Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.075.077 [Categoria DeCS]
Referências encontradas : 81 [refinar]
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  1 / 81 MEDLINE  
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PMID:28254010
Autor:El-Zaeddi H; Calín-Sánchez Á; Nowicka P; Martínez-Tomé J; Noguera-Artiaga L; Burló F; Wojdylo A; Carbonell-Barrachina ÁA
Endereço:Universidad Miguel Hernández de Elche (UMH), Escuela Politécnica Superior de Orihuela (EPSO), Department of Agro-Food Technology, Research Group "Food Quality and Safety", Carretera Beniel, km 3.2, 03312-Orihuela, Alicante, Spain.
Título:Preharvest treatments with malic, oxalic, and acetylsalicylic acids affect the phenolic composition and antioxidant capacity of coriander, dill and parsley.
Fonte:Food Chem; 226:179-186, 2017 Jul 01.
ISSN:0308-8146
País de publicação:England
Idioma:eng
Resumo:The effects of a preharvest treatment with malic (MA), oxalic (OA), or acetylsalicylic (ASA) acid at three concentrations (1, 2 and 3mM) on the bioactivity and antioxidant capacity of coriander, dill, and parsley were investigated. The antioxidant capacity of the herbs extracts was assayed by spectrophotometric methods by using three different analytical methods: ORAC, FRAP, and ABTS; the effects of treatments were very positive in coriander, produced intermediate results in dill, and no effects were found in parsley plants. Polyphenol compounds were identified by LC-MS-QTof and quantified by UPLC-PDA-FL. Thirty phenolic compounds were identified in these three herbs. The major compounds were (i) coriander: dimethoxycinnamoyl hexoside and quercetin-3-O-rutinoside, (ii) dill: neochlorogenic acid and quercetin glucuronide, and (iii) parsley: apigenin-7-apiosylglucoside (apiin) and isorhamnetin-3-O-hexoside. The application of these three organic acids favored the accumulation of phenolic compounds in coriander plants, but had no significant positive effects on dill and parsley. The treatments leading to the best results in all three plants were the application of MA or OA at 1mM.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Malates); 0 (Phenols); 817L1N4CKP (malic acid); 9E7R5L6H31 (Oxalic Acid); R16CO5Y76E (Aspirin)


  2 / 81 MEDLINE  
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PMID:27916506
Autor:Taddeo VA; Genovese S; Medina P; Palmisano R; Epifano F; Fiorito S
Endereço:Department of Pharmacy, University "G. d'Annunzio" - Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Título:Quantification of biologically active O-prenylated and unprenylated phenylpropanoids in dill (Anethum graveolens), anise (Pimpinella anisum), and wild celery (Angelica archangelica).
Fonte:J Pharm Biomed Anal; 134:319-324, 2017 Feb 05.
ISSN:1873-264X
País de publicação:England
Idioma:eng
Resumo:An analytical strategy based on different extraction methodologies and HPLC with spectrophotometric (UV-vis) detection has been developed to investigate the presence of and to quantitate biologically active selected unprenylated and O-prenylated phenylpropanoids, namely umbelliferone, 4'-geranyloxyferulic acid, 7-isopentenyloxycoumarin, auraptene, and umbelliprenin in dill (Anethum graveolens L.), anise (Pimpinella anisum L.), and wild celery (Angelica archangelica L.). Absolute ethanol or 7:3 water/ethanol mixtures were seen to be the most powerful extraction solvents to perform "classic" maceration or ultrasound-assisted one in terms of yields in secondary metabolites. For anethum and anise, umbelliprenine was found to be the most abundant prenyloxy secondary metabolite, while in wild celery 4'-geranyloxyferulic acid recorded the highest concentration. Our experimental approach demonstrated to be efficient for the simultaneous identification and quantitation of the above mentioned prenyloxyphenylpropanoids in the title plant species, that is reported herein for the first time in the literature.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Phytochemicals); 0 (Plant Extracts)


  3 / 81 MEDLINE  
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PMID:27392118
Autor:El-Zaeddi H; Martínez-Tomé J; Calín-Sánchez Á; Burló F; Carbonell-Barrachina ÁA
Endereço:Research Group 'Food Quality and Safety', Department of Agro-Food Technology, Universidad Miguel Hernández de Elche, Escuela Politécnica Superior de Orihuela, Carretera Beniel, km 3.2, E-03312, Orihuela, Alicante, Spain.
Título:Irrigation dose and plant density affect the volatile composition and sensory quality of dill (Anethum graveolens L.).
Fonte:J Sci Food Agric; 97(2):427-433, 2017 Jan.
ISSN:1097-0010
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Two independent field experiments were carried out to investigate the influence of (i) three irrigation treatments (ID0 = 1585 m ha , considered as a control; ID1 = 1015 m ha ; and ID2 = 2180 m ha ) and (ii) three plant density treatments (PD0 = 5.56 plants m , considered as a control; PD1 = 4.44 plants m ; and PD2 = 7.41 plants m ) on the production, volatile composition of essential oil, and sensory quality of dill. RESULTS: The highest plant yield was obtained with intermediate conditions of both irrigation dose (ID0) and plant density (PD0). The main compounds of the essential oil were α-phellandrene, dill ether and ß-phellandrene. The highest irrigation dose (ID2) produced the highest concentrations of most of the main compounds: α-phellandrene (49.5 mg per 100 g), ß-phellandrene (6.89 mg per 100 g) and limonene (2.49 mg per 100 g). A similar pattern was found for the highest plant density (PD2): α-phellandrene (71.0 mg per 100 g), dill ether (16.7 mg per 100 g) and ß-phellandrene (9.70 mg per 100 g). The use of descriptive sensory analysis helped in reaching a final decision, and the dill plants with the highest sensory quality were those of the ID2 and PD0 treatments. CONCLUSION: The final recommendation is to use the irrigation dose ID2 and the plant density PD2 if the objective is to produce dill samples with the highest aromatic and sensory quality; however, if the only objective is to produce high amounts of dill, the best options are ID0 and PD0. © 2016 Society of Chemical Industry.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Cyclohexenes); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plant Oils); 0 (Terpenes); 2KK225M001 (beta-phellandrene); 49JV13XE39 (alpha phellandrene); 9MC3I34447 (limonene)


  4 / 81 MEDLINE  
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PMID:27782086
Autor:Snuossi M; Trabelsi N; Ben Taleb S; Dehmeni A; Flamini G; De Feo V
Endereço:Laboratoire de Traitement et Valorisation des Rejets Hydriques (LR 15 CERTEO5), Technopole de Borj-Cédria, BP 273, Soliman 8020, Tunisie. snmejdi@yahoo.fr.
Título:Laurus nobilis, Zingiber officinale and Anethum graveolens Essential Oils: Composition, Antioxidant and Antibacterial Activities against Bacteria Isolated from Fish and Shellfish.
Fonte:Molecules; 21(10), 2016 Oct 22.
ISSN:1420-3049
País de publicação:Switzerland
Idioma:eng
Resumo:Several bacterial strains were isolated from wild and reared fish and shellfish. The identification of these strains showed the dominance of the species in all seafood samples, followed by spp., , , , and . The isolates were studied for their ability to produce exoenzymes and biofilms. The chemical composition of the essential oils from leaves, rhizomes and aerial parts was studied by GC and GC/MS. The essential oils' antioxidant and antibacterial activities against the isolated microorganisms were studied. Low concentrations of the three essential oils were needed to inhibit the growth of the selected bacteria and the lowest MBCs values were obtained for the laurel essential oil. The selected essential oils can be used as a good natural preservative in fish food due to their antioxidant and antibacterial activities.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Oils)


  5 / 81 MEDLINE  
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PMID:27622989
Autor:Kalangi SK; Dayakar A; Gangappa D; Sathyavathi R; Maurya RS; Narayana Rao D
Endereço:Dept. of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India.
Título:Biocompatible silver nanoparticles reduced from Anethum graveolens leaf extract augments the antileishmanial efficacy of miltefosine.
Fonte:Exp Parasitol; 170:184-192, 2016 Nov.
ISSN:1090-2449
País de publicação:United States
Idioma:eng
Resumo:Despite the existence of chemotherapy, there is no effective cure for leishmaniasis. In the light of recommended therapeutic regimen is attributed for toxicity and development of clinical resistance, exploration of an efficient method of drug delivery could be one of the option in reducing the dosage and toxicity of drugs. This work is aimed in such fashion to study the enhanced antileishmanial activity of miltefosine with silver-nanoparticles (AgNPs) synthesized by using Anethum graveolens (dill) leaf extract as reducing agent. AgNPs were synthesized in a single step process and characterized by UV-visible, X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FTIR) to understand the crystal structure and functional groups on their surface. TEM analysis showed that the synthesized AgNPs are of an average size of 35 nm. By performing MTT assay, we found that, AgNPs (between 20 and 100 µM) are biocompatible in nature through pertaining >80% viability of macrophages. Furthermore, AgNPs alone (50 µM) have not shown antileishmanial effect on promastigote stage of Leishmania parasite but in combination with miltefosine (12.5 µM and 25 µM), it magnifies the leishmanicidal effect of miltefosine by ∼2-folds (i.e. AgNPs cut down the IC of miltefosine about to half). Scanning electron microscopic (SEM) observation for morphological aberration and genomic DNA fragmentation in promastigotes confirmed the enhanced effect of meltefosine in combination with AgNPs (50 µM AgNPs plus 12.5 µM miltefosine). Similarly, this combination has likely shown a slight augmentation (p = 0.057) of miltefosine (2.5 µM) leishmanicidal efficacy on amastigote stage of the parasite in infected human macrophages by reducing their intracellular growth.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antiprotozoal Agents); 0 (Biocompatible Materials); 0 (Plant Extracts); 107-73-3 (Phosphorylcholine); 3M4G523W1G (Silver); 53EY29W7EC (miltefosine)


