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Pesquisa : B01.650.940.800.575.912.250.875.077 [Categoria DeCS]
Referências encontradas : 138 [refinar]
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  1 / 138 MEDLINE  
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PMID:29378653
Autor:Kalyana Sundaram I; Sarangi DD; Sundararajan V; George S; Sheik Mohideen S
Endereço:Department of Biotechnology, Dayanandasagar College of Engineering, Kumaraswamy Layout, Bangalore, 560078, Karnataka, India.
Título:Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging.
Fonte:BMC Complement Altern Med; 18(1):33, 2018 Jan 29.
ISSN:1472-6882
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the skin. Extrinsic factors that affect skin aging such as UV radiation can also cause malignant melanoma. Here we selected four medicinal plant materials, namely, leaves of Nyctanthes arbor-tristis, unripe and ripe Aegle marmelos fruit pulp and the terminal meristem of Musa paradisiaca flower and investigated their anti-aging properties and cytotoxicity in vitro individually as well as in a poly herbal formulation containing the four plant extracts in different ratios. METHODS: The phytochemical contents of the plant extracts were investigated for radical scavenging activity and total reducing power. Based upon its anti-oxidant properties, a poly herbal formulation containing leaves of Nyctanthes arbor-tristis, unripe and ripe fruit pulp of Aegle marmelos, and the terminal meristem of Musa paradisiaca flower in the ratio 6:2:1:1 (Poly Herbal Formulation 1) and 1:1:1:1 (Poly Herbal Formulation 2), respectively were formulated. RESULT: It has been observed that the Poly Herbal Formulation 1 was more potent than Poly Herbal Formulation 2 due to better anti-oxidant and anti-elastase activities in NIH3T3 fibroblast cells. In addition Poly Herbal formulation 1 also had better anti-cancer activity in human malignant melanoma cells. CONCLUSION: Based on these results these beneficial plant extracts were identified for its potential application as an anti-aging agent in skin creams as well as an anti-proliferation compound against cancer cells.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 31C4KY9ESH (Nitric Oxide); EC 3.4.21.36 (Pancreatic Elastase)


  2 / 138 MEDLINE  
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PMID:28431540
Autor:Hafizur RM; Momin S; Fatima N
Endereço:Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan. hafizpcmd@yahoo.com.
Título:Prevention of advanced glycation end-products formation in diabetic rats through beta-cell modulation by Aegle marmelos.
Fonte:BMC Complement Altern Med; 17(1):227, 2017 Apr 21.
ISSN:1472-6882
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Although the anti-diabetic activity of Aegle marmelos (AM) is known, however, its anti-glycation activity is not reported yet. In this study, we have investigated its anti-glycation activity under in vitro and in vivo conditions and determined possible mechanism(s) in streptozotocin-induced diabetic rats. METHODS: Effective dose of AM (400 mg/kg) was administrated orally to diabetic rats for 42 days. Thereafter, blood glucose, serum insulin, HbA1c, antioxidant status, and advanced glycation end-products (AGEs) were measured. AGEs and its receptor (RAGE) in kidney were analyzed by immunohistochemistry and immunoblotting. Additionally, pancreatic sections were co-stained for insulin and glucagon and images were acquired using NIKON TE2000E fluorescence microscopy. RESULTS: Oral administration of AM extract resulted in a significant increase in serum insulin by better functioning of ß-cell and preserving pancreatic ß-cell integrity in diabetic rats. Treatment of AM extract significantly (p = 0.000) prevented the formation of HbA1c in the diabetic rats (8.20 ± 0.18% vs. 11.92 ± 0.59%). The circulatory AGEs level found in diabetic rat was significantly (p = 0.002) attenuated by AM treatment (0.66 ± 0.05 mg/ml vs. 1.18 ± 0.19 mg/ml). AM treatment also reduced AGEs accumulation around Bowman's capsule and in tubular basement membrane around arteries in diabetic rat kidney. The accumulation of RAGE was very similar to that of AGEs in diabetic rats and RAGE accumulation was also prevented by AM treatment. The extract showed potent antioxidant activity both under in vitro and in vivo systems. Eugenol, one of the active constituent of AM fruit extract, showed acute blood glucose-lowering activity in diabetic rats and enhanced glucose-stimulated insulin secretion from mice islets. CONCLUSION: AM extract prevents AGEs formation by modulating ß-cell function, and eugenol may play important role in preventing complications of diabetes in this rat model.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Blood Glucose); 0 (Glycation End Products, Advanced); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts); 3T8H1794QW (Eugenol)


