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  1 / 169 MEDLINE  
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PMID:22510076
Autor:Ruppin M; Sullivan S; Condon F; Perkins N; Lee L; Jeffcott LB; Dart AJ
Endereço:Research and Clinical Training Unit, Veterinary Teaching Hospital Camden, The University of Sydney, New South Wales, Australia.
Título:Retrospective study of 103 presumed cases of tick (Ixodes holocyclus) envenomation in the horse.
Fonte:Aust Vet J; 90(5):175-80, 2012 May.
ISSN:1751-0813
País de publicação:England
Idioma:eng
Resumo:OBJECTIVE: Review 103 cases of presumed tick envenomation in horses. DESIGN: Retrospective study. METHOD: Variables, including date of presentation, age, breed, weight, presence of ticks, gait and respiration scores, duration of recumbency, treatment, outcome and complications were recorded. A series of univariable screening tests were performed and used in a multivariable logistic regression model. RESULTS: There were a total of 103 cases affecting 10 breeds, aged between 1 week and 18 years of age. Horses >6 months old and weighing >100 kg had a higher odds of death than those <6 months old and <100 kg. Cases were seen from North Queensland to the central coast of New South Wales and were more likely to present in the warmer months. There was no association between the number of ticks found on an animal and death. Horses with a higher respiratory score had higher odds of dying, but there was no association between gait score and survival. Horses recumbent >120 h after presentation had higher odds of dying. Complications were reported in 35% of horses. The odds ratio for survival was higher for horses receiving >0.5 mL/kg of tick antiserum. Overall, 74% of horses survived. Multivariable modelling was limited by the small sample size. CONCLUSION: In general, tick envenomation in horses follows the geographic distribution of Ixodes holocyclus. Tick antiserum administered at >0.5 mL/kg increases the odds of survival. It would appear that the complications associated with managing a recumbent horse increase the odds of death.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Arthropod Venoms); 88254-04-0 (holocyclotoxin)


  2 / 169 MEDLINE  
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PMID:21827517
Autor:Reck J; Soares JF; Termignoni C; Labruna MB; Martins JR
Endereço:Laboratório de Parasitologia, Instituto de Pesquisas Veterinárias Desidério Finamor (IPVDF), Fundação Estadual de Pesquisa Agropecuária (FEPAGRO), Eldorado do Sul, RS, Brazil. jose.reck@gmail.com
Título:Tick toxicosis in a dog bitten by Ornithodoros brasiliensis.
Fonte:Vet Clin Pathol; 40(3):356-60, 2011 Sep.
ISSN:1939-165X
País de publicação:United States
Idioma:eng
Resumo:Ticks are hematophagous parasites of people and animals and are a public health hazard in several countries. They are vectors of infectious diseases; in addition, the bite of some ticks, mainly from the Ornithodoros genus, may lead to local lesions and systemic illness, referred to as tick toxicosis. In this report, we describe a dog bitten by Ornithodoros brasiliensis, popularly known as the mouro tick. The main clinical findings were disseminated skin rash, pruritus, mucosal hyperemia, lethargy, and fever. Laboratory abnormalities 48 hours after the bites occurred included mild nonregenerative anemia, eosinophilia, basophilia, increased serum creatine kinase activity, increased serum C-reactive protein concentration, and prolonged coagulation times. Tick-borne pathogens were not detected by PCR analysis or serologic testing, supporting the diagnosis of a noninfectious syndrome due to tick bite, compatible with tick toxicosis.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:9007-41-4 (C-Reactive Protein)


  3 / 169 MEDLINE  
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PMID:17706447
Autor:Schull DN; Litster AL; Atwell RB
Endereço:School of Veterinary Science, University of Queensland, St. Lucia, Queensland 4072, Australia.
Título:Tick toxicity in cats caused by Ixodes species in Australia: a review of published literature.
Fonte:J Feline Med Surg; 9(6):487-93, 2007 Dec.
ISSN:1098-612X
País de publicação:England
Idioma:eng
Resumo:Tick toxicity in cats caused by Ixodes holocyclus and related species is a common medical condition on the east coast of Australia. Intoxication typically causes a flaccid ascending neuromuscular paralysis and clinical signs can include anxiety, dysphonia, hind limb weakness and/or ataxia, pupillary dilation, respiratory signs and possible bladder voiding dysfunction. Diagnosis is made with a combination of appropriate clinical signs and visualisation of tick(s) on a thorough body search. Cases are classified clinically using a scoring system, which grades neuromuscular weakness and respiratory compromise. The mainstays of treatment are tick removal, administration of tick antitoxin serum and intensive supportive care. Given a prompt and appropriate management regimen, prognosis is good, according to available literature. Most of the literature concerning tick toxicity in cats is anecdotal in nature and an evidence-based review of what is known of this condition has not previously been published.
Tipo de publicação: JOURNAL ARTICLE; REVIEW