  6 / 81 MEDLINE  
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PMID:27100701
Autor:Semenov VV; Tsyganov DV; Semenova MN; Chuprov-Netochin RN; Raihstat MM; Konyushkin LD; Volynchuk PB; Marusich EI; Nazarenko VV; Leonov SV; Kiselyov AS
Endereço:N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
Título:Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity.
Fonte:J Nat Prod; 79(5):1429-38, 2016 May 27.
ISSN:1520-6025
País de publicação:United States
Idioma:eng
Resumo:A concise six-step protocol for the synthesis of isoflavone glaziovianin A (GVA) and its alkoxyphenyl derivatives 9 starting with readily available plant metabolites from dill and parsley seeds was developed. The reaction sequence involved an efficient conversion of the key intermediate epoxides 7 into the respective ß-ketoaldehydes 8 followed by their Cu(I)-mediated cyclization into the target series 9. The biological activity of GVA and its derivatives was evaluated using a panel of seven human cancer cell lines and an in vivo sea urchin embryo assay. Both screening platforms confirmed the antimitotic effect of the parent GVA (9cg) and its alkoxy derivatives. Structure-activity relationship studies suggested that compounds 9cd and 9cf substituted with trimethoxy- and dillapiol-derived B-rings, respectively, were less active than the parent 9cg. Of the evaluated human cancer cell lines, the A375 melanoma cell line was the most sensitive to the tested molecules. Notably, the target compounds were not cytotoxic against human peripheral blood mononuclear cells up to 10 µM concentration. Phenotypic readouts from the sea urchin assay unequivocally suggest a direct microtubule-destabilizing effect of isoflavones 9cg, 9cd, and 9cf.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antimitotic Agents); 0 (Antineoplastic Agents); 0 (Isoflavones); 0 (Tubulin Modulators); 0 (glaziovianin A)


  7 / 81 MEDLINE  
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PMID:27028988
Autor:Danesi F; Govoni M; D'Antuono LF; Bordoni A
Endereço:Department of Agri-Food Science and Technology (DISTAL), University of Bologna, Cesena, FC, Italy.
Título:The molecular mechanism of the cholesterol-lowering effect of dill and kale: The influence of the food matrix components.
Fonte:Electrophoresis; 37(13):1805-13, 2016 07.
ISSN:1522-2683
País de publicação:Germany
Idioma:eng
Resumo:Foods are complex matrices containing many different compounds, all of which contribute to the overall effect of the food itself, although they have different mechanisms of action. While evaluating the effect of bioactive compounds, it is important to consider that the use of a single compound can hide the effects of the other molecules that can act synergistically or antagonistically in the same food. The aim of the present study was to evaluate the influence of food matrix components by comparing two edible plants (dill and kale) with cholesterol-lowering potential and similar contents of their most representative bioactive, quercetin. The molecular effects of the extracts were evaluated in HepG2 cells by measuring the expression of sterol-regulatory element-binding proteins (SREBPs), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and low density lipoprotein receptor (LDLR) at the mRNA and protein level. The results reported here show that both extracts reduced the cellular cholesterol level with a similar trend and magnitude. It is conceivable that the slightly different results are due to the diverse composition of minor bioactive compounds, indicating that only by considering food as a whole is it possible to understand the complex relationship between food, nutrition, and health in a foodomics vision.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (RNA, Messenger); 0 (Receptors, LDL); 0 (SREBF2 protein, human); 0 (Sterol Regulatory Element Binding Protein 2); 97C5T2UQ7J (Cholesterol); EC 1.1.1.- (HMGCR protein, human); EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases)


  8 / 81 MEDLINE  
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PMID:26910798
Autor:Tsyganov DV; Krayushkin MM; Konyushkin LD; Strelenko YA; Semenova MN; Semenov VV
Endereço:N. D. Zelinsky Institute of Organic Chemistry, RAS , Leninsky Prospect, 47, 119991, Moscow, Russian Federation.
Título:Facile Synthesis of Natural Alkoxynaphthalene Analogues from Plant Alkoxybenzenes.
Fonte:J Nat Prod; 79(4):923-8, 2016 Apr 22.
ISSN:1520-6025
País de publicação:United States
Idioma:eng
Resumo:Analogues of the bioactive natural alkoxynaphthalene pycnanthulignene D were synthesized by an efficient method. The starting plant allylalkoxybenzenes (1) are easily available from the plant essential oils of sassafras, dill, and parsley. The target 1-arylalkoxynaphthalenes (5) exhibited antiproliferative activity in a phenotypic sea urchin embryo assay.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Antineoplastic Agents); 0 (Lignans); 0 (Oils, Volatile); 0 (Plant Oils); 0 (pycnanthulignene D)


  9 / 81 MEDLINE  
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PMID:26872137
Autor:El Mansouri L; Bousta D; El Youbi-El Hamsas A; Boukhira S; Akdime H
Endereço:1LPAMSN, Department of Valorization and Industrial Application, National Institute of Medicinal and Aromatic Plants, LAMEC, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco; 2LPAMSN, Department of Valorization and Industrial Application, National Institute of Medicinal and Aromatic Plants, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco; and 3Faculty of Sciences and Technics, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco.
Título:Phytochemical Screening, Antidepressant and Analgesic Effects of Aqueous Extract of Anethum graveolens L. From Southeast of Morocco.
Fonte:Am J Ther; 23(6):e1695-e1699, 2016 Nov/Dec.
ISSN:1536-3686
País de publicação:United States
Idioma:eng
Resumo:This study aims to investigate the antidepressant and analgesic properties of the aqueous extract of Anethum graveolens L. from South of Morocco (Rissani-Errachidia region). Extract of plant is obtained by aqueous decoction and administered to Wistar rats orally. The extract has a significant antidepressant and analgesic effects compared with the drug references (sertraline and tramadol) without any adverse effects. The dose of 250 mg/kg, body weight shows the best antidepressant and analgesic effects than 1 g/kg, body weight. Phytochemical study of the aqueous extract of the plant has to show its highlight in polyphenols, flavonoids, and tannins.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Analgesics); 0 (Antidepressive Agents); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Tannins); 39J1LGJ30J (Tramadol); QUC7NX6WMB (Sertraline)


  10 / 81 MEDLINE  
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PMID:26680443
Autor:Melnikova DN; Mineev KS; Finkina EI; Arseniev AS; Ovchinnikova TV
Endereço:Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya str., 16/10, 117997, Moscow, Russia.
Título:A novel lipid transfer protein from the dill Anethum graveolens L.: isolation, structure, heterologous expression, and functional characteristics.
Fonte:J Pept Sci; 22(1):59-66, 2016 Jan.
ISSN:1099-1387
País de publicação:England
Idioma:eng
Resumo:A novel lipid transfer protein, designated as Ag-LTP, was isolated from aerial parts of the dill Anethum graveolens L. Structural, antimicrobial, and lipid binding properties of the protein were studied. Complete amino acid sequence of Ag-LTP was determined. The protein has molecular mass of 9524.4 Da, consists of 93 amino acid residues including eight cysteines forming four disulfide bonds. The recombinant Ag-LTP was overexpressed in Escherichia coli and purified. NMR investigation shows that the Ag-LTP spatial structure contains four α-helices, forming the internal hydrophobic cavity, and a long C-terminal tail. The measured volume of the Ag-LTP hydrophobic cavity is equal to ~800 A(3), which is much larger than those of other plant LTP1s. Ag-LTP has weak antifungal activity and unpronounced lipid binding specificity but effectively binds plant hormone jasmonic acid. Our results afford further molecular insight into biological functions of LTP in plants.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Carrier Proteins); 0 (Cyclopentanes); 0 (Oxylipins); 0 (Plant Proteins); 0 (Recombinant Proteins); 0 (lipid transfer protein); 6RI5N05OWW (jasmonic acid)



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