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  1 / 136 MEDLINE  
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PMID:29361938
Autor:Maia-Landim A; Ramírez JM; Lancho C; Poblador MS; Lancho JL
Endereço:Department of Morphological Sciences, School of Medicine, University of Córdoba, Avenida de Menéndez Pidal s/n, 14071, Córdoba, Spain.
Título:Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms.
Fonte:BMC Complement Altern Med; 18(1):26, 2018 Jan 24.
ISSN:1472-6882
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life. Both conditions have a high prevalence across the world reaching epidemic numbers. Our aim was to evaluate the effects of the administration of Garcinia cambogia (GC) and Glucomannan (GNN) on long-term weight loss in people with overweight or obesity. METHODS: Prospective, not-randomized controlled intervention trial was conducted. We treated 214 subjects with overweight or obesity with GC and GNN (500 mg twice a day, each) for 6 months evaluating weight, fat mass, visceral fat, basal metabolic rate, and lipid and glucose blood profiles comparing them with basal values. Some patients were carriers of polymorphisms PLIN4 -11482G > A-, fat mass and obesity-associated (FTO) -rs9939609 A/T- and ß-adrenergic receptor 3 (ADRB3) -Trp64Arg. RESULTS: Treatment produced weight loss, reducing fat mass, visceral fat, lipid and blood glucose profiles while increasing basal metabolic rate. Results were independent of sex, age or suffering from hypertension, diabetes mellitus type 2 or dyslipidemia and were attenuated in carriers of PLIN4, FTO, Trp64Arg polymorphisms. CONCLUSIONS: Administration of GC and GNN reduce weight and improve lipid and glucose blood profiles in people with overweight or obesity, although the presence of polymorphisms PLIN4, FTO and ADRB3 might hinder in some degree these effects. ISRCTN78807585, 19 September 2017, retrospective study.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (ADRB3 protein, human); 0 (Mannans); 0 (PLIN4 protein, human); 0 (Perilipin-4); 0 (Plant Extracts); 0 (Receptors, Adrenergic, beta-3); 36W3E5TAMG ((1-6)-alpha-glucomannan); EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO); EC 1.14.11.33 (FTO protein, human)


  2 / 136 MEDLINE  
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PMID:28750276
Autor:Kite GC; Hetterscheid WLA
Endereço:Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, UK. Electronic address: g.kite@kew.org.
Título:Phylogenetic trends in the evolution of inflorescence odours in Amorphophallus.
Fonte:Phytochemistry; 142:126-142, 2017 Oct.
ISSN:1873-3700
País de publicação:England
Idioma:eng
Resumo:The chemical composition of inflorescence odours of 80 species of Amorphophallus (Araceae) were determined by headspace-thermal desorption GC-MS. When compared to published molecular phylogenies of the genus, the data reveal evidence both of phylogenetic constraint and plasticity of odours. Dimethyl oligosulphides were found as common constituents of Amorphophallus odours and were the most abundant components in almost half of the species studied. Odours composed mainly of dimethyl oligosulphides, and perceived as being 'gaseous', were only found among Asian species, and some of these species clustered in certain clades in molecular phylogenies; e.g. in two clades in Amorphophallus subgenus Metandrium. However, some species with gaseous odours were found to be closely related to species producing odours more reminiscent of rotting meat in which various minor components accompany the dominant dimethyl oligosulphides. These two broad types of odours have co-evolved with other inflorescence characteristics such as colour, with species with rotting meat odours having darker inflorescences. Species producing pleasant odours characterised by benzenoid compounds constitute two broad groups that are not related in published phylogenies. Species having fruity odours containing 1-phenylethanol derivatives mainly occur in a clade in subgenus Metandrium while those with anise odours composed almost solely of the 2-phenylethanol derivative 4-methoxyphenethyl alcohol are restricted to a clade in subgenus Scutandrium. Phylogenetic mapping of odours also indicates that the evolution of some odour types is likely to have been influenced by ecological factors. For example, species producing fishy odours dominated by trimethylamine and occurring in N and NE Borneo are not all closely related. Conversely, two sister species, A. mossambicensis and A. abyssinicus, which are morphologically very similar and have overlapping geographical distribution, produce odours which are very different chemically. The pressure of pollinator resource has therefore been a factor influencing the evolution of odours in Amorphophallus, driving both the divergence of odour types in some taxa and the convergence of odour types in others.
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Benzyl Alcohols); 0 (Sulfides); E6O895DQ52 (methylphenyl carbinol); ML9LGA7468 (Phenylethyl Alcohol)


