Base de dados : MEDLINE
Pesquisa : D01.248.497.158.291.370 [Categoria DeCS]
Referências encontradas : 1522 [refinar]
Mostrando: 1 .. 10   no formato [Longo]

página 1 de 153 ir para página                         

  1 / 1522 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
PMID:29254315
Autor:Akhtar T; Sheikh N; Shan T; Ghazanfar R
Endereço:Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Q-A Campus, Lahore, Pakistan.
Título:Tacrolimus induced nephrotoxicity and pulmonary toxicity in Wistar rats.
Fonte:J Biol Regul Homeost Agents; 31(4):1061-1066, 2017 Oct-Dec.
ISSN:0393-974X
País de publicação:Italy
Idioma:eng
Resumo:Transplantation has evolved into an accepted treatment for end-stage organ failure. The major limitation for solid organ transplantation is organ rejection, which is an adaptive immune response caused by the activation of T-cells. Immunosuppressant drugs are used to overcome this problem. Tacrolimus is a powerful immunosuppressive drug which is used to minimize the risk of organ rejection. The present study was designed to find the toxic effects of tacrolimus on lungs and kidneys. Wistar rats were divided into 4 experimental groups and one control group (n=9). Each rat of the experimental group was orally given the aqueous suspension of tacrolimus powder (3mg/ml) and dissected after 6, 12, 24 and 48 hours of tacrolimus suspension dose. Lungs and kidneys were excised and processed for histopathological and histochemical alterations. Kidney tissues presented signs of toxic potential on tissue architecture such as increased interstitial spaces, necrosis, especially acute tubular necrosis, glomerular shrinkage, dilated blood vessels and enlargement of Bowman’s capsule. Lung sections also confirmed the toxic potential, characterized by bronchiolar wall thickening, alveolar cells necrosis, collapsing of alveolar spaces and interstitial round cell infiltrate. Results of Prussian blue iron staining showed no iron deposition in kidney architecture while in lung sections, iron accumulation was evident. Taken together from these observations we can conclude that tacrolimus may induce toxicity to a certain extent with structural distortion of the kidneys and lungs.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Ferrocyanides); 0 (Immunosuppressive Agents); TLE294X33A (ferric ferrocyanide); WM0HAQ4WNM (Tacrolimus)


  2 / 1522 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28873536
Autor:Soo Lim H; Young Hwang J; Choi E; Lee G; Sun Yoon S; Kim M
Endereço:Food Additives and Packaging Division, Ministry of Food and Drug Safety, Cheongju, Chungcheongbuk-do 28159, Republic of Korea.
Título:Development and validation of HPLC method for the determination of ferrocyanide ion in food grade salts.
Fonte:Food Chem; 239:1167-1174, 2018 Jan 15.
ISSN:0308-8146
País de publicação:England
Idioma:eng
Resumo:A rapid, simple, and reliable HPLC method was developed and validated to determine the presence of ferrocyanide ions (FeCNs) in food grade salts. An analytical column coupled with a guard column and mobile phase comprised of sodium perchlorate and sodium hydroxide (NaOH) were employed at a detection wavelength of 221nm. Samples were dissolved in 0.02M NaOH solution and filtered. For processed salts including herbs and spices, a C cartridge was applied to minimize interference from salt matrices. The method validation was based on linearity, accuracy (recovery), precision, LOD, LOQ, and measurement uncertainty. This method exhibits good linearity from 0.1-10mg/L (r =0.9999). The LOD and LOQ values were determined to be 0.02 and 0.07mg/kg, respectively. The FeCN recoveries in six salt matrices ranged from 80.3-102.2% (RSD=0.3-4.4%). These results indicate that the proposed method is suitable for FeCN ion determination in various food grade salts.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Ferrocyanides); 0 (Indicators and Reagents); 0 (Ions); FLX0VIC39Y (hexacyanoferrate II)


