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Pesquisa : C16.614.053 [Categoria DeCS]
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PMID:29341561
Autor:Dobrosavljevic A; Martic J; Rakic S; Pazin V; Jankovic-Raznatovic S; Sreckovic S; Dobrosavljevic B
Título:Massive fetomaternal hemorrhage as a cause of severe fetal anemia.
Fonte:Vojnosanit Pregl; 73(11):1068-71, 2016 Nov.
ISSN:0042-8450
País de publicação:Serbia
Idioma:eng
Resumo:Introduction: Fetomaternal hemorrhage (FMH) is a transfu-sion of fetal blood into the maternal circulation. A volume of transfused fetal blood required to cause severe, life-threatening fetal anemia, is not clearly defined. Some authors suggest vol-umes of 80 mL and 150 mL as a threshold which defines mas-sive FMH. Therefore, a rate of massive FMH is 1 : 1,000 and 1 : 5,000 births, respectively. Fetal and neonatal anemia is one of the most serious complications of the FMH. Clinical manifesta-tions of FMH are nonspecific, and mostly it presented as re-duced fetal movements and changes in cardiotocography (CTG). The standard for diagnosing FMH is Kleihaurer-Betke test. Case report: A 34-year-old gravida (G) 1, para (P) 1 was hospitalized due to uterine contractions at 39 weeks of gesta-tion. CTG monitoring revealed sinusoidal fetal heart rate and clinical examination showed complete cervical dilatation. Im-mediately after admission, the women delivered vaginally. Ap-gar scores were 1 and 2 at the first and fifth minute, respec-tively. Immediately baby was intubated and mechanical ventila-tion started. Initial analysis revealed pronounced acidosis and severe anemia. The patient received intravenous fluid therapy with sodium-bicarbonate as well as red cell transfusion. With all measures, the condition of the baby improved with normaliza-tion of hemoglobin level and blood pH. Kleihaurer-Betke test revealed the presence of fetal red cells in maternal circulation, equivalent to 531 mL blood loss. The level of maternal fetal hemoglobin (HbF) and elevated alpha fetoprotein also con-firmed the diagnosis of massive FMH. Conclusion: For the successful diagnosis and management of FMH direct commu-nication between the obstetrician and the pediatrician is neces-sary as presented in this report.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (AFP protein, human); 0 (Biomarkers); 0 (alpha-Fetoproteins); 9034-63-3 (Fetal Hemoglobin)


  2 / 650 MEDLINE  
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PMID:28774940
Autor:Rajabian F; Mohri M; Heidarpour M
Endereço:Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Islamic Republic of Iran.
Título:Relationships between oxidative stress, haematology and iron profile in anaemic and non-anaemic calves.
Fonte:Vet Rec; 181(10):265, 2017 Sep 09.
ISSN:2042-7670
País de publicação:England
Idioma:eng
Resumo:The aim of this study was to investigate the relationships between oxidative stress, haematology and iron profile in neonatal dairy calves. Serum and haemolysate malondialdehyde (MDA), serum total antioxidant capacity, thiol groups, iron, total iron binding capacity, transferrin saturation and red blood cell (RBC) parameters were assessed in two groups: anaemic calves (n=14) and non-anaemic calves (n=16). Blood samples were collected from all of the calves within 24-48 hours after birth and at 7, 14, 21 and 28 days of age. A significant decrease in serum iron amount and transferrin saturation value (P<0.05) and a significant increase in haemolysate MDA concentration (P<0.05) in the anaemic calves were observed, when compared with non-anaemic calves. Total antioxidant capacity and thiol groups showed a significant positive correlation with iron profile and RBC parameters (haematocrit and haemoglobin) in the anaemic calves at day 21 (P<0.05). On the other hand, the concentration of haemolysate MDA was inversely correlated with the value of serum total antioxidant capacity (P<0.05). The results of the present study revealed that anaemic calves showed more severe oxidative stress than non-anaemic calves. In addition, iron insufficiency may be linked to the impairment of antioxidant defence system and oxidative damage of erythrocytes in the neonatal calves.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:E1UOL152H7 (Iron)