  3 / 138 MEDLINE  
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PMID:28254574
Autor:Bera K; Ray S; Raja W; Ray B
Endereço:Natural Products Laboratory, Department of Chemistry, Golapbag, Burdwan, The University of Burdwan, West Bengal 713 104, India.
Título:Structural insight of an antioxidative arabinogalactan protein of Aegle marmelos fruit gum and it's interaction with ß-lactoglobulin.
Fonte:Int J Biol Macromol; 99:300-307, 2017 Jun.
ISSN:1879-0003
País de publicação:Netherlands
Idioma:eng
Resumo:The complication of arabinogalactan protein (AGP) structure, a significant ingredient of gum polysaccharides, not merely hinders the allocation of its role, but restricts its utilization as well. Here, we describe structural details of an AGP purified from Aegle marmelos fruit gum. This AGP (310×10 g/mol), which is water-soluble, contains ß-1,3-linked galactopyranosyl main chain substituted at O-6 position with side chains containing galactose and arabinose residues. Also data on sugar composition, ring size, glycosidic linkage pattern, anomeric configuration and sequence of monosaccharide units of a number of oligosaccharides produced from this AGP by chemical and enzymatic methods were acquired. Biochemical analysis reveals resemblance in antioxidative potential between this arabinogalactan protein and standard antioxidants. Moreover, mixture of AGP and ß-lactoglobulin form stable water soluble complex having binding constant K=2.38×10 /M. As gum polysaccharides are important raw materials of food industry discovering an antioxidative gum with the ability of creating stable water soluble complex with ß-lactoglobulin may have important implication.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Lactoglobulins); 0 (Mucoproteins); 0 (Plant Gums); 0 (Plant Proteins); 0 (arabinogalactan proteins)


  4 / 138 MEDLINE  
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PMID:28002030
Autor:Ansari P; Afroz N; Jalil S; Azad SB; Mustakim MG; Anwar S; Haque SM; Hossain SM; Tony RR; Hannan JM
Título:Anti-hyperglycemic activity of Aegle marmelos (L.) corr. is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption.
Fonte:J Pediatr Endocrinol Metab; 30(1):37-47, 2017 Jan 01.
ISSN:2191-0251
País de publicação:Germany
Idioma:eng
Resumo:BACKGROUND: Aegle marmelos (commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, of A. marmelos extracts on carbohydrate absorption, glucose utilization, and α-amylase inhibition and insulin content in pancreases of type 2 diabetic rats. METHODS: This research begins with fasting blood glucose and oral glucose tolerance test (OGTT) to evaluate the primary anti-hyperglycemic effect in chemically induced type 2 diabetic rats. Furthermore, the plasma insulin concentration and serum glucose level were studied, which include measuring the sucrose content in six different segments of the gastrointestinal (GI) tract of the rats following oral sucrose feeding. An in situ, perfused, intestinal model in rats and glucose-fiber binding assay were conducted to find the effects of A. marmelos extracts on glucose absorption. Extract effects on carbohydrate breakdown, intestinal disaccharidase enzyme activity, and α-amylase inhibition were assessed. Effect on GI motility was evaluated using BaSO4 milk traverse test. RESULTS: Treatment of extracts suppressed blood glucose elevation after oral sucrose (2.5 g/kg) administration and significantly (p<0.05) improved oral glucose tolerance in type 2 diabetic rats. Aegle marmelos extracts showed remarkable (p<0.05) changes in plasma insulin secretion at 30 min and 60 min, respectively. A noticeable reduction in glucose absorption was observed in the in situ perfused rat intestinal model at two different doses (250 and 500 mg/kg). The extract was also found to inhibit the action of both α-amylase and intestinal disaccharidase enzyme, and this study was affirmed again by the sucrose malabsorption test, where sucrose digestion was inhibited throughout the length of the GI tract. During this chronic study, body mass of rats became normal and their polydipsic and polyphagic conditions were ameliorated also. CONCLUSIONS: The findings demonstrate that anti-hyperglycemic activity of A. marmelos is mediated by the inhibition of carbohydrate digestion and absorption, and improvement of insulin action to uptake glucose in peripheral tissue. Additional study is required to correlate A. marmelos extracts' specific mechanism of glucose-fiber binding capacity and glucose transporters.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts); EC 3.2.1.1 (alpha-Amylases); IY9XDZ35W2 (Glucose)