  3 / 136 MEDLINE  
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PMID:28658282
Autor:Santosa E; Lian CL; Sugiyama N; Misra RS; Boonkorkaew P; Thanomchit K
Endereço:Department of Agronomy and Horticulture, Faculty of Agriculture, Bogor Agricultural University, Bogor, West Java, Indonesia.
Título:Population structure of elephant foot yams (Amorphophallus paeoniifolius (Dennst.) Nicolson) in Asia.
Fonte:PLoS One; 12(6):e0180000, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:The corms and leaves of elephant foot yams (Amorphophallus paeoniifolius (Dennst.) Nicolson) are important foods in the local diet in many Asian regions. The crop has high productivity and wide agroecological adaptation and exhibits suitability for the agroforestry system. Although the plant is assumed to reproduce via panmixia, a comprehensive study on the genetic background across regions to enhance wider consumer palatability is still lacking. Here, ten informative microsatellites were analyzed in 29 populations across regions in India, Indonesia and Thailand to understand the genetic diversity, population structure and distribution to improve breeding and conservation programs. The genetic diversity was high among and within regions. Some populations exhibited excess heterozygosity and bottlenecking. Pairwise FST indicated very high genetic differentiation across regions (FST = 0.274), and the Asian population was unlikely to be panmictic. Phylogenetic tree construction grouped the populations according to country of origin with the exception of the Medan population from Indonesia. The current gene flow was apparent within the regions but was restricted among the regions. The present study revealed that Indonesia and Thailand populations could be alternative centers of the gene pool, together with India. Consequently, regional action should be incorporated in genetic conservation and breeding efforts to develop new varieties with global acceptance.
Tipo de publicação: JOURNAL ARTICLE


  4 / 136 MEDLINE  
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PMID:28551237
Autor:Suriya M; Rethina C; Bashir M; Koteswara Reddy C; Harsha N; Haripriya S
Endereço:Department of Food Science and Technology, Pondicherry University, Puducherry 605014, India.
Título:Impact of γ-irradiation on physicochemical properties of freeze dried Amorphophallus paeoniifolius flour.
Fonte:Food Chem; 234:276-284, 2017 Nov 01.
ISSN:0308-8146
País de publicação:England
Idioma:eng
Resumo:Freeze dried raw (FDR) and freeze dried blanched (FDB) Amorphophallus paeoniifolius flours were irradiated at doses of 3, 6 and 12kGy. The irradiated flours were investigated for physicochemical, pasting, textural, thermal and morphological properties. Reduction in amylose content was observed with increasing irradiation dose. Carboxyl content of the flours increased significantly at higher doses. Decline in lightness (L ) and increase in redness (a ) were found to increase with the elevation of dosage. Irradiation caused reduction in the values of pasting parameters of freeze dried raw as well as freeze dried blanched samples. Hardness of the flour gels exhibited increase at all the doses except at 3kGy. Decrease in onset gelatinization temperature of both FDR and FDB flours was observed with increasing irradiation dose. FDR as well as FDB flours exhibited increasing trend in their enthalpy (ΔHgel) values following irradiation treatment. Raman spectroscopy revealed that no new functional groups were introduced by irradiation treatment. However, band intensity of functional groups in irradiated FDR flours was reduced with increment of dose.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Gels); 9005-82-7 (Amylose)


