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  1 / 582 MEDLINE  
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PMID:29273038
Autor:Villareal MO; Ikeya A; Sasaki K; Arfa AB; Neffati M; Isoda H
Endereço:Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki, 305-8572, Japan.
Título:Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil.
Fonte:BMC Complement Altern Med; 17(1):549, 2017 Dec 22.
ISSN:1472-6882
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Mood disorder accounts for 13 % of global disease burden. And while therapeutic agents are available, usually orally administered, most have unwanted side effects, and thus making the inhalation of essential oils (EOs) an attractive alternative therapy. Rosmarinus officinalis EO (ROEO), Mediterranean ROEO reported to improve cognition, mood, and memory, the effect on stress of which has not yet been determined. Here, the anti-stress effect of ROEO on stress was evaluated in vivo and in vitro. METHODS: Six-week-old male ICR mice were made to inhale ROEO and subjected to tail suspension test (TST). To determine the neuronal differentiation effect of ROEO in vitro, induction of ROEO-treated PC12 cells differentiation was observed. Intracellular acetylcholine and choline, as well as the Gap43 gene expression levels were also determined. RESULTS: Inhalation of ROEO significantly decreased the immobility time of ICR mice and serum corticosterone level, accompanied by increased brain dopamine level. Determination of the underlying mechanism in vitro revealed a PC12 differentiation-induction effect through the modulation of intracellular acetylcholine, choline, and Gap43 gene expression levels. ROEO activates the stress response system through the NGF pathway and the hypothalamus-pituitary-adrenal axis, promoting dopamine production and secretion. The effect of ROEO may be attributed to its bioactive components, specifically to α-pinene, one of its major compounds that has anxiolytic property. CONCLUSIONS: The results of this study suggest that ROEO inhalation has therapeutic potential against stress-related psychiatric disorders.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Catecholamines); 0 (GAP-43 Protein); 0 (Oils, Volatile); 8LGU7VM393 (rosemary oil); EC 3.1.1.7 (Acetylcholinesterase)


  2 / 582 MEDLINE  
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PMID:29266099
Autor:Protsyuk I; Melnik AV; Nothias LF; Rappez L; Phapale P; Aksenov AA; Bouslimani A; Ryazanov S; Dorrestein PC; Alexandrov T
Endereço:Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
Título:3D molecular cartography using LC-MS facilitated by Optimus and 'ili software.
Fonte:Nat Protoc; 13(1):134-154, 2018 Jan.
ISSN:1750-2799
País de publicação:England
Idioma:eng
Resumo:Our skin, our belongings, the world surrounding us, and the environment we live in are covered with molecular traces. Detecting and characterizing these molecular traces is necessary to understand the environmental impact on human health and disease, and to decipher complex molecular interactions between humans and other species, particularly microbiota. We recently introduced 3D molecular cartography for mapping small organic molecules (including metabolites, lipids, and environmental molecules) found on various surfaces, including the human body. Here, we provide a protocol and open-source software for 3D molecular cartography. The protocol includes step-by-step procedures for sample collection and processing, liquid chromatography-mass spectrometry (LC-MS)-based metabolomics, quality control (QC), molecular identification using MS/MS, data processing, and visualization with 3D models of the sampled environment. The LC-MS method was optimized for a broad range of small organic molecules. We enable scientists to reproduce our previously obtained results, and illustrate the broad utility of our approach with molecular maps of a rosemary plant and an ATM keypad after a PIN code was entered. To promote reproducibility, we introduce cartographical snapshots: files that describe a particular map and visualization settings, and that can be shared and loaded to reproduce the visualization. The protocol enables molecular cartography to be performed in any mass spectrometry laboratory and, in principle, for any spatially mapped data. We anticipate applications, in particular, in medicine, ecology, agriculture, biotechnology, and forensics. The protocol takes 78 h for a molecular map of 100 spots, excluding the reagent setup.
Tipo de publicação: JOURNAL ARTICLE