  4 / 169 MEDLINE  
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PMID:17636380
Autor:Venzal JM; Estrada-Peña A; Fernández de Luco D
Endereço:Departamento de Parasitología Veterinaria, Facultad de Veterinaria, Universidad de la República, Av. Alberto Lasplaces 1550, CP 11600, Montevideo, Uruguay.
Título:Effects produced by the feeding of larvae of Ornithodoros aff. puertoricensis (Acari: Argasidae) on laboratory mice.
Fonte:Exp Appl Acarol; 42(3):217-23, 2007.
ISSN:0168-8162
País de publicação:Netherlands
Idioma:eng
Resumo:The clinical picture produced by the feeding of larvae of Ornithodoros aff. puertoricensis on laboratory mice, was studied using different larval infestation protocols that included 30, 40 or 50 larvae per mouse and control uninfested groups. Clinical effects appeared around 72 h of larval feeding, having a first stage characterized by hyperaemia in both nasal and ocular mucosa, followed by respiratory symptoms (96-120 h) and nervous incoordination (120-144 h). No one mouse evidenced paralysis, and nervous symptoms were never observed in animals infested with only 30 larvae. High mortality (commonly up to 70%) was observed in mice with respiratory symptoms, while 100% of animals in the nervous phase died between 168 and 192 h after the beginning of larval feeding. When some infested mice were treated with a solution of Amitraz the larvae were killed and reversion of symptoms was observed. These effects are ascribed to the presence of a toxin in the saliva of the feeding larvae.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T


  5 / 169 MEDLINE  
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PMID:15938507
Autor:Mans BJ; Gothe R; Neitz AW
Endereço:Department of Biochemistry, University of Pretoria, Pretoria, 0002, South Africa.
Título:Biochemical perspectives on paralysis and other forms of toxicoses caused by ticks.
Fonte:Parasitology; 129 Suppl:S95-111, 2004.
ISSN:0031-1820
País de publicação:England
Idioma:eng
Resumo:Tick toxicoses, of which paralysis is the most widespread and dominant form, are important elements of pathogenesis induced by ticks. Tick paralysis is the most widespread and dominant form of tick toxicoses. Non-paralytic forms of tick toxicoses do occur and evidence suggests that these forms of toxicoses are not evolutionary related. While functional significance has been suggested for tick toxins, the advantages for tick survival in general are not clear. This review considers the molecular nature of tick toxins, the possibility that tick toxins have originated more than once independently and whether these toxins could have unrecognized benign functions.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
Nome de substância:0 (Protease Inhibitors); 0 (Toxins, Biological)


  6 / 169 MEDLINE  
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PMID:14723893
Autor:Mans BJ; Neitz AW
Endereço:Department of Biochemistry, University of Pretoria, Pretoria 0002, South Africa. ben.mans@bioagric.up.ac.za
Título:Adaptation of ticks to a blood-feeding environment: evolution from a functional perspective.
Fonte:Insect Biochem Mol Biol; 34(1):1-17, 2004 Jan.
ISSN:0965-1748
País de publicação:England
Idioma:eng
Resumo:Ticks had to adapt to an existing and complex vertebrate hemostatic system from being free-living scavengers. A large array of anti-hemostatic mechanisms evolved during this process and includes blood coagulation as well as platelet aggregation inhibitors. Several questions regarding tick evolution exist. What was the nature of the ancestral tick? When did ticks evolve blood-feeding capabilities? How did these capabilities evolve? Did host specificity influence the adaptation of ticks to a blood-feeding environment? What are the implications of tick evolution for future research into tick biology and vaccine development? We investigate these questions in the light of recent research into protein superfamilies from tick saliva. Our conclusions are that the main tick families adapted independently to a blood-feeding environment. This is supported by major differences observed in all processes involved with blood-feeding for hard and soft ticks. Gene duplication events played a major role in the evolution of novel protein functions involved in tick-host interactions. This occurred during the late Cretaceous and was stimulated by the radiation of birds and placental mammals, which provided numerous new niches for ticks to adapt to a new lifestyle. Independent adaptation of the main tick families to a blood-feeding environment has several implications for future tick research in terms of tick genome projects and vaccine development.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
Nome de substância:0 (Anticoagulants); 0 (Carrier Proteins); 0 (Platelet Aggregation Inhibitors); 0 (Trypsin Inhibitors)


  7 / 169 MEDLINE  
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PMID:12465812
Autor:Campbell FE; Atwell RB
Endereço:School of Veterinary Science, The University of Queensland, Queensland 4072.
Título:Long QT syndrome in dogs with tick toxicity (Ixodes holocyclus).
Fonte:Aust Vet J; 80(10):611-6, 2002 Oct.
ISSN:0005-0423
País de publicação:England
Idioma:eng
Resumo:OBJECTIVE: To evaluate cardiac electrical function in dogs with tick toxicity. DESIGN: A prospective clinical investigation of 39 client-owned dogs treated for naturally occurring tick toxicity. PROCEDURE: An ECG was performed on each dog on several occasions; at admission to hospital with tick toxicity, 24 h later, at discharge from hospital when clinically normal and approximately 12 months later. RESULTS: The mean QT interval corrected for heart rate (QTc) was prolonged at admission, 24 h and at discharge compared to the QTc measured 12 months later. T wave morphology was altered in dogs at admission. All other parameters were within normal limits. CONCLUSIONS: The prolonged QTc interval and altered T wave morphology of dogs with tick toxicity reflects delayed cardiac repolarisation and is comparable with long QT syndrome (LQTS) in people who are predisposed to polymorphic ventricular tachycardia and sudden death. Resolution of ECG changes lagged behind clinical recovery.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T


  8 / 169 MEDLINE  
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PMID:16883685
Autor:Buczek A; Sodowska H; Baranska E; Pabis B; Pabis A
Endereço:Katedra i Zaklad Biologii i Parazytologii, AM 20-080 Lublin, ul. Radziwillowska 11.
Título:[Toxicoses of ticks (Acari: Ixodida)].
Título:Toksykozy kleszczowe (Acari: Ixodida)..
Fonte:Wiad Parazytol; 46(3):305-13, 2000.
ISSN:0043-5163
País de publicação:Poland
Idioma:pol
Resumo:Toxins have been shown to present in the salivary glands, whole body extracts, and eggs of ticks. They cause histological lesions in the skin, and in various organs of tick hosts. Among toxicoses, tick paralysis is of the greatest medical and veterinary importance. Toxins are secreted by cells "b" of acinus II in salivary glands during tick feeding.
Tipo de publicação: ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Arthropod Venoms); 0 (Biomarkers)


  9 / 169 MEDLINE  
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PMID:10945054
Autor:Yeruham I; Hadani A; Aroch I; Galker F; Gilor H; Rodrig S
Endereço:Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel. chk1357@netvision.net.il
Título:Cases of apparent tick toxicosis in humans and dogs, caused by Ixodes redikorzevi s.l.
Fonte:Ann Trop Med Parasitol; 94(4):413-5, 2000 Jun.
ISSN:0003-4983
País de publicação:England
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE


  10 / 169 MEDLINE  
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PMID:10188170
Autor:Berdyev AB
Título:[A review of the types of parasite-host relations in ixodid ticks].
Título:Obzor tipov parazitno-khoziainnykh otnoshenii iksodoidnykh kleshchei..
Fonte:Parazitologiia; 32(6):481-8, 1998 Nov-Dec.
ISSN:0031-1847
País de publicação:Russia (Federation)
Idioma:rus
Resumo:In the first type of mutual relationships the ixodid ticks expose an evident pathogenicity to vertebrate hosts (tick toxicoses) and in the second type the hosts expose a resistance on a base of organism immune system activisation in a response to blood sucking. In the third type of relationships an interaction between the ticks and hosts have a dynamic character (tolerability of host). The first type of relationships leading to a selective elimination of hosts according to our opinion means a comparatively youth of relationships. The third type represent ancient and long term relationships. The second type probably having been widely spread in a historical past occupies an intermediate position. Depending upon areal the ticks of the same type expose different degree of the pathogenicity. Even an acquired resistance of the host does exist in natural conditions, it is a transient phenomenon.
Tipo de publicação: ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW



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