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  1 / 511 MEDLINE  
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Chebli, Júlio Maria Fonseca
Texto completo SciELO Brasil
PMID:28489125
Autor:Chebli JMF; Chebli LA; Ribeiro TCDR; Gaburri PD
Endereço:Gastroenterology Professor at School of Medicine of Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
Título:Severe hypoproteinemia as a harbinger of Ménétrier's disease in autoimmune pancreatitis.
Fonte:Rev Assoc Med Bras (1992); 63(3):215-218, 2017 Mar.
ISSN:1806-9282
País de publicação:Brazil
Idioma:eng
Resumo:Ménétrier's disease is an extremely rare disease of unknown etiology causing gastric mucosal hypertrophy and protein-losing gastropathy. Rare cases of this condition have been reported in patients with autoimmune diseases. However, to the best of our knowledge, Ménétrier's disease associated with autoimmune pancreatitis (AIP) has never been reported. We described a case of severe hypoproteinemia as a harbinger of Ménétrier's disease associated with AIP. The patient was successfully treated with octreotide and high-protein diet, which led to symptomatic remission and significant improvement in serum levels of albumin and recovery of the nutritional status. Thus, in AIP patients presenting with severe and persistent hypoproteinemia without apparent cause, clinicians need to consider Ménétrier's disease in the differential diagnosis. In this setting, endoscopic evaluation with histological examination of gastric biopsy material, including a full-thickness mucosal biopsy of involved mucosa, may be helpful in promptly establishing the diagnosis and allowing appropriate and timely therapy.
Tipo de publicação: CASE REPORTS


  2 / 511 MEDLINE  
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PMID:28225680
Autor:Akita C; Saikawa Y
Endereço:Kanazawa Medical University, Ishikawa, Japan saikawa@kanazawa-med.ac.jp.
Título:Gastric Gyri - Pediatric Ménétrier's Disease.
Fonte:N Engl J Med; 376(8):774, 2017 Feb 23.
ISSN:1533-4406
País de publicação:United States
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE


  3 / 511 MEDLINE  
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PMID:28013292
Autor:Piccolo P; Attanasio S; Secco I; Sangermano R; Strisciuglio C; Limongelli G; Miele E; Mutarelli M; Banfi S; Nigro V; Pons T; Valencia A; Zentilin L; Campione S; Nardone G; Lynnes TC; Celestino-Soper PB; Spoonamore KG; D'Armiento FP; Giacca M; Staiano A; Vatta M; Collesi C; Brunetti-Pierri N
Endereço:Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy.
Título:MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy.
Fonte:Hum Mol Genet; 26(1):33-43, 2017 Jan 01.
ISSN:1460-2083
País de publicação:England
Idioma:eng
Resumo:We performed whole exome sequencing in individuals from a family with autosomal dominant gastropathy resembling Ménétrier disease, a premalignant gastric disorder with epithelial hyperplasia and enhanced EGFR signalling. Ménétrier disease is believed to be an acquired disorder, but its aetiology is unknown. In affected members, we found a missense p.V742G variant in MIB2, a gene regulating NOTCH signalling that has not been previously linked to human diseases. The variant segregated with the disease in the pedigree, affected a highly conserved amino acid residue, and was predicted to be deleterious although it was found with a low frequency in control individuals. The purified protein carrying the p.V742G variant showed reduced ubiquitination activity in vitro and white blood cells from affected individuals exhibited significant reductions of HES1 and NOTCH3 expression reflecting alteration of NOTCH signalling. Because mutations of MIB1, the homolog of MIB2, have been found in patients with left ventricle non-compaction (LVNC), we investigated members of our family with Ménétrier-like disease for this cardiac abnormality. Asymptomatic left ventricular hypertrabeculation, the mildest end of the LVNC spectrum, was detected in two members carrying the MIB2 variant. Finally, we identified an additional MIB2 variant (p.V984L) affecting protein stability in an unrelated isolated case with LVNC. Expression of both MIB2 variants affected NOTCH signalling, proliferation and apoptosis in primary rat cardiomyocytes.In conclusion, we report the first example of left ventricular hypertrabeculation/LVNC with germline MIB2 variants resulting in altered NOTCH signalling that might be associated with a gastropathy clinically overlapping with Ménétrier disease.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE
Nome de substância:0 (Receptors, Notch); EC 2.3.2.27 (MIB2 protein, human); EC 2.3.2.27 (Ubiquitin-Protein Ligases)


  4 / 511 MEDLINE  
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PMID:28703568
Autor:García de Paredes AG; Martínez González J; Crespo Pérez L
Título:[An infrequent cause of iron-deficiency anemia: Ménétrier disease].
Título:Una causa infrecuente de anemia ferropénica: Enfermedad de Ménétrier..
Fonte:Acta Gastroenterol Latinoam; 46(2):118-21, 2016 06.
ISSN:0300-9033
País de publicação:Argentina
Idioma:spa
Resumo:Ménétrier disease is a rare condition of an unknown origin, with a wide spectrum of clinical signs and symptoms at presentation. Diagnosis is made through the combination of clinical, analytical, endoscopic and histological data. Surgery is the classical treatment. However, new medical approaches have emerged.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW


  5 / 511 MEDLINE  
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Texto completo SciELO Brasil
PMID:27849224
Autor:Silva PH; Rigo P; Batista RP; Toma RK; Oliveira LA; Suzuki L
Endereço:Resident Radiologist, Instituto de Radiologia (INRAD), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.
Título:Ménétrier's disease associated with gastric adenocarcinoma in a child - imaging aspect.
Fonte:Rev Assoc Med Bras (1992); 62(6):485-489, 2016 Sep.
ISSN:1806-9282
País de publicação:Brazil
Idioma:eng
Tipo de publicação: CASE REPORTS


  6 / 511 MEDLINE  
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PubMed Central Texto completo
Texto completo
PMID:27603362
Autor:Ding Q; Lu P; Ding S; Fan Y; Yan W; Wang Y; Tian D; Xia Y; Liu M
Endereço:Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Título:Ménétrier disease manifested by polyposis and involved in both the small bowel and entire colon: A Case Report.
Fonte:Medicine (Baltimore); 95(36):e4685, 2016 Sep.
ISSN:1536-5964
País de publicação:United States
Idioma:eng
Resumo:INTRODUCTION: Ménétrier disease (MD) is rare that is involved in both the small bowel and entire colon. THE MAIN SYMPTOMS AND THE IMPORTANT CLINICAL FINDINGS: We describe a case of a 76-year-old male patient whose clinical presentations include intermittent diarrhea, epigastric pain, nausea, vomiting, asitia, and weight loss. An endoscopy was performed showing a large number of irregular forms and different sizes of polypoid lesions in the gastrointestinal tract, which is rare for MD. THE MAIN DIAGNOSES, THERAPEUTICS INTERVENTIONS, AND OUTCOMES: Herein, this case was diagnosed as MD, mainly dependent on endoscopic evaluation, typical clinical symptoms, and histopathological examination of biopsy. As this patient was also infected with Helicobacter pylori, the eradication of H pylori was administered. Meanwhile, a high-protein diet was enjoined, the aforementioned patient's symptoms were alleviated evidently after 1 month. CONCLUSION: Although the etiology of MD remained undetermined, we showed that eradication of H pylori in this case might contribute to the disease remission. This study enlarged the present understanding of MD.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE


  7 / 511 MEDLINE  
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PMID:27375208
Autor:Burmester JK; Bell LN; Cross D; Meyer P; Yale SH
Endereço:Department of Research, Gundersen Medical Foundation, LaCrosse, WI, United States.
Título:A SMAD4 mutation indicative of juvenile polyposis syndrome in a family previously diagnosed with Menetrier's disease.
Fonte:Dig Liver Dis; 48(10):1255-9, 2016 Oct.
ISSN:1878-3562
País de publicação:Netherlands
Idioma:eng
Resumo:BACKGROUND: Menetrier's disease (MD) is a rare disease with unknown aetiology, characterized by hypertrophic folds within the fundus and body of the stomach. AIMS: We investigated mutations of the candidate genes SMAD4, BMPR1A, TGF-α, and PDX1 within a family with MD. METHODS: A large 4-generation family with MD was identified. This family had 5 cases of MD, 1 case of MD and juvenile polyposis syndrome (JPS) and 3 cases of JPS. Participants provided saliva for DNA extraction and completed a health questionnaire designed to assess conditions that may be found in patients with MD. Following pedigree analysis, we sequenced the coding regions of the SMAD4 and BMPR1A genes and the regulatory regions of the TGF-α and PDX1 genes in affected and non-affected family members. RESULTS: No mutations were identified in the sequenced regions of BMPR1A, TGF-α, or PDX1. A dominant 1244_1247delACAG mutation of SMAD4 was identified in each of the subjects with JPS as well as in each of the subjects with MD. Although this mutation segregated with disease, there were also unaffected/undiagnosed carriers. CONCLUSION: The 1244_1247delACAG mutation of SMAD4 is the cause of JPS and the likely cause of MD in a large family initially diagnosed with MD.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Homeodomain Proteins); 0 (SMAD4 protein, human); 0 (Smad4 Protein); 0 (Trans-Activators); 0 (Transforming Growth Factor alpha); 0 (pancreatic and duodenal homeobox 1 protein); EC 2.7.11.30 (BMPR1A protein, human); EC 2.7.11.30 (Bone Morphogenetic Protein Receptors, Type I)


  8 / 511 MEDLINE  
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PMID:27308642
Autor:Bancila I; Popescu I; Herlea V; Becheanu G; Dumbrava M; Gheorghe C
Endereço:Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. ibancila@yahoo.com.
Título:Ménétrier's disease: a rare entity which mimicks gastric cancer.
Fonte:J Gastrointestin Liver Dis; 25(2):137, 2016 Jun.
ISSN:1842-1121
País de publicação:Romania
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE


  9 / 511 MEDLINE  
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PMID:27264429
Autor:Sato N; Nakahara K; Morita R; Suetani K; Michikawa Y; Nakano H; Koizumi S; Otsubo T; Fujino T; Itoh F
Endereço:Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine.
Título:A case of Ménétrier's disease seemingly caused by hilar cholangiocarcinoma.
Fonte:Nihon Shokakibyo Gakkai Zasshi; 113(6):975-82, 2016.
ISSN:0446-6586
País de publicação:Japan
Idioma:jpn
Resumo:A 54-year-old man presented to our department with abdominal discomfort and anorexia and was diagnosed as having Ménétrier's disease (MD) with hilar cholangiocarcinoma. Based on his clinical examination, there was no evidence of Helicobacter pylori or cytomegalovirus (CMV) infection. Although we administered proton pump inhibitor and high-calorie enteral nutrition, hypoproteinemia did not improve, and the refractory protein-losing enteropathy persisted. However, interestingly, MD improved immediately after resection of the hilar cholangiocarcinoma. Generally, the etiology of MD is unknown, but H. pylori and CMV infections have been implicated. To our knowledge, there has been no previous report indicating that a malignant tumor could be involved in the etiology of MD. Thus, we report an extremely rare case of MD which is seemingly caused by malignancy.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE


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PMID:27031414
Autor:Watson VE; Sycamore KF; Rissi DR
Título:Pathology in Practice. Diffuse, invasive, undifferentiated gastric carcinoma in a dog.
Fonte:J Am Vet Med Assoc; 248(8):893-5, 2016 Apr 15.
ISSN:1943-569X
País de publicação:United States
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE



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