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  1 / 219 MEDLINE  
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PMID:29241322
Autor:Ekeleme-Egedigwe CA; Ijeh II; Okafor PN
Endereço:Department of Chemistry/Biochemistry, Federal University Ndufu Alike Ikwo, Nigeria.
Título:Modulatory effects of dietary supplementation by Vernonia amygdalina on high-fat-diet-induced obesity in Wistar rats.
Fonte:Acta Sci Pol Technol Aliment; 16(4):431-442, 2017 Oct-Dec.
ISSN:1898-9594
País de publicação:Poland
Idioma:eng
Resumo:BACKGROUND: Obesity is a growing public health problem arising from energy imbalance. The effect of 10% dietary incorporation of Vernonia amygdalina (VA) leaves into high-fat diets on some biological markers of adiposity and dyslipidaemia was investigated. METHODS: Experimental diets consisted of the following – CD (control diet); HFD (high-fat diet); and HFD- VA (HFD containing 10% Vernonia amygdalina leaves) supplementation. Fifteen male Wistar rats were randomly divided into three groups of five animals each. After twelve weeks of feeding, serum lipid profile, blood glucose concentrations, body weight, adiposity index, feed intake, fecal loss and relative organ weight were investigated. RESULTS: Vernonia amygdalina (VA) inhibited HFD-induced weight gain and adiposity in rats. HFD-induced obese rats showed a significant increase in the levels of serum TG and TC compared to rats on a normal diet. However, the levels of serum TG, TC, LDL-C in HFDVA rats reduced significantly relative to the levels in HFD rats. Our results indicate that HFDVA reversed fatty infiltration leading to decreased body weight and fat tissue mass in the rats. CONCLUSIONS: These results suggested that incorporation of Vernonia amygdalina into high-fat diets may have therapeutic potentials for obesity and related metabolic disorders. Further studies to explore its possibility as an alternative pharmacologic agent to treat obesity are warranted.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Dietary Fats); 0 (Plant Extracts)


  2 / 219 MEDLINE  
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PMID:28856944
Autor:Boonruang S; Prakobsri K; Pouyfung P; Srisook E; Prasopthum A; Rongnoparut P; Sarapusit S
Endereço:a Bioengineering Program, Faculty of Engineering , Burapha University , Muang , Chonburi , Thailand.
Título:Inhibition of human cytochromes P450 2A6 and 2A13 by flavonoids, acetylenic thiophenes and sesquiterpene lactones from Pluchea indica and Vernonia cinerea.
Fonte:J Enzyme Inhib Med Chem; 32(1):1136-1142, 2017 Dec.
ISSN:1475-6374
País de publicação:England
Idioma:eng
Resumo:The human liver cytochrome P450 (CYP) 2A6 and the respiratory CYP2A13 enzymes play role in nicotine metabolism and activation of tobacco-specific nitrosamine carcinogens. Inhibition of both enzymes could offer a strategy for smoking abstinence and decreased risks of respiratory diseases and lung cancer. In this study, activity-guided isolation identified four flavonoids 1-4 (apigenin, luteolin, chrysoeriol, quercetin) from Vernonia cinerea and Pluchea indica, four hirsutinolide-type sesquiterpene lactones 5-8 from V. cinerea, and acetylenic thiophenes 9-11 from P. indica that inhibited CYP2A6- and CYP2A13-mediated coumarin 7-hydroxylation. Flavonoids were most effective in inhibition against CYP2A6 and CYP2A13, followed by thiophenes, and hirsutinolides. Hirsutinolides and thiophenes exhibited mechanism-based inhibition and in irreversible mode against both enzymes. The inactivation kinetic K values of hirsutinolides against CYP2A6 and CYP2A13 were 5.32-15.4 and 0.92-8.67 µM, respectively, while those of thiophenes were 0.11-1.01 and 0.67-0.97 µM, respectively.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Enzyme Inhibitors); 0 (Flavonoids); 0 (Lactones); 0 (Sesquiterpenes); 0 (Thiophenes); EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases); EC 1.14.14.1 (CYP2A13 protein, human); EC 1.14.14.1 (Cytochrome P-450 CYP2A6)


  3 / 219 MEDLINE  
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PMID:28653918
Autor:Jamil S; Khan RA; Ahmed S; Fatima S
Endereço:Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan.
Título:Evaluation of anti-inflammatory and anti-oxidant potential of seed extracts of Vernonia anthelmintica.
Fonte:Pak J Pharm Sci; 30(3):755-760, 2017 May.
ISSN:1011-601X
País de publicação:Pakistan
Idioma:eng
Resumo:Seeds of Vernonia anthelmintica in the form of Ethanol seed extract of Vernonia anthelmintica (EEVA), Hexane extract of Vernonia anthelmintica (HEVA) and water decoction of Vernonia anthelmintica (WDVA) were evaluated for their in-vivo anti-Inflammatory potential in carrageenan induced rat paw model. The results were compared to anti-inflammatory activity of standard drug (ibuprofen) and untreated groups. In-vitro evaluation of antioxidant potential of EEVA and HEVA were also conducted by "DPPH scavenging assay". The results of present study depicts that HEVA and EEVA in higher dose possess a strong anti-inflammatory potential as compared to standard anti-inflammatory drugs, whereas WDVA showed milder anti-inflammatory potential. DPPH assay has revealed strong anti-oxidant potential of EEVC with the percentage Radical Scavenging activity (%RSA) of 89.709 at concentrations of 500 ul as compared to standard drugs gallic acid (23.436±0.43) and acetyl salicylic acid (111.44±0.7) at concentrations of 95.95 µM. The other extract HEVC has shown to have insignificant %RSA at the concentration of 500µl. Hence the present study revealed that selected extracts of Vernonia anthelmintica exhibited significant in-vitro antioxidant and in-vivo anti-inflammatory potential.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Plant Extracts)


  4 / 219 MEDLINE  
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PMID:28397756
Autor:Kimani NM; Matasyoh JC; Kaiser M; Brun R; Schmidt TJ
Endereço:Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, D-48149 Münster, Germany. m_kima01@uni-muenster.de.
Título:Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm.
Fonte:Molecules; 22(4), 2017 Apr 08.
ISSN:1420-3049
País de publicação:Switzerland
Idioma:eng
Resumo:Sleeping sickness or human African trypanosomiasis (HAT) is a neglected tropical disease (NTD) threatening millions of peoples' lives with thousands infected. The disease is endemic in poorly developed regions of sub-Saharan Africa and is caused by the kinetoplastid "protozoan" parasite . The parasites are transmitted to humans through bites of infected tsetse flies of the genus . The few available drugs for treatment of this disease are highly toxic, difficult to administer, costly and unavailable to poor rural communities bearing the major burden of this infection. Therefore, the search for new efficacious, safe and affordable drugs is of high importance. O. Hoffm., an indigenous African plant of the Asteraceae family, has been extensively reported to be used ethno-medicinally as a treatment for malaria. Its crude extracts obtained with solvents of different polarity were screened in vitro for anti-protozoal activity and the dichloromethane extract was found to be particularly active against (IC = 0.17 µg/mL). Bioassay-guided chromatographic fractionation of the dichloromethane extract led to the isolation and identification of six elemanolide type sesquiterpene lactones: 8-desacylvernolide, vernolepin, vernomenin, vernodalol, vernodalin and 11,13-dihydrovernodalin. All these elemanolide sesquiterpene lactones showed in vitro anti-trypanosomal activity. They were also tested for cytotoxicity against mammalian cells (L6 cell line). Vernolepin, the main component in the extract, was also the most potent with an IC value of 0.05 µg/mL against trypomastigotes. This compound showed a selectivity index of 14.5, which makes it an interesting candidate for in vivo tests and determination of its mechanism of action.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Lactones); 0 (Plant Extracts); 0 (Trypanocidal Agents)


  5 / 219 MEDLINE  
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PMID:28321929
Autor:Huo SX; Wang Q; Liu XM; Ge CH; Gao L; Peng XM; Yan M
Endereço:Prescription Laboratory of Xinjiang Traditional Uyghur Medicine, Xinjiang Institute of Traditional Uyghur Medicine, Urumqi, 830049, China.
Título:The Effect of Butin on the Vitiligo Mouse Model Induced by Hydroquinone.
Fonte:Phytother Res; 31(5):740-746, 2017 May.
ISSN:1099-1573
País de publicação:England
Idioma:eng
Resumo:Vernonia anthelmintica (L.) Willd has been traditionally used in the treatment of vitiligo in Uyghur medicine. This study used butin, the main component of V. anthelmintica, to study the influence on hydroquinone-induced vitiligo in mice. The animals were randomly divided into six groups: control, model, 8-methoxypsoralen (8-MOP, 4.25 mg/kg), and butin (0.425, 4.25, and 42.5 mg/kg) groups. The number of melanin-containing hair follicles, basal layer melanocytes, melanin-containing epidermal cells, the expression of tyrosinase (TYR) and tyrosinase-related protein-1 (TRP-1), the malondialdehyde (MDA), and cholinesterase (CHE) activity in serum were measured. Our results indicated that compared with the model group, the melanin-containing hair follicles, the expression of TYR and TRP-1 increased, the activity of CHE decreased after treatment with 8-MOP and all doses of butin (p < 0.05, p < 0.01), the basal layer melanocytes and melanin-containing epidermal cells increased significantly after treatment with butin 4.25 and 42.5 mg/kg (p < 0.05, p < 0.01), and the MDA activity decreased after using butin 4.25 and 42.5 mg/kg and 8-MOP (p < 0.05, p < 0.01). Our results support the use of butin on vitiligo, and its possible mechanisms may be related to increase the TYR and TRP-1 protein expression and decrease the activity of MDA and CHE in hydroquinone-induced vitiligo model in mice. Copyright © 2017 John Wiley & Sons, Ltd.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Benzopyrans); 0 (Hydroquinones); 492-14-8 (butin); 4Y8F71G49Q (Malondialdehyde); XV74C1N1AE (hydroquinone)


  6 / 219 MEDLINE  
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PMID:28243061
Autor:Ketsuwan N; Leelarungrayub J; Kothan S; Singhatong S
Endereço:Department of Physical Therapy.
Título:Antioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Less.
Fonte:Drug Des Devel Ther; 11:383-391, 2017.
ISSN:1177-8881
País de publicação:New Zealand
Idioma:eng
Resumo:(VC) Less has been proposed as a medicinal plant with interesting activities, such as an aid for smoking cessation worldwide. Despite its previous clinical success in smoking cessation by exhibiting reduced oxidative stress, it has not been approved. The aim of this study was to investigate various antioxidant activity and active compounds that have not been approved, including the protective activity in human red blood cells (RBCs), from the stem, flower, and leaf extracts of VC Less in vitro. These extracts were tested for their antioxidant activity in scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and analyzed by high-performance liquid chromatography (HPLC) for their active compounds: total tannin, five catechin (C) compounds (epicatechin gallate [ECG], C, epicatechin [EC], epigallocatechin gallate [EGCG], and (-)-epigallocatechin [EGC]), flavonoid, nitrite, nitrate, caffeine, and nicotine. Moreover, antioxidant activities of the extracts were evaluated in 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-treated RBCs. The results showed that the flower and leaf of VC Less had higher activity than the stem in scavenging DPPH radicals. The tannin content in the flower and leaf was higher than that in the stem. The leaf had the highest content of the five catechins (C, EC, EGCG, ECG, and EGC), the same as in the flavonoid, when compared to the stem and flower. Furthermore, the leaf extract had higher nitrate and nitrite than the stem. Nicotine content was found to be higher in the leaf when compared to the flower. In addition, the leaf showed protective activity in glutathione (GSH), malondialdehyde (MDA), and protein carbonyl, with a dose response in AAPH-oxidized RBCs, the same as in standard EGCG. Thus, this study concluded that radical scavenging and antioxidant compounds such as catechins, flavonoid, nitrate and nitrite, and nicotine are present in different VC Less parts and are included in the AAPH-oxidized RBC model.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Picrates); 6M3C89ZY6R (Nicotine); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)


