Base de dados : MEDLINE
Pesquisa : D12.776.124.486.485 [Categoria DeCS]
Referências encontradas : 40862 [refinar]
Mostrando: 1 .. 10   no formato [Longo]

página 1 de 4087 ir para página                         

  1 / 40862 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:28465230
Autor:Zhu F; Xiao S; Zhang Y; Shao Y; Tang F; Chen S; Bai X
Endereço:Institute of Sericulture and Apiculture, Yunnan Academy of Agricultural Sciences, Mengzi 661101, Yunnan, China. Electronic address: 18287322700@163.com.
Título:Molecular characterization and expression analysis of Turtle protein in silkworm that is associated with Nosema bombycis infection.
Fonte:Infect Genet Evol; 52:67-74, 2017 Aug.
ISSN:1567-7257
País de publicação:Netherlands
Idioma:eng
Resumo:In this report, we describe the cloning and characterization of a member of the immunoglobulin superfamily (IgSF); i.e., Turtle. The cDNA of Turtle was cloned from the silkworm Bombyx mori using the rapid amplification of cDNA ends (RACE) technique. Three isoforms of Bombyx Turtle were obtained, including Bmtutl-464, Bmtutl-519, and Bmtutl-810. The three isoforms had identical 27-amino acid signal peptides and four extracellular immunoglobulin (Ig) domains (IgI-IgIV). Sequence similarity and phylogenic analysis indicated that Bmtutl-810 belongs to the group of insect Turtle isoforms and shares 76.2% identity with Drosophila Turtle. Quantitative real-time PCR analysis revealed that the Bombyx Turtle isoforms were expressed throughout the entire development period, the highest levels of expression of Bmtutl-464 and Bmtutl-519 were observed at the second instar larvae stage, whereas that of Bmtutl-810 peaked at the embryonic stage. The ubiquitous expression of Bmtutl-464, Bmtutl-519, and Bmtutl-810 were observed in all studied tissues, except for Bmtutl-519 in the silk gland. The expression level of Bmtutl-464 was highest in the ovary, whereas that of Bmtutl-519 and Bmtutl-810 was highest in the hemolymph. Bmtutl-519 was upregulated in BmN cells infected by Nosema bombycis, We speculated that Bombyx Turtle was not only involved in neural development in silkworm, as well as Drosophila Turtle, but was also involved in the regulation of other biological functions. For example, Bmtutl-519 might be involved in N. bombycis infection and may play an important role in the immune response of silkworms to N. bombycis infection.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Immunoglobulins); 0 (Insect Proteins); 0 (Protein Isoforms)


  2 / 40862 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29231166
Autor:Gasser M; Lissner R; Waaga-Gasser AM
Título:Effect of polyvalent immunoglobulins on the cytokine cascade in monocytes from colorectal cancer patients: Basis for a new adjuvant therapy
.
Fonte:Int J Clin Pharmacol Ther; 56(1):34-37, 2018 Jan.
ISSN:0946-1965
País de publicação:Germany
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Cytokines); 0 (Immunoglobulins); 1C6V77QF41 (Cholecalciferol)


  3 / 40862 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29231165
Autor:Cuny C; Vaerst B; Gabrielpillai J; Tahtali A; Balster S; Lissner R; Woodcock BG
Título:Polyvalent immunoglobulins with vitamin D3 and vitamin B12 in the treatment of Sjogren's syndrome in a vegetarian with stomatitis, glossodynia, xerostomia, and elevated antinuclear antibodies: Case report
.
Fonte:Int J Clin Pharmacol Ther; 56(1):24-27, 2018 Jan.
ISSN:0946-1965
País de publicação:Germany
Idioma:eng
Resumo:BACKGROUND: Sjogren's syndrome, involving sicca symptoms with xerostomia, stomatitis, and considerable pain is a difficult-to-treat autoimmune disease where the treatment options are limited and, as in the case of methotrexate, have a low therapeutic index. CASE REPORT: This case report concerns a male patient, aged 75 years and vegetarian, with Sjogren's syndrome subsequently confirmed by salivary gland biopsy. Serum antinuclear antibodies (ANA) were elevated (1 : 320). Low serum vitamin B12 and iron levels could be improved after 20 days using vitamin B12 and iron oral supplements. Despite symptomatic treatment, xerostomia, glossitis, and glossodynia were still present, at times marked, after 12 months when the ANA titer was unchanged. Following treatment with an anti-inflammatory polyvalent immunoglobulin formulation (Lactobin®N, 7 g daily), a bovine colostrum concentrate given orally in combination with oral vitamin D3 (2,000 IU daily), sicca symptoms and xerostomia progressively decreased and at day 750 were confined to occasional and minor glossitis of the upper lip. CONCLUSION: This case report demonstrates the satisfactory control of Sjogren's syndrome using oral polyvalent immunoglobulins with vitamin D3. In contrast to treatment options involving antimalarial drugs and methotrexate, there are no safety issues in patients tolerant to milk products.
.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Antibodies, Antinuclear); 0 (Immunoglobulins); 1C6V77QF41 (Cholecalciferol); P6YC3EG204 (Vitamin B 12)


  4 / 40862 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29296153
Autor:Tamandjou CR; Maponga TG; Chotun N; Preiser W; Andersson MI
Endereço:Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Título:Is hepatitis B birth dose vaccine needed in Africa?
Fonte:Pan Afr Med J; 27(Suppl 3):18, 2017.
ISSN:1937-8688
País de publicação:Uganda
Idioma:eng
Resumo:This commentary describes the need for a birth dose monovalent hepatitis B virus (HBV) vaccine and an effective programme for the prevention of mother-to-child-transmission (MTCT) of HBV in Africa. Current World Health Organization guidelines recommend routine maternal screening for HBV followed by treatment of highly infectious HBV-infected mothers, and HBV birth dose vaccination and the administration of hepatitis B immunoglobulin for HBV-exposed infants as an effective strategy for the prevention of HBV MTCT. None of these practices are currently in place in most parts of Africa. To date, fewer than 10 African countries vaccinate children at birth against HBV. Despite the hurdles associated with implementing this practice, its expansion to the rest of Africa is feasible and crucial to reducing the global number of new HBV infections by 90% by 2030, as targeted by the current Global Health Strategy for the elimination of viral hepatitis.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Hepatitis B Vaccines); 0 (Immunoglobulins); XII270YC6M (hepatitis B hyperimmune globulin)


  5 / 40862 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29208016
Autor:Thibodeau A; Fravalo P; Perron A; Lewandowski SL; Letellier A
Endereço:Chaire de recherche industrielle du CRSNG en salubrité des viandes, Faculté de médecine vétérinaire, Université de Montréal, 3200 rue Sicotte, Saint-Hyacinthe, QUÉBEC, Canada.
Título:Production and characterization of anti-Campylobacter jejuni IgY derived from egg yolks.
Fonte:Acta Vet Scand; 59(1):80, 2017 Dec 06.
ISSN:1751-0147
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Campylobacter jejuni is a major cause of foodborne disease having chickens as an important reservoir. Its control at the farm would lower the contamination of the final products and therefore also lower the risk of transmission to humans. At the farm, C. jejuni is rarely found in chickens before they reach 2 weeks of age. Past studies have shown that maternal antibodies could hamper C. jejuni gut colonization. The objective of this study was to compare protocols to use in order to produce anti-C. jejuni antibodies derived from egg yolks in the perspective to be used as feed additives for the control of chicken C. jejuni colonization. Laying hens were naturally contaminated with four well-characterized strains or injected with either outer membrane proteins or formalin-killed whole bacteria derived from these same strains. Eggs were collected and IgYs present in the yolks were extracted. The amount and the specificity of the recovered antibodies were characterized. RESULTS: It was observed that injection yielded eggs with superior concentrations of both total and anti-C. jejuni antibodies. Equivalent performances for antibodies recovered from all protocols were observed for the ability of the antibodies to agglutinate the live C. jejuni homologous strains, to hinder their motility or to lyse the bacteria. Western blot analyses showed that proteins from all strains could be recognized by all IgY extracts. All these characteristics were strain specific. The characterization assays were also made for heterologous strains and weaker results were observed when compared to the homologous strains. CONCLUSIONS: Based on these results, only an IgY quantitative based selection can be made in regards to which protocol would give the best anti-C. jejuni IgY enriched egg-yolks as all tested protocols were equivalent in terms of the recovered antibody ability to recognized the tested C. jejuni strains.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Bacterial Proteins); 0 (IgY); 0 (Immunoglobulins)


  6 / 40862 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29255086
Autor:Gearhart PJ; Mock BA; Casellas R; Cancro MP
Endereço:Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; gearhartp@mail.nih.gov cancro@pennmedicine.upenn.edu.
Título:The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops.
Fonte:J Immunol; 200(1):23-26, 2018 01 01.
ISSN:1550-6606
País de publicação:United States
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, N.I.H., INTRAMURAL; COMMENT
Nome de substância:0 (Antibodies); 0 (Immunoglobulins)


  7 / 40862 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29235825
Autor:Danilova VM; Vynogradova RP; Torkhova SG
Título:[Inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine].
Fonte:Ukr Biochem J; 88(5):116-35, 2016 Sep-Oct.
ISSN:2409-4943
País de publicação:Ukraine
Idioma:rus; ukr
Resumo:The article is devoted to the inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and in the context of scholarly and organizational activities of Sergii Vasyl'ovych Komisarenko. This autumn marks 50th anniversary since young Sergii Komisarenko (now ­ Academician of NAS and NAMS of Ukraine, Dr. Biol. Sci., Professor) has joined the Palladin Institute of Biochemistry, has completed all stages of the academic carrier from PhD student to Head of the Institute. He is the first in Ukraine who started the new branch of research ­ molecular immunology, created a strong scientific school, which earned worldwide acclaim and made significant contribution to finding solutions to current problems in human health sciences. S.V. Komisarenko was among those, who were first in the USSR to use immunoenzyme and flow cytofluometric assays, hybridoma technology for producing monoclonal antibodies and immunochemical assay of proteins, which became the basis for development of highly sensitive and highly specific immunodiagnostic systems, which are of high necessity in medicine, veterinary, development of immunotechnologies, environment monitoring, etc. Under his leadership the Department has made a series of important discoveries and developments including relating to antitumour immunotoxins, effects of low dose radiation on the immune system of Chernobyl liquidators, immunochemical structure of neurotoxin apamine, cytochrom c, fibrinogen and fibrin molecules at different stages of polymerization, diphtheria toxin and its receptor, tuberculosis causing micobacterium, roles of protease-activated receptors (PARs) and nicotinic acetylcholine receptors of lymphocytes, nature of polyreactive immunoglobulins (PRIGs), among other important scientific contributions. S.V. Komisarenko and his colleagues also hold numerous (more than 80) author's certificates and patents in Ukraine and USSR.
Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
Nome de substância:0 (Immunoglobulins)


  8 / 40862 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29235322
Autor:Bobrovnik SA; Demchenko MO; Komisarenko SV
Título:Kinetic parameters of polyreactive immunoglobulins interaction with antigens in the presence of protamine.
Fonte:Ukr Biochem J; 88(3):29-35, 2016 May-Jun.
ISSN:2409-4943
País de publicação:Ukraine
Idioma:eng
Resumo:The discovered earlier phenomenon of the enhancment of polyreactive immunoglobulines (PRIGs) binding to antigens in the presence of protamine and Tween 20 was investigated in more details. The comparative analysis of PRIGs reaction dynamics with immobilized antigen was provided. In addition, the rate constants for the reaction and the affinity constants of PRIGs-antigen binding in the presence or absence of optimal protamine concentration were determined. The rate constant of PRIGs-antigen reaction did not increase in the presence of protamine optimal concentration and was even reduced approximately twice. However, in the presence of protamine the concentration of reactive PRIGs molecules, that were able to interact with antigen, increased approximately 30 times, and this led to strong reaction rate increase. Protamine also influenced the affinity constant of PRIGs-antigen binding, which increased approximately three times. The suggestion was made that such protamine effect was due to its influence on the PRIGs molecules special structure, and, as a result of the conformational change PRIGs became able to bind more effectively to the antigens.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antigens); 0 (Immobilized Proteins); 0 (Immunoglobulins); 0 (Polysorbates); 0 (Protamines); 27432CM55Q (Serum Albumin, Bovine)


  9 / 40862 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29176789
Autor:Meunier M; Guyard-Nicodème M; Vigouroux E; Poezevara T; Beven V; Quesne S; Bigault L; Amelot M; Dory D; Chemaly M
Endereço:HQPAP-Unit of Hygiene and Quality of Poultry and Pork Products, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan, France.
Título:Promising new vaccine candidates against Campylobacter in broilers.
Fonte:PLoS One; 12(11):e0188472, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the incidence of human diseases. At the primary production level, several measures have been identified to reach this goal, including vaccination of poultry. Despite many studies, however, no efficient vaccine is currently available. We have recently identified new vaccine candidates using the reverse vaccinology strategy. This study assessed the in vivo immune and protective potential of six newly-identified vaccine antigens. Among the candidates tested on Ross broiler chickens, four (YP_001000437.1, YP_001000562.1, YP_999817.1, and YP_999838.1) significantly reduced cecal Campylobacter loads by between 2 and 4.2 log10 CFU/g, with the concomitant development of a specific humoral immune response. In a second trial, cecal load reductions results were not statistically confirmed despite the induction of a strong immune response. These vaccine candidates need to be further investigated since they present promising features.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Bacterial Vaccines); 0 (IgY); 0 (Immunoglobulins)


  10 / 40862 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
PMID:29184600
Autor:Ezzaitouni F; Thiyfa Y; Tahiri M; Haddad F; Hliwa W; Bellabah A; Badre W
Endereço:Service d'Hépato-Gastro-Entérologie, CHU Ibn Rochd, Casablanca, Maroc.
Título:[Common variable immune deficiency lately revealed by gastrointestinal problems: about a case].
Título:Le déficit immunitaire commun variable à révélation tardive par des manifestations digestives: à propos d'un cas..
Fonte:Pan Afr Med J; 28:48, 2017.
ISSN:1937-8688
País de publicação:Uganda
Idioma:fre
Resumo:Common Variable Immune Deficiency (CVID) is rare. It is a constitutional deficit of humoral immunity characterized by recurrent bacterial infections and by increased frequency of tumors, autoimmune or granulomatous diseases. Gastrointestinal manifestations are very variable and sometimes reveal common variable immune deficiency. We report the case of a 31-year old patient with a history of childhood recurrent respiratory infections complicated by bronchiectasis and with a 3-year history of recurrent glairy diarrhea. Etiological balance was in favor of CVID with autoimmune manifestation (vitiligo). Patient's treatment was based on monthly immunoglobulin (Ig) infusions with favorable outcome at 2-year follow-up.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Immunoglobulins)



página 1 de 4087 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde