Base de dados : MedCarib
Pesquisa : D09.400.430.937 [Categoria DeCS]
Referências encontradas : 14 [refinar]
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  1 / 14 MedCarib  
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Fotocópia
Id: 11725
Autor: Moutet, J. P; Pileire, Jacques; Bangou, Jacques; Ragoucy, C; Kangambega Nouvier, P; Donnet, J. P.
Título: The assays of glycosylated proteins in haemoglobinopathies and their use in screening for diabetes mellitus
Fonte: West Indian med. j;37(1):36-40, Mar. 1988.
Idioma: En.
Resumo: We compare the relative validity of HbA1c and fructosamine as indices of long-term blood glucose levels in populations with a common occurence of haemoglobinopathies. In these patients, HbA1c levels are lower than HbA1c levels in non-haemoglobinopathy patients and do not reflect the gludicic status of the patient, unlike the fructosamine assay. This last test has a good potential to be used a a mass screening for diabetes mellitus in these populations (Africa, Caribbean, USA) in either homozygous or heterozygous haemoglobinopathy patients. Moreover, fructosamine presents numerous technical advantages which facilitates the screening (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  2 / 14 MedCarib  
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Fotocópia
Id: 11708
Autor: Morrison, Errol Y. St. A; Bennett, Franklyn I.
Título: Assessment of patient compliance in a diabetic clinic using glycated proteins compared with blood sugar measurements
Fonte: West Indian med. j;37(3):158-61, Sept. 1988.
Idioma: En.
Resumo: Thirty non-insulin-dependent (NID) and 10 insulin-requiring (IR) patients were randomly selected in the Diabetic Outpatients Clinic at the University Hospital of the West Indies. There were 29 (72.5 percent) female and 11 (27.5 percent) male patients with a medium age of 53.1 years (range 11-79) and a mean body mass index of 25.5 (range 17.7-35.3). Mean duration of diabetes 10+ years (range 2-25 years) They had all been attending the diabetic clinic for a minimum of two years. The patients were followed up at 30-day intervals for 90 days and at each visit, detailed checks were done of their blood count, chemistry and metabolic profile; in particular, the fasting blood sugar, fructosamine in the IR group, glycosylated haemoglobin and fasting insulin levels in the NID group were determined. Despite the close monitoring of this select group, their control as assessed by fasting blood sugar and glycated protein levels revealed uniformly insatisfactory results. These findings have an important implication on recent Pan American World Health data which reveal that diabetes mellitus is now the leading cause of death in the Caribbean (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  3 / 14 MedCarib  
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Fotocópia
Id: 11323
Autor: Choo Kang, Eric; Campbell, Marie A; Anderson, John C.
Título: The measurement of glycosylated haemoglobins by the cation exchange chromatographic method in subjects with abnormal haemoglobins
Fonte: West Indian med. j;30(4):188-92, Dec. 1981.
Idioma: En.
Resumo: Glycosylated haemoglobins were estimated in subjects with normal and abnormal haemoglobins by a cation exchange chromatographic method. Lower values were obtained in the subjects with abnormal haemoglobins. Diabetic subjects tend to have higher values. In interpreting the values in subjects with abnormal haemoglobins either different reference ranges must be used or a correction factor can be employed (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  4 / 14 MedCarib  
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Fotocópia
Id: 10473
Autor: Bennett, Franklyn I.
Título: A fresh look at the role of laboratory investigations in the diagnosis and monitoring of diabetes mellitus
Fonte: Assoc Gen Pract Jamaica Newsl;6(1):14-5, June 1986.
Idioma: En.
Responsável: JM3.1 - Médical Library
JM3.1; R18.N4


  5 / 14 MedCarib  
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Fotocópia
Id: 10022
Autor: Ozsoylu, Sinasi.
Título: Clinical diversity of sickle-cell anaemia - letter; comment
Fonte: Lancet;335(8696):1035, Apr. 28, 1990.
Idioma: En.
Responsável: JM3.1 - Médical Library
JM3.1; R31.L3


  6 / 14 MedCarib  
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Fotocópia
Id: 6001
Autor: Alexis, Sunny D; Beckles, Gloria L. A; Byam, Neville T. A; Mahabir, S.
Título: Estimation of glycosylated haemoglobin by a procedure appropriate for general laboratory conditions in the Caribbean: the St. James Cardivasculary Survey - abstract
Fonte: West Indian med. j;36(Suppl):29, 1987.
Idioma: En.
Conferência: Apresentado em: 32nd Scientific Meeting of Commonwealth Caribbean Medical Research Council, Tortola, April 22-25, 1987.
Resumo: Glycosylation of haemoglobin was measured in 759 women who comprised a subsample of those that took part in the St. James Cardiovascular Survey. A colorimetric assay was utilized. The glucose moiety of glycosylated haemoglobin was converted to 5-hydroxymethylfurfural was then measured by reaction with 2-thiobarbituric acid. Glycosylation of haemoglobin was expressed as µmol/l of fructose. A mean concentration of 52.2 µmol/l (sd 8.4) was obtained for non-diabetic women while in diabetic women the mean concentration was 68 µmol/l (sd 14.8). There was a significant correlation between fasting blood glucose level and glycosylated haemoglobin (r = 0.74, p =.05). This procedure gave an inter-assay co-efficient of variation of 3.6 percent and an intra-assay co-efficient of variation of 2.4 percent. As a screening device for diabetes, the method has a sensitivity of 70 percent and a specificity of 96 percent (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  7 / 14 MedCarib  
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Fotocópia
Id: 5523
Autor: Rizza, R.
Título: Aetiology, treatment and prevention of diabetic nephropathy: an overview - abstract
Fonte: West Indian med. j;42(suppl.2):2, July 1993.
Idioma: En.
Conferência: Apresentado em: Diabetic Nephropathy Symposium, Kingston, Jan. 23-4, 1993.
Resumo: In the studies of the aetiology, treatment and prevention of diabetic nephropathy, several end-points can be used, including death due to renal failure, uraemia, azotaemia, proteinuria, microalbuminuria and changes in glomerular and tubular functions. The two parameters commonly used, though not ideal, are glomerular filtration rate and protein excretion. Several factors contribute to the development and progression of diabetic nephropathy. These include hereditary factors, severity of hyperglycaemia, hypertension and hyperlipidaemia. Siblings of probands free of diabetic nephropathy have less evidence of renal disease than do siblings of probands with diabetic nephropathy. Several studies have also shown that individuals with high glycosylated haemoglobin concentrations (poor glycaemic control) are more likely to develop diabetic nephropathy. It is not clear, however, if this is a direct relationship (e.g. via glycosylation) or indirect (e.g. increased flux through the aldose reductase pathway, or alteration in vascular permeability). It is also unclear whether there is a direct relationship between glucose level and the development of diabetic nephropathy. The route of administration of insulin, e.g. into systemic circulation or into the portal system, may be important in the development of diabetic nephropathy. Specific inhibitors in the metabolic pathways (e.g. aldose reductase inhibitors, glycosylation inhibitors) may slow or prevent the development of diabetic nephropathy. Several studies have shown that increase in albumin excretion rate and decrease in glomerular filtration rate precede the development of hypertension and, once present, contribute to the rate of progression of diabetic nephropathy. Some, on the other hand, feel that hypertension reduces protein excretion, and a few studies have shown that it also preserves renal function and/or prevents azotaemia. It is also not clear at what level blood pressure should be treated, as urinary albumin excretion decreases when normotensive individuals are treated with angiotensin-converting enzyme inhibitors. Reduction of protein consumption in humans (to approximately 0.6 gm protein/kg body weight per day) can slow the rate of decline in glomerular filtration. Also influencing the rate of development of hyperlipidaemia, if necessary, with hypolipidaemic drugs is potentially beneficial in hypertensive diabetic patients. In summary, although definite data are lacking, an attempt should be made to optimize glycaemic control and hypertension should be treated early and vigorously. Hyperlipidaemia which persists in the presence of normoglycaemia should be treated with diet and hypolipidaemic drugs (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  8 / 14 MedCarib  
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Fotocópia
Id: 2116
Autor: Forrester, Terrence E; Wilks, Rainford J; Bennett, Franklyn I; Simeon, Donald T; Osmond, Clive; Allen, Mureen; Chung, Andrene S.
Título: Fetal growth and cardiovascular risk factors in Jamaican school children
Fonte: BMJ;312(7024):156-60, Jan. 1996.
Idioma: En.