  7 / 219 MEDLINE  
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PMID:28126045
Autor:da Silva Fugita JM; Pereira TBC; Banzato TC; Kitajima EW; da Souto ER; Bedendo IP
Endereço:1​Departamento de Agronomia, Universidade Estadual de Maringá, 87020-900, Maringá, PR, Brazil.
Título:Molecular characterization of a phytoplasma affiliated with the 16SrVII group representative of the novel 16SrVII-F subgroup.
Fonte:Int J Syst Evol Microbiol; 67(8):3122-3126, 2017 Aug.
ISSN:1466-5034
País de publicação:England
Idioma:eng
Resumo:Vernonia brasiliana is a wild perennial shrub frequently found in pasture areas. Plants of this species have been observed displaying typical symptoms induced by phytoplasmas, which were characterized by shoot proliferation, deformed leaves and leaf chlorosis. The present study confirmed the presence of phytoplasmas in association with affected plants. Sequencing of the 16S rRNA gene, computer-simulated RFLP analysis and phylogenetic analysis revealed that one of the phytoplasmas identified was representative of novel subgroup. The sequence identity scores between the novel strain and those of previously described 'CandidatusPhytoplasma fraxini'-related strains was 99 %, while similarity coefficient values were lower than 0.97. These findings provide support to delineate the phytoplasma found in vernonia plants as a reference phytoplasma for a novel subgroup designated 16SrVII-F. This representative of the novel subgroup was denominated VbSP phytoplasma (Vernonia brasiliana Shoot Proliferation; GenBank KX342018). The results of the present study revealed V. brasiliana to be a host of phytoplasmas, evidenced a novel phytoplasma associated with phytoplasmal disease in Brazil and extended the knowledge of the genetic diversity existing within the 16SrVII group.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S)


  8 / 219 MEDLINE  
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PMID:28115286
Autor:Silva JB; Mendes RF; Tomasco V; Pinto NC; de Oliveira LG; Rodrigues MN; Aragão DM; Aguiar JA; Alves MS; Castañon MC; Ribeiro A; Scio E
Endereço:Laboratory of Bioactive Natural Products, Department of Biochemistry, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora, MG 36036-900, Brazil.
Título:New aspects on the hepatoprotective potential associated with the antioxidant, hypocholesterolemic and anti-inflammatory activities of Vernonia condensata Baker.
Fonte:J Ethnopharmacol; 198:399-406, 2017 Feb 23.
ISSN:1872-7573
País de publicação:Ireland
Idioma:eng
Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Vernonia condensata Baker (Asteraceae) is traditionally used in South American Countries as an anti-inflammatory, analgesic and hepatoprotective. AIM OF THE STUDY: This study aimed to investigate the in vivo hepatoprotective and antioxidant, and the in vitro anti-inflammatory activities of the ethyl acetate partition (EAP) from the ethanolic extract of this medicinal plant leaves. MATERIALS AND METHODS: For the in vivo hepatoprotective activity, rats were pretreated orally for seven days with vehicle, silymarin 100mg/kg or EAP 50, 100 and 200mg/kg. Then, acetaminophen 3g/kg was also orally administrated. Animals were euthanatized 24h after the damage inducement. The levels of the serum enzymes ALT, AST and ALP were determined, as well as the triglycerides, total cholesterol and fractions. The antioxidant activity was evaluated by TBARS assay and by the measurement of glutathione reductase, superoxide dismutase and catalase activities in the rats liver tissue. The in vitro anti-inflammatory assay using Raw 264.7 cell line induced by lipopolysaccharide was conducted to verify EAP ability to inhibit pro-inflammatory cytokines. RESULTS: EAP was able to inhibit all the acute biochemical alterations caused by acetaminophen overdose. EAP inhibited malondialdehyde formation, maintained the catalase and increased the glutathione reductase activities. Also, EAP decreased NO, IL-6 and TNF-α levels at concentrations from 10 to 20µg/mL. 1,5-dicaffeoylquinic acid was isolated and identified as the major compound in EAP. Apigenin, luteolin, chlorogenic acid were also identified. EAP anti-inflammatory action may be due to its antioxidant activity or its capacity to inhibit the pro-inflammatory cytokines. CONCLUSION: These results strongly suggested that V. condensata may be useful as a possible therapy against liver damage.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Anticholesteremic Agents); 0 (Antioxidants); 0 (Cytokines); 0 (Plant Extracts); 0 (Silymarin); 362O9ITL9D (Acetaminophen)


