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Pesquisa : B01.650.940.800.575.912.250.618.050.750.066 [Categoria DeCS]
Referências encontradas : 43 [refinar]
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  1 / 43 MEDLINE  
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PMID:28780427
Autor:Huang W; Yi X; Feng J; Wang Y; He X
Endereço:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China.
Título:Piperidine alkaloids from Alocasia macrorrhiza.
Fonte:Phytochemistry; 143:81-86, 2017 Nov.
ISSN:1873-3700
País de publicação:England
Idioma:eng
Resumo:Six previously undescribed piperidine alkaloids were isolated from the rhizomes of Alocasia macrorrhiza (L.) Schott. Their structures were elucidated based on 1D and 2D NMR, IR, HR-ESI-MS spectroscopic analysis and the application of a modified Mosher method. All isolated alkaloids were evaluated for cytotoxicity against five human cancer cell lines (CNE-1, Detroit 562, Fadu, MGC-803, and MCF-7) using the MTT method. Only one compound exhibited cytotoxic effects against Detroit 562, Fadu, and MCF-7 cell lines with IC values less than 10 µM.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Drugs, Chinese Herbal); 0 (Piperidines)


  2 / 43 MEDLINE  
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PMID:28260730
Autor:Hagino K; Nakano H; Shimizu M; Terai A; Ogai M; Aragane M; Abe T; Sasamoto T
Endereço:Tokyo Metropolitan Institute of Public Health.
Título:Identification of Alocasia odora (Kuwazuimo in Japanese) Using PCR Method.
Fonte:Shokuhin Eiseigaku Zasshi; 58(1):32-35, 2017.
ISSN:1882-1006
País de publicação:Japan
Idioma:jpn
Resumo:Kuwazuimo (Alocasia odora) and shimakuwazuimo (Alocasia cucullata) are evergreen perennial plants that originated in East Asia. Although inedible, they are occasionally eaten by mistake because they resemble satoimo (Colocasia esculenta), and this has caused food poisoning in Japan. It is not easy to determine the cause of a food poisoning outbreak from the shape or chemical composition when the available sample is small. Therefore, we developed a new primer pair for PCR to identify kuwazuimo and shimakuwazuimo in small samples, based on the internal transcribed spacer (ITS) region of ribosomal DNA. Using PCR with the developed primer pair, we detected all samples of kuwazuimo obtained from the market, while excluding 17 other kinds of crops. The samples were identified as shimakuwazuimo by DNA sequencing of the PCR products. The present PCR method showed high specificity and was confirmed to be applicable to the identification of kuwazuimo and shimakuwazuimo from various crops.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (DNA, Ribosomal)


  3 / 43 MEDLINE  
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PMID:28161134
Autor:Huang W; Li C; Wang Y; Yi X; He X
Endereço:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China.
Título:Anti-inflammatory lignanamides and monoindoles from Alocasia macrorrhiza.
Fonte:Fitoterapia; 117:126-132, 2017 Mar.
ISSN:1873-6971
País de publicação:Netherlands
Idioma:eng
Resumo:Five new lignanamides (1-5), and one new monoindole alkaloid (6), along with eight known compounds (7-14) were isolated and identified from the rhizomes of Alocasia macrorrhiza (giant taro). All purified compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells, and the antiproliferative activities against human nasopharyngeal carcinoma epithelial (CNE-1), human gastric carcinoma (MGC-803), and human breast cancer (MCF-7) cell lines by MTT method. Compounds 2, 4, 7 and 8 exhibited significant inhibitory effects on NO production with the IC values of 2.35±0.38, 9.20±0.94, 3.45±0.39 and 7.96±0.56µM, respectively. The results suggested the lignanamides and monoindoles might be responsible for the anti-inflammatory activity of giant taro and might be potential anti-inflammatory candidates.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Indoles); 0 (Lignans); 0 (Lipopolysaccharides); 31C4KY9ESH (Nitric Oxide)


