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Pesquisa : C11.187.183.220.250 [Categoria DeCS]
Referências encontradas : 606 [refinar]
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  1 / 606 MEDLINE  
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PMID:28693667
Autor:Balla E; Petrovay F; Erdosi T; Balázs A; Henczkó J; Urbán E; Donders GGG
Endereço:1​Department of Bacteriology II, National Public Health Institute, Budapest, Hungary.
Título:Distribution of Chlamydia trachomatis genotypes in neonatal conjunctivitis in Hungary.
Fonte:J Med Microbiol; 66(7):915-918, 2017 Jul.
ISSN:1473-5644
País de publicação:England
Idioma:eng
Resumo:The objective of the present study was to determine the frequency and age distribution of different Chlamydia trachomatis (CT) genotypes causing ophthalmia neonatorum (ON) in Hungary. Using CT specific PCR, we tested 76 conjunctival samples from symptomatic infants up to 3 months old in the National Centre for Epidemiology, Budapest between 2008 and 2016. CT tested positive in 30 of 76 conjunctival samples (39.5 %). The sequencing of the positive samples was successful in every case but one, and resulted in 48 % dominance for genotype E (14/29), followed by 24 % for genotype G (7/29), 10 % for J (3/29), 6.9 % for K and F (2/29), and 3.4 % for H (1/29). CT must still be regarded as a common pathogen causing ON in Hungary. Routine screening and treatment of pregnant women can be recommended to prevent these conditions. Chronic ON cases can be reduced by early diagnosis. Further research is needed to explain the dominance of genotypes E and G.
Tipo de publicação: JOURNAL ARTICLE


  2 / 606 MEDLINE  
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PMID:26616738
Autor:Roberts Ch; Franklin CS; Makalo P; Joof H; Sarr I; Mahdi OS; Sillah A; Bah M; Payne F; Jeffreys AE; Bottomley W; Natividad A; Molina-Gonzalez S; Burr SE; Preston M; Kwiatkowski D; Rockett KA; Clark TG; Burton MJ; Mabey DC; Bailey R; Barroso I; Holland MJ
Endereço:London School of Hygiene and Tropical Medicine, London, UK.
Título:Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study.
Fonte:Sci Rep; 5:17447, 2015 Nov 30.
ISSN:2045-2322
País de publicação:England
Idioma:eng
Resumo:Chlamydia trachomatis causes both trachoma and sexually transmitted infections. These diseases have similar pathology and potentially similar genetic predisposing factors. We aimed to identify polymorphisms and pathways associated with pathological sequelae of ocular Chlamydia trachomatis infections in The Gambia. We report a discovery phase genome-wide association study (GWAS) of scarring trachoma (1090 cases, 1531 controls) that identified 27 SNPs with strong, but not genome-wide significant, association with disease (5 × 10(-6) > P > 5 × 10(-8)). The most strongly associated SNP (rs111513399, P = 5.38 × 10(-7)) fell within a gene (PREX2) with homology to factors known to facilitate chlamydial entry to the host cell. Pathway analysis of GWAS data was significantly enriched for mitotic cell cycle processes (P = 0.001), the immune response (P = 0.00001) and for multiple cell surface receptor signalling pathways. New analyses of published transcriptome data sets from Gambia, Tanzania and Ethiopia also revealed that the same cell cycle and immune response pathways were enriched at the transcriptional level in various disease states. Although unconfirmed, the data suggest that genetic associations with chlamydial scarring disease may be focussed on processes relating to the immune response, the host cell cycle and cell surface receptor signalling.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T


  3 / 606 MEDLINE  
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PMID:26423146
Autor:Bohlin J
Endereço:Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Lovisenberggata 6, P.O. Box 4404, 0403, Oslo, Norway. jon.bohlin@fhi.no.
Título:Genome expansion in bacteria: the curios case of Chlamydia trachomatis.
Fonte:BMC Res Notes; 8:512, 2015 Sep 30.
ISSN:1756-0500
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Recent findings indicated that a correlation between genomic % AT and genome size within strains of microbial species was predominantly associated with the uptake of foreign DNA. One species however, Chlamydia trachomatis, defied any explanation. In the present study 79 fully sequenced C. trachomatis genomes, representing ocular- (nine strains), urogenital- (36 strains) and lymphogranuloma venereum strains (LGV, 22 strains), in three pathogroups, in addition to 12 laboratory isolates, were scrutinized with the intent of elucidating the positive correlation between genomic AT content and genome size. RESULTS: The average size difference between the strains of each pathogroup was largely explained by the incorporation of genetic fragments. These fragments were slightly more AT rich than their corresponding host genomes, but not enough to justify the difference in AT content between the strains of the smaller genomes lacking the fragments. In addition, a genetic region predominantly found in the ocular strains, which had the largest genomes, was on average more GC rich than the host genomes of the urogenital strains (58.64% AT vs. 58.69% AT), which had the second largest genomes, implying that the foreign genetic regions cannot alone explain the association between genome size and AT content in C. trachomatis. 23,492 SNPs were identified for all 79 genomes, and although the SNPs were on average slightly GC rich (~47% AT), a significant association was found between genome-wide SNP AT content, for each pathogroup, and genome size (p < 0.001, R (2) = 0.86) in the C. trachomatis strains. CONCLUSIONS: The correlation between genome size and AT content, with respect to the C. trachomatis pathogroups, was explained by the incorporation of genetic fragments unique to the ocular and/or urogenital strains into the LGV- and urogential strains in addition to the genome-wide SNP AT content differences between the three pathogroups.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Bacterial Outer Membrane Proteins); 0 (DNA Transposable Elements); 149024-69-1 (OMPA outer membrane proteins)


  4 / 606 MEDLINE  
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PMID:25439605
Autor:Kowalski RP; Karenchak LM; Raju LV; Ismail N
Endereço:The Charles T. Campbell Eye Microbiology Laboratory, Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: kowalskirp@upmc.edu.
Título:The verification of nucleic acid amplification testing (Gen-Probe Aptima Assay) for chlamydia trachomatis from ocular samples.
Fonte:Ophthalmology; 122(2):244-7, 2015 Feb.
ISSN:1549-4713
País de publicação:United States
Idioma:eng
Resumo:OBJECTIVE: Chlamydia trachomatis conjunctivitis may present with extended symptoms, and it can have social ramifications as a sexually transmitted disease. For appropriate therapy, C. trachomatis conjunctivitis should be diagnosed definitively. This study presents the verification of nucleic acid amplification testing (NAAT; Gen-Probe Aptima Combo 2 assay) for detection of C. trachomatis ribosomal RNA (rRNA) from direct ocular samples. DESIGN: Retrospective laboratory verification study. SUBJECTS: Patients with infectious conjunctivitis. METHODS: A battery of 25 true-positive specimens (direct ocular specimens from patients with symptoms consistent with C. trachomatis conjunctivitis and with previously demonstrated positive polymerase chain reaction [PCR] results for C. trachomatis DNA by Roche Amplicor) and 25 true-negative specimens (direct ocular specimens with culture-positive results for herpes simplex virus [n = 5], adenovirus [n = 5], Haemophilus influenzae [n = 5], and Streptococcus pneumoniae [n = 5]), and transport medium (n = 5) were tested for C. trachomatis rRNA by NAAT. These true-negative specimens have differential etiologic agents of infectious conjunctivitis. The 25 C. trachomatis specimens with PCR-positive results (obtained May 1994-May 2012) and 20 true-negative infectious ocular specimens (obtained December 2008-August 2013) were collected with soft-tipped applicators and placed in transport medium. All excess specimens were stored at -80°C. All samples were centrifuged at 13,000 rpm for 1 hour at 6°C. For each sample, using the Aptima Unisex collection blue swab, a specimen was collected from the conical apex of the storage tube where a pellet was formed. The Aptima Unisex collection swab was placed in a tube of Aptima swab transport medium for testing. All samples were tested in duplicate. MAIN OUTCOME MEASURES: Detection of C. trachomatis rRNA. RESULTS: Of 25 true-positive samples, 24 (96%) were positive by NAAT, whereas 25 of 25 true-negative samples (100%) showed negative results. The sensitivity, specificity, positive predictive value, negative predictive value, and efficiency were determined to be 96%, 100%, 100%, 96%, and 98%, respectively. CONCLUSIONS: The detection of C. trachomatis in ocular specimens by NAAT was verified for laboratory diagnosis. The test will be evaluated prospectively to determine future test performance precisely.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
Nome de substância:0 (DNA, Bacterial); 0 (RNA, Ribosomal)