  9 / 219 MEDLINE  
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PMID:28099876
Autor:Alexandre Schefer F; Ricardo S; Zozula Blind CL; Luis P; de Oliveira Souza BL; Branco Filippin MF; Weber BM; Regina Orofino KM
Endereço:Universidade do Vale do Itajaí, Brazil.
Título:Antitumoral activity of sesquiterpene lactone diacethylpiptocarphol in mice.
Fonte:J Ethnopharmacol; 198:262-267, 2017 Feb 23.
ISSN:1872-7573
País de publicação:Ireland
Idioma:eng
Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Sesquiterpene lactones are organic compounds derived from plants that exhibit anti-inflammatory and antitumor activities being one of the locking mechanisms of action of NF-kB pathway and synthesis of cytokines such as IL-1 and TNF- α. AIM OF THE STUDY: The overall objective of the present study was to evaluate the antitumor activity of the sesquiterpene lactone diacethylpiptocarphol (DPC) from Vernonia scorpioides (Lam.) Pers. in animal models Ehrlich tumors that has shown antitumor activity. MATERIALS AND METHODS: The antitumor effects of Intraperitonial administration of DPC (5mg/kg/day) were evaluated in Balb/c mice on Ehrlich tumors, and further the body weight, the ascitic cells volume measurement, solid tumor measured and TNF-α level was determinate. RESULTS: Balb/c mice bearing Ehrlich tumors were treated daily with 5mg/kg/day of the DPC for one week and showed no tumor in the peritoneum after treatment, besides presenting a reduction of TNF-α cytokine. Also the solid tumor reduced size after one week of treatment with DPC. CONCLUSIONS: Sesquiterpene lactone DPC, isolated from Vernonia scorpioides showed antitumor activity because it decreased the size of the solid tumor and abolished the ascitic tumor development, and also did not affect the mice body weight, however the treatment reduced the TNF-α level in mice.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents, Phytogenic); 0 (Lactones); 0 (Sesquiterpenes); 0 (Tumor Necrosis Factor-alpha); 0 (diacethylpiptocarphol)


  10 / 219 MEDLINE  
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PMID:28019108
Autor:Maimaiti Z; Turak A; Aisa HA
Endereço:a State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
Título:Two new compounds from the seeds of Vernonia anthelmintica.
Fonte:J Asian Nat Prod Res; 19(9):862-868, 2017 Sep.
ISSN:1477-2213
País de publicação:England
Idioma:eng
Resumo:Two new compounds, named benzoyl-vernovan (1) and 2-(4'-hydroxyphenyl)-6-methyl-4H-pyran-4-one (2), together with one biflavonoid (3), one aurone (4) and six flavonoids were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by extensive spectroscopic analyses and comparison with published data, and their influence on melanin content in B16 melanoma cells were tested. 5 and 9 increased melanin content by 2.2% and 30.9% higher than positive control 8-methoxypsoralen.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (2-(4'-hydroxyphenyl)-6-methyl-4H-pyran-4-one); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Glycosides); 0 (Melanins); 0 (Pyrones); 0 (benzoyl-vernovan)



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