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Pesquisa : C11.187.183.220.538 [Categoria DeCS]
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  1 / 511 MEDLINE  
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PMID:28471562
Autor:Ulanovsky I; Shnaider M; Geffen Y; Smolkin T; Mashiah T; Makhoul IR
Endereço:Department of Neonatology, Rappaport Children's Hospital, Rambam Health Care Campus, affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Título:Erythromycin Prophylaxis for Neonatal Conjunctivitis: Ointment Versus Drops.
Fonte:Isr Med Assoc J; 18(7):404-406, 2016 Jul.
ISSN:1565-1088
País de publicação:Israel
Idioma:eng
Resumo:BACKGROUND: Due to a shortage of individualized erythromycin ointment (IEO), we switched to shared erythromycin drops (SED). Following this change, nurses claimed observing more cases of eye discharge. OBJECTIVES: To test whether switching from IEO to SED affected the rate of neonatal conjunctivitis (NC). METHODS: The study group included 14,916 neonates > 35 weeks of gestation, further divided into two birth periods of 12 months each: 1 January 2013 to 31 December 2013 (IEO) and 1 February 2014 to 31 January 2015 (SED). We compared the two birth periods with regard to three variables: clinical NC (number of conjunctival swabs/1000 neonates), bacterial NC (number of culture-positive swabs/1000 neonates), and bacterial growth percentage (number of culture-positive swabs/100 samples). RESULTS: Compared to 2012-2013, the period 2014-2015 included fewer cesarean deliveries and shorter length of stay (LOS). Clinical NC, bacterial NC and bacterial-growth percentage were not different between the two periods. Variables that were independently significantly associated with increased clinical NC included male gender (OR 1.48, CI 1.21-1.81) and LOS (OR 1.24, CI 1.18-1.29). LOS was associated with bacterial NC (OR 1.19, CI 1.11-1.28). Coagulase-negative staphylococci, Escherichia coli and Pseudomonas aeruginosa were the prevalent pathogens, though without difference between periods. CONCLUSIONS: Rates of clinical NC, bacterial NC and bacterial-growth percentage were not different between the study periods. Switching from IEO to SED had no effect on the NC rate.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE
Nome de substância:0 (Anti-Bacterial Agents); 0 (Ointments); 0 (Ophthalmic Solutions); 63937KV33D (Erythromycin)


  2 / 511 MEDLINE  
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PMID:27351039
Autor:Fishman R
Título:The Earliest Success of Penicillin.
Fonte:Am J Ophthalmol; 163:204, 2016 Mar.
ISSN:1879-1891
País de publicação:United States
Idioma:eng
Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE
Nome de substância:0 (Anti-Bacterial Agents); 0 (Penicillins)


  3 / 511 MEDLINE  
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PMID:26876399
Autor:Khan FA; Hussain MA; Khan Niazi SP; Haq Zu; Akhtar N
Endereço:Department of Ophthalmology, Combined Military Hospital, Sargodha.
Título:Efficacy of 2.5% and 1.25% Povidone-Iodine Solution for Prophylaxis of Ophthalmia Neonatorum.
Fonte:J Coll Physicians Surg Pak; 26(2):121-4, 2016 Feb.
ISSN:1681-7168
País de publicação:Pakistan
Idioma:eng
Resumo:OBJECTIVE: To determine the efficacy of 2.5% and 1.25% Povidone-Iodine solution for Ophthalmia neonatorum prophylaxis. STUDY DESIGN: Interventional study. PLACE AND DURATION OF STUDY: Eye Department, Combined Military Hospital, Sargodha, from May to November 2014. METHODOLOGY: Atotal of 200 eyes of 100 newborn babies were enrolled and divided into two groups of 100 right eyes and 100 left eyes. Aconjunctival swab for bacterial culture was taken within 30 minutes after delivery. Asingle drop of 2.5% Povidone-Iodine was then placed in the right eye while in the left eye a single drop of 1.25% Povidone-Iodine was placed. Thirty minutes after placing Povidone-Iodine, a conjunctival swab was again taken. Abacterial suspension was prepared from each swab in determining bacterial counts. The bacterial suspension was inoculated on yeast extract agar and the number of colony forming units were counted. At each culture, the number of colony forming units before and after instillation of 2.5% Povidone-Iodine and 1.25% Povidone-Iodine were compared. Wilcoxon's signed rank test was used for statistical analysis. RESULTS: The 2.5% Povidone-Iodine solution caused a statistically significant decrease in the number of colony forming units (p=0.001). Similarly, the 1.25% Povidone-Iodine solution also reduced the number of colony forming units to a statistically significant level (p=0.001). CONCLUSION: The 1.25% concentration of Povidone-Iodine is as effective as the 2.5% concentration of Povidone-Iodine in reducing the number of colony forming units in healthy conjunctivae of newborns.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Infective Agents, Local); 0 (Ophthalmic Solutions); 85H0HZU99M (Povidone-Iodine)


  4 / 511 MEDLINE  
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PMID:26872748
Autor:Poliquin V; Wylie J; Cole R; Yudin MH; Van Caesseele P
Endereço:Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB.
Título:Preparedness for Implementing Change in Neonatal Ocular Prophylaxis Policies.
Fonte:J Obstet Gynaecol Can; 38(1):7-8, 2016 Jan.
ISSN:1701-2163
País de publicação:Netherlands
Idioma:eng
Tipo de publicação: LETTER
Nome de substância:0 (Anti-Bacterial Agents); 0 (Ointments); 63937KV33D (Erythromycin)


  5 / 511 MEDLINE  
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PMID:26850150
Autor:Tribolet S; Gillard P; Lefèvre A; Rigo V
Endereço:Service de pédiatrie, université de Liège, CHR Citadelle, boulevard du XII(e) de Ligne, 4000 Liège, Belgique. Electronic address: tribolet.sophie@gmail.com.
Título:[Gonococcal ophthalmia neonatorum: Clinical illustration, prevention, and future prospects].
Título:Conjonctivite néonatale à Neisseria Gonorrhoeae : illustration clinique, prophylaxie et perspectives d'avenir..
Fonte:Arch Pediatr; 23(3):297-300, 2016 Mar.
ISSN:1769-664X
País de publicação:France
Idioma:fre
Resumo:A 6-day-old infant presented with a bilateral suppurative ocular discharge with a conjunctival erythema. Polymerase chain reaction was performed on the pus and showed the presence of Neisseria gonorrhoeae DNA. Therapy with intravenous cefotaxime was initiated and completed with local application of tobramycin. This infection was associated with a small unilateral corneal lesion, with rapid resolution. This case provides the opportunity to focus on newborn suppurative conjunctivitis and its treatment. The different prophylaxes available (silver nitrate, povidone-iodine, local antibiotics, etc.) and their respective advantages and disadvantages are reviewed. There is no clear consensus on the most effective solution. Additionally, universal prophylaxis is challenged in several countries, where it is no longer recommended.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE


  6 / 511 MEDLINE  
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PMID:26810921
Autor:Zloto O; Gharaibeh A; Mezer E; Stankovic B; Isenberg S; Wygnanski-Jaffe T
Endereço:Department of Ophthalmology, Sheba Medical Center, Goldschleger Eye Institute, Tel Hashomer, 52621, Israel.
Título:Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study.
Fonte:Graefes Arch Clin Exp Ophthalmol; 254(3):577-82, 2016 Mar.
ISSN:1435-702X
País de publicação:Germany
Idioma:eng
Resumo:INTRODUCTION: Characteristics of ophthalmia neonatorum (ON) amongst paediatric ophthalmologists remain unclear. The purpose of this current study is to examine the incidence, diagnosis, treatment, and prophylaxis of ON cases presenting to members of the American Association of Paediatric Ophthalmology and Strabismus (AAPOS). METHODS: An email containing a web link to a survey was sent to all members of AAPOS. The questionnaire examined the incidence of ON, etiology, diagnostic methods, treatment, and prophylaxis of the disease in different countries around the world. RESULTS: Two hundred and ninety-one ophthalmologists answered the questionnaire. Most were from North America (52.94 %). One hundred and seventy-six (60.69 %) ophthalmologists encountered 0-5 cases of ON per year. The most common pathogens causing ON was Chlamydia trachomatis (35.37 %). Two hundred and forty-two (85.21 %) treat empirically when encountering ON during the first 10 days of life and 205 (75.09 %) after the first 10 days of life. In both cases, erythromycin was the most common first line of treatment. Two hundred and twenty-two (78.72 %) ophthalmologists replied that prophylactic treatment is required in their country. The most common agent for prophylaxis was erythromycin ointment (71.50 %). CONCLUSIONS: We found that the incidence of ON per year per practitioner is 0-5 cases, the most common etiology is C. trachomatis, and most infants receive prophylaxis and treatment.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Infective Agents)


  7 / 511 MEDLINE  
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PMID:26691043
Autor:Kumar JB; Silverstein E; Wallace DK
Endereço:Department of Ophthalmology, Duke University, Durham, North Carolina. Electronic address: jaya.badhwar@dm.duke.edu.
Título:Klebsiella pneumonia: An unusual cause of ophthalmia neonatorum in a healthy newborn.
Fonte:J AAPOS; 19(6):564-6, 2015 Dec.
ISSN:1528-3933
País de publicação:United States
Idioma:eng
Resumo:Ophthalmia neonatorum is one of the most common infections during the neonatal period. Chlamydia trachomatis and Neisseria gonorrhoea must be ruled out, given their high virulence and systemic complications. We describe a case of ophthalmia neonatroum from Klebsiella pneumonia. Gram-negative organisms have been reported in hospital-acquired conjunctivitis (HAC), but we are unaware of any published reports of K. pneumonia conjunctivitis in an otherwise healthy full-term infant born in the United States who has received prophylaxis. It is important to promptly identify and treat Klebsiella conjunctivitis because it can lead to severe complications.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Anti-Bacterial Agents); 0 (Ophthalmic Solutions); VZ8RRZ51VK (Tobramycin)


  8 / 511 MEDLINE  
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PMID:25949092
Autor:Ranjit R
Endereço:Department of Ophthalmology, University of South Florida Eye Institute, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
Título:Response to maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi.
Fonte:Middle East Afr J Ophthalmol; 22(2):262, 2015 Apr-Jun.
ISSN:0975-1599
País de publicação:India
Idioma:eng
Tipo de publicação: COMMENT; LETTER


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PMID:25949091
Autor:Al-Mendalawi MD
Endereço:Department of Paediatrics, Al-Kindy College of Medicine, Baghdad University, Baghdad, Iraq.
Título:Maternal and neonatal risk factors associated with vertical transmission of ophthalmia neonatorum in neonates receiving health care in Blantyre, Malawi.
Fonte:Middle East Afr J Ophthalmol; 22(2):261, 2015 Apr-Jun.
ISSN:0975-1599
País de publicação:India
Idioma:eng
Tipo de publicação: COMMENT; LETTER


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PMID:25907207
Autor:McAnena L; Knowles SJ; Curry A; Cassidy L
Endereço:Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
Título:Prevalence of gonococcal conjunctivitis in adults and neonates.
Fonte:Eye (Lond); 29(7):875-80, 2015 Jul.
ISSN:1476-5454
País de publicação:England
Idioma:eng
Resumo:PURPOSE: To report the prevalence of gonococcal conjunctivitis (GC) presenting to a tertiary referral maternity hospital (NMH) and a tertiary referral ophthalmic hospital (RVEEH) from 2011 to 2013 and describe the demographics, clinical presentation, and antibiotic susceptibility of Neisseria gonorrhoeae ocular infections. METHODS: Demographic, clinical, and microbiological data were collected from patients with laboratory confirmed GC. RESULTS: There were 27 556 live births at NMH during the study period, and no case of neonatal GC was identified. Fourteen cases of GC were identified at RVEEH in this period, representing a prevalence of 0.19 cases per 1000 eye emergency attendees. Antibiotic susceptibility data were available on nine cases, of which, all were ceftriaxone- and ciprofloxacin sensitive. 64.3% of patients were male, with a mean age of 18 years. The mean duration of symptoms was 3 days. All patients presented with unilateral conjunctival injection and purulent discharge. Eight cases had visual impairment at presentation and their mean visual acuity was 6/15. Corneal involvement was present in 25% of patients. Uveitis was not detected. On receipt of positive culture and/or PCR results, treatment was altered in two thirds of patients. All patients were referred for full STI screening and all patients showed a full clinical recovery 1 week posttreatment. CONCLUSION: We observed that GC presented in young adults with a male predominance and was rare in neonates. In cases of unilateral purulent conjunctivitis, there should be a high clinical suspicion of GC, early swab for PCR and culture, and knowledge of current CDC-recommended antibiotic guidelines.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin); 75J73V1629 (Ceftriaxone)



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