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  1 / 281 MEDLINE  
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PMID:28764778
Autor:Naidoo DB; Chuturgoon AA; Phulukdaree A; Guruprasad KP; Satyamoorthy K; Sewram V
Endereço:Discipline of Medical Biochemistry, Faculty of Health Sciences, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4013, South Africa.
Título:Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's).
Fonte:BMC Complement Altern Med; 17(1):377, 2017 Aug 01.
ISSN:1472-6882
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Cancer cachexia is associated with increased pro-inflammatory cytokine levels. Centella asiatica (C. asiatica) possesses antioxidant, anti-inflammatory and anti-tumour potential. We investigated the modulation of antioxidants, cytokines and cell death by C. asiatica ethanolic leaf extract (C ) in leukaemic THP-1 cells and normal peripheral blood mononuclear cells (PBMC's). METHODS: Cytotoxcity of C was determined at 24 and 72 h (h). Oxidant scavenging activity of C was evaluated using the 2, 2-diphenyl-1 picrylhydrazyl (DPPH) assay. Glutathione (GSH) levels, caspase (-8, -9, -3/7) activities and adenosine triphosphate (ATP) levels (Luminometry) were then assayed. The levels of tumour necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1ß and IL-10 were also assessed using enzyme-linked immunosorbant assay. RESULTS: C decreased PBMC viability between 33.25-74.55% (24 h: 0.2-0.8 mg/ml C and 72 h: 0.4-0.8 mg/ml C ) and THP-1 viability by 28.404% (72 h: 0.8 mg/ml C ) (p < 0.0001). Oxidant scavenging activity was increased by C (0.05-0.8 mg/ml) (p < 0.0001). PBMC TNF-α and IL-10 levels were decreased by C (0.05-0.8 mg/ml) (p < 0.0001). However, PBMC IL-6 and IL-1ß concentrations were increased at 0.05-0.2 mg/ml C but decreased at 0.4 mg/ml C (p < 0.0001). In THP-1 cells, C (0.2-0.8 mg/ml) decreased IL-1ß and IL-6 whereas increased IL-10 levels (p < 0.0001). In both cell lines, C (0.05-0.2 mg/ml, 24 and 72 h) increased GSH concentrations (p < 0.0001). At 24 h, caspase (-9, -3/7) activities was increased by C (0.05-0.8 mg/ml) in PBMC's whereas decreased by C (0.2-0.4 mg/ml) in THP-1 cells (p < 0.0001). At 72 h, C (0.05-0.8 mg/ml) decreased caspase (-9, -3/7) activities and ATP levels in both cell lines (p < 0.0001). CONCLUSION: In PBMC's and THP-1 cells, C proved to effectively modulate antioxidant activity, inflammatory cytokines and cell death. In THP-1 cells, C decreased pro-inflammatory cytokine levels whereas it increased anti-inflammatory cytokine levels which may alleviate cancer cachexia.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Centella asiatica extract); 0 (Cytokines); 0 (Oxidants); 0 (Triterpenes); 8L70Q75FXE (Adenosine Triphosphate); EC 3.4.22.- (Caspases)


  2 / 281 MEDLINE  
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PMID:28490089
Autor:Ngamwonglumlert L; Devahastin S; Chiewchan N
Endereço:Advanced Food Processing Research Laboratory, Department of Food Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, 126 Pracha u-tid Road, Tungkru, Bangkok 10140, Thailand. Electronic address: solu_ping@yahoo.com.
Título:Molecular structure, stability and cytotoxicity of natural green colorants produced from Centella asiatica L. leaves treated by steaming and metal complexations.
Fonte:Food Chem; 232:387-394, 2017 Oct 01.
ISSN:0308-8146
País de publicação:England
Idioma:eng
Resumo:Stability of extracts from Centella asiatica L. leaves treated by steaming and metal-chlorophylls complexations against combined acid-heat was compared with that from untreated leaves and synthetic colorant. Formation of metal-chlorophylls complexes was confirmed by FTIR spectroscopy. Molecular structure changes during stability test and cytotoxicity of the extracts against Vero cells were evaluated. Utilization of the extracts as colorant was also assessed in selected beverage ingredient and food. Copper-chlorophylls extracts exhibited similar green hue to those from untreated and steamed leaves, while zinc-chlorophylls extracts exhibited yellow-green color. Metal-chlorophylls extracts possessed higher stability against combined acid-heat than those from untreated and steamed leaves. Use of metal-chlorophylls extracts in beverage ingredient led to increased hue value due to their structural rearrangement, which was confirmed by changes in Q band of VIS spectra. Cytotoxicity of zinc- and copper-chlorophylls extracts was slightly different and higher than those of extracts from untreated/steamed leaves and synthetic colorant.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Metals); 0 (Pigments, Biological); 0 (Plant Extracts)


  3 / 281 MEDLINE  
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PMID:28342050
Autor:Basílico G; Magdaleno A; Paz M; Moretton J; Faggi A; de Cabo L
Endereço:Museo Argentino de Ciencias Naturales "Bernardino Rivadavia" - Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Ángel Gallardo 470, C1405DJR, Ciudad Autónoma de Buenos Aires, Argentina. gabrielomarbasilico@hotmail.com.
Título:Sewage pollution: genotoxicity assessment and phytoremediation of nutrients excess with Hydrocotyle ranunculoides.
Fonte:Environ Monit Assess; 189(4):182, 2017 Apr.
ISSN:1573-2959
País de publicação:Netherlands
Idioma:eng
Resumo:The discharge of sewage effluents into low-order streams has negative effects on water quality. Macrophytes can be efficient in the treatment of this wastewater due to the removal of the main pollutants. The genotoxicity of sewage-polluted water discharging into La Choza stream was evaluated by testing with Allium cepa. Also, a phytoremediation assay with continuous recirculation of the residual water was conducted for 12 days. Three treatments were carried out. One treatment (Hr) was performed with a macrophyte (Hydrocotyle ranunculoides), and two treatments were conducted without macrophytes: with lighting (Ai) and without lighting (Ao). The wastewater was toxic according to all the evaluated indexes (mitotic index, frequency of chromosomal aberrations and micronucleus). High concentrations of ammonium, dissolved inorganic nitrogen (DIN), total (TP) and soluble reactive phosphorous (SRP) and indicators of faecal contamination were determined in the wastewater. The ammonium, DIN, SRP and TP loads at the end of the assay were significantly lower in the treatments with light (Hr and Ai). So, the nutrient removal was due to their absorption and adsorption by the periphyton and H. ranunculoides. Our results lead us to recommend the maintenance and planting of macrophytes in lowland streams subject to sewage pollution.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Sewage); 0 (Water Pollutants, Chemical); 27YLU75U4W (Phosphorus); N762921K75 (Nitrogen)


  4 / 281 MEDLINE  
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PMID:28289808
Autor:Kumwimba MN; Zhu B
Endereço:Key Laboratory of Mountain Surface Processes and Ecological Regulation, Chinese Academy of Sciences, #.9, Block 4, Ren min nan Road, Chengdu, 610041, People's Republic of China.
Título:Effectiveness of Vegetated Drainage Ditches for Domestic Sewage Effluent Mitigation.
Fonte:Bull Environ Contam Toxicol; 98(5):682-689, 2017 May.
ISSN:1432-0800
País de publicação:United States
Idioma:eng
Resumo:Plant species have an important role in eco-ditches; however, the Michaelis-Menten kinetic parameters of nutrient uptake, growth rate and purification efficiency of ditch plants and their influences on domestic sewage treatment efficiency are still unclear. Growth rates of all nine species, but especially Lemna gibba, Cladophora and Myriophyllum verticillatum were best in undiluted domestic sewage as opposed to a mixture of domestic sewage. Performance of species to accumulate nutrients was not only species-specific, but was also affected by both sewage treatments. Removal efficiency of nutrients was dependent on both plant species and treatment. Uptake kinetic parameters were significantly affected by both nutrient form and plant species. The maximum uptake rate (Vmax) of NH -N was higher than NO -N. Similarly, Km values for NH -N were greater than NO -N. These results could be used to identify plants for sewage treatment efficiency and enhance water quality in eco-ditch treatment systems.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Ammonium Compounds); 0 (Nitrates); 0 (Sewage); 27YLU75U4W (Phosphorus); N762921K75 (Nitrogen)