  5 / 136 MEDLINE  
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PMID:28356275
Autor:Ho HVT; Jovanovski E; Zurbau A; Blanco Mejia S; Sievenpiper JL; Au-Yeung F; Jenkins AL; Duvnjak L; Leiter L; Vuksan V
Endereço:Clinical Nutrition and Risk Factor Modification Centre.
Título:A systematic review and meta-analysis of randomized controlled trials of the effect of konjac glucomannan, a viscous soluble fiber, on LDL cholesterol and the new lipid targets non-HDL cholesterol and apolipoprotein B.
Fonte:Am J Clin Nutr; 105(5):1239-1247, 2017 May.
ISSN:1938-3207
País de publicação:United States
Idioma:eng
Resumo:Evidence from randomized controlled trials (RCTs) suggests the consumption of konjac glucomannan (KJM), a viscous soluble fiber, for improving LDL-cholesterol concentrations. It has also been suggested that the cholesterol-lowering potential of KJM may be greater than that of other fibers. However, trials have been relatively scarce and limited in sample size and duration, and the effect estimates have been inconsistent. The effect of KJM on new lipid targets of cardiovascular disease (CVD) risk is also unknown. This systematic review and meta-analysis aimed to assess the effect of KJM on LDL cholesterol, non-HDL cholesterol, and apolipoprotein B. Medline, Embase, CINAHL, and the Cochrane Central databases were searched. We included RCTs with a follow-up of ≥3 wk that assessed the effect of KJM on LDL cholesterol, non-HDL cholesterol, or apolipoprotein B. Data were pooled by using the generic inverse-variance method with random-effects models and expressed as mean differences (MDs) with 95% CIs. Heterogeneity was assessed by the Cochran Q statistic and quantified by the statistic. Twelve studies ( = 370), 8 in adults and 4 in children, met the inclusion criteria. KJM significantly lowered LDL cholesterol (MD: -0.35 mmol/L; 95% CI: -0.46, -0.25 mmol/L) and non-HDL cholesterol (MD: -0.32 mmol/L; 95% CI: -0.46, -0.19 mmol/L). Data from 6 trials suggested no impact of KJM on apolipoprotein B. Our findings support the intake of ∼3 g KJM/d for reductions in LDL cholesterol and non-HDL cholesterol of 10% and 7%, respectively. The information may be of interest to health agencies in crafting future dietary recommendations related to reduction in CVD risk. This study was registered at clinicaltrials.gov as NCT02068248.
Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW
Nome de substância:0 (Anticholesteremic Agents); 0 (Apolipoproteins B); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Dietary Fiber); 0 (Mannans); 36W3E5TAMG ((1-6)-alpha-glucomannan); 97C5T2UQ7J (Cholesterol)


  6 / 136 MEDLINE  
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PMID:28169529
Autor:Li MY; Feng GP; Wang H; Yang RL; Xu Z; Sun YM
Endereço:Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University , Guangzhou 510642, China.
Título:Deacetylated Konjac Glucomannan Is Less Effective in Reducing Dietary-Induced Hyperlipidemia and Hepatic Steatosis in C57BL/6 Mice.
Fonte:J Agric Food Chem; 65(8):1556-1565, 2017 Mar 01.
ISSN:1520-5118
País de publicação:United States
Idioma:eng
Resumo:Konjac gel foods that mainly consist of deacetylated konjac glucomannan (Da-KGM) are considered to have the same health benefits as native konjac glucomannan (KGM); however, no definitive data support this notion. The objective of this study was to compare the effects of Da-KGM and KGM on the hyperlipidemia and liver steatosis induced by high-fat diet feeding and to investigate the underlying molecular mechanisms. C57BL/6 mice were fed (1) normal chow diet, (2) high-fat diet, (3) HFD with KGM, or (4) HFD with Da-KGM for 10 weeks. KGM, but not Da-KGM, showed decreased fat accumulation, improved blood and liver lipid profiles, and prevention of liver lipid droplet deposition compared with HFD. Compared with Da-KGM, KGM increased the outputs of fecal bile acid (KGM 22.5 ± 2.34 mg/g vs Da-KGM 19.3 ± 1.87 mg/g), fat (KGM 5.56 ± 0.68 mg/g vs Da-KGM 4.42 ± 0.57 mg/g) and cholesterol (KGM2.67 ± 0.43 mg/g vs Da-KGM 1.78 ± 0.28 mg/g), fecal concentrations of total short-chain fatty acids (KGM 103 ± 14.8 µmol/g vs Da-KGM 74.5 ± 8.49 µmol/g), and improved hepatic antioxidant status and upregulated CYP7A1 and LDLR gene expression. These findings suggest that deacetylation of KGM negatively affects its fermentation characteristics and its inhibition of lipid absorption, which thereby reduces Da-KGM's health benefits.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Mannans); 0 (Plant Extracts); 0 (Receptors, LDL); 36W3E5TAMG ((1-6)-alpha-glucomannan); EC 1.14.14.23 (Cholesterol 7-alpha-Hydroxylase); EC 1.14.14.23 (Cyp7a1 protein, mouse)


  7 / 136 MEDLINE  
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PMID:27600166
Autor:Dey YN; Sharma G; Wanjari MM; Kumar D; Lomash V; Jadhav AD
Endereço:a National Research Institute for Ayurveda-Siddha Human Resource Development , Gwalior , Madhya Pradesh , India , (Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, New Delhi, India).
Título:Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats.
Fonte:Pharm Biol; 55(1):53-62, 2017 Dec.
ISSN:1744-5116
País de publicação:England
Idioma:eng
Resumo:CONTEXT: The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders. OBJECTIVE: The present study evaluated the effects of extracts of Amorphophallus paeoniifolius tubers on acetic acid-induced ulcerative colitis (UC) in rats. MATERIALS AND METHODS: Wistar rats were orally administered methanol extract (APME) or aqueous extract (APAE) (250 and 500 mg/kg) or standard drug, prednisolone (PRDS) (4 mg/kg) for 7 days. On 6th day of treatment, UC was induced by transrectal instillation of 4% acetic acid (AA) and after 48 h colitis was assessed by measuring colitis parameters, biochemical estimations and histology of colon. RESULTS: APME or APAE pretreatment significantly (p < .05-.001) prevented AA-induced reduction in body weight and increase in colitis parameters viz. stool consistency, colon weight/length ratio and ulcer score, area and index. Extracts treatment attenuated (p < .001) increase in alkaline phosphatase and lactate dehydrogenase in serum and myeloperoxidase activity and cytokines in colon tissue due to AA administration. Extracts treatment prevented AA-induced elevation in lipid peroxidation and decline in activities of superoxide dismutase and catalase and reduced-glutathione content (p < .05-.001) along with histopathological alterations. PRDS also showed similar ameliorative effect on colitis. DISCUSSION AND CONCLUSION: APME and APAE showed a preventive effect on UC, and ameliorated inflammation and oxidative damage in colon. The effects may be attributed to presence of phytochemicals, betulinic acid, ß-sitosterol, and glucomannan. In conclusion, the tuber of Amorphophallus paeoniifolius exhibited an anticolitic effect through anti-inflammatory and antioxidant action.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (Cytokines); 0 (Gastrointestinal Agents); 0 (Inflammation Mediators); 0 (Plant Extracts); 0 (Solvents); 9PHQ9Y1OLM (Prednisolone); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 1.11.1.6 (Catalase); EC 1.11.1.7 (Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 3.1.3.1 (Alkaline Phosphatase); GAN16C9B8O (Glutathione); Q40Q9N063P (Acetic Acid)