  5 / 606 MEDLINE  
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PMID:24643518
Autor:Mohamed-Noriega K; Mohamed-Noriega J; Valdés-Navarro MA; Cuervo-Lozano EE; Fernández-Espinosa MC; Mohamed-Hamsho J
Endereço:Department of Ophthalmology, Faculty of Medicine and "Dr. Jose Eleuterio Gonzalez" University Hospital, Autonomous University of Nuevo Leon (UANL), Av. Madero y Gonzalitos s/n, Colonia Mitras Centro, 64460, Monterrey, Nuevo León, Mexico, drkmohamed1@gmail.com.
Título:Conjunctival infection with Chlamydia trachomatis in sexual partners of patients with adult inclusion conjunctivitis.
Fonte:Int Ophthalmol; 35(2):179-85, 2015 Apr.
ISSN:1573-2630
País de publicação:Netherlands
Idioma:eng
Resumo:To compare the incidence of conjunctival infection with Chlamydia trachomatis in sexual partners of patients with newly diagnosed adult inclusion conjunctivitis (AIC) and a control group with healthy eyes. We also compare the observed signs and symptoms of conjunctival infection in patients with newly diagnosed AIC and their sexual partners. We performed a prospective comparative case-control study between patients with newly diagnosed AIC confirmed with direct fluorescent antibody (DFA) (n = 11), their sexual partners (n = 11), and a control group of healthy subjects (n = 11). Clinical history, physical examination, and a DFA test for C. trachomatis of a conjunctival scrapping from the tarsal conjunctiva were performed in all patients. A significantly higher frequency of positive DFA tests for C. trachomatis was observed in the sexual partner group (n = 8, 73 %) compared with the healthy control group (n = 2, 18.2 %) (P = 0.03). Ocular symptoms and signs were observed significantly more often in patients from the confirmed clinically active AIC group (n = 11, 100 %) than in their sexual partners (n = 2, 12.5 %). Sexual partners of patients with AIC are at greater risk of having an asymptomatic conjunctival infection with C. trachomatis than healthy subjects. Sexual partners might be considered a bacterial reservoir and a possible source for chlamydia reinfection. Not treating sexual partners might increase the probability of reinfection. More extended studies with a greater sample size should be done.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T


  6 / 606 MEDLINE  
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PMID:24654238
Autor:Rothschild PR; Brezin AP; Dupin N
Endereço:Department of Ophthalmology, Groupe hospitalier Cochin-Hôtel-Dieu, AP-HP, Paris, France.
Título:A 22-year-old man with chronic red eye and dysuria.
Fonte:BMJ Case Rep; 2014, 2014 Mar 20.
ISSN:1757-790X
País de publicação:England
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Anti-Bacterial Agents); N12000U13O (Doxycycline)


  7 / 606 MEDLINE  
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PMID:24047438
Autor:Malamos P; Georgalas I; Rallis K; Andrianopoulos K; Georgopoulos G; Theodossiadis P; Vergados I; Markomichelakis NN
Endereço:Ocular Immunology and Inflammation Service, Department of Ophthalmology, "G.Gennimatas" General Hospital , Athens , Greece .
Título:Evaluation of single-dose azithromycin versus standard azithromycin/doxycycline treatment and clinical assessment of regression course in patients with adult inclusion conjunctivitis.
Fonte:Curr Eye Res; 38(12):1198-206, 2013 Dec.
ISSN:1460-2202
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Single-dose azithromycin (AZT) has been proved efficient in treating various human Chlamydia infections. However, it has not been thoroughly tested in patients with adult inclusion conjunctivitis (AIC). It is the aim of this study to perform a comparative evaluation of efficacy and safety of one-day AZT with long-term AZT and doxycycline (DOX) regimens in AIC and to present a clinical profile of regression course of the disease. MATERIALS: Eighty-three consecutive adults, with symptoms and signs of chronic conjunctivitis and positive Polymerase Chain Reaction (PCR) for chlamydia, were randomly assigned in four treatment groups; AZT 1-day 1000 mg orally, AZT 500 mg daily 9 and 14 days and DOX 200 mg 21 days orally. Follow-up visits were scheduled 1 and 2 weeks, 1, 3 and 6 months after treatment completion. PCR was repeated at the 2nd post-treatment week to confirm elimination of infectious agent. Detailed record of subjective symptoms and objective signs was performed at all visits. Retreatment rate among groups was evaluated as primary outcome. Regression rate of symptoms/signs among groups was recorded as secondary outcomes. RESULTS: All treatment groups provided statistically equivalent results of retreatment rate. Statistically significant regression of symptoms/signs was documented, initially from the 1st post-treatment week in general, but 1 month was required for complete patients' relief. Follicles were the most common clinical sign with the earliest regression after successful treatment. CONCLUSION: Single-dose azithromycin should be considered as equally reliable treatment option, comparing to long-term alternative regimens for AIC. Patients should wait for one week, until first signs of significant regression become obvious and should consider approximately one month to total relief. Follicles could be reasonably used as a key sign for clinical assessment of treatment success.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
Nome de substância:0 (Anti-Bacterial Agents); 83905-01-5 (Azithromycin); N12000U13O (Doxycycline)


  8 / 606 MEDLINE  
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PMID:23909922
Autor:Ackert J; Friedman A; Tannen B
Endereço:Mount Sinai Department of Ophthalmology, New York , New York , USA.
Título:Chlamydia trachomatis masquerading as a chronic allergic conjunctivitis.
Fonte:Ocul Immunol Inflamm; 21(6):486-7, 2013 Dec.
ISSN:1744-5078
País de publicação:England
Idioma:eng
Tipo de publicação: CASE REPORTS; LETTER


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PMID:23728751
Autor:Lockington D; MacDonald R; King S; Weir C; Winter A; Aitken C
Endereço:ST6 Ophthalmology, Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK. davidlockington@hotmail.com
Título:Multiplex PCR testing requires a robust multi-disciplinary strategy to effectively manage identified cases of chlamydial conjunctivitis.
Fonte:Scott Med J; 58(2):77-82, 2013 May.
ISSN:0036-9330
País de publicação:Scotland
Idioma:eng
Resumo:INTRODUCTION: Implementation of an in-house polymerase chain reaction (PCR) multiplex assay by West of Scotland Specialist Virology Centre to improve sample processing means all viral eye swabs are now routinely tested for Adenovirus, Herpes simplex, Varicella and Chlamydia. Concern was raised regarding subsequent management and sexual health attendance for Chlamydia-positive patients identified in eye casualty. METHODS: A retrospective review of virology results identified 76 Chlamydia-positive patients from 1914 eye swabs (4%) from May 2007 to April 2008. Of these results, 12 originated from Glasgow eye casualty and available clinical notes were cross-referenced with the sexual health network (Sandyford). RESULTS: Identified issues included no documentation of implications of testing, poor communication of positive results and poor referral pathways to sexual health for assessment; all leading to inadequate management. A shared care network was created to address these issues. A designated sexual health advisor was identified to improve sexual health referral, specialist assessment, standardised management and contact tracing. Re-audit showed more consistent follow-up. CONCLUSION: New PCR technology has resulted in a shared care approach to address corresponding implications of testing. Effective communication with a structured protocol and a central point of contact has improved follow-up and ensures appropriate best practice management of chlamydial conjunctivitis.
Tipo de publicação: JOURNAL ARTICLE


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PMID:23692878
Autor:Arvai M; Ostorházi E; Mihalik N; Kárpáti S; Marschalkó M
Endereço:Bajcsy-Zsilinszky Kórház Borgyógyászati Szakrendelo Budapest. arvaimariann@freemail.hu
Título:[Purulent keratoconjunctivitis due to Neisseria gonorrhoeae and Chlamydia trachomatis coinfection].
Título:Conjunctivitis gonorrhoica szövodése Chlamydia trachomatis-infekcióval..
Fonte:Orv Hetil; 154(21):834-7, 2013 May 26.
ISSN:0030-6002
País de publicação:Hungary
Idioma:hun
Resumo:Gonococcal conjunctivitis is a rare infection induced by Neisseria gonorrhoeae and it usually manifests as a hyperacute purulent conjunctivitis. Ocular access of the infectious secretion during sexual intercourse is the way of transmission among adults. Inclusion conjunctivitis caused by the serovars D-K of Chlamydia trachomatis also affects the sexually active population. Authors present a case of a 33-year-old homosexual man who was treated for late latent syphilis formerly. Clinical symptoms were yellow purulent discharge for 3 weeks without any urological or upper respiratory tract symptoms. Conjunctival Neisseria gonorrhoeae and Chlamydia trachomatis infection was identified using cultures and polymerase chain reaction; pharyngeal swab culture and polymerase chain reaction showed positive results for both pathogens. The patient was probably under influence of party drugs at the time of sexual abuse when he became infected. After parenteral and oral cephalosporin and azithromycin therapy the patient had complete recovery within three weeks.
Tipo de publicação: CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
Nome de substância:0 (Anti-Bacterial Agents); 0 (Cephalosporins); 83905-01-5 (Azithromycin)



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