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  1 / 1078 MEDLINE  
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PMID:28554544
Autor:Joseph J; Kent N; Bowen A; Hart J; Sheel M; Wardrop R; Abbs S; Bazely S; Rybak M
Endereço:PathWest Laboratory Medicine, QE2 Medical Centre Redevelopment, Australia. Electronic address: john.joseph@health.wa.gov.au.
Título:Immuno-nephelometric determination of group streptococcal anti-streptolysin O titres (ASOT) from dried blood spots: Method for validating a new assay.
Fonte:J Immunol Methods; 448:59-65, 2017 Sep.
ISSN:1872-7905
País de publicação:Netherlands
Idioma:eng
Resumo:This study was designed to determine the sensitivity and reproducibility of recovering anti-streptolysin O titres (ASOT) from dried blood spot (DBS) samples, a methodologic subcomponent of the penicillin pharmacokinetic studies in children receiving secondary prophylaxis with intramuscular benzathine penicillin for acute rheumatic fever.
Tipo de publicação: JOURNAL ARTICLE; VALIDATION STUDIES
Nome de substância:0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Biomarkers); 0 (Streptolysins); 0 (streptolysin O); 9006-92-2 (Antistreptolysin); RIT82F58GK (Penicillin G Benzathine)


  2 / 1078 MEDLINE  
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PMID:27848011
Autor:Trushin V; Englender M
Endereço:Department of Otolaryngology, Barzilai Medical Center, Ashkelon, Israel. vovick2005@gmail.com.
Título:Clinical value of antistreptolysin O levels in adult patients with tonsillitis: report I.
Fonte:Eur Arch Otorhinolaryngol; 274(4):2035-2039, 2017 Apr.
ISSN:1434-4726
País de publicação:Germany
Idioma:eng
Resumo:To assess the clinical value of antistreptolysin O (ASO) level in adult patients with acute tonsillitis of group A beta-hemolytic streptococcus (GABHS) etiology and its interaction with the Centor score and throat cultures data. ASO antibody titers and throat cultures were obtained from 260 adult patients with acute tonsillitis of GABHS etiology initially proven by the Centor score. The results were compared with the group of 100 adult patients with recurrent tonsillitis who underwent tonsillectomy and with the group of 100 healthy adults. Throat cultures revealed GABHS-positive results in 69 acute cases (26.5%) and in 24 recurrent cases (24%), i.e., with no significant differences between the groups (p = 0.845). There was no significant difference between cases with GABHS-positive and with GABHS-negative throat culture in ASO titers results (mean 250 and 280, respectively, p = 0.44) but these titers were significantly higher than established normative data (p < 0.01). For the group of recurrent tonsillitis cases, the mean ASO titer was 363 being significantly higher in comparison with acute cases (p = 0.015). The ASO antibody titers are significantly higher than normative ranges in cases of acute tonsillitis in adults. The detection of the elevated titers may lead to early antibiotherapy to tonsillitis. The Centor score is supported by the ASO data and less supported by throat cultures data. Further research should reveal if these titers might have predictive value for possible further recurrence or serve as an indicator for tonsillectomy in cases of recurrent tonsillitis.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:9006-92-2 (Antistreptolysin)


  3 / 1078 MEDLINE  
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PMID:28002702
Autor:Saito M; Hatakeyama S
Endereço:University of Tokyo Hospital, Tokyo, Japan.
Título:Acute Rheumatic Fever with Erythema Marginatum.
Fonte:N Engl J Med; 375(25):2480, 2016 Dec 22.
ISSN:1533-4406
País de publicação:United States
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:9006-92-2 (Antistreptolysin)


  4 / 1078 MEDLINE  
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PMID:27619043
Autor:Sahin MS; Yalcin MU; Kocyigit D
Endereço:Department of Otolaryngology, Hakkari State Hospital, Hakkari, Turkey.
Título:Prevalence of rheumatic heart disease in patients with recurrent tonsillitis and elevated anti-streptolysin O titers.
Fonte:Int J Pediatr Otorhinolaryngol; 89:133-5, 2016 Oct.
ISSN:1872-8464
País de publicação:Ireland
Idioma:eng
Resumo:INTRODUCTION: Patients with elevated anti-streptolysin O (ASO) titers (ASOT) and recurrent tonsillitis episodes are known to be at higher risk for rheumatic heart disease (RHD). However, there is no data regarding prevalence of RHD in this high risk population. In this study, we aimed to screen ambulatory patients with elevated ASOT and recurrent tonsillitis episodes using echocardiography for identification of RHD. We hypothesized that prevalence of RHD is higher in this patient group compared to general population. METHODS: 102 patients (10.33 ± 4.01 years, 50.98% female) who were diagnosed with recurrent tonsillitis and had elevated ASOT were included this study. Echocardiographic evaluation was performed by an experienced cardiologist. RESULTS: Echocardiographic examination revealed definite RHD in 2/102 (1.96%) patients and borderline RHD in 3/102 (2.94%) patients. CONCLUSION: Our study demonstrates a high prevalence of RHD in patients with recurrent tonsillitis episodes and high ASOT. Screening with echocardiography is beneficial to improve the detection rates of subclinical RHD in such high-risk populations.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:9006-92-2 (Antistreptolysin)


  5 / 1078 MEDLINE  
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Texto completo SciELO Brasil
PMID:27553592
Autor:Oner T; Ozdemir R; Genc DB; Kucuk M; Karadeniz C; Demirpence S; Yilmazer MM; Mese T; Tavli V; Genel F
Endereço:Izmir Dr. Behcet Uz Children's Hospital, Pediatric Cardiology, Izmir, Turkey.
Título:Parameters indicative of persistence of valvular pathology at initial diagnosis in acute rheumatic carditis: the role of albumin and CD19 expression.
Fonte:J Pediatr (Rio J); 92(6):581-587, 2016 Nov - Dec.
ISSN:1678-4782
País de publicação:Brazil
Idioma:eng
Resumo:OBJECTIVE: The aim of this study is to define the predictors of chronic carditis in patients with acute rheumatic carditis (ARC). METHODS: Patients diagnosed with ARC between May 2010 and May 2011 were included in the study. Echocardiography, electrocardiography, lymphocyte subset analysis, acute phase reactants, plasma albumin levels, and antistreptolysin-O (ASO) tests were performed at initial presentation. The echocardiographic assessments were repeated at the sixth month of follow-up. The patients were divided into two groups according to persistence of valvular pathology at 6th month as Group 1 and Group 2, and all clinical and laboratory parameters at admission were compared between two groups of valvular involvement. RESULTS: During the one-year study period, 22 patients had valvular disease. Seventeen (77.2%) patients showed regression in valvular pathology. An initial mild regurgitation disappeared in eight patients (36.3%). Among seven (31.8%) patients with moderate regurgitation initially, the regurgitation disappeared in three, and four patients improved to mild regurgitation. Two patients with a severe regurgitation initially improved to moderate regurgitation (9.1%). In five (22.8%) patients, the grade of regurgitation [moderate regurgitation in one (4.6%), and severe regurgitation in 4 (18.2%)] remained unchanged. The albumin level was significantly lower at diagnosis in Group 2 (2.6±0.48g/dL). Lymphocyte subset analysis showed a significant decrease in the CD8 percentage and a significant increase in CD19 percentage at diagnosis in Group 2 compared to Group 1. CONCLUSION: The blood albumin level and the percentage of CD8 and CD19 (+) lymphocytes at diagnosis may help to predict chronic valvular disease risk in patients with acute rheumatic carditis.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Antigens, CD19); 0 (Serum Albumin); 9006-92-2 (Antistreptolysin)


  6 / 1078 MEDLINE  
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Texto completo SciELO Chile
PMID:26928506
Autor:Gutiérrez C; Chacón M; Pérez-Ybarra L; Rivero H; Straga S; Luis-León J
Título:[Reference values of antistreptolysin O and asymptomatic carriers of ß-hemolytic streptococci in adolescents and adults at Municipality Francisco Linares Alcántara, Venezuela].
Título:Valores referenciales de antiestreptolisina O y portadores asintomáticos de estreptococos ß-hemolíticos en adolescentes y adultos del Municipio Francisco Linares Alcántara, Venezuela..
Fonte:Rev Chilena Infectol; 32(6):689-94, 2015 Dec.
ISSN:0717-6341
País de publicação:Chile
Idioma:spa
Resumo:INTRODUCTION: ß-hemolytic streptococci (Streptococcus pyogenes) groups A, C or G, secretes streptolysin O, toxin which causes in the infected individual an adaptive humoral immune response with production of serum antibodies called anti-streptolysin O (ASO). OBJECTIVES: To determine the reference value of ASO in a sample of 159 individuals aged 16-72 years from municipality Francisco Linares Alcántara, Aragua state, applying indirect (passive) agglutination test. By using a throat swab sample which was sown in blood agar 5% the frequency of asymptomatic carriers of ß-hemolytic streptococci was also determined. RESULTS AND DISCUSSION: As reference value for determining ASO by agglutination method a title of up to 200 IU/mL was obtained, this reference value differs from that recommended by the commercial equipment. Asymptomatic carriers frequency was 21.2% (n = 34). The distribution of ß-hemolytic streptococci isolated were: group A (17.6%), group B (32.3%), group C (20.5%), group D (2.9%), group F (8.8%), group G (14.7%) and unclusterable (2.9%). CONCLUSIONS: The new ASO reference value for teens and adults of the mentioned municipality is up to 200 IU/mL. ß-hemolytic Streptococcus group B was the most frequently isolated.
Tipo de publicação: ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Biomarkers); 9006-92-2 (Antistreptolysin)


