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  1 / 32 MEDLINE  
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PMID:27916506
Autor:Taddeo VA; Genovese S; Medina P; Palmisano R; Epifano F; Fiorito S
Endereço:Department of Pharmacy, University "G. d'Annunzio" - Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Título:Quantification of biologically active O-prenylated and unprenylated phenylpropanoids in dill (Anethum graveolens), anise (Pimpinella anisum), and wild celery (Angelica archangelica).
Fonte:J Pharm Biomed Anal; 134:319-324, 2017 Feb 05.
ISSN:1873-264X
País de publicação:England
Idioma:eng
Resumo:An analytical strategy based on different extraction methodologies and HPLC with spectrophotometric (UV-vis) detection has been developed to investigate the presence of and to quantitate biologically active selected unprenylated and O-prenylated phenylpropanoids, namely umbelliferone, 4'-geranyloxyferulic acid, 7-isopentenyloxycoumarin, auraptene, and umbelliprenin in dill (Anethum graveolens L.), anise (Pimpinella anisum L.), and wild celery (Angelica archangelica L.). Absolute ethanol or 7:3 water/ethanol mixtures were seen to be the most powerful extraction solvents to perform "classic" maceration or ultrasound-assisted one in terms of yields in secondary metabolites. For anethum and anise, umbelliprenine was found to be the most abundant prenyloxy secondary metabolite, while in wild celery 4'-geranyloxyferulic acid recorded the highest concentration. Our experimental approach demonstrated to be efficient for the simultaneous identification and quantitation of the above mentioned prenyloxyphenylpropanoids in the title plant species, that is reported herein for the first time in the literature.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Phytochemicals); 0 (Plant Extracts)


  2 / 32 MEDLINE  
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PMID:27322374
Autor:Le MT; Lanaspa MA; Cicerchi CM; Rana J; Scholten JD; Hunter BL; Rivard CJ; Randolph RK; Johnson RJ
Endereço:Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Título:Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase.
Fonte:PLoS One; 11(6):e0157458, 2016.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:OBJECTIVE: In developed countries with westernized diets, the excessive consumption of added sugar in beverages and highly refined and processed foods is associated with increased risk for obesity, diabetes, and cardiovascular diseases. As a major constituent of added sugars, fructose has been shown to cause a variety of adverse metabolic effects, such as impaired insulin sensitivity, hypertriglyceridemia, and oxidative stress. Recent studies have shown that ketohexokinase isoform C is the key enzyme responsible in fructose metabolism that drive's fructose's adverse effects. The objective of this study was to identify botanical ingredients with potential for inhibitory activity against ketohexokinase-C and fructose-induced metabolic effects by using a series of in vitro model systems. METHODS: Extracts from 406 botanicals and 1200 purified phytochemicals were screened (initial concentration of 50 µg/mL and 50 µM, respectively) for their inhibitory activity using a cell free, recombinant human ketohexokinase-C assay. Dose response evaluations were conducted on botanical extracts and phytochemicals that inhibited ketohexokinase-C by > 30% and > 40%, respectively. Two different extract lots of the top botanical candidates were further evaluated in lysates of HepG2 cells overexpressing ketohexokinase-C for inhibition of fructose-induced ATP depletion. In addition, extracts were evaluated in intact Hep G2 cells for inhibition of fructose-induced elevation of triglyceride and uric acid production. RESULTS: Among the botanical extracts, phloretin (Malus domestica) extracts were the most potent (IC50: 8.9-9.2 µg/mL) followed by extracts of Angelica archangelica (IC50: 22.6 µg/mL-57.3 µg/mL). Among the purified phytochemicals, methoxy-isobavachalcone (Psoralea corylifolia, IC50 = 0.2 µM) exhibited the highest potency against ketohexokinase isoform C activity followed by osthole (Angelica archangelica, IC50 = 0.7 µM), cratoxyarborenone E (Cratoxylum prunifolium, IC50 = 1.0 µM), and α-/γ-mangostin (Cratoxylum prunifolium, IC50 = 1.5 µM). Extracts of Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis exhibited ketohexokinase inhibitory activity and blocked fructose-induced ATP depletion and fructose-induced elevation in triglyerides and uric acid. CONCLUSIONS: Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C. Future studies are needed to show proof of mechanism and the efficacy of these botanical extracts in humans to blunt the negative metabolic effects of fructose-containing added sugars.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Enzyme Inhibitors); 0 (Insulin); 0 (Phytochemicals); 0 (Plant Extracts); 30237-26-4 (Fructose); EC 2.7.1.- (Fructokinases); EC 2.7.1.3 (ketohexokinase)


  3 / 32 MEDLINE  
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PMID:24788027
Autor:Fraternale D; Flamini G; Ricci D
Endereço:1 Department of Biomolecular Science, University of Urbino "Carlo Bo ," Urbino, Italy .
Título:Essential oil composition and antimicrobial activity of Angelica archangelica L. (Apiaceae) roots.
Fonte:J Med Food; 17(9):1043-7, 2014 Sep.
ISSN:1557-7600
País de publicação:United States
Idioma:eng
Resumo:In this paper, the chemical composition and the antimicrobial activity of the essential oil of Angelica archangelica L. (Apiaceae) roots from central Italy were analyzed. The major constituents of the oil were α-pinene (21.3%), δ-3-carene (16.5%), limonene (16.4%) and α-phellandrene (8.7%). The oil shows a good antimicrobial activity against Clostridium difficile, Clostridium perfringens, Enterococcus faecalis, Eubacterium limosum, Peptostreptococcus anaerobius, and Candida albicans with minimum inhibitory concentration (MIC) values of 0.25, 0.25, 0.13, 0.25, 2.25, and 0.50% v/v, respectively. A weaker antimicrobial activity against bifidobacteria and lactobacilli-very useful in the intestinal microflora-has also been shown with MIC values >4.0% v/v.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Antifungal Agents); 0 (Cyclohexenes); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Terpenes); 9MC3I34447 (limonene); H2M15SNR6N (3-carene); JPF3YI7O34 (alpha-pinene)


  4 / 32 MEDLINE  
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PMID:24140410
Autor:Sigurdsson S; Gudbjarnason S
Endereço:SagaMedica, Vatnagardar 18, IS-104 Reykjavik, Iceland. Electronic address: steinthor@sagamedica.is.
Título:Effect of oral imperatorin on memory in mice.
Fonte:Biochem Biophys Res Commun; 441(2):318-20, 2013 Nov 15.
ISSN:1090-2104
País de publicação:United States
Idioma:eng
Resumo:The aim of this study was to explore the effect of the acetylcholinesterase inhibiting mixture of extracts of Angelica archangelica fruit and Geranium sylvaticum on memory. Furthermore the effect of the main compound, the furanocoumarin imperatorin, which has been shown to affect several neurotransmitters, was studied. Passive avoidance was measured by step-down latency and step-through latency of 10 months old mice receiving 0.79 mg/kg of imperatorin daily, pure or as part of the extracts, for 14 days or longer. Step-down latency was significantly higher in both groups receiving imperatorin than in the control group. In contrast, no difference was found between treatment groups regarding step-through latency. The results indicate that the imperatorin is the main active component of the extract mixture.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Cholinesterase Inhibitors); 0 (Furocoumarins); 0 (Plant Extracts); K713N25C78 (imperatorin)


  5 / 32 MEDLINE  
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PMID:23980425
Autor:Noda Y; Mamiya N; Kashin H
Endereço:Department of Chemical Biology and Applied Chemistry, College of Engineering, Nihon University, Tamura-machi, Koriyama, Fukushima 963-8642, Japan. noda@chem.ce.nihon-u.ac.jp
Título:Synthesis of both enantiomers of 12-methyl-13-tridecanolide and 14-methyl-15-pentadecanolide (muscolide).
Fonte:Nat Prod Commun; 8(7):925-8, 2013 Jul.
ISSN:1934-578X
País de publicação:United States
Idioma:eng
Resumo:Both enantiomers of 12-methyl-13-tridecanolide{(R)-(+)-1, (S)-(-)-1} and 14-methyl-15-pentadecanolide (muscolide) {(R)-(+)-2, (S)-(-)-2} were synthesized from either (S)-(+)- or (R)-(-)-3-bromo-2-methyl-1-propanol 8 as a chiral building block.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (12-methyl-13-tridecanolide); 0 (14-methyl-15-pentadecanolide); 0 (Fatty Acids, Monounsaturated); 0 (Lactones); 095I377U8F (musk)


  6 / 32 MEDLINE  
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PMID:23323790
Autor:Sigurdsson S; Geirsson G; Gudmundsdottir H; Egilsdottir PB; Gudbjarnason S
Endereço:SagaMedica, Reykjavik, Iceland. steinthor@sagamedica.is
Título:A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men.
Fonte:Scand J Urol; 47(1):26-32, 2013 Feb.
ISSN:2168-1813
País de publicação:England
Idioma:eng
Resumo:OBJECTIVE: This study aimed to investigate the effect of SagaPro, a product derived from Angelica archangelica leaf, on nocturia. MATERIAL AND METHODS: Sixty-nine male patients 45 years or older with at least two nocturnal voids were randomized to receive SagaPro or placebo in a double-blind design for 8 weeks. Voiding diaries were assessed before and after the treatment. RESULTS: The results indicate that SagaPro is safe. The actual number of nocturnal voids (ANV), nocturnal polyuria index (NPi) and nocturnal bladder capacity index (NBC index) decreased in the test population, but there was no significant difference between the treatment groups. Subsequent subgroup analysis showed that SagaPro significantly reduced the NBC index and nocturnal voids per sleeping hour in comparison to the placebo in participants with baseline NBC index above 1.3. When participants with sleep disorders were excluded from this group, ANV was also significantly reduced for the SagaPro group in comparison to the placebo group. CONCLUSION: SagaPro, made from an extract of the medicinal herb Angelica archangelica, is safe. This study did not show that SagaPro improved nocturia overall compared to placebo. Subgroup analysis suggested a beneficial effect in individuals with decreased nocturnal bladder capacity, which warrants further study.
Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Plant Extracts)