  5 / 138 MEDLINE  
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PMID:27765350
Autor:Arora D; Sharma N; Singamaneni V; Sharma V; Kushwaha M; Abrol V; Guru S; Sharma S; Gupta AP; Bhushan S; Jaglan S; Gupta P
Endereço:Quality Control & Quality Assurance Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR, New Delhi, 110025, India.
Título:Isolation and characterization of bioactive metabolites from Xylaria psidii, an endophytic fungus of the medicinal plant Aegle marmelos and their role in mitochondrial dependent apoptosis against pancreatic cancer cells.
Fonte:Phytomedicine; 23(12):1312-1320, 2016 Nov 15.
ISSN:1618-095X
País de publicação:Germany
Idioma:eng
Resumo:BACKGROUND: The genus Xylaria has been reported as a rich source of biologically active secondary metabolites. In the present study, an endophytic fungus Xylaria psidii has been isolated from the leaf sample of Aegle marmelos (L.) Corr., characterized on the basis of its morphological features and sequence data for the ITS region (KU291350) of the nuclear ribosomal DNA. Biological screening of ethyl acetate extract of Xylaria psidii displayed a potential therapeutic effect on pancreatic cancer cells. HYPOTHESIS: This study was designed systematically to explore Xylaria psidii, an endophytic fungus for the identification of biologically active secondary metabolites against pancreatic cancer cells. METHODS: While exploring the bioactive secondary metabolites, a sensitive and reliable LC-MS based dereplication approach was applied to identify four compounds A-D from fungal extract. Further bioactivity guided isolation of fungal extract yielded two major metabolites 1 and 2. The structures of 1 and 2 have been determined by detailed spectroscopic analysis including MS, NMR, IR and UV data and similarity with published data. Xylarione A (1) is new whereas (-) 5-methylmellein (2) is reported for the first time from X. psidii. Both the isolated compounds were screened for their effect on the viability and proliferation against a panel of cancer cell lines (MCF-7, MIA-Pa-Ca-2, NCI-H226, HepG2 and DU145) of different tissue origin. RESULTS: Compounds 1 and 2 exhibited cytotoxicity against pancreatic cancer (MIA-Pa-Ca-2) cells with IC values of 16.0 and 19.0 µm, respectively. The cell cycle distribution in MIA-Pa-Ca-2 cells, confirmed a cell cycle arrest at the sub-G1 phase. Cell death induced by 1 and 2 displayed features characteristic of apoptosis. Flow cytometry based analysis of 1 and 2 using Rhodamine-123 displayed substantial loss of mitochondrial membrane potential in a concentration dependent manner by both the compounds. CONCLUSION: Results conclude that the isolated compounds 1 and 2 are responsible for the activity shown by crude ethyl acetate extract and may act as potential leads for medicinal chemists for designing more potent analogs.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Acetates); 0 (Antibiotics, Antineoplastic); 0 (Solvents); 76845O8NMZ (ethyl acetate)


  6 / 138 MEDLINE  
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PMID:27393425
Autor:Rahman A; Imran H; Iqbal L; STaqvi SI; Fatima N; Yaqeen Z
Endereço:Pharmacology Section, PCSIR Labs Complex, Karachi, Pakistan.
Título:Dry and ripe fruit of Aegle marmelos. L: A potent source of antioxidant, lipoxygenase inhibitors and free radical scavenger.
Fonte:Pak J Pharm Sci; 29(4):1127-31, 2016 Jul.
ISSN:1011-601X
País de publicação:Pakistan
Idioma:eng
Resumo:The antioxidant, lipoxygenase inhibitory activities and free radical scavenging capacity of the crude extract, aqueous and some organic fractions of dry and ripe fruit of Aeglemarmelos. L were studied to understand the protective and therapeutic role for the use of the fruit as a remedy in different ailments. All the tested fractions and extracts showed to possess significant antioxidant, free radical scavenging capacity and lipoxygenase inhibitory potential. However, chloroform and aqueous fractions showed significant ability to quench radicals, to reduce ferric chloride and to inhibit soyabean lipoxygenase. Their antioxidant and lipoxygenase inhibition was estimated by IC50 values, for antioxidant ranging from 88-65% activity at concentration of 5-0.15µ/mL and similarly for lipoxygenase inhibition ranging from 89-69% at various concentrations of 5-0.15µ/mL, in chloroform and aqueous fractions respectively. The scavenger molecules in the dry and ripe fruit of A. marmelos may attribute to therapeutic and protective effect during different progressive stages of ailments.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antioxidants); 0 (Free Radical Scavengers); 0 (Lipoxygenase Inhibitors); 0 (Plant Extracts)


  7 / 138 MEDLINE  
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PMID:27279580
Autor:Sharma CK; Sharma M; Sharma V
Endereço:Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India 304022.
Título:Therapeutic Potential of the Medicinal Plant Aegle Marmelos (Linn.) Correa: Insight.
Fonte:J Environ Pathol Toxicol Oncol; 35(1):1-10, 2016.
ISSN:2162-6537
País de publicação:United States
Idioma:eng
Resumo:Various plant species are used globally for therapeutic purposes and have been authenticated by the World Health Organization. Aegle marmelos (L.) Corr., one of only three species in the genus Aegle, is a subtropical, fruit-bearing, deciduous tree that grows throughout the hills and plains of sub-Himalayan countries. Plants with medicinal importance have been used in almost every culture since ancient times. Various studies are underway to understand more about the qualities and components of medicinal plants, including drug preparation, phytochemical analysis, cultivation, toxicology, and pharmacology. According to the Indian conventional system of medicine, A. marmelos can successfully treat many diseases and conditions; for example, its extracts have been found to reduce the intensities of hepatic lipid peroxidation and augment the levels of hepatic antioxidants such as catalase, superoxide dismutase, and glutathione. The essential oils present in the foliage (leaves), fruits, and bark of A. marmelos provide strong antifungal action. A. marmelos is thus cytoprotective, works against ulcers and diarhea, promotes skin and bone healing, and acts as a hypoglycemic, antidiabetic, hepatoprotective, antimicrobial, analgesic, antiinflammatory, antipyretic, and anticancer agent. Such qualities have been well documented with scientific evidence.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Oils, Volatile); 0 (Plant Extracts)


  8 / 138 MEDLINE  
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PMID:27054911
Autor:Avula B; Chittiboyina AG; Wang YH; Sagi S; Raman V; Wang M; Khan IA
Endereço:National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS, USA.
Título:Simultaneous Determination of Aegeline and Six Coumarins from Different Parts of the Plant Aegle marmelos Using UHPLC-PDA-MS and Chiral Separation of Aegeline Enantiomers Using HPLC-ToF-MS.
Fonte:Planta Med; 82(6):580-8, 2016 Apr.
ISSN:1439-0221
País de publicação:Germany
Idioma:eng
Resumo:A fast UHPLC-PDA method was developed for the simultaneous analysis of one alkaloid, aegeline, and six coumarins, viz., umbelliferone, scopoletin, marmesinin, 8-hydroxypsoralen, angelicin, and marmelosin, from the leaf, fruit, root, and bark of Aegle marmelos. The UHPLC method was validated for linearity, accuracy, repeatability, limits of detection and limits of quantification. The linearity range (r(2) > 0.99) of the seven compounds was found to be 0.5-250 µg/mL, and the limits of detection and limits of quantification for the seven compounds were found to be 0.1 and 0.5 µg/mL, respectively. The developed UHPLC method is simple, fast, and especially suitable for quality control analysis of coumarins and aegeline from A. marmelos and commercial dietary supplements. Single quadrupole mass spectrometry was used for the identification and confirmation of coumarins and aegeline from different plant parts and dietary supplements. In addition, a novel chiral HPLC-ToF-MS method was developed for the resolution of aegeline enantiomers. By applying this chiral method, the distribution of enantiomers of aegeline from different parts of A. marmelos and aegeline-containing dietary supplements is reported for the first time.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
Nome de substância:0 (Amides); 0 (Coumarins); 0 (aegeline)


