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  1 / 57 MEDLINE  
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PMID:28606766
Autor:Bernardo J; Ferreres F; Gil-Izquierdo Á; Valentão P; Andrade PB
Endereço:REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal.
Título:Medicinal species as MTDLs: Turnera diffusa Willd. Ex Schult inhibits CNS enzymes and delays glutamate excitotoxicity in SH-SY5Y cells via oxidative damage.
Fonte:Food Chem Toxicol; 106(Pt A):466-476, 2017 Aug.
ISSN:1873-6351
País de publicação:England
Idioma:eng
Resumo:One of the most promising approaches to confront the complexity of central nervous system disorders are new multi-target directed ligands (MTDLs). Five medicinal species (Cereus grandiflorus (L.) Mill., Hyssopus officinalis L., Acorus calamus L., Silybum marianum L. Gaertn. and Turnera diffusa Willd. Ex Schult), selected for their ethnopharmacological relevance, were object for in vitro screening. The aqueous extract of T. diffusa revealed the strongest neuroactive potential, inhibiting monoamine oxidase-A (IC = 129.80 ± 11.97 µg/mL), and acetyl- and butyrylcholinesterase (IC = 0.352 ± 0.011 and 0.370 ± 0.036 mg/mL, respectively). Its phenolic profile was established for the first time by HPLC-DAD-ESI/MS . Twenty-six out of thirty-seven compounds were newly identified in this species. The pre-treatment with this flavonoid-rich extract promoted a rightward shift of the glutamate concentration neuronal cell (SH-SY5Y) death response curve. Furthermore, it significantly reduced the early phase formation of intracellular reactive species after glutamate and t-BHP exposure, suggesting that neuroprotection in SH-SY5Y cells was, in part, mediated by antioxidant mechanisms.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 3KX376GY7L (Glutamic Acid)


  2 / 57 MEDLINE  
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PMID:28397755
Autor:Parra-Naranjo A; Delgado-Montemayor C; Fraga-López A; Castañeda-Corral G; Salazar-Aranda R; Acevedo-Fernández JJ; Waksman N
Endereço:Departmento de Química Analítica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, N.L., C.P. 64460, Mexico. ap._183@hotmail.com.
Título:Acute Hypoglycemic and Antidiabetic Effect of Teuhetenone A Isolated from Turnera diffusa.
Fonte:Molecules; 22(4), 2017 Apr 08.
ISSN:1420-3049
País de publicação:Switzerland
Idioma:eng
Resumo:Diabetes mellitus is a chronic degenerative disease that causes long-term complications and represents a serious public health problem. (damiana) is a shrub that grows throughout Mexico and is traditionally used for many illnesses including diabetes. Although a large number of plant metabolites are known, there are no reports indicating which of these are responsible for this activity, and this identification was the objective of the present work. Through bioassay-guided fractionation of a methanolic extract obtained from the aerial part of , teuhetenone A was isolated and identified as the main metabolite responsible for the plant's hypoglycemic activity. Alpha-glucosidase inhibitory activity and cytotoxicity of this metabolite were determined. Hypoglycemic and antidiabetic activities were evaluated in a murine model of diabetes in vivo, by monitoring glucose levels for six hours and comparing them with levels after administering various controls. Teuhetenone A was not cytotoxic at the tested concentrations, and did not show inhibitory activity in the glucosidase test, and the in vivo assays showed a gradual reduction in glucose levels in normoglycemic and diabetic mice. Considering these results, we suggest that teuhetenone A has potential as an antidiabetic compound, which could be further submitted to preclinical assays.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Blood Glucose); 0 (Glycoside Hydrolase Inhibitors); 0 (Hypoglycemic Agents); 0 (Plant Extracts); EC 3.2.1.20 (alpha-Glucosidases)