  3 / 582 MEDLINE  
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PMID:28722406
Autor:Reyer H; Zentek J; Männer K; Youssef IMI; Aumiller T; Weghuber J; Wimmers K; Mueller AS
Endereço:Leibniz Institute for Farm Animal Biology (FBN), Institute for Genome Biology , Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Título:Possible Molecular Mechanisms by Which an Essential Oil Blend from Star Anise, Rosemary, Thyme, and Oregano and Saponins Increase the Performance and Ileal Protein Digestibility of Growing Broilers.
Fonte:J Agric Food Chem; 65(32):6821-6830, 2017 Aug 16.
ISSN:1520-5118
País de publicação:United States
Idioma:eng
Resumo:Phytogenic feed additives represent a potential alternative to antibiotics with attributed health and growth-promoting effects. Chickens supplemented with an essential oil blend, a Quillaja saponin blend, or a combination of both phytogenic preparations showed a comprehensively and significantly improved apparent ileal digestibility of crude protein and amino acids compared to control birds. Accordingly, holistic transcriptomic analyses of jejunum and liver samples indicated alterations of macromolecule transporters and processing pathways likely culminating in an increased uptake and metabolizing of carbohydrates and fatty acids. Complementary analyses in Caco-2 showed a significant increase in transporter recruitment to the membrane (SGLT1 and PEPT1) after addition of essential oils and saponins. Although the penetrance of effects differed for the used phytogenic feed additives, the results indicate for an overlapping mode of action including local effects at the intestinal border and systemic alterations of macronutrient metabolism resulting in an improved performance of broilers.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Food Additives); 0 (Oils, Volatile); 0 (Proteins); 0 (Saponins)


  4 / 582 MEDLINE  
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PMID:28701064
Autor:Cornejo A; Aguilar Sandoval F; Caballero L; Machuca L; Muñoz P; Caballero J; Perry G; Ardiles A; Areche C; Melo F
Endereço:a Escuela de Tecnología Médica, Facultad de Medicina , Universidad Andres Bello , Santiago , Chile.
Título:Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to ß sheet in tau protein linked to Alzheimer's disease.
Fonte:J Enzyme Inhib Med Chem; 32(1):945-953, 2017 Dec.
ISSN:1475-6374
País de publicação:England
Idioma:eng
Resumo:Alzheimer's disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-ß plaques have succeeded to remove plaques but failed in clinical trials to improve cognition; thus, the current therapeutic strategy is at preventing tau aggregation. Here, we demonstrated that four phenolic diterpenoids and rosmarinic acid inhibit fibrillization. Since, rosmarinic acid was the most active compound, we observe morphological changes in atomic force microscopy images after treatment. Hence, rosmarinic acid leads to a decrease in amide regions I and III, indicating that rosmarinic acid prevents ß-sheet assembly. Molecular docking study inside the steric zipper model of the hexapeptide VQIVYK involved in fibrillization and ß sheet formation, suggests that rosmarinic acid binds to the steric zipper with similar chemical interactions with respect to those observed for orange G, a known pharmacofore for amyloid.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Cinnamates); 0 (Depsides); 0 (Protein Aggregates); 0 (tau Proteins); MQE6XG29YI (rosmarinic acid)