  5 / 281 MEDLINE  
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PMID:28279707
Autor:Gray NE; Zweig JA; Murchison C; Caruso M; Matthews DG; Kawamoto C; Harris CJ; Quinn JF; Soumyanath A
Endereço:Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA. Electronic address: grayn@ohsu.edu.
Título:Centella asiatica attenuates Aß-induced neurodegenerative spine loss and dendritic simplification.
Fonte:Neurosci Lett; 646:24-29, 2017 Apr 12.
ISSN:1872-7972
País de publicação:Ireland
Idioma:eng
Resumo:The medicinal plant Centella asiatica has long been used to improve memory and cognitive function. We have previously shown that a water extract from the plant (CAW) is neuroprotective against the deleterious cognitive effects of amyloid-ß (Aß) exposure in a mouse model of Alzheimer's disease, and improves learning and memory in healthy aged mice as well. This study explores the physiological underpinnings of those effects by examining how CAW, as well as chemical compounds found within the extract, modulate synaptic health in Aß-exposed neurons. Hippocampal neurons from amyloid precursor protein over-expressing Tg2576 mice and their wild-type (WT) littermates were used to investigate the effect of CAW and various compounds found within the extract on Aß-induced dendritic simplification and synaptic loss. CAW enhanced arborization and spine densities in WT neurons and prevented the diminished outgrowth of dendrites and loss of spines caused by Aß exposure in Tg2576 neurons. Triterpene compounds present in CAW were found to similarly improve arborization although they did not affect spine density. In contrast caffeoylquinic acid (CQA) compounds from CAW were able to modulate both of these endpoints, although there was specificity as to which CQAs mediated which effect. These data suggest that CAW, and several of the compounds found therein, can improve dendritic arborization and synaptic differentiation in the context of Aß exposure which may underlie the cognitive improvement observed in response to the extract in vivo. Additionally, since CAW, and its constituent compounds, also improved these endpoints in WT neurons, these results may point to a broader therapeutic utility of the extract beyond Alzheimer's disease.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Amyloid beta-Peptides)


  6 / 281 MEDLINE  
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PMID:28248871
Autor:Saeidinia A; Keihanian F; Lashkari AP; Lahiji HG; Mobayyen M; Heidarzade A; Golchai J
Endereço:aMedicinal Plants Research Center of Student Basij, Guilan University of Medical Sciences, Rasht bCardiology Department & Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad cPharmacognosy Department and Research and Development Center of Plants and Medicinal Chemistry dFellowship of Burn Surgery, Velayat Hospital eSocial Medicine Department fDermatology Department, Guilan University of Medical Sciences, Rasht, Iran.
Título:Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm.
Fonte:Medicine (Baltimore); 96(9):e6168, 2017 Mar.
ISSN:1536-5964
País de publicação:United States
Idioma:eng
Resumo:BACKGROUND: Burns are common event and associated with a high incidence of death, disability, and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. On the basis of previous studies, we compared the efficacy of Centiderm versus silver sulfadiazine (SSD) in partial thickness burning patients. METHODS: Study population comprised burn victims referred to Velayat Burning Hospital at Rasht, Iran. The intervention group received Centiderm and control group SSD cream. Burn wounds were treated once daily at home. All of the wounds were evaluated till complete healing occurred and at the admission, days 3, 7, 14 objective signs; visual acuity score (VAS) and subjective signs were recorded. Re-epithelialization time and complete healing days were recorded. We used random fixed block for randomization. The randomization sequence was created using the computer. Patients and burning specialist physician were blinded. RESULTS: Seventy-five patients randomized into 2 groups; (40 patients: Centiderm group; 35 patients: SSD group). The mean age of them was 30.67 ±â€Š9.91 years and 19 of them were male (31.7%). Thirty patients in Centiderm and 30 patients in SSD group were analyzed. All of objective and subjective signs and mean of re-epithelialization and complete healing were significantly better in Centiderm group rather than SSD group (P < 0.05). There was no infection in Centiderm group. CONCLUSIONS: We showed that use of Centiderm ointment not only improved the objective and subjective signs in less than 3 days, but also the re-epithelialization and complete healing rather than SSD without any infection in the subjects.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
Nome de substância:0 (Anti-Infective Agents, Local); 0 (Centella asiatica extract); 0 (Triterpenes); W46JY43EJR (Silver Sulfadiazine)


  7 / 281 MEDLINE  
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PMID:27992940
Autor:Anukunwithaya T; Tantisira MH; Tantisira B; Khemawoot P
Endereço:Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Título:Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats.
Fonte:Planta Med; 83(8):710-717, 2017 May.
ISSN:1439-0221
País de publicação:Germany
Idioma:eng
Resumo:ECa 233, a standardized extract of , has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intravenously or orally administered at doses from 50 to 200 mg/kg. Plasma, tissues, urine, and feces were collected at time points from 0 to 48 h after dosing. The levels of madecassoside and asiaticoside, as well as their postulated triterpenic metabolites, madecassic acid and asiatic acid, in biological samples, were simultaneously measured by liquid chromatography-tandem mass spectrometry. The results showed that all animals had a good tolerability for ECa 233, whereas madecassic and asiatic acids were found in negligible amounts after pharmacokinetic assessment. Madecassoside and asiaticoside demonstrated rather similar absorption and tissue distribution profiles. They were rapidly absorbed, reaching maximum levels within 5-15 min after oral administration, but they had poor oral bioavailability, less than 1 %. Both triterpenoids were extensively distributed in the brain, stomach, and skin within 1 h and remained there for at least 4 h after dosing. Madecassoside and asiaticoside in ECa 233 were mainly excreted as an unchanged form after being injected, and exclusively as triterpenic acid metabolites in feces after oral administration. The pharmacokinetic results obtained could provide some guidance for an appropriate dosing regimen of ECa 233 in future studies. This study also provided the first evidence demonstrating the presence of madecassoside and asiaticoside in their target tissues.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (ECa 233 extract); 0 (Plant Extracts); 0 (Triterpenes); CQ2F5O6YIY (madecassoside); PKO39VY215 (asiaticoside)


  8 / 281 MEDLINE  
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PMID:27068291
Autor:Prasad A; Prakash O; Mehrotra S; Khan F; Mathur AK; Mathur A
Endereço:Division of Plant Biotechnology, CSIR-Central Institute of Medicinal & Aromatic Plants (CSIR-CIMAP); PO CIMAP, Lucknow, 226015, India.
Título:Artificial neural network-based model for the prediction of optimal growth and culture conditions for maximum biomass accumulation in multiple shoot cultures of Centella asiatica.
Fonte:Protoplasma; 254(1):335-341, 2017 Jan.
ISSN:1615-6102
País de publicação:Austria
Idioma:eng
Resumo:An artificial neural network (ANN)-based modelling approach is used to determine the synergistic effect of five major components of growth medium (Mg, Cu, Zn, nitrate and sucrose) on improved in vitro biomass yield in multiple shoot cultures of Centella asiatica. The back propagation neural network (BPNN) was employed to predict optimal biomass accumulation in terms of growth index over a defined culture duration of 35 days. The four variable concentrations of five media components, i.e. MgSO (0, 0.75, 1.5, 3.0 mM), ZnSO (0, 15, 30, 60 µM), CuSO (0, 0.05, 0.1, 0.2 µM), NO (20, 30, 40, 60 mM) and sucrose (1, 3, 5, 7 %, w/v) were taken as inputs for the ANN model. The designed model was evaluated by performing three different sets of validation experiments that indicated a greater similarity between the target and predicted dataset. The results of the modelling experiment suggested that 1.5 mM Mg, 30 µM Zn, 0.1 µM Cu, 40 mM NO and 6 % (w/v) sucrose were the respective optimal concentrations of the tested medium components for achieving maximum growth index of 1654.46 with high centelloside yield (62.37 mg DW/culture) in the cultured multiple shoots. This study can facilitate the generation of higher biomass of uniform, clean, good quality C. asiatica herb that can efficiently be utilized by pharmaceutical industries.
Tipo de publicação: JOURNAL ARTICLE


  9 / 281 MEDLINE  
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PMID:27030208
Autor:Kar A; Pandit S; Mukherjee K; Bahadur S; Mukherjee PK
Endereço:School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India.
Título:Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study.
Fonte:J Sci Food Agric; 97(1):333-340, 2017 Jan.
ISSN:1097-0010
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Andrographis paniculata, Bacopa monnieri and Centella asiatica are mentioned in Ayurveda for the management of neurodegenerative disorders. These plants and their phytomolecules, such as andrographolide, bacoside A and asiaticoside, were studied for their inhibition potential on pooled CYP450 as well as human CYP3A4, CYP2D6, CYP2C9 and CYP1A2 by CYP-CO complex assay and fluorogenic assay respectively followed by IC determination. Quantification of bioactive compounds present in the extracts was done by RP-HPLC. Heavy metal content in the selected medicinal plants was determined by atomic absorption spectroscopy. RESULT: CYP-CO complex assay indicated significantly less inhibition potential than standard inhibitor (P < 0.05 and above). A. paniculata showed highest inhibitory activity against CYP3A4 and CYP2D6 (IC = 63.06 ± 1.35 µg mL ; 88.80 ± 3.32 µg mL ), whereas C. asiatica and B. monnieri showed least inhibitory activity against CYP1A2 (IC = 288.83 ± 1.61 µg mL ) and CYP2C9 (184.68 ± 3.79 µg mL ), respectively. In all cases the extract showed higher inhibition than the single bioactive compounds. The heavy metals content in the plant extracts were within the permissible limits. CONCLUSION: The findings suggested that selected food plants and bioactive compounds contributed negligible interaction potential with CYP isozymes and may not possess any harmful effect with regard to their therapeutic application. © 2016 Society of Chemical Industry.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Cytochrome P-450 Enzyme Inhibitors); 0 (Diterpenes); 0 (Metals, Heavy); 0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes); 0 (bacoside A); 410105JHGR (andrographolide); PKO39VY215 (asiaticoside)


  10 / 281 MEDLINE  
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PMID:28375122
Autor:Li SQ; Xie YS; Meng QW; Zhang J; Zhang T
Endereço:Department of Neurology, Qian Foshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Título:Neuroprotective properties of Madecassoside from Centella asiatica after hypoxic-ischemic injury.
Fonte:Pak J Pharm Sci; 29(6):2047-2051, 2016 Nov.
ISSN:1011-601X
País de publicação:Pakistan
Idioma:eng
Resumo:Madecassoside is one of increasingly used constituent of Centella asiatica, a frequently prescribed crude drug in South eastern Asia and China for wound healing. In the present experiment, it exposes the neuroprotective nature of Madecassoside in GT1-7 cell lines, further, which the antioxidant activities are performed. The cellular toxicity was assessed using 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay with increased cell viability with IC 2.5µg/ml. the regulation of antioxidant levels showed changes in madecassoside treated cell lysate viz., SOD assay. Also, the antioxidative assays confirmed the negligible cellular damage caused to the GT1-7 cell lines. Hence, the results advocate that the current antioxidant and antitumor activity be justified by the high concentration of phenolic constituents, primarily the triterpene present in the C. asiatica.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Centella asiatica extract); 0 (Neuroprotective Agents); 0 (Picrates); 0 (Triterpenes); CQ2F5O6YIY (madecassoside); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 1.15.1.1 (Superoxide Dismutase)



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