  4 / 43 MEDLINE  
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PMID:27497869
Autor:Elsbaey M; Ahmed KF; Elsebai MF; Zaghloul A; Amer MM; Lahloub MI
Título:Cytotoxic constituents of Alocasia macrorrhiza.
Fonte:Z Naturforsch C; 72(1-2):21-25, 2017 Jan 01.
ISSN:0939-5075
País de publicação:Germany
Idioma:eng
Resumo:An indole alkaloid, 2-(5-hydroxy-1H-indol-3-yl)-2-oxo-acetic acid (1) isolated for the first time from nature, in addition to the nine known compounds 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (2), alocasin B (3), hyrtiosin B (4), α-monopalmitin (5), 1-O-ß-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2(R)-hydroctadecanoyl) amido]-4,8-octadecadiene-1,3-diol (6), 3-epi-betulinic acid (7), 3-epi-ursolic acid (8), ß-sitosterol (9) and ß-sitosterol 3-O-ß-D-glucoside (10) were isolated from the rhizomes of Alocasia macrorrhiza (Araceae). Their structures were elucidated by 1D and 2D NMR spectroscopic data. Of these compounds, 6 exhibited the strongest cytotoxicity against the four tested human cancer cell lines (IC50 of about 10 µM against Hep-2 larynx cancer cells).
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents, Phytogenic); 0 (Cytotoxins); 0 (Indole Alkaloids)


  5 / 43 MEDLINE  
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PMID:27120176
Autor:Peng W; Liang S; Hu J; Chen Z; Zheng X
Endereço:Department of Medical Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, People's Republic of China.
Título:The cytotoxic and tyrosine kinase inhibitory properties of C21 steroids and iridoids from the tubers of Alocasia cucullata.
Fonte:J Nat Med; 70(3):602-9, 2016 Jul.
ISSN:1861-0293
País de publicação:Japan
Idioma:eng
Resumo:Ten steroids and iridoids were isolated from the tubers of Alocasia cucullata (Lour.) G. Don. Among them, alocasgenin A (1) and alocasgenoside B-C (2-3) were new compounds and the aglycone of compound 1, obtained from the acid hydrolysis of 1, was named alocasgenol (1a). Also, for the first time, tenacigenin B (4), 17ß-tenacigenin-B (5), 3-O-6-deoxy-3-O-methyl-ß-D-allopyranosyl-(1→4)-ß-D-oleandropyranosyl-tenacigenin C (6), marsdenoside A-B (7-8) and tenacigenoside A-B (9-10) were isolated from the genus Alocasia. The chemical structures were elucidated by the extensive analysis of spectral data and compared with the literature. By evaluation of the cytotoxic and tyrosine kinase inhibition, compounds 1-10, 1a and compound 2 showed significant growth inhibition against two tumour cell lines, MGC-803 and HT-29, while compounds 1, 1a, 3, 6 and 8 presented moderate inhibition. Furthermore, compound 2 had the inhibitory property against the enzyme activity biochemically.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Iridoids); 0 (Steroids); EC 2.7.10.1 (Protein-Tyrosine Kinases)


  6 / 43 MEDLINE  
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PMID:26897473
Autor:Hei L; Lee CC; Wang H; Lin XY; Chen XH; Wu QT
Endereço:Key Laboratory of Soil Environment and Waste Reuse in Agriculture of Guangdong Higher Education Institutes, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of the Pearl River Estuarine Dynamics and Associated Process Regulati
Título:Using a high biomass plant Pennisetum hydridum to phyto-treat fresh municipal sewage sludge.
Fonte:Bioresour Technol; 217:252-6, 2016 Oct.
ISSN:1873-2976
País de publicação:England
Idioma:eng
Resumo:The study was carried out to investigate the use of a high biomass plant, Pennisetum hydridum, to treat municipal sewage sludge (MSS). An experiment composed of plots with four treatments, soil, fresh sludge, soil-sludge mixture and phyto-treated sludge, was conducted. It showed that the plant could not survive directly in fresh MSS when cultivated from stem cuttings. The experiment transplanting the incubated cutting with nurse medium of P. hydridum in soil and fresh MSS, showed that the plants grew normally in fresh MSS. The pilot experiment of P. hydridum and Alocasia macrorrhiza showed that the total yield and nutrient amount of P. hydridum were 9.2 times and 3.6 times more than that of A. macrorrhiza. After plant treatment, MSS was dried, stabilized and suitable to be landfilled or incinerated, with a calorific value of about 5.6MJ/kg (compared to the initial value of 1.9MJ/kg fresh sludge).
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Sewage)


  7 / 43 MEDLINE  
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PMID:26744062
Autor:Kidanemariam DB; Abraham AD; Sukal AC; Holton TA; Dale JL; James AP; Harding RM
Endereço:Centre for Tropical Crops and Biocommodities, Queensland University of Technology (QUT), Brisbane, 4001, Australia.
Título:Complete genome sequence of a novel zantedeschia mild mosaic virus isolate: the first report from Australia and from Alocasia sp.
Fonte:Arch Virol; 161(4):1079-82, 2016 Apr.
ISSN:1432-8798
País de publicação:Austria
Idioma:eng
Resumo:The complete genome of an Australian isolate of zantedeschia mild mosaic virus (ZaMMV) causing mosaic symptoms on Alocasia sp. (designated ZaMMV-AU) was cloned and sequenced. The genome comprises 9942 nucleotides (excluding the poly-A tail) and encodes a polyprotein of 3167 amino acids. The sequence is most closely related to a previously reported ZaMMV isolate from Taiwan (ZaMMV-TW), with 82 and 86 % identity at the nucleotide and amino acid level, respectively. Unlike the amino acid sequence of ZaMMV-TW, however, ZaMMV-AU does not contain a polyglutamine stretch at the N-terminus of the coat-protein-coding region upstream of the DAG motif. This is the first report of ZaMMV from Australia and from Alocasia sp.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Viral Proteins)


  8 / 43 MEDLINE  
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PMID:26625266
Autor:Kim SH; Sperry J
Endereço:School of Chemical Sciences, University of Auckland , 23 Symonds Street, Auckland 1142, New Zealand.
Título:Synthesis of Alocasin A.
Fonte:J Nat Prod; 78(12):3080-2, 2015 Dec 24.
ISSN:1520-6025
País de publicação:United States
Idioma:eng
Resumo:Herein is reported a synthesis of alocasin A (1), an alkaloid component of Alocasia macrorrhiza, a herbaceous plant used in folk medicine throughout southern Asia. A double Suzuki-Miyaura cross-coupling reaction between a 3-borylindole and 2,5-dibromopyrazine was used to assemble the heteroaromatic framework of the natural product. Removal of the protecting groups gave a synthetic sample of 1, the spectroscopic data of which matched those in the isolation report of this compound.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Alkaloids); 0 (Biological Products); 0 (alocasin A)


  9 / 43 MEDLINE  
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PMID:26519202
Autor:Latif MA; Zaki MZ; Leng TM; Rahman NH; Arshad SA; Hamid A
Endereço:Programme of Biomedical Science, School of Diagnostic & Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Título:Alocasia denudata Engler treatment enhance open wound healing activities in Wistar rat's skin.
Fonte:J Ethnopharmacol; 176:258-67, 2015 Dec 24.
ISSN:1872-7573
País de publicação:Ireland
Idioma:eng
Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: A. denudata is traditionally used to treat various skin disorders, including wounds. It is widely used by the traditional healers as an effective wound treatment. AIM OF STUDY: This study was done to determine A. denudata treatment effects on open wound healing activities in Wistar rat's skin. MATERIALS AND METHODS: 120 Wistar rats (250-300 g) were divided into four main groups, 1.5% and 3% A. denudata stem juice treated group, 10% Solcoseryl® gel treated group as positive control and phosphate buffer saline (PBS) treated group as negative control. Six full thicknesses wounds (6mm) were induced bilaterally on the dorsal of the rat's skin. Rats were sacrificed on day 1, 3, 6, 10 and 14. The percentage of wound contraction, biochemical estimations, macroscopic observation and histological examinations were done to evaluate the wound healing activities. RESULTS: Results showed wounds treated with A. denudata stem juice possess a significant higher rate of wound contraction (p<0.001), total protein concentration (p<0.05), hexosamine concentration (p<0.001) and uronic acid concentration (p<0.001). Moreover, cathepsin B (p<0.05) and hydroxyproline (p<0.05) level showed lower concentration in wounds treated with A. denudata stem juice. Histological observation of wounds treated with A. denudata stem juice displayed organized epithelial layer with dense and compact collagen fibers. CONCLUSION: Both doses of A. denudata stem juice were found to enhance wound healing process. However, wounds treated with 3% A. denudata stem juice were reported to be more effective as a wound healing agent thus support its traditional usage.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Dermatologic Agents); 0 (Hexosamines); 0 (Plant Extracts); 0 (Plant Proteins); 0 (Uronic Acids); EC 3.4.22.1 (Cathepsin B); RMB44WO89X (Hydroxyproline)


  10 / 43 MEDLINE  
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PMID:25888009
Autor:Wei P; Zhiyu C; Xu T; Xiangwei Z
Endereço:Department of Medical Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China. pengwei8324@126.com.
Título:Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo.
Fonte:BMC Complement Altern Med; 15:33, 2015 Feb 26.
ISSN:1472-6882
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Alocasia cucullata (Lour.) G. Don was applied in traditional Chinese medicine for the treatment of cancer in Chinese Southwest area. Its antitumor effect was scrutinized in vitro and in vivo. And for the first time, the mechanism of extract of A. cucullata (EAC) against human gastric cancer cell was well examined. METHODS: To detect the most effective fraction, the antiproliferation efficacy of four fractions (namely derivatives by adding EAC to n-BuOH, petroleum ether, EtOAc and water until dissolve fully) against five cancer cell lines were screened by MTT assay. Among four fractions, the IC50s of n-BuOH fraction of EAC (EAC-B) against the five cell lines and time-dependent inhibition to gastric cancer cell line (MGC-803) were further investigated (MTT assay). In vivo antitumor efficacy of EAC-B was examined by MGC-803 bearing tumor nude mice. Especially, the paper focused on the relevant mechanism study of EAC-B against MGC-803 included cell cycle distribution (flow cytometry) and cyclin D1 expression (RT-PCR and western blot), apoptosis (Hoechst 33342 stain and flow cytometry), apoptosis-related protein expression (Akt, p-Akt, ERK, p-ERK, Bcl-2, Bax) by western blot, and caspase3/7 activity assay. RESULTS: EAC-B showed its cytotoxicity against various tumor cell lines, particularly against gastric cancer cells with IC50 value of 18.8 µg/mL in vitro. Tumor weight was significantly reduced by EAC-B in vivo. In the mechanism study, EAC-B increased cell ratio at G0/G1 phase and reduced cyclin D1 expression both at protein and mRNA level on MGC-803. Chromatin condensation and apoptosis were also observed. EAC-B down-regulated p-Akt, p-ERK expression and up-regulated Bax/Bcl-2 ratio. Further, caspase 3/7 activation was enhanced as well. CONCLUSIONS: This study demonstrated that EAC-B had potent antitumor activity both in vitro and in vivo. Its mechanism is primarily via antiproliferation of G0/G1 arrest and cell pro-apoptosis, including PI-3 K/Akt pathway, ERK activity, stimulated cytochrome C release and caspase 3/7 activity accompanied with an increase of Bax/Bcl-2 ratio. EAC-B may be a potential source of novel compounds for gastric cancer treatment.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Antineoplastic Agents, Phytogenic); 0 (Drugs, Chinese Herbal); 0 (RNA, Messenger); 136601-57-5 (Cyclin D1); EC 3.4.22.- (Caspases)



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