Leukotrienes); 820484N8I3 (Histamine)


  9 / 30 MEDLINE  
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PMID:24411541
Autor:Jan M
Endereço:Department of Pharmacology, College of Medicine, University of Dammam, Dammam, Saudi Arabia.
Título:Effects of Ammi visnaga (Bisnaga) extract on the volume and acidity of stimulated gastric secretion in fasting rabbits.
Fonte:J Coll Physicians Surg Pak; 24(1):39-42, 2014 Jan.
ISSN:1681-7168
País de publicação:Pakistan
Idioma:eng
Resumo:OBJECTIVE: To determine the efficacy of extract of Ammi visnaga on volume and acidity of stimulated gastric secretion in rabbits and also its safety on liver and kidney function. STUDY DESIGN: Quasi experimental study. PLACE AND DURATION OF STUDY: Pharmacology Department, Saidu Medical College, Swat, in the years 2008-9. METHODOLOGY: Thirty rabbits weighing 1 - 1.5 kg were divided into groups A, B and C each having 10 animals. After fasting for 48 hours, pylorus of animals of group A and B was ligated. Group A was administered Carbachol and group B was given extracts of Ammi visnaga followed by Carbachol after 15 minutes intraperitoneally. After 4 hours, stomach contents were measured for volume and then centrifuged and estimated for acidity. The extract was also administered to group C animals for 45 days to observe its effects on liver and kidney function. RESULTS: In group B, reduction in volume, free and total acidity of gastric juice was highly significant when the mean values were compared with group A. In group C, mean values of liver and kidney function test compared with pre-treated values, were found statistically non-significant. CONCLUSION: Ammi visnaga extract can be used effectively and safely in the treatment of hyper acidity conditions and peptic ulcer after evaluation of its effects in human being.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Calcium Channel Blockers); 0 (Cholinergic Agonists); 0 (Plant Extracts); 8Y164V895Y (Carbachol)


  10 / 30 MEDLINE  
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PMID:23993295
Autor:Sellami HK; Napolitano A; Masullo M; Smiti S; Piacente S; Pizza C
Endereço:University of El-Manar II, Faculty of Sciences, Unity of Research of Vegetal Ecology, Campus Academia, 2092 Tunis, Tunisia.
Título:Influence of growing conditions on metabolite profile of Ammi visnaga umbels with special reference to bioactive furanochromones and pyranocoumarins.
Fonte:Phytochemistry; 95:197-206, 2013 Nov.
ISSN:1873-3700
País de publicação:England
Idioma:eng
Resumo:The medicinal plant Ammi visnaga is a valuable source of furanochromones and pyranocoumarins used as vasodilator agents. Its ability to germinate under unfavourable growth conditions, such as saline soil and hypoxia characterizing clay soils and marshes ecosystems, prompted us to qualitatively characterize secondary metabolites in umbels of A. visnaga plants grown under different conditions (in field, hydroponically controlled, and contrasted by salinity and/or hypoxia) by HPLC-ESI/IT/MS(n) analysis. Subsequently, the quantitative analysis of the bioactive compounds, above all furanochromones and pyranocoumarins, was carried out by HPLC-ESI/QqQ/MS/MS. The results show the influence of growing conditions on the quali-quantitative profile of A. visnaga secondary metabolites and evidence that hydroponic culture leads to increased level of A. visnaga active principles. Furthermore, two furanochromones never reported before were identified and characterized by 1D- and 2D-NMR analysis.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Chromones); 0 (Furans); 0 (Plant Extracts); 0 (Pyranocoumarins); 0 (furanochromone); 451W47IQ8X (Sodium Chloride); S88TT14065 (Oxygen)



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