  3 / 650 MEDLINE  
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PMID:28632783
Autor:Le VT; Klebanoff MA; Talavera MM; Slaughter JL
Endereço:Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America.
Título:Transient effects of transfusion and feeding advances (volumetric and caloric) on necrotizing enterocolitis development: A case-crossover study.
Fonte:PLoS One; 12(6):e0179724, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:OBJECTIVE: To evaluate the short-term effects of feed fortification, feed volume increase, and PRBC transfusion on the odds of developing NEC. STUDY DESIGN: Case-crossover study of neonatal intensive care infants born at ≤ 32 weeks' gestation who were admitted to 5 central Ohio intensive care units from January 2012-July 2016 and developed NEC Bell Stage ≥2. Each patient served as their own control, with exposure during the 48-hour period just prior to NEC onset (hazard period) being compared to a preceding 48-hour control period, thus eliminating confounding by patient factors fixed between both intervals. NEC onset was determined by chart review as the earliest occurrence of one of the following within 24 hours of confirmatory x-ray: (1) antibiotic initiation, (2) enteral feeding cessation, (3) physician first notified of abdominal concerns, or (4) abdominal x-ray ordered. Conditional logistic regression compared exposures to feed volume increase, fortification, and PRBC transfusion during the 48-hour period prior to NEC onset to those during a preceding 48-hour control period. Analyses were stratified by gestational age and anemia (defined: hemoglobin ≤ 9.3 g/dL within 7 days of NEC onset). RESULTS: We included 63 infants with confirmed NEC. Acute exposure to fortification (odds ratio [OR]: 1.67, 95% confidence interval [CI]: 0.61, 4.59), feed volume increase (OR: 0.63, 95% CI: 0.28, 1.38), and PRBC transfusion (OR: 1.80, 95% CI: 0.60, 5.37) was not associated with the onset of NEC. Gestational age and anemia did not significantly modify the associations. Sensitivity testing substituting 24- and 72-hour hazard and control periods produced similar results. CONCLUSION: Using a case-crossover design, we did not detect an association between NEC development and feed fortification, feed volume increase, or PRBC transfusion within 48-hours prior to NEC-onset. Replication in a larger set of cases is needed.
Tipo de publicação: JOURNAL ARTICLE


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PMID:28503958
Autor:Ree IMC; Smits-Wintjens VEHJ; van der Bom JG; van Klink JMM; Oepkes D; Lopriore E
Endereço:a Department of Pediatrics , Leiden University Medical Center , Leiden , The Netherlands.
Título:Neonatal management and outcome in alloimmune hemolytic disease.
Fonte:Expert Rev Hematol; 10(7):607-616, 2017 Jul.
ISSN:1747-4094
País de publicação:England
Idioma:eng
Resumo:INTRODUCTION: Hemolytic disease of the fetus and newborn (HDFN) occurs when fetal and neonatal erythroid cells are destroyed by maternal erythrocyte alloantibodies, it leads to anemia and hydrops in the fetus, and hyperbilirubinemia and kernicterus in the newborn. Postnatal care consists of intensive phototherapy and exchange transfusions to treat severe hyperbilirubinemia and top-up transfusions to treat early and late anemia. Other postnatal complications have been reported such as thrombocytopenia, iron overload and cholestasis requiring specific management. Areas covered: This review focusses on the current neonatal management and outcome of hemolytic disease and discusses postnatal treatment options as well as literature on long-term neurodevelopmental outcome. Expert commentary: Despite major advances in neonatal management, multiple issues have to be addressed to optimize postnatal management and completely eradicate kernicterus. Except for strict adherence to guidelines, improvement could be achieved by clarifying the epidemiology and pathophysiology of HDFN. Several pharmacotherapeutic agents should be further researched as alternative treatment options in hyperbilirubinemia, including immunoglobulins, albumin, phenobarbital, metalloporphyrins, zinc, clofibrate and prebiotics. Larger trials are warranted to evaluate EPO, folate and vitamin E in neonates. Long-term follow-up studies are needed in HDFN, especially on thrombocytopenia, iron overload and cholestasis.
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Immunoglobulins, Intravenous); 0 (Isoantibodies)


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PMID:28143845
Autor:Planutis A; Xue L; Trainor CD; Dangeti M; Gillinder K; Siatecka M; Nebor D; Peters LL; Perkins AC; Bieker JJ
Endereço:Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Título:Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.
Fonte:Development; 144(3):430-440, 2017 02 01.
ISSN:1477-9129
País de publicação:England
Idioma:eng
Resumo:Transcription factor control of cell-specific downstream targets can be significantly altered when the controlling factor is mutated. We show that the semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in the adult and alter correct development in the early embryo. Even when expressed as a heterozygote, the Nan-EKLF protein accomplishes this by direct binding and aberrant activation of genes encoding secreted factors that exert a negative effect on erythropoiesis and iron use. Our data form the basis for a novel mechanism of physiological deficiency that is relevant to human dyserythropoietic anemia and likely other disease states.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (CTRP15 protein, mouse); 0 (Cytokines); 0 (Kruppel-Like Transcription Factors); 0 (Muscle Proteins); 0 (Mutant Proteins); 0 (erythroid Kruppel-like factor); 9007-49-2 (DNA)


  6 / 650 MEDLINE  
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PMID:27723391
Autor:Fillon G; Heaton PA; Paul SP
Endereço:Registrar in Paediatrics in the Department of Paediatrics, Yeovil District Hospital, Higher Kingston, Yeovil.
Título:Severe late onset anaemia following intrauterine transfusion.
Fonte:Br J Hosp Med (Lond); 77(10):600-601, 2016 Oct.
ISSN:1750-8460
País de publicação:England
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE


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Priore, Silvia Eloiza
PubMed Central Texto completo
Texto completo SciELO Brasil
PMID:27626474
Autor:Freitas BA; Lima LM; Moreira ME; Priore SE; Henriques BD; Carlos CF; Sabino JS; Franceschini Sdo C
Endereço:Universidade Federal de Viçosa (UFV), Departamento de Medicina e Enfermagem, Viçosa/MG, Brazil.
Título:Micronutrient supplementation adherence and influence on the prevalences of anemia and iron, zinc and vitamin A deficiencies in preemies with a corrected age of six months.
Fonte:Clinics (Sao Paulo); 71(8):440-8, 2016 Aug.
ISSN:1980-5322
País de publicação:Brazil
Idioma:eng
Resumo:OBJECTIVE: To analyze adherence to the recommended iron, zinc and multivitamin supplementation guidelines for preemies, the factors associated with this adherence, and the influence of adherence on the occurrence of anemia and iron, zinc and vitamin A deficiencies. METHODS: This prospective cohort study followed 58 preemies born in 2014 until they reached six months corrected age. The preemies were followed at a referral secondary health service and represented 63.7% of the preterm infants born that year. Outcomes of interest included high or low adherence to iron, zinc and multivitamin supplementation guidelines; prevalence of anemia; and prevalences of iron, zinc, and vitamin A deficiencies. The prevalence ratios were calculated by Poisson regression. RESULTS: Thirty-eight (65.5%) preemies presented high adherence to micronutrient supplementation guidelines. At six months of corrected age, no preemie had vitamin A deficiency. The prevalences of anemia, iron deficiency and zinc deficiency were higher in the low-adherence group but also concerning in the high-adherence group. Preemies with low adherence to micronutrient supplementation guidelines were 2.5 times more likely to develop anemia and 3.1 times more likely to develop zinc deficiency. Low maternal education level increased the likelihood of nonadherence to all three supplements by 2.2 times. CONCLUSIONS: Low maternal education level was independently associated with low adherence to iron, zinc and vitamin A supplementation guidelines in preemies, which impacted the prevalences of anemia and iron and zinc deficiencies at six months of corrected age.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Micronutrients); E1UOL152H7 (Iron); J41CSQ7QDS (Zinc)


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PMID:27573700
Autor:Boer B; Tisack A; Shwayder T
Endereço:College of Human Medicine, Michigan State University, Grand Rapids, MI.
Título:Transient Porphyrinemia in a Neonate: A Case Report.
Fonte:Pediatr Dermatol; 33(6):e375-e376, 2016 Nov.
ISSN:1525-1470
País de publicação:United States
Idioma:eng
Resumo:We describe a neonate with anemia, thrombocytopenia, and hyperbilirubinemia secondary to hemolytic disease of the newborn. After phototherapy for hyperbilirubinemia, the neonate developed a photodistributed eruption with high serum and urine porphyrin levels. This transient porphyrinemia resolved at 1 month.
Tipo de publicação: CASE REPORTS
Nome de substância:0 (Porphyrins)


  9 / 650 MEDLINE  
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PMID:27288395
Autor:Wüest A; Manser H; Küster H; Löllgen RM; Arenz T; Arenz S; Nelle M; Gerull R
Endereço:Department of Neonatology, Children's Hospital Kantonsspital Aarau, Aarau, Switzerland.
Título:Comparison of treatment strategies for anaemia of prematurity in extremely low birthweight infants between 1997 and 2011.
Fonte:Arch Dis Child Fetal Neonatal Ed; 101(5):F480-1, 2016 Sep.
ISSN:1468-2052
País de publicação:England
Idioma:eng
Tipo de publicação: LETTER
Nome de substância:11096-26-7 (Erythropoietin)


  10 / 650 MEDLINE  
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PMID:27192764
Autor:Malloy ME
Título:Delayed Cord Clamping Requires a New Table for Stressed Newborns.
Fonte:Midwifery Today Int Midwife; (117):59-62, 2016.
ISSN:1551-8892
País de publicação:United States
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE



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