  7 / 1078 MEDLINE  
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PMID:26549396
Autor:Oba Y; Watanabe H; Nishimura Y; Ueno S; Nagashima T; Imai Y; Shimpo M; Kario K
Endereço:Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University.
Título:A Case of Adult-Onset Acute Rheumatic Fever With Long-Lasting Atrioventricular Block Requiring Permanent Pacemaker Implantation.
Fonte:Int Heart J; 56(6):664-7, 2015.
ISSN:1349-3299
País de publicação:Japan
Idioma:eng
Resumo:A 45-year-old hypertensive Japanese woman presented with epigastric pain on inspiration, fever, complete atrioventricular block and polyarthritis. Her antistreptolysin O levels were markedly elevated. A diagnosis of rheumatic fever was made according to the modified Jones criteria. She was prescribed loxoprofen sodium, which was partially effective for her extracardiac clinical symptoms. However, she had syncope due to complete atrioventricular block with asystole longer than 10 seconds. Consequently, we implanted a permanent pacemaker. Although we prescribed prednisolone, the efficacy of which was limited for the patient's conduction disturbance, the complete atrioventricular block persisted. In our systematic review of 12 similar cases, the duration of complete heart block was always transient and there was no case requiring a permanent pacemaker. We thus encountered a very rare case of adult-onset acute rheumatic fever with persistent complete atrioventricular block necessitating permanent pacemaker implantation.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Anti-Inflammatory Agents); 0 (Phenylpropionates); 3583H0GZAP (loxoprofen); 9006-92-2 (Antistreptolysin); 9PHQ9Y1OLM (Prednisolone)


  8 / 1078 MEDLINE  
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PMID:26481515
Autor:Nambudiri VE; Nambudiri NS; Nazarian RM; Tsao SS
Endereço:Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA Department of Dermatology, Massachusetts General Hospital, Boston vinod.nambudiri@gmail.com.
Título:A rash starting on the palms and soles.
Fonte:BMJ; 351:h5452, 2015 Oct 19.
ISSN:1756-1833
País de publicação:England
Idioma:eng
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE
Nome de substância:0 (Dermatologic Agents); 143NQ3779B (calcipotriene); 9006-92-2 (Antistreptolysin); F446C597KA (Triamcinolone Acetonide); FXC9231JVH (Calcitriol)


  9 / 1078 MEDLINE  
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PMID:26270790
Autor:Steer AC; Smeesters PR; Curtis N
Endereço:From the *Department of Paediatrics, The University of Melbourne; †Infection and Immunity Theme, Murdoch Children's Research Institute; ‡Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, Australia; and §Department of Paediatrics, Université Libre de Bruxelles, Brussels, Belgium.
Título:Streptococcal Serology: Secrets for the Specialist.
Fonte:Pediatr Infect Dis J; 34(11):1250-2, 2015 Nov.
ISSN:1532-0987
País de publicação:United States
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Antibodies, Bacterial); 0 (Bacterial Proteins); 9006-92-2 (Antistreptolysin); EC 3.1.- (Deoxyribonucleases); EC 3.1.4.- (deoxyribonuclease B)


  10 / 1078 MEDLINE  
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PMID:26091201
Autor:Pozzi M; Pisano S; Bertella S; Lombardi P; Pellegrino P; Molteni M; Clementi E; Bravaccio C; Radice S
Endereço:1 Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Eugenio Medea , Lecco, Italy .
Título:On the Possible Relationship Between Anti-Streptolysin-O Titer and Neuropsychiatric Disorders Other than PANS.
Fonte:J Child Adolesc Psychopharmacol; 25(5):452-3, 2015 Jun.
ISSN:1557-8992
País de publicação:United States
Idioma:eng
Tipo de publicação: LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
Nome de substância:0 (Bacterial Proteins); 0 (Streptolysins); 0 (streptolysin O); 9006-92-2 (Antistreptolysin)



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