  3 / 1522 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28822912
Autor:Li SL; Bai MD; Hsiao CJ; Cheng SS; Nealson KH
Endereço:Department of Earth Sciences, University of Southern California, Los Angeles, CA 90089, USA; Department of Environmental Engineering, National Cheng Kung University, No. 1, University Road, Tainan, 701, Taiwan, ROC. Electronic address: reedli0227@ntu.edu.tw.
Título:A metabolic-activity-detecting approach to life detection: Restoring a chemostat from stop-feeding using a rapid bioactivity assay.
Fonte:Bioelectrochemistry; 118:147-153, 2017 Dec.
ISSN:1878-562X
País de publicação:Netherlands
Idioma:eng
Resumo:A mediated glassy carbon electrode covered by a thin-film polyviologen was used in the present study to rapidly detect bioactivity in a mixed-culture chemostat (dominated by Clostridium sp.). With the addition of 1mM hexacyanoferrate and 9mM glucose, the current increasing rate (dI/dt) measured under a poised potential of 500mV (vs. Ag/AgCl) can be defined as the quantity of metabolic activity. In the experiment of restoring the chemostat from stop-feeding, it is suggested that when the dI/dt was >2µAmin , the influent pump could be directly turned on to maintain the high dilution rate of 0.5h ; when the dI/dt was lower than 2µAmin , reducing the dilution rate would be needed to avoid cell wash out. Since the soluble mediators and polyviologen film will enhance performances by favorable electron transfer and positively charged surfaces, respectively, we suggest that the method can also be employed to detect the bioactivities in environmental samples.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Ferrocyanides); FLX0VIC39Y (hexacyanoferrate II); IY9XDZ35W2 (Glucose)


  4 / 1522 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28686995
Autor:Soda N; Arotiba OA
Endereço:Department of Applied Chemistry, University of Johannesburg, South Africa.
Título:A polyamidoamine dendrimer-streptavidin supramolecular architecture for biosensor development.
Fonte:Bioelectrochemistry; 118:14-18, 2017 Dec.
ISSN:1878-562X
País de publicação:Netherlands
Idioma:eng
Resumo:A novel polyamidoamine dendrimer-streptavidin supramolecular architecture suitable as a versatile platform for biosensor development is reported. The dendrimer was electrodeposited on a glassy carbon electrode via cyclic voltammetry. The dendrimer electrode was further modified with streptavidin by electrostatic attraction upon drop coating. The platform i.e. the dendrimer-streptavidin modified electrode was electrochemically interrogated in phosphate buffer, ferrocyanide and H O . The dendrimer-streptavidin platform was used in the preparation of a simple DNA biosensor as a proof of concept. The supramolecular architecture of dendrimer-streptavidin was stable, electroactive and thus lends itself as a versatile immobilisation layer for any biotinylated bioreceptors in biosensor development.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Dendrimers); 0 (Ferrocyanides); 0 (Phosphates); 0 (Poly(amidoamine)); 0 (Polyamines); 9013-20-1 (Streptavidin); BBX060AN9V (Hydrogen Peroxide); FLX0VIC39Y (hexacyanoferrate II)


  5 / 1522 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28255343
Autor:Yang Y; Jing L; Li X; Lin L; Yue X; Dai Z
Endereço:School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
Título:Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics.
Fonte:Theranostics; 7(2):466-481, 2017.
ISSN:1838-7640
País de publicação:Australia
Idioma:eng
Resumo:A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS -ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles. The obtained nanoagent could serve as an efficient contrast agent to simultaneously enhance near infrared (NIR) fluorescence and magnetic resonance (MR) imaging greatly. The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field. Both NIR fluorescence and MR imaging proved high accumulation of the nanoagent at tumor site due to its excellent CD44 receptor/magnetic dual targeting capability. After intravenous injection of the nanoagent and treatment of external magnetic field, the tumor in nude mice was efficiently ablated upon NIR laser irradiation and the tumor growth inhibition was more than 89.95%. Such nanotheranostic agent is of crucial importance for accurately identifying the size and location of the tumor before therapy, monitoring the photothermal treatment procedure in real-time during therapy, assessing the effectiveness after therapy.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Contrast Media); 0 (Drug Carriers); 0 (Ferrocyanides); 0 (Magnetite Nanoparticles); 0 (Photosensitizing Agents); TLE294X33A (ferric ferrocyanide)


  6 / 1522 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28183644
Autor:Manasa G; Mascarenhas RJ; Satpati AK; D'Souza OJ; Dhason A
Endereço:Electrochemistry Research Group, Department of Chemistry, St. Joseph's College, Lalbagh Road, Bangalore, 560027, Karnataka, India.
Título:Facile preparation of poly(methylene blue) modified carbon paste electrode for the detection and quantification of catechin.
Fonte:Mater Sci Eng C Mater Biol Appl; 73:552-561, 2017 Apr 01.
ISSN:1873-0191
País de publicação:Netherlands
Idioma:eng
Resumo:Free radicals are formed as byproducts of metabolism, and are highly unstable due to the presence of unpaired electrons. They readily react with other important cellular components such as DNA causing them damage. Antioxidants such as (+)-catechin (CAT), neutralize free radicals in the blood stream. Hence there is a need for detection and quantification of catechin concentration in various food sources and beverages. Electro-oxidative properties of catechin were investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A carbon paste working electrode modified by electropolymerizing methylene blue (MB) was fabricated. Field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) techniques were used to study the surface morphology of the electrode. Quasi-reversible electron transfer reaction occurred at +0.260V through a diffusion controlled process. In comparison to the bare carbon paste electrode (CPE), there was a significant 5.3 times increment in anodic current sensitivity at the modified electrode at physiological pH. Our findings indicate that for the electro-oxidation of CAT, CPE is a better base material for electropolymerization of MB compared to glassy carbon electrode (GCE). Nyquist plot followed the theoretical shape, indicating low interfacial charge transfer resistance of 0.095kΩ at the modified electrode. Calibration plots obtained by DPV were linear in two ranges of 1.0×10 to 1.0×10 and 1.0×10 to 0.1×10 M. The limit of detection (LOD) and limit of quantification (LOQ) was 4.9nM and 14nM respectively. Application of the developed electrode was demonstrated by detecting catechin in green tea and spiked fruit juice with satisfactory recoveries. The sensor was stable, sensitive, selective and reproducible.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Ferrocyanides); 0 (Solutions); 0 (Tea); 7440-44-0 (Carbon); 8R1V1STN48 (Catechin); GTP1P30292 (potassium ferrocyanide); T42P99266K (Methylene Blue)


  7 / 1522 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28024640
Autor:Qiu W; Zhu Q; Gao F; Gao F; Huang J; Pan Y; Wang Q
Endereço:College of Chemistry and Environment, Fujian Province Key Laboratory of Morden Analytical Science and Separation Technology, Minnan Normal University, Zhangzhou 363000, PR China.
Título:Graphene oxide directed in-situ synthesis of Prussian blue for non-enzymatic sensing of hydrogen peroxide released from macrophages.
Fonte:Mater Sci Eng C Mater Biol Appl; 72:692-700, 2017 Mar 01.
ISSN:1873-0191
País de publicação:Netherlands
Idioma:eng
Resumo:A novel electrochemical non-enzymatic hydrogen peroxide (H O ) sensor has been developed based on Prussian blue (PB) and electrochemically reduced graphene oxide (ERGO). The GO was covalently modified on glassy carbon electrode (GCE), and utilized as a directing platform for in-situ synthesis of electroactive PB. Then the GO was electrochemically treated to reduction form to improve the effective surface area and electroactivity of the sensing interface. The fabrication process was characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM). The results showed that the rich oxygen containing groups play a crucial role for the successful synthesis of PB, and the obtained PB layer on the covalently immobilized GO has good stability. Electrochemical sensing assay showed that the modified electrode had tremendous electrocatalytic property for the reduction of H O . The steady-state current response increased linearly with H O concentrations from 5µM to 1mM with a fast response time (less than 3s). The detection limit was estimated to be 0.8µM. When the sensor was applied for determination of H O released from living cells of macrophages, satisfactory results were achieved.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Ferrocyanides); 0 (Lipopolysaccharides); 0 (Oxides); 7440-44-0 (Carbon); 7782-42-5 (Graphite); BBX060AN9V (Hydrogen Peroxide); TLE294X33A (ferric ferrocyanide)


  8 / 1522 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:27911491
Autor:Zhu X; Kim T; Rahimi M; Gorski CA; Logan BE
Endereço:Department of Civil and Environmental Engineering, Penn State University, University Park, PA, 16802, USA.
Título:Integrating Reverse-Electrodialysis Stacks with Flow Batteries for Improved Energy Recovery from Salinity Gradients and Energy Storage.
Fonte:ChemSusChem; 10(4):797-803, 2017 Feb 22.
ISSN:1864-564X
País de publicação:Germany
Idioma:eng
Resumo:Salinity gradient energy can be directly converted into electrical power by using reverse electrodialysis (RED) and other technologies, but reported power densities have been too low for practical applications. Herein, the RED stack performance was improved by using 2,6-dihydroxyanthraquinone and ferrocyanide as redox couples. These electrolytes were then used in a flow battery to produce an integrated RED stack and flow battery (RED-FB) system capable of capturing, storing, and discharging salinity gradient energy. Energy captured from the RED stack was discharged in the flow battery at a maximum power density of 3.0 kW m -anode, which was similar to the flow batteries charged by electrical power and could be used for practical applications. Salinity gradient energy captured from the RED stack was recovered from the electrolytes as electricity with 30 % efficiency, and the maximum energy density of the system was 2.4 kWh m -anolyte. The combined RED-FB system overcomes many limitations of previous approaches to capture, store, and use salinity gradient energy from natural or engineered sources.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Anthraquinones); 0 (Electrolytes); 0 (Ferrocyanides); FLX0VIC39Y (hexacyanoferrate II); W83883330W (2,6-dihydroxyanthraquinone)


  9 / 1522 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:27865108
Autor:Wang Y; Gao C; Ge S; Zhang L; Yu J; Yan M
Endereço:School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.
Título:Self-powered sensing platform equipped with Prussian blue electrochromic display driven by photoelectrochemical cell.
Fonte:Biosens Bioelectron; 89(Pt 2):728-734, 2017 Mar 15.
ISSN:1873-4235
País de publicação:England
Idioma:eng
Resumo:By incorporating the Prussian Blue (PB) electrochromic display as cathode, a solar-driven photoelectrochemical (PEC) cell was constructed through combining sandwich-structured graphite-like carbon nitride (g-C N )-Au-branched-titanium dioxide (B-TiO ) nanorods as photoanode for self-powered hydrogen peroxide (H O ) sensing, which exhibits both direct photoelectrochemical and electrochromic response. The gold nanoparticles (Au NPs) sandwiched between the B-TiO nanorods and the g-C N layer served as electron relay as well as plasmonic photosensitizer to enhance the solar-to-chemical energy conversion efficiency. Owing to the effective disproportionation of H O and specific recognition of mannose on cell surface, concanavalin-A conjugated porous AuPd alloy nanoparticles were introduced as the catalytically active nanolabels promoting generation of hydroxyl radicals (·OH). Based on the cleavage of DNA with the participation of ·OH radicals generated by the decomposition of H O under the catalysis of AuPd alloy result in the disassembly of cancer cells to achieve further signal enhancement. The multiple-signal-output sensing response not only provides a promising strategy for different analytical purposes based on novel stimuli-responsive materials, but also enhances the reliability in the analyte detection.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Coloring Agents); 0 (Ferrocyanides); 15FIX9V2JP (titanium dioxide); 7440-57-5 (Gold); 7782-42-5 (Graphite); BBX060AN9V (Hydrogen Peroxide); D1JT611TNE (Titanium); TLE294X33A (ferric ferrocyanide)


  10 / 1522 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:27836615
Autor:Yang P; Peng J; Chu Z; Jiang D; Jin W
Endereço:State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 210009, PR China.
Título:Facile synthesis of Prussian blue nanocubes/silver nanowires network as a water-based ink for the direct screen-printed flexible biosensor chips.
Fonte:Biosens Bioelectron; 92:709-717, 2017 Jun 15.
ISSN:1873-4235
País de publicação:England
Idioma:eng
Resumo:The large-scale fabrication of nanocomposite based biosensors is always a challenge in the technology commercialization from laboratory to industry. In order to address this issue, we have designed a facile chemical method of fabricated nanocomposite ink applied to the screen-printed biosensor chip. This ink can be derived in the water through the in-situ growth of Prussian blue nanocubes (PBNCs) on the silver nanowires (AgNWs) to construct a composite nanostructure by a facile chemical method. Then a miniature flexible biosensor chip was screen-printed by using the prepared nanocomposite ink. Due to the synergic effects of the large specific surface area, high conductivity and electrocatalytic activity from AgNWs and PBNCs, the as-prepared biosensor chip exhibited a fast response (<3s), a wider linear response from 0.01 to 1.3mM with an ultralow LOD=5µm, and the ultrahigh sensitivities of 131.31 and 481.20µAmM cm for the detections of glucose and hydrogen peroxide (H O ), respectively. Furthermore, the biosensor chip exhibited excellent stability, good reproducibility and high anti-interference ability towards physiological substances under a very low working potential of -0.05. Hence, the proposed biosensor chip also showed a promising potential for the application in practical analysis.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Blood Glucose); 0 (Enzymes, Immobilized); 0 (Ferrocyanides); 059QF0KO0R (Water); 3M4G523W1G (Silver); BBX060AN9V (Hydrogen Peroxide); EC 1.1.3.4 (Glucose Oxidase); TLE294X33A (ferric ferrocyanide)



página 1 de 153 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde