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Pesquisa : B01.650.940.800.575.912.250.075.300 [Categoria DeCS]
Referências encontradas : 266 [refinar]
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  1 / 266 MEDLINE  
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PMID:29273556
Autor:Sobhani Najafabadi A; Naghavi MR
Endereço:Agricultural Biotechnology Research Institute of Iran - Isfahan Branch, Agricultural Research, Education and Extension Organization (AREEO), P.O. Box: 85135-487, Isfahan, Iran. Electronic address: ahmad.sobhani@ut.ac.ir.
Título:Mining Ferula gummosa transcriptome to identify miRNAs involved in the regulation and biosynthesis of terpenes.
Fonte:Gene; 645:41-47, 2018 Mar 01.
ISSN:1879-0038
País de publicação:Netherlands
Idioma:eng
Resumo:Ferula gummosa is a well-known medicinal and industrial plant for its oleo-gum-resin named galbanum. So far, there is no information about the role of miRNAs on the production of terpenes as the major secondary metabolite of galbanum. In the present study, RNA-seq data on the root and flower of the plant were used to predict miRNAs and their targets using computational approaches. Additionally, biological network analyses were used to unravel the direct or indirect regulatory effects of miRNAs on the targets involved in terpene biosynthesis. For the first time, 220 miRNAs from 94 families have been reported in F. gummosa. miR5658, miR1533, miR5021, miR414, and miR1436 are the top five miRNAs with high abundance. Gene ontology (GO) analysis of the identified targets showed that in the biological process category, the miRNA-regulated genes were highly involved in transcription. According to the KEGG and PlantCyc results, six miRNAs from five miRNA families including miR2919, miR5251, miR838, miR5021, and miR5658 were found to be related to the pathway of terpene biosynthesis. Moreover, network analysis showed that three terpene-regulating TFs namely SPL7, SPL11, and ATHB13 are putatively regulated by three miRNAs including miR1533, miR5021, and miR5658 respectively. Differential gene expression results showed that the expression levels of these miRNAs are negatively correlated to the expression levels of both TFs and their co-expressed terpene biosynthesis genes.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (MicroRNAs); 0 (Plant Proteins); 0 (RNA, Plant); 0 (Terpenes); 0 (Transcription Factors)


  2 / 266 MEDLINE  
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PMID:28423422
Autor:Sadeghi R; Hadizadeh Raeisi N; Jamshidnia A
Endereço:Department of Entomology and Plant Pathology, College of Aburaihan, University of Tehran, Iran.
Título:Immunological Responses of Sesamia cretica to Ferula ovina Essential Oil.
Fonte:J Insect Sci; 17(1), 2017 Jan 01.
ISSN:1536-2442
País de publicação:United States
Idioma:eng
Resumo:The current research was performed aiming to investigate the effects of Ferula ovina essential oil on the fourth instar larval hemogram of Sesamia cretica. Four main sorts of circulating hemocytes, including prohemocytes, plasmatocytes, granulocytes (GRs), and oenocytoides, were identified in the fourth instar larvae. Treatment of the larvae with the concentration of 1000 ppm of the essential oil led to an enhancement of the total hemocyte and GR count followed by a dose-dependent decrease at the concentrations of 2500 and 7000 ppm. Plasmatocyte numbers declined in all the treatments with more significant effects at increased doses. The greatest numbers of GRs, plasmatocytes, and total hemocytes were found after 48 h of treatment. The highest phenol-oxidase activity was recorded 12 h after treatment at the concentration of 2500 ppm. The highest effect on nodule formation was exerted by the concentration of 7000 ppm 12 h after treatment. The results of the present study clearly indicated that the treatment of larvae by the essential oil of F. ovina decreased the numbers of total and differential hemocyte counts although phenol-oxidase activity and the number of nodules showed no decline in the treated larvae. These results demonstrated that Ferula ovina essential oil has a significant effect on the immune ability of the studied insect and can be useful and usable for future research to practical management of this pest.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Insect Proteins); 0 (Oils, Volatile); EC 1.14.18.1 (Monophenol Monooxygenase)


  3 / 266 MEDLINE  
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PMID:28258152
Autor:Özek G; Schepetkin IA; Utegenova GA; Kirpotina LN; Andrei SR; Özek T; Baser KHC; Abidkulova KT; Kushnarenko SV; Khlebnikov AI; Damron DS; Quinn MT
Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Título:Chemical composition and phagocyte immunomodulatory activity of essential oils.
Fonte:J Leukoc Biol; 101(6):1361-1371, 2017 Jun.
ISSN:1938-3673
País de publicação:United States
Idioma:eng
Resumo:Essential oil extracts from have been used traditionally in Kazakhstan for treatment of inflammation and other illnesses. Because little is known about the biologic activity of these essential oils that contributes to their therapeutic properties, we analyzed their chemical composition and evaluated their phagocyte immunomodulatory activity. The main components of the extracted essential oils were ( )-propenyl -butyl disulfide (15.7-39.4%) and ( )-propenyl -butyl disulfide (23.4-45.0%). essential oils stimulated [Ca ] mobilization in human neutrophils and activated ROS production in human neutrophils and murine bone marrow phagocytes. Activation of human neutrophil [Ca ] flux by essential oils was dose-dependently inhibited by capsazepine, a TRPV1 channel antagonist, indicating that TRPV1 channels mediate this response. Furthermore, essential oils stimulated Ca influx in TRPV1 channel-transfected HEK293 cells and desensitized the capsaicin-induced response in these cells. Additional molecular modeling with known TRPV1 channel agonists suggested that the active component is likely to be ( )-propenyl -butyl disulfide. Our results provide a cellular and molecular basis to explain at least part of the beneficial therapeutic properties of FEOs.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Oils, Volatile); 0 (TRPV Cation Channels); SY7Q814VUP (Calcium)


  4 / 266 MEDLINE  
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PMID:27886594
Autor:Ahmadi F; Shokoohinia Y; Javaheri S; Azizian H
Endereço:Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran. Electronic address: fahmadi@kums.ac.ir.
Título:Proposed binding mechanism of galbanic acid extracted from Ferula assa-foetida to DNA.
Fonte:J Photochem Photobiol B; 166:63-73, 2017 Jan.
ISSN:1873-2682
País de publicação:Switzerland
Idioma:eng
Resumo:Recently, galbanic acid (GA), a sesquiterpenoid coumarin, has been introduced as an apoptotic and geno/cytotoxicity agent. In the present study, GA has been extracted from Ferula assa-foetida, a native medicinal plant in Iran, and characterized by H NMR, mass spectroscopy. Additionally, spectroscopic studies have been performed in order to investigate its DNA-interaction mode. The electrochemical behavior of GA has been studied by cyclic voltammetry (CV) in various scan rates. In neutral media (pH=7.3) one irreversible cathodic peak was obtained at -1.46 V, while in higher scan rates an irreversible one was determined at -1.67 V. According to the voltametric data GA can be easily reduced by 2e /2H mechanism at hanging mercury drop electrode (HMDE). The interaction of GA with ct-DNA was evaluated by CV, differential pulse voltammetry (DPV), enhancement fluorescence, UV-Vis, FT-IR spectroscopy and molecular docking. The molecular docking study shows that the GA interacts to DNA on partial intercalation mode via DNA groove binding and forms a complex by van der Waals and electroastatic interactions. In addition, the thermodynamic parameters of GA-DNA complex were investigated with ΔH°, ΔS° and ΔG° values of 15.81KJmol , 133.95Jmol and -23.10KJmol , respectively. All data revealed that the GA is binding to DNA by van der Waals and electrostatic interactions through the partial intercalations from the DNA's grooves.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Coumarins); 9007-49-2 (DNA); 9OFS0HWC92 (galbanic acid)


  5 / 266 MEDLINE  
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PMID:27638478
Autor:Znati M; Filali I; Jabrane A; Casanova J; Bouajila J; Ben Jannet H
Endereço:Laboratory Heterocyclic Chemistry, Natural Products and é (LR11SE39), Team: Medicinal Chemistry and Natural Products and Reactivity, Faculty of Science of Monastir, University of Monastir, 5019, Monastir, Tunisia.
Título:Chemical Composition and In Vitro Evaluation of Antimicrobial, Antioxidant and Antigerminative Properties of the Seed Oil from the Tunisian Endemic Ferula tunetana Pomel ex Batt.
Fonte:Chem Biodivers; 14(1), 2017 Jan.
ISSN:1612-1880
País de publicação:Switzerland
Idioma:eng
Resumo:Essential oil of the seeds from the endemic Tunisian plant Ferula tunetana Pomel ex Batt. was analyzed for its chemical composition and screened for its antimicrobial, antioxidant and antigerminative properties. The chemical composition of the isolated oil is reported for the first time. According to the GC/FID, GC/MS and C-NMR analysis results; 18 compounds were identified accounting for 84.6% of the total oil. The chemical composition of this essential oil was characterized by the presence of a high proportion of monoterpene hydrocarbons (77.3%) followed by oxygenated sesquiterpenes (4.1%) and sesquiterpene hydrocarbons (3.2%). α-Pinene (39.8%), ß-pinene (11.5%) and (Z)-ß-ocimene (7.5%) were the predominant compounds. Moreover, the isolated oil was tested for its antimicrobial activity using the disc-diffusion and the microdilution assays against six Gram-positive and five Gram-negative bacteria as well as towards two Candida species. The isolated oil was tested also for its antioxidant activity against DPPH, ABTS, O2∙ and hydrogen peroxide (H O ), and for its antigerminative potential. It was found that it exhibited interesting antimicrobial activity against Salmonella typhimurium LT2 DT104 (inhibition zone (IZ) 16.2 ± 1.0 mm) and Bacillus cereus ATCC 14579 (IZ 15.8 ± 1.0 mm). However, it exerted a moderate antioxidant activity against H O (IC 78.2 ± 2.98 µg/ml) and towards O2∙ (IC 89.2 ± 3.82 µg/ml). The antigerminative effect of this oil was also evaluated in this work. Results showed a toxic effect.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Plant Oils); 0 (Terpenes)


  6 / 266 MEDLINE  
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PMID:27420353
Autor:Xing Y; Li N; Zhou D; Chen G; Jiao K; Wang W; Si Y; Hou Y
Endereço:School of Traditional Chinese Materia Medica 49﹟, Shenyang Pharmaceutical University, Shenyang, China.
Título:Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors.
Fonte:Planta Med; 83(1-02):135-142, 2017 Jan.
ISSN:1439-0221
País de publicação:Germany
Idioma:eng
Resumo:Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer's disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identified sixteen bioactive sesquiterpene coumarins (two new and fourteen known ones) in the effective extract of . Further, the anti-neuroinflammatory activities in BV-2 microglial cells were evaluated by monitoring LPS-induced nitric oxide production. In conclusion, the major constituent, (3' , 5' , 8' , 9' , 10' )-kellerin (1.5 %, w/w), should be responsible for the anti-neuroinflammatory effect exhibited by Awei. Furthermore, it might be a potential natural therapeutic agent for Alzheimer's disease. The research indicated moreover, that its primary mechanism is the inhibition of mRNA expression of the inflammatory cytokines nitric oxide, tumor necrosis factor-α, cyclooxygenase-2, interleukin-6 and interleukin-1 .
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Coumarins); 0 (Cytokines); 0 (Lipopolysaccharides); 0 (Neuroprotective Agents); 0 (RNA, Messenger); 0 (Resins, Plant); 0 (Sesquiterpenes); 31C4KY9ESH (Nitric Oxide)


  7 / 266 MEDLINE  
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PMID:27586050
Autor:Schepetkin IA; Kushnarenko SV; Özek G; Kirpotina LN; Sinharoy P; Utegenova GA; Abidkulova KT; Özek T; Baser KH; Kovrizhina AR; Khlebnikov AI; Damron DS; Quinn MT
Endereço:Department of Microbiology and Immunology, Montana State University , Bozeman, Montana 59717, United States.
Título:Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents.
Fonte:J Agric Food Chem; 64(38):7156-70, 2016 Sep 28.
ISSN:1520-5118
País de publicação:United States
Idioma:eng
Resumo:Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, ß-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, ß-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca(2+)]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 µM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 µM). In addition, treatment of neutrophils with ß-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis. The effects of ß-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca(2+)]i flux were inhibited by transient receptor potential (TRP) channel blockers. Furthermore, the most potent compound, geranylacetone, activated Ca(2+) influx in TRPV1-transfected HEK293 cells. In contrast, myristicin inhibited neutrophil [Ca(2+)]i flux stimulated by fMLF and IL-8 and inhibited capsaicin-induced Ca(2+) influx in TRPV1-transfected HEK293 cells. These findings, as well as pharmacophore modeling of TRP agonists, suggest that geranylacetone is a TRPV1 agonist, whereas myristicin is a TRPV1 antagonist. Thus, at least part of the medicinal properties of Ferula essential oils may be due to modulatory effects on TRP channels.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Aldehydes); 0 (Bornanes); 0 (Immunologic Factors); 0 (Interleukin-8); 0 (Oils, Volatile); 0 (Plant Oils); 0 (TRPV Cation Channels); 0 (TRPV1 protein, human); 0 (Terpenes); 0 (Transient Receptor Potential Channels); 2463-53-8 (2-nonenal); 54T6CCU09Z (pichtosin); 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine); 59881-08-2 (methionyl-leucyl-phenylalanine); 9B7RY79U9Z (geranylacetone); S07O44R1ZM (Capsaicin)