  3 / 57 MEDLINE  
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PMID:28288755
Autor:Oliveira AF; Costa Junior LM; Lima AS; Silva CR; Ribeiro MN; Mesquista JW; Rocha CQ; Tangerina MM; Vilegas W
Endereço:Universidade Federal do Maranhão, Centro de Ciências Biológicas e da Saúde, CEP 65080-805 São Luís, MA, Brazil.
Título:Anthelmintic activity of plant extracts from Brazilian savanna.
Fonte:Vet Parasitol; 236:121-127, 2017 Mar 15.
ISSN:1873-2550
País de publicação:Netherlands
Idioma:eng
Resumo:Helminth infections represent a serious problem for the production of small ruminants that is currently aggravated by resistance to anthelmintic products and has induced a search for control alternatives, such as natural products. In this study, extracts of Turnera ulmifolia L. (leaves and roots), Parkia platycephala Benth. (leaves and seeds) and Dimorphandra gardneriana Tul. (leaves and bark), which have been cited in ethnoveterinary studies and selected naturally by goats in the cerrado (Brazilian savanna), were tested in vitro against Haemonchus contortus. Hydroacetonic (ACT) and hydroalcoholic (ETH) extracts were evaluated using an Egg Hatching Assay (EHA), a Larval Exsheathment Inhibition Assay (LEIA) and a Larval Development Assay (LDA). A second set of incubations was performed using polyvinylpolypyrrolidone (PVPP) to determine the influence of polyphenols on the anthelmintic effects of EHA and LEIA. Data from each extract were used to calculate inhibition concentrations (IC ). All tested extracts showed activity against at least one life stage of H. contortus. The use of PVPP revealed that the tannins are not the only extracts of secondary metabolites responsible for the anthelmintic effects. The results showed clear in vitro anthelmintic activities against H. contortus at different stages and indicated the potential use of these species as a promising alternative approach to control helminthic infections of small ruminants.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anthelmintics); 0 (Plant Extracts)


  4 / 57 MEDLINE  
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Texto completo SciELO Brasil
PMID:27074236
Autor:Bezerra AG; Negri G; Duarte-Almeida JM; Smaili SS; Carlini EA
Endereço:Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Título:Phytochemical analysis of hydroethanolic extract of Turnera diffusa Willd and evaluation of its effects on astrocyte cell death.
Fonte:Einstein (Sao Paulo); 14(1):56-63, 2016 Jan-Mar.
ISSN:2317-6385
País de publicação:Brazil
Idioma:eng; por
Resumo:OBJECTIVE: To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae; T. diffusa), as well as its toxicity in astrocytes. METHODS: Chemical analyses of hydroethanolic extract from powdered aerial parts ofT. diffusa were carried out using HPLC-DAD-ESI-MS/MS.In vitro assays using astrocytes culture were performed to evaluate cell death. RESULTS: Flavone-C, O-diglycosides, such as, luteolin-8-C-[6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside, apigenin-8-C-[6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside and apigenin-7-O-6"-p-coumaroylglucoside were the main compounds found in this hydroethanolic extract. Concentration time-effect demonstrated the toxicity of this extract at a concentration of 1,000µg/mL in astrocyte culture, after 6 and 24 hours of incubation. CONCLUSION: In phytochemical analyses, important antioxidants (mainly flavonoids) were observed. T. diffusa extracts presented cytotoxic effect in high concentrations, leading to increased cell death in astrocyte culture.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Antioxidants); 0 (Flavones); 0 (Plant Extracts)


  5 / 57 MEDLINE  
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PMID:26794024
Autor:Roggero Luque JM; Moreno EM; Kovalsky IE; Seijo JG; Solís Neffa VG
Endereço:a Instituto de Botánica del Nordeste (UNNE-CONICET). CC 209. 3400, Corrientes, Argentina.
Título:Evidence of the occurrence of structural chromosome changes at the initial diploid diversification of the autopolyploid Turnera sidoides L. (Passifloraceae) complex.
Fonte:Genome; 59(2):127-36, 2016 Feb.
ISSN:1480-3321
País de publicação:Canada
Idioma:eng
Resumo:Turnera sidoides is an autopolyploid complex of obligate outcrossing perennial herbs. It includes five subspecies and five morphotypes in which diploid to octoploid cytotypes were found. Based on phenetic analyses of the complex and karyotype data of polyploid cytotypes, it has been hypothesized that morphological and chromosome differentiation of T. sidoides occurred at the diploid level. To test this hypothesis, we present the first detailed chromosome analysis of diploid populations of three subspecies and four morphotypes. CMA(+)/DAPI(-) bands were restricted to secondary constrictions (except in the andino morphotype) and varied in number and position among taxa. By contrast, DAPI staining was uniform in all the materials investigated. The number and position of 45S rDNA loci were coincident with the CMA(+)/DAPI(-) bands associated with secondary constrictions. Only one pair of 5S rDNA loci was detected in all the taxa (except in subsp. holosericea), but its position was variable. The identified chromosome markers varied among the three subspecies analyzed, but they were more conserved among the morphotypes of subsp. pinnatifida. Cluster analysis of these chromosome markers supports the current taxonomic arrangement of diploids and demonstrates that structural chromosome changes would have led or accompanied the initial differentiation of T. sidoides at the diploid level.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (DNA, Plant); 0 (DNA, Ribosomal)


  6 / 57 MEDLINE  
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PMID:26473510
Autor:Williams K; Wells RJ; McLean MK
Endereço:From the Emergency Animal Clinic, Gilbert, AZ.
Título:Suspected synthetic cannabinoid toxicosis in a dog.
Fonte:J Vet Emerg Crit Care (San Antonio); 25(6):739-44, 2015 Nov-Dec.
ISSN:1476-4431
País de publicação:United States
Idioma:eng
Resumo:OBJECTIVE: To describe the effects of suspected synthetic cannabinoid (SC) toxicosis and the response to intravenous lipid emulsion (ILE) therapy in a dog. CASE SUMMARY: A 2-year-8-month-old male Boxer dog was evaluated at an emergency hospital for progressive ataxia and inappropriate mentation. The initial physical examination identified marked hypothermia (32.7°C [90.9°F]), intermittent sinus bradycardia (60/min), stuporous mentation with intermittent aggression, and severe ataxia. Neurologic status deteriorated to comatose mentation within 2 hours of presentation. The initial diagnostic evaluation (eg, CBC, serum biochemistry profile, venous blood gas, and electrolyte determination) revealed a respiratory acidosis and thrombocytopenia. The owner reported that the dog was exposed to an SC containing Damiana leaf, Marshmallow leaf, and Athaea leaves. Initial treatment included IV fluids and supplemental oxygen. Mechanical ventilation was provided due to hypoventilation and periods of apnea. Intravenous lipid emulsion therapy was administered as a bolus (1.5 mL/kg) and continued as a continuous rate infusion (0.5 mL/kg/h) for a total of 6 hours. The dog became rousable and was weaned from mechanical ventilation approximately 15 hours following presentation. The dog was eating and walking with no ataxia, had a normal mentation at approximately 33 hours following presentation, and was discharged home at that time. Communication with the owners 5 days following discharge revealed that the dog was apparently normal. NEW OR UNIQUE INFORMATION PROVIDED: Based on this case and other reports in the literature regarding human exposures, SC ingestion may result in more severe clinical signs than marijuana ingestion in dogs. Significant clinical intervention may be necessary. Intravenous lipid emulsion treatment may be beneficial due to the lipophilicity of SC.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Cannabinoids); S88TT14065 (Oxygen)


  7 / 57 MEDLINE  
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PMID:26220657
Autor:Ochoa-López S; Villamil N; Zedillo-Avelleyra P; Boege K
Endereço:Instituto de Ecología, Universidad Nacional Autónoma de México, Apartado Postal 70-275, Ciudad Universitaria, CP 04510, Mexico DF, Mexico.
Título:Plant defence as a complex and changing phenotype throughout ontogeny.
Fonte:Ann Bot; 116(5):797-806, 2015 Oct.
ISSN:1095-8290
País de publicação:England
Idioma:eng
Resumo:BACKGROUND AND AIMS: Ontogenetic changes in anti-herbivore defences are common and result from variation in resource availability and herbivore damage throughout plant development. However, little is known about the simultaneous changes of multiple defences across the entire development of plants, and how such changes affect plant damage in the field. The aim of this study was to assess if changes in the major types of plant resistance and tolerance can explain natural herbivore damage throughout plant ontogeny. METHODS: An assessment was made of how six defensive traits, including physical, chemical and biotic resistance, simultaneously change across the major transitions of plant development, from seedlings to reproductive stages of Turnera velutina growing in the greenhouse. In addition, an experiment was performed to assess how plant tolerance to artificial damage to leaves changed throughout ontogeny. Finally, leaf damage by herbivores was evaluated in a natural population. KEY RESULTS: The observed ontogenetic trajectories of all defences were significantly different, sometimes showing opposite directions of change. Whereas trichome density, leaf toughness, extrafloral nectary abundance and nectar production increased, hydrogen cyanide and compensatory responses decreased throughout plant development, from seedlings to reproductive plants. Only water content was higher at the intermediate juvenile ontogenetic stages. Surveys in a natural population over 3 years showed that herbivores consumed more tissue from juvenile plants than from younger seedlings or older reproductive plants. This is consistent with the fact that juvenile plants were the least defended stage. CONCLUSIONS: The results suggest that defensive trajectories are a mixed result of predictions by the Optimal Defence Theory and the Growth-Differentiation Balance Hypothesis. The study emphasizes the importance of incorporating multiple defences and plant ontogeny into further studies for a more comprehensive understanding of plant defence evolution.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T


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PMID:25299247
Autor:Avelino-Flores Mdel C; Cruz-López Mdel C; Jiménez-Montejo FE; Reyes-Leyva J
Endereço:1 Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional , Tepetitla, Tlaxcala, México .
Título:Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells.
Fonte:J Med Food; 18(3):299-305, 2015 Mar.
ISSN:1557-7600
País de publicação:United States
Idioma:eng
Resumo:Turnera diffusa Willd, commonly known as Damiana, is employed in traditional medicine as a stimulant, aphrodisiac, and diuretic. Its leaves and stems are used for flavoring and infusion. Damiana is considered to be safe for medicinal use by the FDA. Pharmacological studies have established the hypoglycemic, antiaromatase, prosexual, estrogenic, antibacterial, and antioxidant activity of T. diffusa. The aim of the present study was to evaluate the possible cytotoxic effect of extracts and organic fractions of this plant on five tumor cell lines (SiHa, C-33, Hep G2, MDA-MB-231, and T-47D) and normal human fibroblasts. The results show that the methanolic extract (TdM) displayed greater activity on MDA-MB-231 breast cancer cells (with an IC50 of 30.67 µg/mL) than on the other cancer cell lines. Four organic fractions of this extract exhibited activity on this cancer cell line. In the most active fraction (F4), two active compounds were isolated, arbutin (1) and apigenin (2). This is the first report of a cytotoxic effect by T. diffusa on cancer cells. The IC50 values suggest that the methanolic extract of T. diffusa has potential as an anticancer therapy.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 7V515PI7F6 (Apigenin); C5INA23HXF (Arbutin)


  9 / 57 MEDLINE  
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PMID:24951993
Autor:Soriano-Melgar Lde A; Alcaraz-Meléndez L; Méndez-Rodríguez LC; Puente ME; Rivera-Cabrera F; Zenteno-Savín T
Endereço:Planeación Ambiental y Conservación.. tzenteno04@cibnor.mx.
Título:Antioxidant responses of damiana (Turnera diffusa Willd) to exposure to artificial ultraviolet (UV) radiation in an in vitro model; part ii; UV-B radiation.
Fonte:Nutr Hosp; 29(5):1116-22, 2014 May 01.
ISSN:1699-5198
País de publicação:Spain
Idioma:eng
Resumo:INTRODUCTION: Ultraviolet type B (UV-B) radiation effects on medicinal plants have been recently investigated in the context of climate change, but the modifications generated by UV-B radiation might be used to increase the content of antioxidants, including phenolic compounds. OBJECTIVE: To generate information on the effect of exposure to artificial UV-B radiation at different highdoses in the antioxidant content of damiana plants in an in vitro model. METHODS: Damiana plantlets (tissue cultures in Murashige- Skoog medium) were irradiated with artificial UV-B at 3 different doses (1) 0.5 ± 0.1 mW cm-2 (high) for 2 h daily, (2) 1 ± 0,1 mW cm-2 (severe) for 2 h daily, or (3) 1 ± 0.1 mW cm-2 for 4 h daily during 3 weeks. The concentration of photosynthetic pigments (chlorophylls a and b, carotenoids), vitamins (C and E) and total phenolic compounds, the enzymatic activity of superoxide dismutase (SOD, EC 1.15.1.1) and total peroxidases (POX, EC 1.11.1), as well as total antioxidant capacity and lipid peroxidation levels were quantified to assess the effect of high artificial UV-B radiation in the antioxidant content of in vitro damiana plants. RESULTS: Severe and high doses of artificial UV-B radiation modified the antioxidant content by increasing the content of vitamin C and decreased the phenolic compound content, as well as modified the oxidative damage of damiana plants in an in vitro model. CONCLUSION: UV-B radiation modified the antioxidant content in damiana plants in an in vitro model, depending on the intensity and duration of the exposure.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Antioxidants); 0 (Phenols)


  10 / 57 MEDLINE  
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PMID:24951992
Autor:Soriano-Melgar Lde A; Alcaraz-Meléndez L; Méndez-Rodríguez LC; Puente ME; Rivera-Cabrera F; Zenteno-Savín T
Endereço:Planeación Ambiental y Conservación.. tzenteno04@cibnor.mx.
Título:Antioxidant responses of damiana (Turnera diffusa Willd) to exposure to artificial ultraviolet (UV) radiation in an in vitro model; part I; UV-C radiation.
Fonte:Nutr Hosp; 29(5):1109-15, 2014 May 01.
ISSN:1699-5198
País de publicação:Spain
Idioma:eng
Resumo:INTRODUCTION: Ultraviolet type C (UV-C) radiation has higher energy than the UV-B radiation and has been less studied because it is completely absorbed by the ozone layer. However, artificial UV-C radiation can generate diverse modifications in the plants. Given that exposure to UV-C for short periods of time increases the antioxidant content, improving the appearance and shelf-life of products, its potential application in postharvest treatments to modify the antioxidant content of medicinal plants, such as damiana (Turnera diffusa), is novel and relevant. OBJECTIVE: To determine the effects of UV-C radiation on enzymatic and non-enzymatic antioxidant defenses, as well as oxidative damage levels, in damiana (Turnera diffusa) plants in vitro. RESULTS: UV-C radiation decreased superoxide dismutase (SOD, EC 1.15.1.1) and total peroxidases (POX, EC 1.11.1) activities, the concentration of chlorophylls (a and b), carotenes, vitamin C, and total antioxidant capacity. UV-C radiation increased the phenolic compound levels in damiana. Loss of antioxidant defenses was higher in damiana plants exposed to higher UV-C doses and/or for longer periods. This study suggests that UV-C radiation induces oxidative stress, evidenced as increased protein carbonyls and phenolic compound content, in damiana (T. diffusa). CONCLUSION: Low dose, short exposure to UV-C stimulates phenolic compound content in damiana. Thus, controlled UV-C treatments could be used as postharvest treatment to increase phenolic compound content in damiana plants.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Antioxidants); 0 (Phenols)



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