  5 / 582 MEDLINE  
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PMID:28699881
Autor:Waller SB; Madrid IM; Hoffmann JF; Picoli T; Cleff MB; Chaves FC; Faria RO; Meireles MCA; Braga de Mello JR
Endereço:1​Department of Preventive Veterinary, College of Veterinary, Federal University of Pelotas, Pelotas/RS, Brazil.
Título:Chemical composition and cytotoxicity of extracts of marjoram and rosemary and their activity against Sporothrix brasiliensis.
Fonte:J Med Microbiol; 66(7):1076-1083, 2017 Jul.
ISSN:1473-5644
País de publicação:England
Idioma:eng
Resumo:PURPOSE: Motivated by increasing reports of antifungal resistance in human and animal sporotrichosis, this study evaluated the chemical composition, cytotoxicity and anti-Sporothrix brasiliensis activity of extracts of marjoram (Origanum majorana) and rosemary (Rosmarinus officinalis). METHODOLOGY: Ten (INF10) and 60 min (INF60) infusions, a decoction and a hydroalcoholic extract (HAE, 70 %) were prepared from both plants (10 % w/v). The extract composition was analysed by liquid chromatography/mass spectrometry and the cytotoxicity was evaluated using a colorimetric assay in canine and feline kidney cells. Using a broth microdilution assay (CLSI M38-A2) adapted to the extracts, 30 Sporothrix brasiliensis isolates from dogs, cats and humans, and one Sporothrix schenckii were tested.Results/Key findings. The predominant phenolic compounds found in all extracts were 4-hydroxybenzoic acid, caffeic acid and chlorogenic acid. Luteolin was also one of the predominant compounds, but only in the HAE of marjoram. Extracts of marjoram maintained cell viability in concentrations up to 2.5 mg ml-1 for the feline cell line and up to 10 mg ml-1 for the canine cell line, whereas in rosemary, the cell viability for both kidney lines was maintained with concentrations up to 5 mg ml-1. The activity of rosemary extracts was low or absent. Among the marjoram extracts, HAE was highlighted and had fungistatic activity against Sporothrix brasiliensis (MIC5040 mg ml-1), including in all itraconazole-resistant isolates. S. schenckiisensu stricto was sensitive to marjoram extracts (MIC/MFC ≤5 mg ml-1), with the exception of INF10. CONCLUSION: These findings support the potential usefulness of the HAE of marjoram in the treatment of sporotrichosis.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antifungal Agents); 0 (Phytochemicals); 0 (Plant Extracts)


  6 / 582 MEDLINE  
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PMID:28638882
Autor:Eissa FA; Choudhry H; Abdulaal WH; Baothman OA; Zeyadi M; Moselhy SS; Zamzami MA
Endereço:Biochemistry Department, Faculty of science, King Abdulaziz University.
Título:POSSIBLE HYPOCHOLESTEROLEMIC EFFECT OF GINGER AND ROSEMARY OILS IN RATS.
Fonte:Afr J Tradit Complement Altern Med; 14(4):188-200, 2017.
ISSN:2505-0044
País de publicação:Nigeria
Idioma:eng
Resumo:BACKGROUND: Hypercholesterolemia is a major risk factor for development of atherosclerosis. The present study was conducted to evaluate the potential effect of ginger oil alone or combined with rosemary oil as hypocholesterolemic agent in rats fed high fat diet. MATERIALS AND METHODS: Healthy female rats (n=80) weighting about (150-180 g) were included in this study divided into two equal groups; Group (I): were fed on the basal diet. Group (I) were divided into 4 subgroups each 10: Group (Ia): negative control. Group (Ib): Rats received 2.5 g/Kg b.w of ginger oil. Group (Ic): rats received 2.5 g/Kg b.w of rosemary oil. Group (Id): Rats received 5 g/Kg b.w mixture of ginger oil and rosemary oil (1:1). The second main groups; Group (II): high fat diet (HFD) were fed on the basal diet plus cholesterol (1%), bile salt (0.25%) and animal fat (15%) to induce hypercholesterolemia for six weeks. Group (II) was divided into 4subgroups: Group (IIa): HFD. Group (IIb): HFD were treated with 2.5 g/Kg b.w ginger oil. Group (IIc): (n=10) HFD were treated with 2.5 g/Kg b.w rosemary oil. Group (IId): (n=10) HFD were treated with 5 g/Kg b.w mixture of oils. RESULTS: It was found that HFD rats showed a significant elevation in glucose, total cholesterol, triglyceride, GOT, GPT, alkaline phosphatase and a reduction in serum HDL-c compared with negative control. Treatment with ginger oil, rosemary oil and their mixture modulated the elevation of these parameters. Histopathological examination of the liver tissue of HFD rats showed a lipid deposition and macrophage infiltration and stenosis of hepatic vein. Treatment with mixture oils preserves normal structure of liver. CONCLUSION: It was concluded that, hypocholesterolemic effect was related to the active oil content as Rosemary oil contain - α-pinene, Camphor, cineole, borneol and Ginger oil contain Linalool, Terpineol, Borneol, Eucalyptol.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anticholesteremic Agents); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Triglycerides); 8LGU7VM393 (rosemary oil); 97C5T2UQ7J (Cholesterol)


  7 / 582 MEDLINE  
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PMID:28587218
Autor:Wang L; Gan C; Wang Z; Liu L; Gao M; Li Q; Yang C
Endereço:Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, Heilongjiang, China. wangliqian93@163.com.
Título:Determination and Pharmacokinetic Study of Three Diterpenes in Rat Plasma by UHPLC-ESI-MS/MS after Oral Administration of Rosmarinus officinalis L. Extract.
Fonte:Molecules; 22(6), 2017 Jun 04.
ISSN:1420-3049
País de publicação:Switzerland
Idioma:eng
Resumo:L. is commonly used as a spice and flavoring agent. Diterpenes are the main active compounds of . An Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-ESI-MS/MS) method was developed for the determination of carnosol, rosmanol, and carnosic acid isolated from in rat plasma, and applied to a pharmacokinetic study after oral administration of extract. Sample preparation involved a liquid-liquid extraction of the analytes with ethyl acetate. Butylparaben was employed as an internal standard (I.S.). Chromatographic separation was carried out on a C column (ACQUITY UPLC HSS T3, 1.8 µm, 2.1 mm × 100 mm) with a gradient system consisting of the mobile phase solution A (0.1% formic acid in water) and solution B (acetonitrile) at the flow rate of 0.3 mL/min. The quantification was obtained using multiple reaction monitoring (MRM) mode with electrospray ionization (ESI). The UHPLC-MS/MS assay was validated for linearity, accuracy, precision, extraction recovery, matrix effect and stability. This study described a simple, sensitive and validated UHPLC-MS/MS method for the simultaneous determination of three diterpene compounds in rat plasma after oral administration of extract, and investigated on their pharmacokinetic studies as well.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Diterpenes); 0 (Plant Extracts)


  8 / 582 MEDLINE  
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PMID:28498837
Autor:Sadeh D; Nitzan N; Shachter A; Chaimovitsh D; Dudai N; Ghanim M
Endereço:Unit of Aromatic and Medicinal plants, Newe Ya'ar Research Center, ARO, Ramat-Yishay, Israel.
Título:Whitefly attraction to rosemary (Rosmarinus officinialis L.) is associated with volatile composition and quantity.
Fonte:PLoS One; 12(5):e0177483, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:Whitefly (Bemisia tabaci) is an important insect pest, causing severe damage to agricultural crops. The pest was recorded in a commercial rosemary (Rosmarinus officinalis, Lamiaceae) field, colonizing rosemary variety (var.) '2', but not '11'. A series of field and controlled laboratory choice bioassays confirmed the observed phenomenon. Mature potted plants of the two varieties were randomly organized in a lemon verbena (Lippia citrodora) and lemon grass (Cymbopogon spp.) fields. Seven days later var. '2' was significantly more colonized by whiteflies than var. '11'. Under lab conditions, whiteflies were significantly more attracted to var. '2' plantlets than to var. '11' following choice bioassays. Furthermore, cotton plants dipped in an essential oil emulsion of var. '2' had significantly greater colonization than cotton plants dipped in the essential oil emulsion of var. '11'. Similar results were obtained in 'plant-plant', 'plant-no plant' as well as, 'essential oil-essential oil' choice bioassay designs. Analyses of the essential oils of the two varieties identified a set of common and unique volatiles in each variety. Among these volatiles were ß-caryophyllene and limonene, two compounds known to be associated with plant-insect interactions. The attraction of B. tabaci to pure (>95%) ß-caryophyllene and limonene using a range of concentrations was examined in vitro by choice bioassays. The compounds were attractive to the insect at moderate concentration, but not at the lowest or highest concentrations used, where the insect was not attracted or repelled, respectively. Limonene attracted the insects at rates that were 10-fold lower than ß-caryophyllene. The results emphasized the role of host plant volatiles in shaping the structure of B. tabaci populations in nature and in agricultural systems, and provided insights into the factors that contribute to the development of insect populations with unique characteristics. The results could also serve for future development of bio-pesticides and in breeding programs.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Cyclohexenes); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Sesquiterpenes); 0 (Terpenes); 9MC3I34447 (limonene); BHW853AU9H (caryophyllene)