  7 / 32 MEDLINE  
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PMID:22960104
Autor:Kumar D; Bhat ZA; Kumar V; Shah MY
Endereço:Department of Pharmaceutical Sciences, University of Kashmir, Srinagar-190006, India. sharmadinesh82@gmail.com
Título:Coumarins from Angelica archangelica Linn. and their effects on anxiety-like behavior.
Fonte:Prog Neuropsychopharmacol Biol Psychiatry; 40:180-6, 2013 Jan 10.
ISSN:1878-4216
País de publicação:England
Idioma:eng
Resumo:UNLABELLED: TRADITIONAL RELEVANCE: Angelica archangelica Linn. (Apiaceae) is an herb distributed in tropical and subtropical regions of the world. Both in Chinese and Indian system of medicine, it is used for nervous disorders including anxiety, anorexia, migraine and other cerebral diseases. AIM OF STUDY: To evaluate the anxiolytic potential of non polar coumarins isolated from A. archangelica Linn. METHODS AND RESULTS: A. archangelica Linn. (1 kg) was subjected to extraction in a soxhlet apparatus with petroleum ether (40-60 °C), yield 6.9% w/w. The extract of petroleum ether produced a yellow colored precipitate (YP) which was evaluated for anxiolytic like effect using EPM test and was found significant (**P<0.01) in doses of 5 and 10 mg/kg, po. The precipitate was shown to be a mixture of seven constituents in HPTLC and six on the TLC plate which were further subjected to separation by preparative TLC. Non polar coumarins were isolated namely imperatorin (IM) and isoimperatorin (IIM). YP, IM, IIM were tested for anxiolytic like effects in a dose of 5mg/kg, po along with DZ (1mg/kg, po) using EPM, Light & dark arena and hole board models in rats. All the test drugs were found to have significant (*P<0.05, **P<0.01) activity. IM and IIM have the potential to reduce anxiety but yellow precipitate showed the most promising activity as compared to isolated coumarins. This effect may be due to the synergistic action of all compounds present in the YP or by multiple mechanism of action. The test drugs may have the potential for different receptors. CONCLUSION: The mixture of coumarins isolated from A. archangelica and its constituents imperatorin and isoimperatorin have the potential to reduce anxiety but it is the mixture which have more significant activity as compared to its individual components.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Anti-Anxiety Agents); 0 (Coumarins); 0 (Plant Extracts)


  8 / 32 MEDLINE  
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PMID:22294442
Autor:Raafat BM; Saleh A; Shafaa MW; Khedr M; Ghafaar AA
Endereço:Genetic Engineering and Biotechnology Division, National Research Center, Egypt. bassemraafat@hotmail.com
Título:Ginkgo biloba and Angelica archangelica bring back an impartial hepatic apoptotic to anti-apoptotic protein ratio after exposure to technetium 99mTc.
Fonte:Toxicol Ind Health; 29(1):14-22, 2013 Feb.
ISSN:1477-0393
País de publicação:England
Idioma:eng
Resumo:PURPOSE: The aim of this study was to study the effect of ionizing radiation on apoptosis-related protein concentrations as well as the radio-protective role of Ginkgo biloba and Angelica archangelica. The experiments were performed on 68 adult Wistar rats weighing 175 g (±10 g). Animals were subdivided into control group in which the animals received neither the protector nor the isotopes. The second group represents the animals that received 1 mCi of (99m)Tc only. The third group represents the animals that received A. archangelica for 7 days. The fourth group represents the animals that received G. biloba for 7 days. The fifth group represents the animals that received 1 mCi of (99m)Tc once after receiving A. archangelica for 7 days. The sixth group represents the animals that received mCi of (99m)Tc once after receiving G. biloba for 7 days. Radiation was administered as intravenous injection by 1 mCi of (99m)Tc with the legend methoxyisobutylisonitrile for 24 h. The concentration of p53, Bcl2 and malondialdehyde in liver as well as histopathological examination of liver cells were carried out. Results showed that apoptotic to anti-apoptotic protein ratio significantly (p < 0.05) returned to its normal ratio when radioisotopic injection was administered after the protection period for a week by both A. archangelica and G. biloba in a dose based on the animal body weight. Electron microscope photographing supported this finding. CONCLUSION: It was concluded that both antioxidants can be used as radio-protective agents in cases of ionizing radiation exposure.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Plant Extracts); 0 (Radiation-Protective Agents); 0 (Radiopharmaceuticals); 0 (Tumor Suppressor Protein p53); 0 (bcl-X Protein); 4Y8F71G49Q (Malondialdehyde); A0730CX801 (Sodium Pertechnetate Tc 99m)


  9 / 32 MEDLINE  
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PMID:23387854
Autor:Siatka T; Kasparová M; Spilková J
Endereço:Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacognosy. siatka@faf.cuni.cz
Título:Effects of zinc and cadmium ions on cell growth and production of coumarins in cell suspension cultures of Angelica archangelica L.
Fonte:Ceska Slov Farm; 61(6):261-6, 2012 Dec.
ISSN:1210-7816
País de publicação:Czech Republic
Idioma:eng
Resumo:The plant cell may respond to the excess of heavy metals in its environment by various mechanisms, including enhanced biosynthesis of secondary metabolites. In this study, zinc (0 to 1500 µM) and cadmium ions (0 to 100 µM) were tested as potential elicitors of the production of coumarins in angelica cell suspension cultures. In addition, the toxicity of both metals was assessed by evaluating their effect on cell growth (characterized by fresh and dry biomass at the end of a two-week subculture). It has been found that fresh biomass was not influenced up to zinc concentrations of 150 and 300 µM in the dark-grown and light-grown cultures, resp. Then it declined with an increasing zinc level. Zinc at 1500 µM diminished it by 54% and 24% in the dark-grown and light-grown cultures, resp. Dry biomass was influenced in a similar way. Zinc at 1500 µM reduced dry cell weight by 30% and 20% in cultures in the dark and in the light, resp. Cadmium ions did not affect fresh and dry weights of cells up to concentrations of 10 µM and 50 µM in cultures in the dark and in the light, resp. Toxic concentrations of cadmium are by an order of magnitude lower than those of zinc. Cadmium at 50 µM reduced fresh and dry cell weights by 66% and 59%, resp., in the dark-grown cultures. Cadmium at 100 µM caused a decrease in fresh and dry biomass by 40% and 44%, resp., in the light-grown cultures. Neither zinc nor cadmium improved production of coumarins.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Coumarins); 00BH33GNGH (Cadmium); J41CSQ7QDS (Zinc)


  10 / 32 MEDLINE  
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PMID:23297567
Autor:Kumar D; Bhat ZA; Shah MY
Endereço:Department of Pharmaceutical Sciences, University of Kashmir, Jammu and Kashmir, Srinagar-190006, India.
Título:Anti-anxiety activity of successive extracts of Angelica archangelica Linn. on the elevated T-maze and forced swimming tests in rats.
Fonte:J Tradit Chin Med; 32(3):423-9, 2012 Sep.
ISSN:0255-2922
País de publicação:China
Idioma:eng
Resumo:OBJECTIVE: Angelica archangelica Linn. is widely used in food and liquor preparations and also in Kashmiri folk medicine to reduce anxiety. We evaluated the anxiolytic effect of successive extracts of A. archangelica linn. (SAE) on rats tested in the elevated T-maze test (an animal model of generalized anxiety) at doses that exhibit antidepressant-like activity in humans. METHODS: A. archangelica (1 kg) was subjected to successive extraction in a soxhlet apparatus with solvents [petroleum ether (40-60 degrees C), chloroform, ethyl acetate, methanol and decoction with water] in order of increasing polarity (yield: 6.9%, 7.3%, 5.1%, 11.88% and 8.2% w/w, respectively). SAE were evaluated for anxiolytic effects using the elevated T-maze and forced swimming tests in rats. RESULTS: Oral dosing of diazepam (1 mg/kg) and extracts (50, 100 and 200 mg/kg) clearly showed an anxiolytic-like profile in the elevated T-maze test: it increased one-way escape and decreased inhibitory avoidance on the first, third and seventh day. In the forced swimming test, imipramine and SAE showed antidepressant- and anxiolytic-like effects as reflected by increased climbing time, swimming time and decreased immobility time on the first, third and seventh day. Aqueous and methanol extracts showed the most, petroleum ether (40-60 degrees C) and chloroform intermediate, and ethyl acetate the least anxiolytic activity (*P<0.05, **P<0.01, ***P< 0.001) in both models. CONCLUSIONS: These results suggest the anti-anxiety activity of various extracts of A. archangelica and strongly justify its use in traditional Indian medicine for the treatment of anxiety.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Anti-Anxiety Agents); 0 (Plant Extracts)



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