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Pesquisa : E01.370.388.100.100.750 [Categoria DeCS]
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  1 / 954 MEDLINE  
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PMID:28748505
Autor:Ahn SH; Park SY; Choi SI
Endereço:Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University College of Medicine, Bundang Hospital, 300 Goomi-dong, Bundang-gu, Gyeonggi-do, 463-707, South Korea. ahnsh30@snu.ac.kr.
Título:Comparison of Consecutive Results from Fine Needle Aspiration and Core Needle Biopsy in Thyroid Nodules.
Fonte:Endocr Pathol; 28(4):332-338, 2017 Dec.
ISSN:1559-0097
País de publicação:United States
Idioma:eng
Resumo:There are papers suggesting the complementary role of core needle biopsy (CNB) in the diagnosis of thyroid nodules. By comparing the result of CNB and fine needle aspiration (FNA) cytology performed in consecutive cases of thyroid nodules, the role of CNB was evaluated. Retrospective reviews of 2131 FNA and 275 CNB which were performed as first-line biopsy for 2406 thyroid nodules in 2187 patients were performed. The ultrasound (US) feature of thyroid nodule was classified following the risk of malignancy suggested by American Thyroid Association (ATA) guideline. Rate of unsatisfactory and cellular atypia could be decreased significantly by first-line CNB in all US group, and the nodules with highly suspicious feature showed significant decrease in inconclusive result by first-line CNB. However, increased rates of architectural and follicular neoplasm (FN) were identified in CNB group especially in intermediate and low suspicious nodules, and the first-line CNB could not decrease the inconclusive result in these US groups. The diagnostic rate of neoplasm diagnosed by surgery following the result of architectural atypia or FN was not different between FNA and CNB even with significantly higher rate in CNB group. Furthermore, the sensitivity for follicular neoplasm (21.2 vs. 61.9%) was significantly higher in CNB group. The CNB can be considered in nodules with highly suspicious feature with advantage of significantly lower inconclusive diagnostic rate than FNA group. However, significantly increased diagnosis of architectural atypia or FN in other nodules by CNB is recognized and should be evaluated in future to understand the meaning.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE


  2 / 954 MEDLINE  
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PMID:29325246
Autor:Huang RF; Zhang WY; Liu WP; Zhao S; Ye YX; Sun H; Gao LM; Wang JC; Yang QP
Endereço:Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Título:[Diagnostic significance of lymph node core needle biopsy for lymphoproliferative disease: a clinicopathologic study of 1 013 cases].
Fonte:Zhonghua Bing Li Xue Za Zhi; 47(1):19-24, 2018 Jan 08.
ISSN:0529-5807
País de publicação:China
Idioma:chi
Resumo:To study the clinicopathologic features of lymphoproliferative disease by lymph node core needle biopsy(CNB)and to evaluate the diagnostic significance of CNB for lymphoproliferative disease. The annual distribution, entity constitute, clinical finding, gross feature, morphologic change, affiliate study and repeat biopsy diagnosis of 1 013 cases of lymph node CNB diagnosed at West China Hospital of Sichuan University from January 2009 to December 2015 were investigated. (1) Proportion of lymph node CNB in total amount of biopsy specimens increased from 0.2% in 2009 to 0.8% in 2015.(2) The study cohort included 471 lymphomas, 12 atypical lymphoid hyperplasia (ALH), 136 suspected lymphomas, 372 benign lesions, and 22 cases of descriptive diagnoses. The most common types were diffuse large B cell lymphoma and T-lymphoblastic lymphoma. (3) Majority of patients were adolescents and children younger than 20 years or the elderly older than 60 years. 53.1% CNB tumor specimen consisted of ≥4 tissue cores and 40.5% were >2 cm in length. (4) 104 CNB cases with previous history of excision biopsy was included 45 carcinomas(no metastatic carcinoma was found), 32 lymphomas for treatment observation.1/14 suspicious lymphomas, 1/1 ALH and 3/22 cases benign lesions were diagnosed as lymphoma by repeat biopsy respectively. (5) 217 CNB cases were diagnosed as lymphoma by subsequent CNB (70), or subsequent excision biopsy (147) including 78.5%(73/93) suspected lymphomas, 5/7 ALH and 32.3%(20/62)benign lesions. Lymph node CNB has certain clinical indications, although limited for the diagnosis of lymphoproliferative disorders. Suspected lymphomas and ALH diagnosed by CNB should be followed by repeat tissue biopsy. For the benign lesions by CNB it does not rule out additional biopsy to further investigate the lesion.
Tipo de publicação: JOURNAL ARTICLE


  3 / 954 MEDLINE  
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PMID:29281680
Autor:Sabir SH; Krishnamurthy S; Gupta S; Mills GB; Wei W; Cortes AC; Mills Shaw KR; Luthra R; Wallace MJ
Endereço:Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Título:Characteristics of percutaneous core biopsies adequate for next generation genomic sequencing.
Fonte:PLoS One; 12(12):e0189651, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:PURPOSE: Determine the characteristics of percutaneous core biopsies that are adequate for a next generation sequencing (NGS) genomic panel. MATERIALS AND METHODS: All patients undergoing percutaneous core biopsies in interventional radiology (IR) with samples evaluated for a 46-gene NGS panel during 1-year were included in this retrospective study. Patient and procedure variables were collected. An imaging-based likelihood of adequacy score incorporating targeting and sampling factors was assigned to each biopsied lesion. Univariate and multivariate logistic regression was performed. RESULTS: 153 patients were included (58.2% female, average age 59.5 years). The most common malignancy was lung cancer (40.5%), most common biopsied site was lung (36%), and average size of biopsied lesions was 3.8 cm (+/- 2.7). Adequacy for NGS was 69.9%. Univariate analysis showed higher likelihood of adequacy score (p = 0.004), primary malignancy type (p = 0.03), and absence of prior systemic therapy (p = 0.018) were associated with adequacy for NGS. Multivariate analysis showed higher adequacy for lesions with likelihood of adequacy scored 3 (high) versus lesions scored 1 (low) (OR, 7.82; p = 0.002). Melanoma lesions had higher adequacy for NGS versus breast cancer lesions (OR 9.5; p = 0.01). Absence of prior systemic therapy (OR, 6.1; p = 0.02) and systemic therapy 3 months before biopsy yielded greater adequacy for NGS. Lesions <3 cm had greater adequacy for NGS than larger lesions (OR 2.72, p = 0.02). CONCLUSION: As targeted therapy becomes standard for more cancers, percutaneous biopsy specimens adequate for NGS genomic testing will be needed. An imaging-based likelihood of adequacy score assigned by IR physicians and other pre-procedure variables can help predict the likelihood of biopsy adequacy for NGS.
Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T


  4 / 954 MEDLINE  
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PMID:28982848
Autor:Gigli S; Amabile MI; DI Pastena F; DE Luca A; Gulia C; Manganaro L; Monti M; Ballesio L
Endereço:Department of Radiology, Anatomo-pathology and Oncology, Sapienza University of Rome, Rome, Italy.
Título:Lipofilling Outcomes Mimicking Breast Cancer Recurrence: Case Report and Update of the Literature.
Fonte:Anticancer Res; 37(10):5395-5398, 2017 10.
ISSN:1791-7530
País de publicação:Greece
Idioma:eng
Resumo:Breast lipofilling uses autologous fat grafting to correct breast defects after radical or conservative surgery. After early concerns regarding its application in reconstruction after breast cancer (BC), in 2009 the American Society of Plastic Surgeons formed a task force to assess the indications, safety and efficacy of autologous fat grafting. We report the case of a woman who came to our attention for a painful swelling of the left breast. She had undergone breast-conserving therapy for BC, followed by lipofilling. The breast ultrasound (US) examination showed diffuse structural alteration and multiple hypoechoic areas with acoustic shadowing, mainly localized in the subcutaneous tissue. After pharmacological treatment and short-term follow-up US examination, considering the persistence of the clinical symptoms and structural alterations, we performed contrast-enhanced magnetic resonance imaging, that showed multiple enhancing areas in the left breast. Suspecting local tumor recurrence, we carried out US-guided breast core-biopsy, whose histological examination documented liponecrosis. This observation raised a series of diagnostic and therapeutic issues highlighting the diagnostic pitfalls that the radiologist may encounter during the evaluation of patients who have undergone BC surgery and breast reconstruction through lipofilling.
Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW


  5 / 954 MEDLINE  
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PMID:28837268
Autor:Sennerstam RB; Franzén BSH; Wiksell HOT; Auer GU
Endereço:Department of Pathology and Oncology, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden.
Título:Core-needle biopsy of breast cancer is associated with a higher rate of distant metastases 5 to 15 years after diagnosis than FNA biopsy.
Fonte:Cancer; 125(10):748-756, 2017 Oct.
ISSN:1097-0142
País de publicação:United States
Idioma:eng
Resumo:BACKGROUND: The literature offers discordant results regarding whether diagnostic biopsy is associated with the dissemination of cancer cells, resulting in local and/or distant metastasis. The long-term outcomes of patients with breast cancer were compared between those who were diagnosed using either fine-needle aspiration biopsy (FNAB) or core-needle biopsy (CNB) during 2 decades: the 1970s and 1990s. METHODS: In the 1970s, the only diagnostic needle biopsy method used for breast cancer in Sweden was FNAB. CNB was introduced 1989 and became established in Stockholm Gotland County in the early 1990s. The authors compared the clinical outcomes of patients diagnosed using FNAB from 1971 to 1976 (n = 354) versus those of patients diagnosed using CNB from 1991 to 1995 (n = 1729). Adjusting for differences in various treatment modalities, mammography screening, tumor size, DNA ploidy, and patient age between the 2 decades, 2 strictly matched samples representing FNAB (n = 181) and CNB (n = 203) were selected for a 15-year follow-up study. RESULTS: In a comparison of the rates of distant metastasis in the strictly matched patient groups from the FNAB and CNB cohorts, significantly higher rates of late-appearing (5-15 years after diagnosis) distant metastasis were observed among the patients who were diagnosed on CNB compared with those who were diagnosed on FNAB. No significant difference in local metastasis was observed between the 2 groups. CONCLUSIONS: At 5 to 15 years after diagnosis of the primary tumor, CNB-diagnosed patients had significantly higher rates of distant metastases than FNAB-diagnosed patients. Cancer Cytopathol 2017;125:748-56. © 2017 American Cancer Society.
Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE


  6 / 954 MEDLINE  
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PMID:28821190
Autor:Kuba MG; Lester SC; Giess CS; Bertagnolli MM; Wieczorek TJ; Brock JE
Endereço:Department of Pathology.
Título:Fibromatosis of the Breast: Diagnostic Accuracy of Core Needle Biopsy.
Fonte:Am J Clin Pathol; 148(3):243-250, 2017 Sep 01.
ISSN:1943-7722
País de publicação:England
Idioma:eng
Resumo:Objectives: Fibromatosis of the breast is an uncommon neoplasm with potential for local recurrence. Treatment has traditionally been surgical excision with current trends toward conservative management. Given the option of observation after diagnosis by core needle biopsy (CNB), we sought to evaluate the accuracy of CNB for diagnosing fibromatosis. Methods: We identified a total of 31 cases in which fibromatosis had been diagnosed or included in the differential diagnosis on a CNB, an excision, or both. Morphology and immunohistochemical results were reviewed. Results: Aberrant nuclear immunoreactivity for ß-catenin and absent staining for CD34 were the most useful studies to diagnose fibromatosis, and one or both were performed in 21 (68%) cases. High molecular weight cytokeratins and p63 were helpful to exclude spindle cell carcinoma. Of 26 cases confirmed as fibromatosis on excision, 22 (85%) were diagnosed as fibromatosis or fibromatosis was favored in the differential diagnosis on CNB. More frequent use of immunohistochemistry would likely have resulted in a greater number of definitive diagnoses. Fibromatosis was rarely mistaken for other nonmalignant stromal lesions, with no cases misdiagnosed as carcinoma. Conclusions: CNB can be an accurate method of diagnosing fibromatosis, allowing observation for a select group of patients.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:68238-35-7 (Keratins)


  7 / 954 MEDLINE  
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PMID:28807211
Autor:Shea B; Boyan WP; Kamrani K; Lepis G; Dupree D; Chang S; Goldfarb M; Kohli M
Endereço:Department of Surgery, Monmouth Medical Center, Long Branch, New Jersey.
Título:Let us cut to the core: is core biopsy enough for subcentimeter breast cancer?
Fonte:J Surg Res; 216:30-34, 2017 Aug.
ISSN:1095-8673
País de publicação:United States
Idioma:eng
Resumo:BACKGROUND: Breast conservation therapy has become a preferred method of treating early-stage breast cancer. As care continues to evolve, certain lesions allowed less invasive treatment options. A simplified explanation of early breast cancer care is detection, biopsy, surgery, and adjuvant therapy. The authors look to challenge that algorithm for a specific type of disease. METHODS: A retrospective review was performed to identify all subcentimeter breast cancer that underwent surgery after core biopsy. These cases (n = 115) were analyzed for biopsy technique and outcome of final surgical excision to find when no residual disease was found on final pathology, potentially rendering the surgical resection an unneeded procedure. RESULTS: The authors found that 17 of 115 patients (14.8%) who underwent biopsy for subcentimeter breast cancer had no residual disease found on final surgical resection. Although the subsets were small, the largest core needle resulted in negative pathology two of three times, while the smallest gauge, never resulted in negative resection at time of surgery. CONCLUSIONS: Nearly, fifteen percent of patients were found to have no residual disease on final surgical pathology. These results were obtained when the radiologist was simply trying to get tissue diagnosis. The authors postulate that this percentage could be even higher if protocols were initiated to biopsy these small lesions with larger core biopsies and possibly alleviate the need for formal surgery in these specific, small lesion.
Tipo de publicação: JOURNAL ARTICLE


  8 / 954 MEDLINE  
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PMID:28782985
Autor:Jabbar SB; Lynch B; Seiler S; Hwang H; Sahoo S
Endereço:From the Departments of Pathology and Laboratory Medicine (Drs Jabbar, Lynch, Hwang, and Sahoo), and Radiology (Dr Seiler), University of Texas Southwestern Medical Center, Dallas. Dr Jabbar and Dr Lynch contributed equally to the study.
Título:Pathologic Findings of Breast Lesions Detected on Magnetic Resonance Imaging.
Fonte:Arch Pathol Lab Med; 141(11):1513-1522, 2017 Nov.
ISSN:1543-2165
País de publicação:United States
Idioma:eng
Resumo:CONTEXT: - Breast magnetic resonance imaging (MRI) is now used routinely for high-risk screening and in the evaluation of the extent of disease in newly diagnosed breast cancer patients. Morphologic characteristics and the kinetic pattern largely determine how suspicious a breast lesion is on MRI. Because of its high sensitivity, MRI identifies a large number of suspicious lesions. However, the low to moderate specificity and the additional cost have raised questions regarding its frequent use. OBJECTIVES: - To identify the pathologic entities that frequently present as suspicious enhancing lesions and to identify specific MRI characteristics that may be predictive of malignancy. DESIGN: - One hundred seventy-seven MRI-guided biopsies from 152 patients were included in the study. The indication for MRI, MRI features, pathologic findings, and patient demographics were recorded. The MRI findings and the pathology slides were reviewed by a dedicated breast radiologist and breast pathologists. RESULTS: - Seventy-one percent (126 of 177) of MRI-guided breast biopsies were benign, 11% (20 of 177) showed epithelial atypia, and 18% (31 of 177) showed malignancy. The vast majority (84%; 62 of 74) of MRI lesions with persistent kinetics were benign. However, 57% (17 of 30) of lesions with washout kinetics and 65% (62 of 95) of mass lesions were also benign. CONCLUSIONS: - Magnetic resonance imaging detects malignancies undetected by other imaging modalities but also detects a wide variety of benign lesions. Benign and malignant lesions identified by MRI share similar morphologic and kinetic features, necessitating biopsy for histologic confirmation.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Contrast Media)


  9 / 954 MEDLINE  
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PMID:28754227
Autor:Van Houdt WJ; Schrijver AM; Cohen-Hallaleh RB; Memos N; Fotiadis N; Smith MJ; Hayes AJ; Van Coevorden F; Strauss DC
Endereço:Sarcoma Unit, Department of Surgery, The Royal Marsden Hospital, London, UK; Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: w.v.houdt@nki.nl.
Título:Needle tract seeding following core biopsies in retroperitoneal sarcoma.
Fonte:Eur J Surg Oncol; 43(9):1740-1745, 2017 Sep.
ISSN:1532-2157
País de publicação:England
Idioma:eng
Resumo:BACKGROUND: Retroperitoneal tumours often require a preoperative core needle biopsy to establish a histological diagnosis. Literature is scarce regarding the risk of biopsies in retroperitoneal sarcomas, so the aim of this study is to identify the potential risks of core needle biopsies causing needle tract recurrences or local recurrences. METHOD: Patients who underwent resection of a primary retroperitoneal sarcoma between 1990 and 2014 were identified from a prospectively maintained database from two tertiary referral centres. Patient demographics, tumour characteristics and biopsy techniques were examined. The primary endpoint was needle tract recurrence and local intra-abdominal recurrence. RESULTS: 498 patients were included in the analysis. The most common histological subtypes were liposarcoma (66%) and leiomyosarcoma (18%). Of the 498 patients that underwent resection, 255 patients were diagnosed with a preoperative biopsy. Five patients (2%) developed a biopsy site recurrence: 3 patients with leiomyosarcomas and 2 patients with dedifferentiated liposarcomas. All biopsy site recurrences occurred after trans-abdominal biopsies and were not performed with a co-axial technique. There was no significant difference in local recurrence rate between the patients with or without a biopsy (=0.30) or for the biopsy route (trans-abdominal or trans-retroperitoneal (p = 0.72)). CONCLUSION: The risk of a needle tract metastasis after core needle biopsy for retroperitoneal sarcoma is very low but not zero. The safest method seems a trans-retroperitoneal approach with a co-axial technique. Local recurrence rate is not altered after doing a core needle biopsy.
Tipo de publicação: JOURNAL ARTICLE


  10 / 954 MEDLINE  
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PMID:28739753
Autor:Wang Y; Li D; Liu R; Jia C; Jiang A; Lv Y; Xu S; Zhang H; Cao X; Song X
Endereço:Department of Imaging of Head and Neck, Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
Título:Application of Ultrasound-guided Core Needle Biopsy in the Diagnosis of T3 or T4 Stage Laryngeal and Hypopharyngeal Cancer.
Fonte:Anticancer Res; 37(8):4563-4567, 2017 08.
ISSN:1791-7530
País de publicação:Greece
Idioma:eng
Resumo:AIM: To study the value of ultrasound-guided core needle biopsy (CNB) in the diagnosis of T3 or T4 stage laryngeal and hypopharyngeal cancer, which is difficult by routine methods. PATIENTS AND METHODS: Nineteen cases of T3 or T4 stage laryngeal or hypopharyngeal carcinoma with abnormal pharyngeal sensitivity, severe dyspnea, submucous cancer recurrence, cardiovascular and pulmonary dysfunction were reviewed retrospectively from October 2012 to October 2014 in the Yuhuangding Hospital of Qingdao University. Ultrasound-guided coarse needle biopsies were used on primary lesions after assessing the patients with neck-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) scan(s). The clinical value of ultrasound-guided CNB in the diagnosis of laryngeal and hypopharyngeal cancer was analyzed. RESULTS: All patients underwent successful pathological diagnosis by ultrasound-guided CNB without any serious complications. Dyspnea, cardiovascular and pulmonary dysfunction did not deteriorate. CONCLUSION: Ultrasound-guided CNB is a highly safe and efficient method for the pathological diagnosis of T3 or T4 stage laryngeal and hypopharyngeal cancer. It should be used especially when the fiberoptic or laryngoscope biopsy are of high risk.
Tipo de publicação: JOURNAL ARTICLE



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