Base de dados : MEDLINE
Pesquisa : D13.444.308.227 [Categoria DeCS]
Referências encontradas : 1 [refinar]
Mostrando: 1 .. 1   no formato [Longo]

página 1 de 1

  1 / 1 MEDLINE  
para imprimir
Texto completo
Autor:Mazur AK
Endereço:CNRS UPR9080, Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, Paris, France.
Título:The electrostatic origin of low-hydration polymorphism in DNA.
Fonte:Chemphyschem; 9(18):2691-4, 2008 Dec 22.
País de publicação:Germany
Resumo:In recent years, significant progress has been made towards uncovering the physical mechanisms of low-hydration polymorphism in double-helical DNA. The effect appears to be mechanistically similar in different biological systems, and it is due to the ability of water to form spanning H-bonded networks around biomacromolecules via a quasi-two-dimensional percolation transition. In the case of DNA, disintegration of the spanning H-bonded network leads to electrostatic condensation of DNA strands because, below the percolation threshold, water loses its high dielectric permittivity, whereas the concentration of neutralizing counterions becomes high. In this Concept article arguments propose that this simple electrostatic mechanism represents the universal origin of low-hydration polymorphism in DNA.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (DNA, A-Form); 0 (DNA, C-Form); 0 (Ions); 059QF0KO0R (Water); 9007-49-2 (DNA)

página 1 de 1

Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  

Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde