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  1 / 3190 MEDLINE  
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PMID:29180866
Autor:Lapin NA; Vergara LA; Mackeyev Y; Newton JM; Dilliard SA; Wilson LJ; Curley SA; Serda RE
Endereço:Michael E DeBakey Department of Surgery, Baylor College of Medicine.
Título:Biotransport kinetics and intratumoral biodistribution of malonodiserinolamide-derivatized [60]fullerene in a murine model of breast adenocarcinoma.
Fonte:Int J Nanomedicine; 12:8289-8307, 2017.
ISSN:1178-2013
País de publicação:New Zealand
Idioma:eng
Resumo:[60]Fullerene is a highly versatile nanoparticle (NP) platform for drug delivery to sites of pathology owing to its small size and both ease and versatility of chemical functionalization, facilitating multisite drug conjugation, drug targeting, and modulation of its physicochemical properties. The prominent and well-characterized role of the enhanced permeation and retention (EPR) effect in facilitating NP delivery to tumors motivated us to explore vascular transport kinetics of a water-soluble [60]fullerene derivatives using intravital microscopy in an immune competent murine model of breast adenocarcinoma. Herein, we present a novel local and global image analysis of vascular transport kinetics at the level of individual tumor blood vessels on the micron scale and across whole images, respectively. Similar to larger nanomaterials, [60]fullerenes displayed rapid extravasation from tumor vasculature, distinct from that in normal microvasculature. Temporal heterogeneity in fullerene delivery to tumors was observed, demonstrating the issue of nonuniform delivery beyond spatial dimensions. Trends in local region analysis of fullerene biokinetics by fluorescence quantification were in agreement with global image analysis. Further analysis of intratumoral vascular clearance rates suggested a possible enhanced penetration and retention effect of the fullerene compared to a 70 kDa vascular tracer. Overall, this study demonstrates the feasibility of tracking and quantifying the delivery kinetics and intratumoral biodistribution of fullerene-based drug delivery platforms, consistent with the EPR effect on short timescales and passive transport to tumors.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Fullerenes); 059QF0KO0R (Water)


  2 / 3190 MEDLINE  
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PMID:29478628
Autor:Liu J; Zhu R; Xu T; Laipan M; Zhu Y; Zhou Q; Zhu J; He H
Endereço:Key Laboratory of Mineralogy and Metallogeny, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Mineral Physics and Material Research & Development, Guangzhou 510640, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Título:Interaction of polyhydroxy fullerenes with ferrihydrite: adsorption and aggregation.
Fonte:J Environ Sci (China); 64:1-9, 2018 Feb.
ISSN:1001-0742
País de publicação:Netherlands
Idioma:eng
Resumo:The rapid development of nanoscience and nanotechnology, with thousands types of nanomaterials being produced, will lead to various environmental impacts. Thus, understanding the behaviors and fate of these nanomaterials is essential. This study focused on the interaction between polyhydroxy fullerenes (PHF) and ferrihydrite (Fh), a widespread iron (oxyhydr)oxide nanomineral and geosorbent. Our results showed that PHF were effectively adsorbed by Fh. The adsorption isotherm fitted the D-R model well, with an adsorption capacity of 67.1mg/g. The adsorption mean free energy of 10.72kJ/mol suggested that PHF were chemisorbed on Fh. An increase in the solution pH and a decrease of the Fh surface zeta potential were observed after the adsorption of PHF on Fh; moreover, increasing initial solution pH led to a reduction of adsorption. The Fourier transform infrared spectra detected a red shift of C-O stretching from 1075 to 1062cm and a decrease of Fe-O bending, implying the interaction between PHF oxygenic functional groups and Fh surface hydroxyls. On the other hand, PHF affected the aggregation and reactivity of Fh by changing its surface physicochemical properties. Aggregation of PHF and Fh with individual particle sizes increasing from 2nm to larger than 5nm was measured by atomic force microscopy. The uniform distribution of C and Fe suggested that the aggregates of Fh were possibly bridged by PHF. Our results indicated that the interaction between PHF and Fh could evidently influence the migration of PHF, as well as the aggregation and reactivity of Fh.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Ferric Compounds); 0 (Fullerenes); 87PZU03K0K (ferric oxyhydroxide)


  3 / 3190 MEDLINE  
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PMID:29406112
Autor:Liu Y; Fu J; Pan W; Xue Q; Liu X; Zhang A
Endereço:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100190, China. Electronic address: liuyanyan
Título:Inhibition of thrombin by functionalized C nanoparticles revealed via in vitro assays and in silico studies.
Fonte:J Environ Sci (China); 63:285-295, 2018 Jan.
ISSN:1001-0742
País de publicação:Netherlands
Idioma:eng
Resumo:The studies on the human toxicity of nanoparticles (NPs) are far behind the rapid development of engineered functionalized NPs. Fullerene has been widely used as drug carrier skeleton due to its reported low risk. However, different from other kinds of NPs, fullerene-based NPs (C NPs) have been found to have an anticoagulation effect, although the potential target is still unknown. In the study, both experimental and computational methods were adopted to gain mechanistic insight into the modulation of thrombin activity by nine kinds of C NPs with diverse surface chemistry properties. In vitro enzyme activity assays showed that all tested surface-modified C NPs exhibited thrombin inhibition ability. Kinetic studies coupled with competitive testing using 3 known inhibitors indicated that six of the C NPs, of greater hydrophobicity and hydrogen bond (HB) donor acidity or acceptor basicity, acted as competitive inhibitors of thrombin by directly interacting with the active site of thrombin. A simple quantitative nanostructure-activity relationship model relating the surface substituent properties to the inhibition potential was then established for the six competitive inhibitors. Molecular docking analysis revealed that the intermolecular HB interactions were important for the specific binding of C NPs to the active site canyon, while the additional stability provided by the surface groups through van der Waals interaction also play a key role in the thrombin binding affinity of the NPs. Our results suggest that thrombin is a possible target of the surface-functionalized C NPs relevant to their anticoagulation effect.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Fullerenes); EC 3.4.21.5 (Thrombin); NP9U26B839 (fullerene C60)


  4 / 3190 MEDLINE  
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PMID:29191454
Autor:Kraemer ÂB; Parfitt GM; Acosta DDS; Bruch GE; Cordeiro MF; Marins LF; Ventura-Lima J; Monserrat JM; Barros DM
Endereço:Programa de Pós-Graduação em Ciências Fisiológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil.
Título:Fullerene (C60) particle size implications in neurotoxicity following infusion into the hippocampi of Wistar rats.
Fonte:Toxicol Appl Pharmacol; 338:197-203, 2018 01 01.
ISSN:1096-0333
País de publicação:United States
Idioma:eng
Resumo:The buckminsterfullerene (C60) is considered as a relevant candidate for drug and gene delivery to the brain, once it has the ability to cross the blood-brain barrier. However, the biological implications of this nanomaterial are not fully understood, and its safety for intracerebral delivery is still debatable. In this study, we investigated if C60 particle size could alter its biological effects. For this, two aqueous C60 suspensions were used with maximum particle size up to 200nm and 450nm. The suspensions were injected in the hippocampus, the main brain structure involved in memory processing and spatial localization. In order to assess spatial learning, male Wistar rats were tested in Morris water maze, and the hippocampal BDNF protein levels and gene expression were analyzed. Animals treated with C60 up to 450nm demonstrated impaired spatial memory with a significant decrease in BDNF protein levels and gene expression. However, an enhanced antioxidant capacity was observed in both C60 treatments. A decrease in reactive oxygen species levels was observed in the treatments with suspensions containing particles measuring with up to 450nm. Thiobarbituric acid reactive substances, glutamate cysteine ligase, and glutathione levels showed no alterations among the different treatments. In conclusion, different particle sizes of the same nanomaterial can lead to different behavioral outcomes and biochemical parameters in brain tissue.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Brain-Derived Neurotrophic Factor); 0 (Fullerenes); 0 (Reactive Oxygen Species)


  5 / 3190 MEDLINE  
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PMID:28947315
Autor:Hao Y; Ma C; Zhang Z; Song Y; Cao W; Guo J; Zhou G; Rui Y; Liu L; Xing B
Endereço:Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China.
Título:Carbon nanomaterials alter plant physiology and soil bacterial community composition in a rice-soil-bacterial ecosystem.
Fonte:Environ Pollut; 232:123-136, 2018 Jan.
ISSN:1873-6424
País de publicação:England
Idioma:eng
Resumo:The aim of this study was to compare the toxicity effects of carbon nanomaterials (CNMs), namely fullerene (C ), reduced graphene oxide (rGO) and multi-walled carbon nanotubes (MWCNTs), on a mini-ecosystem of rice grown in a loamy potted soil. We measured plant physiological and biochemical parameters and examined bacterial community composition in the CNMs-treated plant-soil system. After 30 days of exposure, all the three CNMs negatively affected the shoot height and root length of rice, significantly decreased root cortical cells diameter and resulted in shrinkage and deformation of cells, regardless of exposure doses (50 or 500 mg/kg). Additionally, at the high exposure dose of CNM, the concentrations of four phytohormones, including auxin, indoleacetic acid, brassinosteroid and gibberellin acid 4 in rice roots significantly increased as compared to the control. At the high exposure dose of MWCNTs and C , activities of the antioxidant enzymes superoxide dismutase (SOD) and peroxidase (POD) in roots increased significantly. High-throughput sequencing showed that three typical CNMs had little effect on shifting the predominant soil bacterial species, but the presence of CNMs significantly altered the composition of the bacterial community. Our results indicate that different CNMs indeed resulted in environmental toxicity to rice and soil bacterial community in the rhizosphere and suggest that CNMs themselves and their incorporated products should be reasonably used to control their release/discharge into the environment to prevent their toxic effects on living organisms and the potential risks to food safety.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Fullerenes); 0 (Nanotubes, Carbon); 0 (Oxides); 0 (Soil); 0 (Soil Pollutants); 7782-42-5 (Graphite); EC 1.11.1.7 (Peroxidase); NP9U26B839 (fullerene C60)


  6 / 3190 MEDLINE  
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PMID:28941714
Autor:Boyle D; Sutton PA; Handy RD; Henry TB
Endereço:School of Biological and Marine Sciences, Plymouth University, Devon, PL4 8AA, UK. Electronic address: david.boyle@plymouth.ac.uk.
Título:Intravenous injection of unfunctionalized carbon-based nanomaterials confirms the minimal toxicity observed in aqueous and dietary exposures in juvenile rainbow trout (Oncorhynchus mykiss).
Fonte:Environ Pollut; 232:191-199, 2018 Jan.
ISSN:1873-6424
País de publicação:England
Idioma:eng
Resumo:Numerous ecotoxicology studies of carbon-based nanomaterials (CNMs) have been conducted in fishes; however, different approaches have been used to make CNM dispersions and dose tanks for aqueous exposures, and to prepare food containing CNMs for dietary studies. This diversity of experimental methods has led to conflicting results and difficulties in comparing studies. The objective of the present study was to evaluate intravenous injection of unfunctionalized CNMs in rainbow trout (Oncorhynchus mykiss), as a means of delivering a known internal dose, on tissue biochemistry and histopathological lesions; then, subsequently, to compare the results with our previous work on aqueous and dietary exposures of rainbow trout to CNMs. Rainbow trout were injected in the caudal vein with corn oil dispersions of 200 µg (approximately 1 µg g ) of either the fullerene C , single-walled carbon nanotubes (SWCNTs), or amorphous carbon black. After 96 h, injected fish were euthanized and tissue samples collected for biochemistry and histology. Histological examination of the kidney of fish injected intravenously indicated the presence of black material consistent with the injected carbon treatments. However, there were no additional lesions associated with CNM exposure compared to controls. There were also no significant changes in haematology, or ionoregulatory disturbance in blood plasma among the intravenously injected fish. Significant elevation in lipid peroxidation (thiobarbituric acid reactive substances TBARS) was detected only in kidney and spleen of fish injected with SWCNTs, but not the other carbon treatments. The elevated TBARS following injection contrasted with CNMs delivered via aqueous or dietary routes in our previous studies, suggesting that the latter exposure routes may not lead to absorption and toxicity in the internal tissues. Comparison of the effects of injected CNMs with aqueous and dietary CNMs exposures indicates that these materials are of minimal environmentally-relevant toxicity in rainbow trout.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Fullerenes); 0 (Nanotubes, Carbon); 0 (Thiobarbituric Acid Reactive Substances); 0 (Water Pollutants, Chemical); NP9U26B839 (fullerene C60)


  7 / 3190 MEDLINE  
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PMID:27771432
Autor:Mousavi SZ; Nafisi S; Maibach HI
Endereço:Department of Dermatology, University of California, San Francisco, CA, USA.
Título:Fullerene nanoparticle in dermatological and cosmetic applications.
Fonte:Nanomedicine; 13(3):1071-1087, 2017 04.
ISSN:1549-9642
País de publicação:United States
Idioma:eng
Resumo:Nanoparticles are equipped with exceptional properties which make them well suitable for diverse and novel applications. Fullerene is one of the nanomaterials that has valuable applications in the field of biomedicine. It possesses exceptional antioxidant capacity which has made it a promising core ingredient in many dermatological and skin care products. However, fullerene has the potentials to display a range of activities resulting in cell death or dysfunction. This review outlines the achievements made so far by reporting studies that have focused on incorporating fullerene in skin care products and cosmetics and assessed their beneficial effects. We have also documented reports that have assessed toxicity of this novel carbon allotrope toward skin cells and discussed its possible dermal reactions. Aside from pointing out the recent developments, areas that can benefit from further researches are identified.
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cosmetics); 0 (Fullerenes); 0 (Sunscreening Agents)


  8 / 3190 MEDLINE  
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PMID:27773235
Autor:Zhang C; Chen X
Endereço:College of Environmental Science and Engineering, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Nankai University, Tianjin, China. Electronic address: zhangchengdong@nankai.edu.cn.
Título:Different effects of sonication pretreatment on carbon nanomaterials under low hydrogen peroxide concentrations.
Fonte:Ultrason Sonochem; 34:19-26, 2017 01.
ISSN:1873-2828
País de publicação:Netherlands
Idioma:eng
Resumo:Dispersing carbon nanomaterials with the aid of sonication has become a widely used procedure for generating homogenous solutions. A systematic study was performed to evaluate the effects of a practical sample preparation procedure that involves mild sonication with/without low concentrations of hydrogen peroxide. Hydrogen peroxide is ubiquitously present in surface water and involved in advanced oxidation processes. Significant oxidation was observed for fullerene in the liquid phase, whereas an appreciable amount of hydrogen was covalently attached to the carbon cage of solid fullerene. Under the same conditions, only the removal of oxidized amorphous carbon was detected for carbon nanotubes. The presence of a low concentration of hydrogen peroxide during sonication exacerbated the effects. The changes in physicochemical properties were characterized quantitatively using X-ray photoelectron spectroscopy and elemental chemical analysis and qualitatively using matrix-assisted laser desorption ionization mass spectroscopy, H nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy and Raman spectroscopy. Our results highlight the effects that can occur during sample preparation step and the potential for misinterpreting the toxicity, reactivity and environmental fate of carbon nanomaterials.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Fullerenes); 0 (Nanotubes, Carbon); BBX060AN9V (Hydrogen Peroxide); NP9U26B839 (fullerene C60)


  9 / 3190 MEDLINE  
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PMID:29227077
Autor:Franskevych DV; Grynyuk II; Prylutska SV; Matyshevs ka OP
Título:Modulation of cisplatin-induced reactive oxygen species production by fullerene C(60) in normal and transformed lymphoid cells
Fonte:Ukr Biochem J; 88(1):44-50, 2016 Jan-Feb.
ISSN:2409-4943
País de publicação:Ukraine
Idioma:eng
Resumo:The early response of normal (Wistar rat thymocytes) and transformed (mice lymphoid leukemia L1210) cells to treatment with anticancer drug cisplatin or to combined treatment with cisplatin and carbon nanostructure fullerene C60 was studied. We demonstrated with fluorescent probes DCFH-DA and TMRE that cisplatin at concentration 1 µg/ml induced reactive oxygen species (ROS) production and decreased the value of mitochondrial membrane potential in both cell types. The combined treatment with cisplatin (1 µg/ml) and fullerene C60 (7.2 µg/ml) was shown to be followed by oppositely directed modulation of ROS production in thymocytes and L1210 cells. Cisplatin-induced ROS production was intensified in L1210 cells, while in thymocytes it was decreased. It is supposed that the different effects of combined treatment are associated with peculiarities of fullerene C60 accumulation and localization in normal and cancer cells.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antineoplastic Agents); 0 (Drug Combinations); 0 (Fluoresceins); 0 (Fluorescent Dyes); 0 (Fullerenes); 0 (Organometallic Compounds); 0 (Reactive Oxygen Species); 0 (tetramethyl rhodamine ethyl ester); 2044-85-1 (diacetyldichlorofluorescein); NP9U26B839 (fullerene C60); Q20Q21Q62J (Cisplatin)


  10 / 3190 MEDLINE  
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PMID:28745220
Autor:Siebert A; Gensicka-Kowalewska M; Cholewinski G; Dzierzbicka K
Endereço:Department of Organic Chemistry, Gdansk University of Technology, Narutowicza St 11/12, PL 80-233 Gdansk, Poland.
Título:Tuftsin - Properties and Analogs.
Fonte:Curr Med Chem; 24(34):3711-3727, 2017 Nov 17.
ISSN:1875-533X
País de publicação:Netherlands
Idioma:eng
Resumo:BACKGROUND: Immunomodulation is one of the significant therapeutic strategies. It includes both stimulation and suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism against infections of varying etiology. An example of such a substance is tuftsin (TKPA) 3 (Fig. (1)). In this paper were included tuftsin derivatives, which were described over the years, their together with biological activity and clinical potential. METHODS: We reviewed a bibliographic database to gather all the important information about the tuftsin peptide. We have delineated the significant information on the activity of the tetrapeptide itself and its derivatives. Analogs were divided because of their anti-tumor, anti-inflammatory, antimicrobial and anti-viral activity. RESULTS: This paper describes eighty-six documents. Thirty-two of them concern on activity of tuftsin in the human organism. The remaining fifty-four describe peptide analogues and their properties, including eleven papers about the tuftsin-based peptides contained in the vaccines, nine papers representing anticancer activity of the tuftsin derivatives, twenty-six about antiinflammatory compounds, and five papers describing the antitumor activity of the tuftsin analogs. CONCLUSION: The findings of this review confirm the importance of the tuftsin and their derivatives. Most of these substances showed anti-tumor, anti-inflammatory or antibacterial activities. A large amount of the compounds may find use in vaccines. Tuftsin can also be used to prepare fusion proteins in the treatment of cancer and as carriers of many biologically active substances.
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Fullerenes); NP9U26B839 (fullerene C60); QF5336J16C (Tuftsin)



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