||Pierce, C(aut); Ogunbiyi, I. A(aut).|
||A comparison of three methods of treatment of pterygia in West Indian population.|
||Caribbean medical journal;68(1):17-23, June 2006. tab.
||INTRODUCTION: Primary pterygium disorder is one of the most common ophthalmic complaints in the West Indies with 20 to 25 per cent prevalence in people of African descent. The pterygium is a degenerative corneal limbal process resulting from fibrovascular overgrowth from the conjunctiva onto the cornea. Initial disruption of the limbal corneal-conjunctival epithelial barrier, is followed by progressive "conjunctivalization" of the cornea. There is associated inflammation, angiogenesis, cellular proliferation and tissue remodeling. It is believed that focal irradiation of basal epithelial stem cells leads to the breakdown of the limbal barrier. Significant evidence links UV light and pterygium pathogenesis and possible disruption of tumour suppressor genes. Growth factors (FGF, PDGF, TGF-beta and TNF-alpha) are believed to be influential in cellular proliferation, angiogenesis and inflammation seen in pterygia. Recurrences after pterygium excision frequently occur within 1-2 months of surgery. Accelerated fibroblast proliferation, similar to keloid formation, is the main cause of recurrence...|
||TT5 - Médical Sciences Library|
||TT5; W1, CA788|