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PMID:19006154
Autor:Mazur AK
Endereço:CNRS UPR9080, Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, Paris, France. alexey@ibpc.fr
Título:The electrostatic origin of low-hydration polymorphism in DNA.
Fonte:Chemphyschem; 9(18):2691-4, 2008 Dec 22.
ISSN:1439-7641
País de publicação:Germany
Idioma:eng
Resumo:In recent years, significant progress has been made towards uncovering the physical mechanisms of low-hydration polymorphism in double-helical DNA. The effect appears to be mechanistically similar in different biological systems, and it is due to the ability of water to form spanning H-bonded networks around biomacromolecules via a quasi-two-dimensional percolation transition. In the case of DNA, disintegration of the spanning H-bonded network leads to electrostatic condensation of DNA strands because, below the percolation threshold, water loses its high dielectric permittivity, whereas the concentration of neutralizing counterions becomes high. In this Concept article arguments propose that this simple electrostatic mechanism represents the universal origin of low-hydration polymorphism in DNA.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (DNA, A-Form); 0 (DNA, C-Form); 0 (Ions); 059QF0KO0R (Water); 9007-49-2 (DNA)



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