  8 / 266 MEDLINE  
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PMID:27463028
Autor:Aldaghi L; Rad A; Arab A; Kasaian J; Iranshahi M; Sadr AS; Soltani F
Endereço:Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Título:In Silico and In Vitro Evaluation of Cytotoxic Activities of Farnesiferol C and Microlobin on MCF-7, HeLa and KYSE Cell Lines.
Fonte:Drug Res (Stuttg); 66(10):532-538, 2016 Oct.
ISSN:2194-9387
País de publicação:Germany
Idioma:eng
Resumo:Cancer is one of the leading causes of death worldwide. Despite certain advances in cancer therapy, still there is considerable demand for developing efficient therapeutic agents. Nowadays, there is a rising interest in the use of natural-based anti-cancer drugs. In this study, the cytotoxicity of farnesiferol C and microlobin isolated from was investigated against MCF-7, HeLa and KYSE cancer cell lines. In addition, the mechanism of binding of these compounds to apoptotic proteins (Bax, Bak and Bcl-2) was analyzed by an method. We used MTT assay in order to assess the cytotoxicity of compounds against cancer cell lines. For study, the AutoDock 4 was adopted. According to the findings, in general, farnesiferol C showed significant cytotoxicity at higher concentrations (>50 µM) following 48 and 72 h incubation with the selected cancer cells; however, microlobin exhibited almost no activity at concentrations up to 100 µM. The results revealed that both compounds could bind to Bax more efficiently rather than to Bcl-2 or Bak proteins. The results obtained by our preliminary and studies suggest that these compounds might induce apoptosis through Bax activation; however further studies, either or are needed to clarify these activities.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents); 0 (BAK1 protein, human); 0 (Coumarins); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Sesquiterpenes); 0 (bcl-2 Homologous Antagonist-Killer Protein); 0 (bcl-2-Associated X Protein); 0 (farnesiferol C); 0 (microlobin)


  9 / 266 MEDLINE  
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PMID:27279325
Autor:Tempark T; Chatproedprai S; Wananukul S
Endereço:Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand.
Título:Localized contact dermatitis from Ferula assa-foetida oleo-gum-resin essential oil, a traditional topical preparation for stomach ache and flatulence.
Fonte:Indian J Dermatol Venereol Leprol; 82(4):467, 2016 Jul-Aug.
ISSN:0973-3922
País de publicação:India
Idioma:eng
Tipo de publicação: LETTER
Nome de substância:0 (Balsams); 0 (Coumarins); 0 (Oils, Volatile); 0 (Sesquiterpenes); 0 (assafoetidnol A); 0 (copaiba balsam)


  10 / 266 MEDLINE  
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PMID:27241284
Autor:Safari R; Hoseinifar SH; Nejadmoghadam S; Jafar A
Endereço:Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. Electronic address: rsafari@gau.ac.ir.
Título:Transciptomic study of mucosal immune, antioxidant and growth related genes and non-specific immune response of common carp (Cyprinus carpio) fed dietary Ferula (Ferula assafoetida).
Fonte:Fish Shellfish Immunol; 55:242-8, 2016 Aug.
ISSN:1095-9947
País de publicação:England
Idioma:eng
Resumo:A 8-weeks feeding trial was conducted to examine the effects of different levels (0, 0.5, 1 and 2%) of dietary Ferula (Ferula assafoetida) on expression of antioxidant enzymes (GSR, GPX and GSTA), immune (TNF-alpha, IL1B, IL- 8 and LYZ) and growth (GH, IGF1 and Ghrl) genes as well as cutaneous mucus and serum non-specific immune response in common carp. The results revealed Ferula significantly increased antioxidant gene expression (GSR and GSTA) in a dose dependent manner (P < 0.05). The expression of immune growth related genes were significantly higher in Ferula fed fish compared control group (P < 0.05). The effects of Ferula on expression of genes was more pronounced in higher doses. Feeding on Ferula supplemented diet remarkably increased skin mucus lysozyme activity (P < 0.05). However, evaluation of mucus total Ig and protease activity revealed no significant difference between control and treated groups (P > 0.05). Regarding non-specific humoral response, serum total Ig, lysozyme and ACH50 showed no remarkable variation between Ferula fed carps and control group (P > 0.05). These results indicated up-regulation of growth and health related genes in Ferula fed common carp. Further studies using pathogen or stress challenge is required to conclude that transcriptional modulation is beneficial in common carp.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Fish Proteins)



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