  9 / 582 MEDLINE  
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PMID:28494028
Autor:Murino Rafacho BP; Portugal Dos Santos P; Gonçalves AF; Fernandes AAH; Okoshi K; Chiuso-Minicucci F; Azevedo PS; Mamede Zornoff LA; Minicucci MF; Wang XD; Rupp de Paiva SA
Endereço:Internal Medicine Department, Botucatu Medical School-UNESP, Botucatu/SP, Brazil.
Título:Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats.
Fonte:PLoS One; 12(5):e0177521, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:BACKGROUND: Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown. METHODS AND RESULTS: To determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0.02% rosemary (R002) (SR002, n = 23); 3) Sham group fed standard chow supplemented with 0.2% rosemary (R02) (SR02, n = 22); 4) group submitted to MI and fed standard chow (IR0, n = 13); 5) group submitted to MI and fed standard chow supplemented with R002 (IR002, n = 8); and 6) group submitted to MI and fed standard chow supplemented with R02 (IR02, n = 9). After 3 months of the treatment, systolic pressure evaluation, echocardiography and euthanasia were performed. Left ventricular samples were evaluated for: fibrosis, cytokine levels, apoptosis, energy metabolism enzymes, and oxidative stress. Rosemary dietary supplementation attenuated cardiac remodeling by improving energy metabolism and decreasing oxidative stress. Rosemary supplementation of 0.02% improved diastolic function and reduced hypertrophy after MI. Regarding rosemary dose, 0.02% and 0.2% for rats are equivalent to 11 mg and 110 mg for humans, respectively. CONCLUSION: Our findings support further investigations of the rosemary use as adjuvant therapy in adverse cardiac remodeling.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (NF-E2-Related Factor 2); 0 (Plant Extracts)


  10 / 582 MEDLINE  
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PMID:28472953
Autor:Samarghandian S; Azimi-Nezhad M; Borji A; Samini M; Farkhondeh T
Endereço:Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran. samarghandians@mums.ac.ir.
Título:Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats.
Fonte:BMC Complement Altern Med; 17(1):249, 2017 May 04.
ISSN:1472-6882
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Oxidative stress through chronic stress destroys the brain function. There are many documents have shown that carnosol may have a therapeutic effect versus free radical induced diseases. The current research focused the protective effect of carnosol against the brain injury induced by the restraint stress. METHODS: The restraint stress induced by keeping animals in restrainers for 21 consecutive days. Thereafter, the rats were injected carnosol or vehicle for 21 consecutive days. At the end of experiment, all the rats were subjected to his open field test and forced swimming test. Afterwards, the rats were sacrificed for measuring their oxidative stress parameters. To measure the modifications in the biochemical aspects after the experiment, the activities of malondialdehyde (MDA), reduced glutathione (GSH), as well as superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and catalase (CAT) were evaluated in the whole brain. RESULTS: Our data showed that the animals received chronic stress had a raised immobility time versus the non-stressed animals (p < 0.01). Furthermore, chronic stress diminished the number of crossing in the animals that were subjected to the chronic stress versus the non-stressed rats (p < 0.01). Carnosol ameliorated this alteration versus the non-treated rats (p < 0.05). In the vehicle treated rats that submitted to the stress, the level of MDA levels was significantly increased (P < 0.001), and the levels of GSH and antioxidant enzymes were significantly decreased versus the non-stressed animals (P < 0.001). Carnosol treatment reduced the modifications in the stressed animals as compared with the control groups (P < 0.001). All of these carnosol effects were nearly similar to those observed with fluoxetine. CONCLUSION: The current research shows that the protective effects of carnosol may be accompanied with enhanced antioxidant defenses and decreased oxidative injury.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Diterpenes, Abietane); 0 (Plant Extracts); 483O455CKD (carnosol); 4Y8F71G49Q (Malondialdehyde); GAN16C9B8O (Glutathione)



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