  8 / 136 MEDLINE  
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PMID:28480351
Autor:Chen D
Endereço:Department of Neurosurgery Tian Jin Huan Hu Hospital, No.122 QiXiang Tai Road, He Xi District, Tian Jin 300060, P.R. China.
Título:NEUROPROTECTIVE EFFECT OF IN STZ INDUCED ALZHEIMER RAT MODEL.
Fonte:Afr J Tradit Complement Altern Med; 13(4):47-54, 2016.
ISSN:2505-0044
País de publicação:Nigeria
Idioma:eng
Resumo:BACKGROUND: The present investigation deals with the assessment of neuroprotective effect (AC) tuber in alzheimer diseased (AD) rat and also postulates its possible mechanism of action. MATERIAL AND METHODS: AD was induced by administering streptozotocin i.e. STZ (3 mg/kg, ICV) day one and 3 day after surgery. Surgery was performed on anesthetized rats by the help of stereotaxic apparatus. STZ induced AD rats were treated with petroleum ether extract of AC (100, 200 and 500 mg/kg, p.o.) for 14 days. Effect of AC tuber in AD rats were assessed by estimating the alteration in the behavior (Y maze apparatus and single trail passive avoidance), biochemical parameter in the brain tissue {Oxidative stress parameters (SOD, CAT and LPO), amyloid ß peptide (Aß) and acetylcholinesterase (AchE)} and histopathological study of brain tissue. RESULT: Treatment with AC shows significant ( <0.01) increased in the % of alteration in the behavior and step through latency in Y maze task and single trial passive avoidance test compared to AD rats. AC significantly ( <0.01) decreases the Aß1-40, Aß1-42 peptides and AchE in the brain tissue compared to AD rats. Whereas, treatment with AC significantly reduces the oxidative stress level in AD rats. Histopathological study reveals that treatment with AC extract reduces the amyloid plaque formation in the brain tissue of AD rat. CONCLUSION: The present study concludes the neuroprotective effect of AC extract in AD rats by reducing oxidative stress, Aß and AchE in the brain tissue.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Amyloid beta-Peptides); 0 (Neuroprotective Agents); 0 (Plant Extracts); 5W494URQ81 (Streptozocin)


  9 / 136 MEDLINE  
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PMID:27709705
Autor:Madsen JT; Andersen KE; Nielsen DT; Hvid L; El-Houri RB; Christensen LP
Endereço:Department of Dermatology and Allergy Centre, Institute of Clinical Research University of Southern Denmark, Odense University Hospital, 5000, Odense C, Denmark. jakob.torp.madsen@rsyd.dk.
Título:Undisclosed presence of methylisothiazolinone in '100% natural' Konjac® sponge.
Fonte:Contact Dermatitis; 75(5):308-309, 2016 Nov.
ISSN:1600-0536
País de publicação:England
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Cosmetics); 0 (Preservatives, Pharmaceutical); 0 (Thiazoles); 229D0E1QFA (2-methyl-4-isothiazolin-3-one)


  10 / 136 MEDLINE  
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PMID:27706095
Autor:Tan C; Wei H; Zhao X; Xu C; Zhou Y; Peng J
Endereço:Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. cooper2005@163.com.
Título:Soluble Fiber with High Water-Binding Capacity, Swelling Capacity, and Fermentability Reduces Food Intake by Promoting Satiety Rather Than Satiation in Rats.
Fonte:Nutrients; 8(10), 2016 Oct 02.
ISSN:2072-6643
País de publicação:Switzerland
Idioma:eng
Resumo:To understand whether soluble fiber (SF) with high water-binding capacity (WBC), swelling capacity (SC) and fermentability reduces food intake and whether it does so by promoting satiety or satiation or both, we investigated the effects of different SFs with these properties on the food intake in rats. Thirty-two male Sprague-Dawley rats were randomized to four equal groups and fed the control diet or diet containing 2% flour (KF), pregelatinized waxy maize starch (PWMS) plus guar gum (PG), and PWMS starch plus xanthan gum (PX) for three weeks, with the measured values of SF, WBC, and SC in the four diets following the order of PG > KF > PX > control. Food intake, body weight, meal pattern, behavioral satiety sequence, and short-chain fatty acids (SCFAs) in cecal content were evaluated. KF and PG groups reduced the food intake, mainly due to the decreased feeding behavior and increased satiety, as indicated by decreased meal numbers and increased inter-meal intervals. Additionally, KF and PG groups increased concentrations of acetate acid, propionate acid, and SCFAs in the cecal contents. Our results indicate that SF with high WBC, SC, and fermentability reduces food intake-probably by promoting a feeling of satiety in rats to decrease their feeding behavior.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Dietary Fiber); 0 (Fatty Acids, Volatile); 0 (Galactans); 0 (Mannans); 0 (Plant Gums); 059QF0KO0R (Water); E89I1637KE (guar gum)



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