Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.100.099 [Categoria DeCS]
Referências encontradas : 76 [refinar]
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  1 / 76 MEDLINE  
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PMID:28472675
Autor:Radulovic NS; Gencic MS; Stojanovic NM; Randjelovic PJ; Stojanovic-Radic ZZ; Stojiljkovic NI
Endereço:Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia. Electronic address: nikoradulovic@yahoo.com.
Título:Toxic essential oils. Part V: Behaviour modulating and toxic properties of thujones and thujone-containing essential oils of Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.
Fonte:Food Chem Toxicol; 105:355-369, 2017 Jul.
ISSN:1873-6351
País de publicação:England
Idioma:eng
Resumo:Neurotoxic thujones (α- and ß-diastereoisomers) are common constituents of plant essential oils. In this study, we employed a statistical approach to determine the contribution of thujones to the overall observed behaviour-modulating and toxic effects of essential oils (Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.) containing these monoterpene ketones. The data from three in vivo neuropharmacological tests on rats (open field, light-dark, and diazepam-induced sleep), and toxicity assays (brine shrimp, and antimicrobial activity against a panel of microorganisms), together with the data from detailed chemical analyses, were subjected to a multivariate statistical treatment to reveal the possible correlation(s) between the content of essential-oil constituents and the observed effects. The results strongly imply that the toxic and behaviour-modulating activity of the oils (hundreds of constituents) should not be associated exclusively with thujones. The statistical analyses pinpointed to a number of essential-oil constituents other than thujones that demonstrated a clear correlation with either the toxicity, antimicrobial effect or the activity on CNS. Thus, in addition to the thujone content, the amount and toxicity of other constituents should be taken into consideration when making risk assessment and determining the regulatory status of plants in food and medicines.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Oils, Volatile); 0 (Plant Oils)


  2 / 76 MEDLINE  
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PMID:27630101
Autor:Govindarajan M; Benelli G
Endereço:Department of Zoology, Unit of Vector Control, Phytochemistry and Nanotechnology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India. drgovind1979@gmail.com.
Título:Artemisia absinthium-borne compounds as novel larvicides: effectiveness against six mosquito vectors and acute toxicity on non-target aquatic organisms.
Fonte:Parasitol Res; 115(12):4649-4661, 2016 Dec.
ISSN:1432-1955
País de publicação:Germany
Idioma:eng
Resumo:The eco-friendly control of mosquito vectors is a crucial challenge of public health importance. Here we evaluated the larvicidal potential of Artemisia absinthium essential oil (EO) and its three major chemical constituents against six mosquito vectors: Anopheles stephensi, Anopheles subpictus, Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Culex tritaeniorhynchus. The EO was obtained by leaf hydro-distillation. Its chemical composition was analyzed using gas chromatography-mass spectrometry. Major components were (E)-ß-farnesene (31.6 %), (Z)-en-yn-dicycloether (11.12 %), and (Z)-ß-ocimene (27.8 %). The EO was toxic effect against larval populations of An. stephensi, An. subpictus, Ae. aegypti, Ae. albopictus, Cx. quinquefasciatus, and Cx. tritaeniorhynchus, with LC values of 41.85, 52.02, 46.33, 57.57, 50.57, and 62.16 µg/ml. (E)-ß-farnesene, (Z)-en-yn-dicycloether, and (Z)-ß-ocimene were highly effective on An. stephensi (LC = 8.13, 16.24 and 25.84 µg/ml) followed by An. subpictus (LC = 10.18, 20.99, and 30.86 µg/ml), Ae. aegypti (LC = 8.83,17.66, and 28.35 µg/ml), Ae. albopictus (LC = 11.38,23.47, and 33.72 µg/ml), Cx. quinquefasciatus (LC = 9.66, 19.76, and 31.52 µg/ml), and Cx. tritaeniorhynchus (LC = 12.51,25.88, and 37.13 µg/ml). Notably, the EO and its major compounds were safer to the non-target organisms Chironomous circumdatus, Anisops bouvieri and Gambusia affinis, with LC values ranging from 207.22 to 4385 µg/ml. Overall, our results highlight that (E)-ß-farnesene, (Z)-en-yn-dicycloether, and (Z)-ß-ocimene from the A. absinthium EO represent promising eco-friendly larvicides against six key mosquito vectors with moderate toxicity against non-target organisms.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Alkenes); 0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 13877-91-3 (beta-ocimene); 18794-84-8 (beta-farnesene); 8008-93-3 (absinthium)


  3 / 76 MEDLINE  
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PMID:27515537
Autor:Ali M; Abbasi BH; Ahmad N; Ali SS; Ali S; Ali GS
Endereço:Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Título:Sucrose-enhanced biosynthesis of medicinally important antioxidant secondary metabolites in cell suspension cultures of Artemisia absinthium L.
Fonte:Bioprocess Biosyst Eng; 39(12):1945-1954, 2016 Dec.
ISSN:1615-7605
País de publicação:Germany
Idioma:eng
Resumo:Natural products are gaining tremendous importance in pharmaceutical industry and attention has been focused on the applications of in vitro technologies to enhance yield and productivity of such products. In this study, we investigated the accumulation of biomass and antioxidant secondary metabolites in response to different carbohydrate sources (sucrose, maltose, fructose and glucose) and sucrose concentrations (1, 3, 5, 7 and 9 %). Moreover, the effects of 3 % repeated sucrose feeding (day-12, -18 and -24) were also investigated. The results showed the superiority of disaccharides over monosaccharides for maximum biomass and secondary metabolites accumulation. Comparable profiles for maximum biomass were observed in response to sucrose and maltose and initial sucrose concentrations of 3 and 5 %. Maximum total phenolic and total flavonoid contents were displayed by cultures treated with sucrose and maltose; however, initial sucrose concentrations of 5 and 7 % were optimum for both classes of metabolites, respectively. Following 3 % extra sucrose feeding, cultures fed on day-24 (late-log phase) showed higher biomass, total phenolic and total flavonoid contents as compared to control cultures. Highest antioxidant activity was exhibited by maltose-treated cultures. Moreover, sucrose-treated cultures displayed positive correlation of antioxidant activity with total phenolics and total flavonoids production. This work describes the stimulatory role of disaccharides and sucrose feeding strategy for higher accumulation of phenolics and flavonoids, which could be potentially scaled up to bioreactor level for the bulk production of these metabolites in suspension cultures of A. absinthium.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Flavonoids); 57-50-1 (Sucrose)


  4 / 76 MEDLINE  
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PMID:27451252
Autor:Bach B; Cleroux M; Saillen M; Schönenberger P; Burgos S; Ducruet J; Vallat A
Endereço:CHANGINS, Viticulture and Oenology, University of Applied Sciences and Arts Western Switzerland, Route de Duillier 50, 1260 Nyon, Switzerland. Electronic address: benoit.bach@changins.ch.
Título:A new chemical tool for absinthe producers, quantification of α/ß-thujone and the bitter components in Artemisia absinthium.
Fonte:Food Chem; 213:813-817, 2016 Dec 15.
ISSN:0308-8146
País de publicação:England
Idioma:eng
Resumo:The concentrations of α/ß-thujone and the bitter components of Artemisia absinthium were quantified from alcoholic wormwood extracts during four phenological stages of their harvest period. A solid-phase micro-extraction method coupled to gas chromatography-mass spectrometry was used to determine the concentration of the two isomeric forms of thujone. In parallel, the combination of ultra-high pressure liquid chromatography and high resolution mass spectrometry allowed to quantify the compounds absinthin, artemisetin and dihydro-epi-deoxyarteannuin B. This present study aimed at helping absinthe producers to determine the best harvesting period.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Monoterpenes); 0 (Plant Extracts); 0 (Sesquiterpenes, Guaiane); 0 (absinthin); 8ZI5R3T54Q (beta-thujone)


  5 / 76 MEDLINE  
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PMID:27313817
Autor:El Makrini NI; Hassam B
Endereço:Department of Dermatology, Ibn Sina Hospital, Rabat, Morocco.
Título:Artemisia absinthium: burning plant!
Fonte:Pan Afr Med J; 23:10, 2016.
ISSN:1937-8688
País de publicação:Uganda
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Plant Preparations)


  6 / 76 MEDLINE  
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PMID:27033043
Autor:Desaulniers AT; Lamberson WR; Safranski TJ
Endereço:Division of Animal Sciences, University of Missouri-Columbia, Columbia, MO, USA.
Título:Prenatal heat stress reduces male anogenital distance at birth and adult testis size, which are rescued by concurrent maternal Artemisia absinthium consumption.
Fonte:J Therm Biol; 57:84-91, 2016 Apr.
ISSN:0306-4565
País de publicação:England
Idioma:eng
Resumo:Boars from sows with elevated plasma cortisol during pregnancy have shorter anogenital distance (AGD), a trait associated with subfertility. Since gestating sows often experience summer heat stress (HS), a mouse model was used to evaluate the effect of prenatal HS on AGD and fertility; efficacy of the heat stress-mitigating supplement Artemisia absinthium (AB) was also evaluated. Dams were treated from d 8-18 of gestation, residing in ambient temperatures from 0700 to 1900h. From 1900 to 0700h females were exposed to 34.13±0.27°C (HS) with access to water (HSW; n=9), HS with access to a 1% w/v decoction of AB (HSA; n=9), 20.81±0.20°C (thermal neutral; TN) with water (TNW; n=10) or TN with AB (TNA; n=10). Daily liquid consumption was measured from d 6-18, and tail temperature was recorded at 0700 and 1900h from d 8-18. Progeny weight and AGD were recorded at birth and weaning. At maturity, males were mated to non-littermate females from each treatment; these females were euthanized after 16 d of TN gestation. Reproductive traits were compared among all male/female treatment combinations; testes were weighed. Average liquid intake differed among treatments with HS and AB animals drinking more (P<0.0004). A treatment by time interaction for tail temperature (P<0.001) was observed; HS increased tail temperature of HSA and HSW animals similarly compared to TNA and TNW. Treatment affected (P<0.01) male birth AGD (HSW shortest; P<0.07). At maturity, HSW males also had the smallest testes (P<0.02). However, we observed no differences in fertility (P>0.10). These data indicate that in utero HS decreases both male birth AGD and adult testis size, effects which maternal AB consumption mitigates.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Plant Extracts)


  7 / 76 MEDLINE  
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PMID:27005506
Autor:Ali A; Rahman K; Jahan N; Jamil A; Rashid A; Shah SM
Endereço:College of Allied Health Professionals, Directorate of Medical Sciences, Government College University Faisalabad, Pakistan / Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan.
Título:Protection of DNA during oxidative stress and cytotoxic potential of Artemisia absinthium.
Fonte:Pak J Pharm Sci; 29(1 Suppl):295-9, 2016 Jan.
ISSN:1011-601X
País de publicação:Pakistan
Idioma:eng
Resumo:Medicinal plants are rich in secondary metabolites (alkoloids, glycosides, coumarins, flavonides, steroids, etc.) and considered to be more effective and a safer alternative source to manage a variety of diseases related to liver, heart and kidney disordered. This study determines in vitro antioxidant and in vivo toxicological profile including hemolytic, brine shrimp lethality and mutagenicity of aerial parts of Artemisia absinthium. DNA protection assay was performed on pUC19 plasmid vector using H(2)O(2) as oxidative agent. Total phenolic and flavonoid content were determined using colorimetric methods. Toxicity of the plant was evaluated by brine shrimp lethality, hemolytic and mutagenic activity. DNA protection assay of the plant showed concentration dependent protective effect and at concentration 10µL/mL revealed complete protective effect against H(2)O(2) induced DNA damage. Highest phenolic and flavonoid content was found to be 167.3 (mg GAE 100g DW(-1)) and 14 (mg CE 100g DW(-1)) respectively. Results showed that A. absinthium is potent against standard toxicological procedures, that indicates the presence of bioactive components in the plant and possess antioxidant activity that protects DNA against H(2)O(2) induced oxidative damage. Thus the results showed/support that A. absinthium provides significant health benefits.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 9007-49-2 (DNA); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)


  8 / 76 MEDLINE  
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PMID:26478321
Autor:Ali M; Kim B; Belfield KD; Norman D; Brennan M; Ali GS
Endereço:Mid-Florida Research and Education Center and Department of Plant Pathology, University of Florida/Institute of Food and Agricultural Sciences, 2725 Binion Rd., Apopka, FL 32703, United States.
Título:Green synthesis and characterization of silver nanoparticles using Artemisia absinthium aqueous extract--A comprehensive study.
Fonte:Mater Sci Eng C Mater Biol Appl; 58:359-65, 2016 Jan 01.
ISSN:1873-0191
País de publicação:Netherlands
Idioma:eng
Resumo:Unlike chemical synthesis, biological synthesis of nanoparticles is gaining tremendous interest, and plant extracts are preferred over other biological sources due to their ample availability and wide array of reducing metabolites. In this project, we investigated the reducing potential of aqueous extract of Artemisia absinthium L. for synthesizing silver nanoparticles (AgNPs). Optimal synthesis of AgNPs with desirable physical and biological properties was investigated using ultra violet-visible spectroscopy (UV-vis), dynamic light scattering (DLS), transmission electron microscopy (TEM) and energy-dispersive X-ray analysis (EDX). To determine their appropriate concentrations for AgNP synthesis, two-fold dilutions of silver nitrate (20 to 0.62 mM) and aqueous plant extract (100 to 0.79 mg ml(-1)) were reacted. The results showed that silver nitrate (2mM) and plant extract (10 mg ml(-1)) mixed in different ratios significantly affected size, stability and yield of AgNPs. Extract to AgNO3 ratio of 6:4v/v resulted in the highest conversion efficiency of AgNO3 to AgNPs, with the particles in average size range of less than 100 nm. Furthermore, the direct imaging of synthesized AgNPs by TEM revealed polydispersed particles in the size range of 5 to 20 nm. Similarly, nanoparticles with the characteristic peak of silver were observed with EDX. This study presents a comprehensive investigation of the differential behavior of plant extract and AgNO3 to synthesize biologically stable AgNPs.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
Nome de substância:0 (Plant Extracts); 3M4G523W1G (Silver)


  9 / 76 MEDLINE  
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PMID:26665406
Autor:Li Y; Zheng M; Zhai X; Huang Y; Khalid A; Malik A; Shah P; Karim S; Azhar S; Hou X
Título:EFFECT OF-GYMNEMA SYLVESTRE, CITRULLUS COLOCYNTHIS AND ARTEMISIA ABSINTHIUM ON BLOOD GLUCOSE AND LIPID PROFILE IN DIABETIC HUMAN.
Fonte:Acta Pol Pharm; 72(5):981-5, 2015 Sep-Oct.
ISSN:0001-6837
País de publicação:Poland
Idioma:eng
Resumo:The aim of this study was to manage diabetes with medicinal plants (Gymnema sylvestre, Artemisia absinthium and Citillus colocynthis) in human patients with type II diabetes. Thirty two patients of type II diabetes from both sexes of 30-60 years age were registered for this study and distributed them into four groups, each having 8 patients. Capsules of each, Gymnema sylvestre, Artemisia absinthium and Citrullus colocynthis were given to patients twice a day for 30 days in 1 g per day dosage and investigated for glucose, triglyceride (TGL) and cholesterol level. Gymnema sylvestre reduced 37% glucose, 5% TGL, 13% cholesterol and 19% low desity lipoproteins (LDL) level in diabetic individuals. Citrullus colocynth reduced glucose, cholesterol and TGL and HDL-cholesterol level by 35, 6, 6, and 5%, respectively. Artemisia absinthium reduced 3% high desity lipoproteins (HDL) and 6% LDL level. From results, it can be concluded that the powdered Gymnema sylvestre, Citrulus colocynthis, and Artemisia absinthium possess good anti-diabetic features, however these herbal products had no significant effect on lipid profiles of the diabetic human.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Blood Glucose); 0 (Lipoproteins, HDL); 0 (Lipoproteins, LDL)


  10 / 76 MEDLINE  
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PMID:26576073
Autor:Algieri F; Rodriguez-Nogales A; Rodriguez-Cabezas ME; Risco S; Ocete MA; Galvez J
Endereço:CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Center for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n, Armilla, 18016 Granada, Spain.
Título:Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review.
Fonte:Mediators Inflamm; 2015:179616, 2015.
ISSN:1466-1861
País de publicação:United States
Idioma:eng
Resumo:Crohn's disease and ulcerative colitis are the two most common categories of inflammatory bowel disease (IBD), which are characterized by chronic inflammation of the intestine that comprises the patients' life quality and requires sustained pharmacological and surgical treatments. Since their aetiology is not completely understood, nonfully efficient drugs have been developed and those that show effectiveness are not devoid of quite important adverse effects that impair their long-term use. Therefore, many patients try with some botanical drugs, which are safe and efficient after many years of use. However, it is necessary to properly evaluate these therapies to consider a new strategy for human IBD. In this report we have reviewed the main botanical drugs that have been assessed in clinical trials in human IBD and the mechanisms and the active compounds proposed for their beneficial effects.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
Nome de substância:0 (Plant Extracts)



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