Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.875.177.538 [Categoria DeCS]
Referências encontradas : 618 [refinar]
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  1 / 618 MEDLINE  
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PMID:28455260
Autor:Mikolajczyk-Stecyna J; Malinowska AM; Chmurzynska A
Endereço:Molecular Metabolism Laboratory, Department of Human Nutrition and Hygiene, Faculty of Food Sciences, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, Poland. Electronic address: joanstec@up.poznan.pl.
Título:TAS2R38 and CA6 genetic polymorphisms, frequency of bitter food intake, and blood biomarkers among elderly woman.
Fonte:Appetite; 116:57-64, 2017 09 01.
ISSN:1095-8304
País de publicação:England
Idioma:eng
Resumo:OBJECTIVE: Taste sensitivity is one of the most important biological determinants of food choice. Three SNPs of the TAS2R38 gene (rs713598, rs1726866, and rs10246939) give rise to two common haplotypes: PAV and AVI. These haplotypes, as well as an SNP within the CA6 gene (rs2274333) that encodes carbonic anhydrase VI (CA6), correlate with bitterness perception. The extent of consumption of bitter food may influence some health outcomes. The aim of this study is thus to investigate the impact of the TAS2R38 and CA6 genetic polymorphisms on the choice of bitter food, BMI, blood lipoprotein, and glucose concentrations as well as systemic inflammation in elderly women. METHODS: The associations between the TAS2R38 diplotype, CA6 genotype, and the intake of bitter-tasting foods were studied in a group of 118 Polish women over 60 years of age. The intake of Brassica vegetables, grapefruit, and coffee was assessed using a food frequency questionnaire. Biochemical parameters were measured using the spectrophotometric method. Genotyping was performed using the high resolution melting method. RESULTS: We found a correlation between lipid profile, glucose and CRP levels, and frequency of bitter food intake. The AVI/AVI subjects drank coffee more frequently than did the PAV/PAV homozygotes, as did the A carriers of CA6 in comparison with the GG homozygotes. We also observed that simultaneous carriers of the PAV haplotype and A allele of TAS2R38 and CA6, respectively, choose white cabbage more frequent and had lower plasma levels of CRP and glucose than did AVI/AVI and GG homozygotes. CONCLUSIONS: In elderly women, the TAS2R38 and CA6 polymorphisms may affect the frequency of consumption of coffee and white cabbage, but not of other bitter-tasting foods.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE
Nome de substância:0 (Biomarkers); 0 (Coffee); 0 (Receptors, G-Protein-Coupled); 0 (taste receptors, type 2); EC 4.2.1.1 (Carbonic Anhydrases); EC 4.2.1.1 (carbonic anhydrase VI)


  2 / 618 MEDLINE  
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PMID:29248344
Autor:Tong C; Peng M; Tong R; Ma R; Guo K; Shi S
Endereço:College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
Título:Use of an online extraction liquid chromatography quadrupole time-of-flight tandem mass spectrometry method for the characterization of polyphenols in Citrus paradisi cv. Changshanhuyu peel.
Fonte:J Chromatogr A; 1533:87-93, 2018 Jan 19.
ISSN:1873-3778
País de publicação:Netherlands
Idioma:eng
Resumo:Chemical profiling of natural products by high performance liquid chromatography (HPLC) was critical for understanding of their clinical bioactivities, and sample pretreatment steps have been considered as a bottleneck for analysis. Currently, concerted efforts have been made to develop sample pretreatment methods with high efficiency, low solvent and time consumptions. Here, a simple and efficient online extraction (OLE) strategy coupled with HPLC-diode array detector-quadrupole time-of-flight tandem mass spectrometry (HPLC-DAD-QTOF-MS/MS) was developed for rapid chemical profiling. For OLE strategy, guard column inserted with ground sample (2 mg) instead of sample loop was connected with manual injection valve, in which components were directly extracted and transferred to HPLC-DAD-QTOF-MS/MS system only by mobile phase without any extra time, solvent, instrument and operation. By comparison with offline heat-reflux extraction of Citrus paradisi cv. Changshanhuyu (Changshanhuyu) peel, OLE strategy presented higher extraction efficiency perhaps because of the high pressure and gradient elution mode. A total of twenty-two secondary metabolites were detected according to their retention times, UV spectra, exact mass, and fragmentation ions in MS/MS spectra, and nine of them were discovered in Changshanhuyu peel for the first time to our knowledge. It is concluded that the developed OLE-HPLC-DAD-QTOF-MS/MS system offers new perspectives for rapid chemical profiling of natural products.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Biological Products); 0 (Polyphenols)


  3 / 618 MEDLINE  
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PMID:29328677
Autor:Suh JH; Niu YS; Wang Z; Gmitter FG; Wang Y
Título:Metabolic Analysis Reveals Altered Long-Chain Fatty Acid Metabolism in the Host by Huanglongbing Disease.
Fonte:J Agric Food Chem; 66(5):1296-1304, 2018 Feb 07.
ISSN:1520-5118
País de publicação:United States
Idioma:eng
Resumo:Candidatus Liberibacter asiaticus (CLas) is the presumed causal agent of Huanglongbing, one of the most destructive diseases in citrus. However, the lipid metabolism component of host response to this pathogen has not been investigated well. Here, metabolic profiling of a variety of long-chain fatty acids and their oxidation products was first performed to elucidate altered host metabolic responses of disease. Fatty acid signals were found to decrease obviously in response to disease regardless of cultivar. Several lipid oxidation products strongly correlated with those fatty acids were also consistently reduced in the diseased group. Using a series of statistical methods and metabolic pathway mapping, we found significant markers contributing to the pathological symptoms and identified their internal relationships and metabolic network. Our findings suggest that the infection of CLas may cause the altered metabolism of long-chain fatty acids, possibly leading to manipulation of the host's defense derived from fatty acids.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Fatty Acids)


  4 / 618 MEDLINE  
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PMID:27770845
Autor:Bailey DG
Endereço:Lawson Health Research Institute and Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ont, Canada.
Título:Better to Avoid Grapefruit with Certain Statins.
Fonte:Am J Med; 129(11):e301, 2016 11.
ISSN:1555-7162
País de publicação:United States
Idioma:eng
Tipo de publicação: LETTER; COMMENT
Nome de substância:0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)


  5 / 618 MEDLINE  
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PMID:28597655
Autor:Nakanishi A; Ito M; Yoshikawa K; Maeda T; Ishizaki S; Kurobayashi Y
Endereço:R&D Center, T. Hasegawa Co., Ltd. , 29-7, Kariyado, Nakahara-ku, Kawasaki-shi, 211-0022, Japan.
Título:Identification and Characterization of 3-epi-Rotundone, a Novel Stereoisomer of Rotundone, in Several Kinds of Fruits.
Fonte:J Agric Food Chem; 65(25):5209-5214, 2017 Jun 28.
ISSN:1520-5118
País de publicação:United States
Idioma:eng
Resumo:A novel stereoisomer of rotundone, 3-epi-rotundone, was identified in the aroma of grapefruit, orange, apple, and mango. 3-epi-Rotundone was prepared by the isomerization of rotundone, and its structural elucidation was confirmed by comparing the 1D and 2D nuclear magnetic resonance and nuclear Overhauser effect spectroscopy spectra with those of rotundone. The odor thresholds of rotundone and 3-epi-rotundone in water were determined by a triangle test as 5 and 19100 ng/kg, respectively. The odor of 3-epi-rotundone was evaluated as woody, spicy, peppery, citrus, grapefruit-like, powdery, and celery-like, which was a greater range of odor characteristics than that for rotundone. Results of odor evaluation of 3-epi-rotundone revealed that its unique organoleptic properties, which were odor description (woody, spicy, and peppery), anosmic properties in neat form, and strong adaptation, were similar to those of rotundone. 3-epi-Rotundone might be a valuable substance to apply new types of woody, peppery, and spicy notes.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Flavoring Agents); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (rotundone)


  6 / 618 MEDLINE  
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PMID:28566583
Autor:Mizuno H; Hatano T; Taketomi A; Kawabata M; Nakabayashi T
Endereço:School of Pharmaceutical Sciences, Mukogawa Women's University.
Título:Bergamottin Promotes Adipocyte Differentiation and Inhibits Tumor Necrosis Factor-α-induced Inflammatory Cytokines Induction in 3T3-L1 Cells.
Fonte:Yakugaku Zasshi; 137(6):775-781, 2017.
ISSN:1347-5231
País de publicação:Japan
Idioma:jpn
Resumo:Nowadays, a lot of food ingredients are marketed as dietary supplements for health. Because the effectiveness and mechanisms of these compounds have not been fully characterized, they might have unknown functions. Therefore, we investigated the effect of several food ingredients (Bergamottin, Chrysin, L-Citrulline and ß-Carotene) known as health foods on adipocyte differentiation by using 3T3-L1 preadipocytes. In this study, we found that Bergamottin, a furanocoumarin isolated from grapefruit juice, promotes adipocyte differentiation. In addition, Bergamottin increases the expression of adiponectin, an anti-inflammatory adipokine, and peroxisome proliferator activated receptor γ (PPARγ), a nuclear receptor regulating adipocyte differentiation. Furthermore, the anti-inflammatory activity of Bergamottin was demonstrated by its inhibition of the activation of nuclear factor-κB (NF-κB), an inflammatory transcription factor. Stimulation of mature 3T3-L1 adipocytes by tumor necrosis factor-α (TNF-α) decreased the expression of the endogeneous NF-κB inhibitor, IκBα. Treatment with Bergamottin further decreased the TNF-α-induced change in IκBα expression, suggesting that Bergamottin mediated the inhibition of NF-κB activation. In addition, Bergamottin decreased the TNF-α-induced increase in the mRNA levels of pro-inflammatory adipokines, monocyte chemoattractant protein-1 and interleukin-6. Taken together, our results show that Bergamottin treatment could inhibit inflammatory activity through promoting adipocyte differentiation, which in turn suggests that Bergamottin has the potential to minimize the risk factors of metabolic syndrome.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Adipokines); 0 (Adiponectin); 0 (Cytokines); 0 (Furocoumarins); 0 (Inflammation Mediators); 0 (NF-kappa B); 0 (PPAR gamma); 0 (Tumor Necrosis Factor-alpha); JMU611YFRB (bergamottin)


  7 / 618 MEDLINE  
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PMID:28560869
Autor:Nakanishi A; Fukushima Y; Miyazawa N; Yoshikawa K; Maeda T; Kurobayashi Y
Endereço:R&D Center, T. Hasegawa Co., Ltd. , 29-7 Kariyado, Nakahara-ku, Kawasaki-shi 211-0022, Japan.
Título:Quantitation of Rotundone in Grapefruit (Citrus paradisi) Peel and Juice by Stable Isotope Dilution Assay.
Fonte:J Agric Food Chem; 65(24):5026-5033, 2017 Jun 21.
ISSN:1520-5118
País de publicação:United States
Idioma:eng
Resumo:Aroma extract dilution analyses of the aromas of peels and juices of white and pink grapefruits revealed that rotundone, responsible for peppery, spicy, and woody odors, was detected for the first time at high flavor dilution factors of 256-1024. In both juices, rotundone was detected at the highest flavor dilution factor of 1024. Rotundone in grapefruits was quantitated by a stable isotope dilution assay with a newly synthesized deuterium-labeled internal standard, rotundone-d : its levels were 2180 and 1920 ng/kg in white and pink grapefruit peels and 29.6 and 49.8 ng/kg in white and pink grapefruit juices, respectively. On the basis of these results, sensory analysis was performed to assess the effects of rotundone on a white grapefruit juice aroma reconstitute. This sensory analysis revealed that rotundone does not impart a woody odor or affect any of the existing attributes, but increases various attributes, thus confirming that rotundone is indispensable for the aroma of grapefruit juice.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Carbon Isotopes); 0 (Flavoring Agents); 0 (Sesquiterpenes); 0 (rotundone)


