Base de dados : MedCarib
Pesquisa : D12.776.124.486.485.114.071 [Categoria DeCS]
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Fotocópia
Id: 12476
Autor: Rodgers Johnson, Pamela E. B; Morgan, Owen St. C; Sarin, Prem S; Ceroni, Mauro; Piccardo, Pedro; Garruto, Ralph M; Gibbs, Clarence J; Gajdusek, D. Carlton.
Título: The role of HTLV-I in tropical spastic paraparesis in Jamaica
Fonte: Ann Neurol;23(suppl):S121-6, 1988.
Idioma: En.
Resumo: We report clinical and laboratory investigations of 47 native-born Jamaican patients with endemic tropical spastic paraparesis and of 1 patient with tropical ataxic neuropathy. Mean age at onset was 40 years, with a female-male preponderance (2.7:1). Neurological features of endemic tropical spastic paraparesis are predominantly those of a spastic paraparesis with variable degrees of proprioceptive and/or superficial sensory impairment. Using enzyme-linked immunoabsorbent assay (ELISA), IgG antibodies to human T-lymphotropic virus type I (HTLV-I) were present in 82 percent of sera and 77 percent of cerebrospinal fluids. On Westren blot analysis, IgG antibodies detected the p19 and p24 gag-encoded core proteins in both serum and cerebrospinal fluid. Titers were tenfold higher by ELISA in serum than in cerebrospinal fluid, and some oligoclonal bands present in fluid were not seen in serum . Serum-cerebrospinal fluid albumin ratios wer normal, and IgG indexes indicated intrathecal IgG synthesis. Histopathological changes showed a chronic inflammatry reaction with mononuclear cell infiltration, perivascular cuffing, and demyelination that was predominant in the lateral colmns. In 1 patient, a retrovirus morphologically similar to HTLV-I on electron microscopy was isolated from spinal fluid. Our investgations show that endemic tropical spastic paraparesis in Jamaica is a retrovirus-assiciated myelopathy and that HTLV-I or an antigenically similar retrovirus is the causal agent. (AU)
Responsável: JM3.1 - Médical Library
JM3.1; RC321.A42; Reprint Collection


  2 / 5 MedCarib  
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Fotocópia
Id: 12475
Autor: Piccardo, Pedro; Ceroni, Mauro; