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Pesquisa : B01.650.940.800.575.912.250.075.088.538 [Categoria DeCS]
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PMID:28458344
Autor:Li F; Tang R; Chen LB; Zhang KS; Huang XP; Deng CQ
Endereço:Molecular Pathology Laboratory, Hunan University of Chinese Medicine.
Título:Effects of Astragalus Combined with Angelica on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice.
Fonte:Biol Pharm Bull; 40(5):598-609, 2017.
ISSN:1347-5215
País de publicação:Japan
Idioma:eng
Resumo:Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis. Following establishment of the model, mice were administered with Astragalus (6.00 g·kg ), Angelica (3.00 g·kg ), and combinations of Astragalus and Angelica at different ratios, including 10 : 1 (Astragalus 9.81 g·kg +Angelica 0.98 g·kg ), 5 : 1 (Astragalus 9.00 g·kg +Angelica 1.80 g·kg ), 2 : 1 (Astragalus 7.71 g·kg +Angelica 3.08 g·kg ), 1 : 1 (Astragalus 5.40 g·kg +Angelica 5.40 g·kg ), 1 : 2.5 (Astragalus 3.08 g·kg +Angelica 7.71 g·kg ), 1 : 5 (Astragalus 1.80 g·kg +Angelica 9.00 g·kg ), and 1 : 10 (Astragalus 0.98 g·kg +Angelica 9.81 g·kg ). Our results suggested that Astragalus mixed with Angelica synergistically promoted hematopoiesis best when the combination ratio of Astragalus and Angelica was 1 : 1, 1 : 2.5 or 1 : 5; moreover, the effect of Angelica was greater than that of Astragalus. The potential mechanisms of the combinations of Astragalus and Angelica that promote hematopoiesis include the dissolution of the effective components, promoting the synthesis and secretion of hematopoietic growth factor (HGF) and the proliferation of hematopoietic progenitor cells (HPCs).
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Drug Combinations); 0 (Drugs, Chinese Herbal); 0 (Immunosuppressive Agents); 0 (Plant Extracts); 0 (danggui buxue decoction); 11096-26-7 (Erythropoietin); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor); 8N3DW7272P (Cyclophosphamide); 9014-42-0 (Thrombopoietin)


  2 / 380 MEDLINE  
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PMID:29207978
Autor:Chiu SC; Chiu TL; Huang SY; Chang SF; Chen SP; Pang CY; Hsieh TF
Endereço:Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
Título:Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells.
Fonte:BMC Complement Altern Med; 17(1):523, 2017 Dec 06.
ISSN:1472-6882
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: N-butylidenephthalide (BP) isolated from Radix Angelica Sinensis (Danggui) exhibits anti-tumorigenic effect in various cancer cells both in vivo and in vitro. The effect of BP in bladder cancer treatment is still unclear and worth for further investigate. METHODS: Changes of patients with bladder cancer after Angelica Sinensis exposure were evaluated by analysis of Taiwan's National Health Insurance Research Database (NHIRD) database. The anti-proliferative effect of BP on human bladder cancer cells was investigated and their cell cycle profiles after BP treatment were determined by flow cytometry. BP-induced apoptosis was demonstrated by Annexin V-FITC staining and TUNEL assay, while the expressions of apoptosis-related proteins were determined by western blot. The migration inhibitory effect of BP on human bladder cancer cells were shown by trans-well and wound healing assays. Tumor model in NOD-SCID mice were induced by injection of BFTC human bladder cancer cells. RESULTS: The correlation of taking Angelica sinensis and the incidence of bladder cancer in NHIRD imply that this herbal product is worth for further investigation. BP caused bladder cancer cell death in a time- and dose- dependent manner and induced apoptosis via the activation of caspase-9 and caspase-3. BP also suppressed the migration of bladder cancer cells as revealed by the trans-well and wound healing assays. Up-regulation of E-cadherin and down-regulation of N-cadherin were evidenced by real-time RT-PCR analysis after BP treatment in vitro. Besides, in combination with BP, the sensitivity of these bladder cancer cells to cisplatin increased significantly. BP also suppressed BFTC xenograft tumor growth, and caused 44.2% reduction of tumor volume after treatment for 26 days. CONCLUSIONS: BP caused bladder cancer cell death through activation of mitochondria-intrinsic pathway. BP also suppressed the migration and invasion of these cells, probably by modulating EMT-related genes. Furthermore, combination therapy of BP with a lower dose of cisplatin significantly inhibited the growth of these bladder cancer cell lines. The incidence of bladder cancer decreased in patients who were exposed to Angelica sinensis, suggesting that BP could serve as a potential adjuvant in bladder cancer therapy regimen.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents); 0 (Phthalic Anhydrides); 0 (Plant Extracts); S9178G4B3F (butylidenephthalide)


  3 / 380 MEDLINE  
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PMID:28683082
Autor:Deng P; Li X; Wei Y; Liu J; Chen M; Xu Y; Dong B; Zhu L; Chai L
Endereço:Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Título:The herbal decoction modified Danggui Buxue Tang attenuates immune-mediated bone marrow failure by regulating the differentiation of T lymphocytes in an immune-induced aplastic anemia mouse model.
Fonte:PLoS One; 12(7):e0180417, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:Angelicae Sinensis, Radix Astragali and Rhizoma Coptidis are all herbs of modified Danggui Buxue Tang (DGBX) and are extensively applied herbs in traditional Chinese medicine for the treatment of anemia and inflammation. In this study, immune-induced AA mice were used as an animal model, and the immunosuppressive agent, Ciclosporin A (CsA), was used as a positive control. Multiple pro-inflammatory cytokines were examined by bead-based multiplex flow cytometry. The T-cell subsets were assessed using a fluorescence-activated cell sorter (FACS). Western blot analysis was used to estimate the protein expression levels of specific transcription factors for T helper cells (Th1, Th2 and Th17) and key molecules of the Janus-activated kinase (Jak)/signal transducer and activator of transcription (Stat3) signaling pathway. DGBX treatment could significantly increase the production of whole blood cells in peripheral blood (PB); inhibit the expansion of Th1 and Th17 cells; increase the differentiation of Th2 and Tregs cells; regulate the expression levels of T-bet, GATA-3, RORγ and proinflammatory cytokines; and decrease the expression levels of key molecules in the Jak/Stat signaling pathway. These results indicate that DGBX can regulate the differentiation of T lymphocytes, resulting in immunosuppressive and hematogenic functions on AA mice. DGBX might be a good candidate for inclusion in a randomized study for AA with more data on the possible side effects and doses used in humans. Ultimately, it may be used for applications of traditional medicine against AA in modern complementary and alternative immunosuppressive therapeutics.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Drugs, Chinese Herbal); 0 (GATA3 Transcription Factor); 0 (Gata3 protein, mouse); 0 (Immunosuppressive Agents); 0 (Nuclear Receptor Subfamily 1, Group F, Member 3); 0 (Rorc protein, mouse); 0 (STAT3 Transcription Factor); 0 (STAT3 protein, human); 0 (T-Box Domain Proteins); 0 (T-box transcription factor TBX21); 0 (danggui buxue decoction); 83HN0GTJ6D (Cyclosporine); 922OP8YUPF (Huang Qi)


  4 / 380 MEDLINE  
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PMID:28163116
Autor:Lin HQ; Gong AG; Wang HY; Duan R; Dong TT; Zhao KJ; Tsim KW
Endereço:Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Título:Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review.
Fonte:J Ethnopharmacol; 199:205-210, 2017 Mar 06.
ISSN:1872-7573
País de publicação:Ireland
Idioma:eng
Resumo:BACKGROUND: Traditional Chinese medicine (TCM) has contributed greatly to human health in past several thousand years. Today, the development of TCM is facing two obstacles: (i) quality control of herbal extract; and (ii) action mechanisms not known. OBJECTIVES: Among thousands of complex TCM formulations, Danggui Buxue Tang (DBT) is the simplest one. DBT is used to treat ailments in women and contains only two herbs, Astragali Radix (Huangqi; AR) and Angelicae Sinensis Radix (Danggui; ASR). The weight ratio of AR to ASR in DBT must be 5:1, as stipulated in AD 1247. By using DBT as a model formula, we develop a strategy to reveal the complexity of a traditional TCM formula. RESULTS: There are 3 levels of research directions: (i) the preparation of DBT and its rationale behind; (ii) the traditional theory of DBT is elucidated by chemical and biological determinations; and (iii) the action mechanisms of DBT are revealed. CONCLUSION: Through the chemical, biological, genomic and proteomic studies, a possible direction in resolving the preparation mythologies, pharmacological and mechanistic analyses of a TCM decoction is being proposed here.
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Drugs, Chinese Herbal); 0 (danggui buxue decoction)


  5 / 380 MEDLINE  
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PMID:28140733
Autor:Hua Y; Yao W; Ji P; Wei Y
Endereço:a College of Veterinary Medicine , Gansu Agricultural University , Lanzhou , Gansu Province , People's Republic of China.
Título:Integrated metabonomic-proteomic studies on blood enrichment effects of Angelica sinensis on a blood deficiency mice model.
Fonte:Pharm Biol; 55(1):853-863, 2017 Dec.
ISSN:1744-5116
País de publicação:England
Idioma:eng
Resumo:CONTEXT: Angelica sinensis (Oliv.) Diels (Umbelliferae) (AS) is a well-known Traditional Chinese Medicine (TCM) that enriches and regulates the blood. OBJECTIVE: An integrated metabonomic and proteomic method was developed and applied to study the blood enrichment effects and mechanisms of AS on blood deficiency (BD) mouse model. MATERIALS AND METHODS: Forty mice were randomly divided into the control, BD, High-dose of AS (ASH), Middle-dose of AS (ASM), and Low-dose of AS (ASL) groups. BD model mice were established by injecting N-acetylphenylhydrazine (APH) and cyclophosphamide (CTX) (ip). The aqueous extract of AS was administered at three dose of 20, 10, or 5 g/kg b. wt. orally for 7 consecutive days before/after APH and CTX administration. Gas chromatography-mass spectrometry (GC-MS) combined with pattern recognition method and 2D gel electrophoresis (2-DE) proteomics were performed in this study to discover the underlying hematopoietic regulation mechanisms of AS on BD mouse model. RESULTS: Unlike in the control group, the HSP90 and arginase levels increased significantly (p < 0.05) in the BD group, but the levels of carbonic anhydrase, GAPDH, catalase, fibrinogen, GSTP, carboxylesterase and hem binding protein in the BD group decreased significantly (p < 0.05). Unlike the levels in the BD group, the levels of these biomarkers were regulated to a normal state near the control group in the ASM group. Unlike in the control group, l-alanine, arachidonic acid, l-valine, octadecanoic acid, glycine, hexadecanoic acid, l-threonine, butanoic acid, malic acid, l-proline and propanoic acid levels increased significantly (p < 0.05) in the BD group, the levels of d-fructose in the BD group decreased significantly (p < 0.05). The relative concentrations of 12 endogenous metabolites were also significantly affected by the ASL, ASM, and ASH treatments. Notably, most of the altered BD-related metabolites were restored to normal state after ASM administration. CONCLUSION: AS can promote hematopoietic activities, inhibit production of reactive oxygen species, regulate energy metabolism, increase antiapoptosis, and potentially contribute to the blood enrichment effects of AS against APH- and CTX-induced BD mice.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (HSP90 Heat-Shock Proteins); 0 (Plant Extracts)


  6 / 380 MEDLINE  
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PMID:28064055
Autor:Gao Z; Zhang C; Tian W; Liu K; Hou R; Yue C; Wu Y; Wang D; Liu J; Hu Y; Yang Y
Endereço:Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, PR China; Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
Título:The antioxidative and hepatoprotective effects comparison of Chinese angelica polysaccharide(CAP)and selenizing CAP (sCAP) in CCl induced hepatic injury mice.
Fonte:Int J Biol Macromol; 97:46-54, 2017 Apr.
ISSN:1879-0003
País de publicação:Netherlands
Idioma:eng
Resumo:Chinese angelica polysaccharides (CAP) and selenizing CAP (sCAP) were prepared and identified through FTIR and SEM observation. Their antioxidant activities in vitro and hepatoprotective effects in vivo were compared by free radical-scavenging tests or with CCl -induced hepatic injury model mice. The results showed that for DPPH radical, superoxide anion and hydroxyl radical, the scavenging capabilities of sCAP were significantly stronger than those of CAP In hepatic injury model mice, sCAP could significantly reduce ALT, AST and ALP contents and raised TP content in serum, significantly reduce MDA and ROS contents and raised SOD and T-AOC activities in liver homogenate in comparison with CAP; obviously relieve the pathological changes of liver and significantly inhibit the expressions of p-ERK, p-JNK and p-p38 protein as compared with those in model control group. These results indicate that selenylation modification can enhance the antioxidant and hepatoprotective actions of Chinese angelica polysaccharide. A action mechanism of sCAP is suppressing the protein expression of MAPK signaling pathway.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Polysaccharides); CL2T97X0V0 (Carbon Tetrachloride); H6241UJ22B (Selenium)


  7 / 380 MEDLINE  
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PMID:27925507
Autor:Younas F; Aslam B; Muhammad F; Mohsin M; Raza A; Faisal MN; Hassan SU; Majeed W
Endereço:a Institute of Pharmacy, Physiology and Pharmacology , University of Agriculture , Faisalabad , Pakistan.
Título:Haematopoietic effects of Angelica sinensis root cap polysaccharides against lisinopril-induced anaemia in albino rats.
Fonte:Pharm Biol; 55(1):108-113, 2017 Dec.
ISSN:1744-5116
País de publicação:England
Idioma:eng
Resumo:CONTEXT: Angelica sinensis L. (Umbelliferae) has medicinal properties. OBJECTIVES: The present study evaluates the haematopoietic effects of A. sinensis polysaccharides (ASP) against lisinopril-induced anaemia. MATERIALS AND METHODS: Thirty healthy adult male albino rats were randomly divided into five groups (n = 6). Group I was control group. Group II was treated with angiotensin-converting enzyme inhibitor (ACEI, 20 mg/kg/day) to induce anaemia. In group III, erythropoietin (EPO, 100 IU/kg/each) was administered in combination with ACEI. Group IV was treated with ASP (1 g/kg/day), extracted from A. sinensis root caps. In Group V, ASP (1 g/kg/day) was treated with ACEI. After 28 days, blood and tissue samples were collected for haematological and histopathological analysis, respectively. RESULTS: The results showed that ACEI significantly reduced the haemoglobin (Hb, 10.0 g/dL), packed cell volume (PCV, 39.5%), red blood cells (RBCs, 6.2 million/mm ), mean corpuscular volume (MCV, 53.5 fL) and mean corpuscular haemoglobin (MCH, 16.2 pg/cell) values. In the group treated with ASP, the Hb (13.7 g/dL) and RBCs (7.8 million/mm ) increased significantly (p < 0.05). The combination of ASP and ACEI led to the significant (p < 0.05) reduction in Hb (10.7 g/dL), PCV (33.3%), RBCs (6.0 million/mm ), MCV (54.42 fL) and MCH (16.44 pg/cell) values. While histopathological examination of the liver and kidney cells showed a mild degree of toxicity in the ASP-treated group. CONCLUSION: ASP has a potentiating effect on haematological parameters when given alone. However, when administered simultaneously with lisinopril, it showed an unfavourable effect with more complicated anaemia so it should not be used with ACEIs.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE
Nome de substância:0 (Biomarkers); 0 (Hematinics); 0 (Hemoglobins); 0 (Plant Extracts); 0 (Polysaccharides); 11096-26-7 (Erythropoietin); E7199S1YWR (Lisinopril)


  8 / 380 MEDLINE  
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PMID:27919656
Autor:Zhou D; Zhang Y; Jiang Z; Hou Y; Jiao K; Yan C; Li N
Endereço:School of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
Título:Biotransformation of isofraxetin-6-O-ß-d-glucopyranoside by Angelica sinensis (Oliv.) Diels callus.
Fonte:Bioorg Med Chem Lett; 27(2):248-253, 2017 01 15.
ISSN:1464-3405
País de publicação:England
Idioma:eng
Resumo:Isofraxetin-6-O-ß-d-glucopyranoside, identified from traditional medicinal herbal Xanthoceras sorbifolia Bunge, has been demonstrated to be a natural neuroinflammatory inhibitor. In order to obtain more derivatives with potential anti-neuroinflammatory effects, biotransformation was carried out. According to the characteristics of coumarin skeleton, suspension cultures of Angelica sinensis (Oliv.) Diels callus (A. sinensis callus) were employed because of the presence of diverse phenylpropanoids biosynthetic enzymes. As a result, 15 products were yielded from the suspension cultures, including a new coumarin: 8'-dehydroxymethyl cleomiscosin A (1), together with 14 known compounds. Their structures were elucidated by extensive spectroscopic analysis. Furthermore, the biotransformed pathways were discussed. Among them, compound 13 was transformed from isofraxetin-6-O-ß-d-glucopyranoside, while compounds 1-6, 10-12, 14-15 were derived from the culture medium stimulated by the substrate. The biotransformation processes include hydroxylation, oxidation and esterification. Furthermore, their inhibitory effects on lipopolysaccharide (LPS)-activated nitric oxide (NO) production were evaluated in BV2 microglial cells. It is worth noting that, 1, 1'-methanediylbis(4-methoxybenzene) (3), obtucarbamates A (5), 2-nonyl-4-hydroxyquinoline N-oxide (10) and 1H-indole-3-carbaldehyde (11) exhibited significant inhibitory effect against neuroinflammation with IC values at 1.22, 10.57, 1.02 and 0.76µM respectively, much stronger than that of the positive control minocycline (IC 35.82µM).
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Coumarins); 0 (Glucosides); 0 (Lipopolysaccharides); 0 (isofraxetin-6-O-glucopyranoside); 31C4KY9ESH (Nitric Oxide)


  9 / 380 MEDLINE  
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PMID:27838456
Autor:Zhong T; Zhang H; Duan X; Hu J; Wang L; Li L; Zhang H; Niu L
Endereço:Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Título:Anti-obesity effect of radix Angelica sinensis and candidate causative genes in transcriptome analyses of adipose tissues in high-fat diet-induced mice.
Fonte:Gene; 599:92-98, 2017 Jan 30.
ISSN:1879-0038
País de publicação:Netherlands
Idioma:eng
Resumo:We have previously reported that radix Angelica sinensis (RAS) suppressed body weight and altered the expression of the fat mass and obesity associated (FTO) gene in mice with high fat diet (HFD)-induced obesity. In the present study we performed RNA sequencing-mediated transcriptome analysis to elucidate the molecular mechanisms underlying the anti-obesogenic effects of RAS in mice. The results revealed that 36 differentially-expressed genes (DEGs) were identified in adipose tissues from the RAS supplementation group (DH) and control group (HC). These 36 DEGs were clustered into 297 functional gene ontology (GO) categories, among which several GO annotations and signaling pathways were associated with lipid homeostasis. Six out of the 36 DEGs were identified to be involved in lipid metabolism, with the APOA2 gene a potential anti-obesogenic influence. The expression pattern revealed by RNA-Seq was identical to the results of quantitative real-time PCR (qPCR). Therefore, RAS supplementation in HFD-induced obese mice was associated with an anti-obesogenic global transcriptomic response. This study provides insight into potential applications of RAS in obesity therapy.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Obesity Agents); 0 (Drugs, Chinese Herbal); 0 (RNA, Messenger); 0 (angelicae sinensis extract)


  10 / 380 MEDLINE  
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PMID:27824860
Autor:Gong AG; Huang VY; Wang HY; Lin HQ; Dong TT; Tsim KW
Endereço:Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Título:Ferulic Acid Orchestrates Anti-Oxidative Properties of Danggui Buxue Tang, an Ancient Herbal Decoction: Elucidation by Chemical Knock-Out Approach.
Fonte:PLoS One; 11(11):e0165486, 2016.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:Ferulic acid, a phenolic acid derived mainly from a Chinese herb Angelica Sinensis Radix (ASR), was reported to reduce the formation of free radicals. Danggui Buxue Tang (DBT), a herbal decoction composing of Astragali Radix (AR) and ASR, has been utilized for more than 800 years in China having known anti-oxidative property. Ferulic acid is a major active ingredient in DBT; however, the role of ferulic acid within the herbal mixture has not been resolved. In order to elucidate the function of ferulic acid within this herbal decoction, a ferulic acid-depleted herbal decoction was created and named as DBTΔfa. The anti-oxidative properties of chemically modified DBT decoction were systemically compared in cultured H9C2 rat cardiomyoblast cell line. The application of DBT and DBTΔfa into the cultures showed functions in (i) decreasing the reactive oxygen species (ROS) formation, detected by laser confocal; (ii) increasing of the activation of Akt; (iii) increasing the transcriptional activity of anti-oxidant response element (ARE); and (iv) increasing the expressions of anti-oxidant enzymes, i.e. NQO1 and GCLM. In all scenario, the aforementioned anti-oxidative properties of DBTΔfa in H9C2 cells were significantly reduced, as compared to authentic DBT. Thus, ferulic acid could be an indispensable chemical in DBT to orchestrate multi-components of DBT as to achieve maximal anti-oxidative functions.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Coumaric Acids); 0 (Drugs, Chinese Herbal); 0 (Reactive Oxygen Species); 0 (danggui buxue decoction); AVM951ZWST (ferulic acid)



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