Resumo: OBJECTIVE-- To determine relationship between school children's blood pressure, glycated haemoglobin level and cholesterol concentration and their anthropometry, socioeconomic status, and birth measurements. DESIGN--Retrospective cohort study. SETTING--27 schools closest to University Hospital of the West Indies, Kingston, Jamaica. SUBJECTS--2337 children aged 6-16 years who were born at University Hospital were recruited, and their birth records were recovered: 1610 had suitable records, 659 had records including birth length, and 610 of these were prepubertal. MAIN OUTCOME MEASURES--Blood pressure, glycated haemoglobin level, serum cholesterol concentration, anthropometry at birth, current anthropometry, and socioeconomic status. RESULTS--Multiple regression analysis showed that children's systolic blood pressure was inversely related to their birth weight (P < 0.0001) and directly related to their currrent weight. Glycated haemoglobin level was higher in children with thicker triceps skinfolds (P < 0.001) and who had been shorter at birth (P = 0.003). Serum cholesterol concentration was inversely related to current height (P = 0.001) and to length at birth (P = 0.09) and was directly related to triceps skinfold thickness and higher socio-economic status (P = 0.001). CONCLUSIONS--Blood pressure in children was inversely related to birth weight and directly to current weight. Glycaemic control and serum cholesterol were related to short length at birth, height deficit in childhood, and childhood obesity (Au).
Responsável: JM3.1 - Médical Library
JM3.1; R31.B75


  9 / 14 MedCarib  
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Fotocópia
Id: 1566
Autor: Richards George, Pamela A; Wright Pascoe, Rosemarie; Choo Kang, Eric; Reid, Harvey L; Mills, James L; Morrison, Errol Y. St. A.
Título: Some clinical factors contributing to the development of the diabetic foot
Fonte: West Indian med. j;48(4):223-6, Dec. 1999. tab.
Idioma: En.
Resumo: Clinical neurological studies, blood pressure measurements and some haematological investigations were performed on a random sample of forty-four patients, at the Diabetes Out-Patient Clinic of the University Hospital of the West Indies (UHWI), to examine some of the factors that predispose to the development of the diabetic foot. Our results revealed that 86 percent of the patients had elevated glycosylated haemoglobin (HbA > 9.0 percent), 82 percent had clinical signs of peripheral sensory neuropathy. 29 percent had signs of autonomic neuropathy in addition to peripheral sensory neuropathy. Sixty-one percent (61 percent) of the patients had ankle/arm systolic blood pressure ration less than 1.0 and were diagnosed as having peripheral vascular disease (PVD). The group with neuropathy was found to have a significantly lower diastolic blood pressure (p < 0.0005) than the group without neuropathy. We believe that hyperglycaemia-induced vasodilation (indicated by a lower diastolic blood pressure) in a significant number of diabetics resulted in compensatory shunting of blood from the deeper tissues, including nerves, to periphery. The resulting endoneural hypoxia could be responsible for the unusually high incidence of peripheral sensory neuropathy detected in this sample of diabetic patients. Metabolic factors may also play a role.(AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  10 / 14 MedCarib  
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Fotocópia
Id: 1552
Autor: Gordon, Lorenzo A; Martorell, Eslaen, Z; Morrison, Errol Y. St. A; Miranda, Cespedes E. M.
Título: Yoga discipline in the control of non-insulin dependent diabetes mellitus
Fonte: West Indian med. j;47(suppl. 1):30, Mar. 5-8, 1998.
Idioma: En.
Resumo: An experimental study was performed at the Higher Institute of Medical Sciences "Victoria de Giron" of Havana City, Cuba, between April 1997 and June 1997 to examine the effect of Yoga Discipline in the control of Non-Insulin Dependent Diabetes Mellitus (NIDDM). Of 64 subjects there were 32 NIDDM on traditional treatment (Yoga Group). The prinicpal results revealed that the body mass index (BMI), at the beginning and the end, in the Traditional Group did not change significantly (BMI-beginning-28.0kg/m2; the end = 28.7 kg/m2 p=0.0831). However, the BMI in the Yoga Group decreased significantly (beginning = 29.7 kg/m2, the end = 27.0kg/m2; p=0.0001). At the end the frequency of normal glycosylated haemoglobin was higher in the Yoga Group (88.4 percent) than in the Traditional group (46.9 percent) showing a significant difference (p =0.0007). Also, for the Traditional Group, at the end the mean triglyceride 0.025 mmol/l (2.23mg/dl) and the mean total cholesterol concentrations 0.126 mmol/l (4.88mg/dl) were not significantly different from the beginning 0.025 mmol/l (2.22mg/dl) and 0.125 mmol (4.83mg/dl) respectively. In the Yoga Group at the end of the mean triglyceride 0.019 mmol/l (1.68 mg/dl) and the total cholesterol concentrations 0.110 mmol/l (4.24 mg/dl) were lower than the beginning 0.026 mmol/l (2.30 mg/dl) and 0.126 mmol/l (4.88 mg/dl), respectively, showing significant differences, p<0.05. Our results indicate that Yoga Discipline combined with the traditional treatment of NIDDM can benefit these patients.(AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4



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