  9 / 138 MEDLINE  
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PMID:26910023
Autor:Tiwari M; Roy R; Tiwari V
Endereço:Department of Biochemistry, Central University of Rajasthan , Ajmer, India .
Título:Screening of Herbal-Based Bioactive Extract Against Carbapenem-Resistant Strain of Acinetobacter baumannii.
Fonte:Microb Drug Resist; 22(5):364-71, 2016 Jul.
ISSN:1931-8448
País de publicação:United States
Idioma:eng
Resumo:Acinetobacter baumannii is grouped in the ESKAPE pathogens by Infectious Disease Society of America, which is linked to high degree of morbidity, mortality, and increased costs. The high level of acquired and intrinsic resistance mechanisms of these bacteria makes it an urgent requirement to find a suitable alternative to carbapenem, a commonly prescribed drug for Acinetobacter infection. In this study, methanolic extracts of six medicinal plants were subjected to phytochemical screening and their antimicrobial activity was tested against two strains of A. baumannii (ATCC 19606, carbapenem-sensitive strain, and RS 307, carbapenem-resistant strain). Synergistic effect of the plant extracts and antibiotics was also tested. Bael or Aegle marmelos contains tannin, phenol, terpenoids, glycoside, alkaloids, coumarine, steroid, and quinones. Flowers of madar or Calotropis procera possess tannin, phenol, terpenoids, glycoside, quinone, anthraquinone, anthocyanin, coumarin, and steroid. An inhibitory growth curve was seen for both the bacterial strains when treated with A. marmelos, Curcuma longa, and leaves and flowers of C. procera. Antibiotics alone showed a small zone of inhibition, but when used with herbal extracts they exhibited larger zone of inhibition. Synergistic effect of A. marmelos and imipenem was the best against both the strains of A. baumannii. From this study, it can be concluded that extracts from A. marmelos and leaves and flowers of C. procera exhibited the most effective antibacterial activity. These herbal extracts may be used to screen the bioactive compound against the carbapenem-resistant strain of A. baumannii.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Alkaloids); 0 (Anti-Bacterial Agents); 0 (Drug Combinations); 0 (Glycosides); 0 (Phenols); 0 (Plant Extracts); 0 (Tannins); 71OTZ9ZE0A (Imipenem)


  10 / 138 MEDLINE  
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PMID:26264423
Autor:Reddy SG; Kirti Dolma S; Koundal R; Singh B
Endereço:a Entomology Laboratory, Plant Health Management Division , CSIR-Institute of Himalayan Bioresource Technology , Palampur , Himachal Pradesh , India.
Título:Chemical composition and insecticidal activities of essential oils against diamondback moth, Plutella xylostella (L.) (Lepidoptera: Yponomeutidae).
Fonte:Nat Prod Res; 30(16):1834-8, 2016 Aug.
ISSN:1478-6427
País de publicação:England
Idioma:eng
Resumo:Five Himalayan plants namely, Acorus calamus, Cedrus deodara, Aegle marmelos, Tagetes minuta and Murraya koenigii were used for the extraction of essential oils through hydrodistillation and the major volatile constituents as identified by GC and GC-MS techniques were ß-asarone (91.1%), ß-himachalene (45.8%), limonene (59.5%), Z-ocimene (37.9%) and α-pinene (54.2%), respectively. Essential oils were tested for their insecticidal properties against larvae of diamondback moth, Plutella xylostella (L.) (Lepidoptera: Yponomeutidae). Results showed that A. calamus was most toxic (LC50 = 0.29 mg mL(-1)) to P. xylostella followed by C. deodara (LC50 = 1.08 mg mL(-1)) and M. koenigii (LC50 = 1.93 mg mL(-1)) via residual toxicity bioassay. Per cent feeding deterrence index and growth inhibition was significantly higher in A. calamus (42.20 and 68.55, respectively) followed by C. deodara (35.41 and 52.47). In repellent activity studies, C. deodara showed high repellence (64.76%) followed by A. calamus (55.05%).
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anisoles); 0 (Insecticides); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (asarone); 0 (himachalene); JPF3YI7O34 (alpha-pinene)



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