  8 / 618 MEDLINE  
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PMID:28516769
Autor:Nakanishi A; Fukushima Y; Miyazawa N; Yoshikawa K; Maeda T; Kurobayashi Y
Endereço:R&D Center, T. Hasegawa Co., Ltd. , 29-7 Kariyado, Nakahara-ku, Kawasaki-shi 211-0022, Japan.
Título:Identification of Rotundone as a Potent Odor-Active Compound of Several Kinds of Fruits.
Fonte:J Agric Food Chem; 65(22):4464-4471, 2017 Jun 07.
ISSN:1520-5118
País de publicação:United States
Idioma:eng
Resumo:An investigation of the aromas of grapefruit, orange, apple, and mango revealed the presence of an odor-active compound that gave off a strong woody odor when assessed by gas chromatography-olfactometry. We isolated the compound from a high-boiling fraction of an orange essential oil, and subsequent nuclear magnetic resonance analyses of the isolated compound identified it as rotundone. Mass spectra and retention indices obtained from aroma concentrates of grapefruit, apple, and mango were identical to those of rotundone, which was therefore determined to be the common woody compound in these fruits. Sensory analyses were performed to assess the effects of rotundone on model beverages of the various fruits. It was revealed that rotundone added at even subthreshold levels to model beverages did not confer directly the woody odor, but had significant effects on the overall flavors of the beverages, helping them to better approximate the natural flavors of the fruits.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Flavoring Agents); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (rotundone)


  9 / 618 MEDLINE  
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PMID:28197590
Autor:Farag MA; Ammar NM; Kholeif TE; Metwally NS; El-Sheikh NM; Wessjohann LA; Abdel-Hamid AZ
Endereço:Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Egypt. Mohamed.farag@pharma.cu.edu.eg.
Título:Rats' urinary metabolomes reveal the potential roles of functional foods and exercise in obesity management.
Fonte:Food Funct; 8(3):985-996, 2017 Mar 22.
ISSN:2042-650X
País de publicação:England
Idioma:eng
Resumo:The complexity of the metabolic changes in obese individuals still presents a challenge for the understanding of obesity-related metabolic disruptions and for obesity management. In this study, a gas chromatography mass spectrometry (GC-MS) based metabolomics approach targeting urine metabolism has been applied to assess the potential roles of functional foods and exercise for obesity management in rats. Male albino rats diagnosed as obese via histopathology and biochemical assays were administered functional foods in common use for obesity management including pomegranate, grapefruit, and red cabbage juice extracts in parallel with swimming exercise. Urine samples were collected from these rats, and likewise from healthy control animals, for metabolite analysis using (GC-MS) coupled to multivariate data analysis. The results revealed a significant elevation in oxalate and phosphate levels in obese rat urine concurrent with lower lactate levels as compared to the control group. Furthermore, and to pinpoint the bioactive agents in the administered functional foods, ultra performance liquid chromatography (UPLC) coupled to high resolution time-of-flight mass spectrometry (TOF-MS) was employed for secondary metabolite profiling. The different phenolic classes found in the examined functional foods, viz. ellagitannins in pomegranate, flavanones in grapefruit and flavonols in red cabbage, are likely to mediate their anti-obesity effects. The results indicate that these functional foods and exercise were quite effective in reverting obesity-related metabolic disruptions back to normal status, as revealed by orthogonal partial least squares-discriminant analysis (OPLS-DA).
Tipo de publicação: JOURNAL ARTICLE


  10 / 618 MEDLINE  
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PMID:28134229
Autor:Cholewka-Stafinska M; Polaniak R; Kardas M; Grajek M; Grochowska-Niedworok E
Endereço:Medical University of Silesia in Katowice, School of Public Health in Bytom, Poland: Department of Human Nutrition.
Título:[Interaction of oral form anticancer drugs with grapefruit juice].
Título:Interaction of oral form anticancer drugs with grapefruit juice..
Fonte:Pol Merkur Lekarski; 42(247):30-33, 2017 Jan 23.
ISSN:1426-9686
País de publicação:Poland
Idioma:pol
Resumo:Oral medication (tablets, capsules, suspensions, liquids, etc.) are frequently used in therapy. This may arise due to the fact that oral medication patient can take at home and it reduce the stress associated with taking the drug. On the Polish pharmaceutical market can be observed more frequent registration to trading anticancer drugs in oral form. Is also growing interest about drug interactions with food, but they are still less accented than drug-drug interactions. The results of pharmacokinetic studies on the interaction of drugs used in antineoplastic therapy with food are particularly important because of the characteristics of cancer patients, and a growing number of people suffering from cancer and which may have a problem. The aim of the study was to collect and present clinically relevant interactions of anticancer drugs in oral form used in oncology with grapefruit juice based on the latest scientific reports and the summary of product characteristics.
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Antineoplastic Agents)



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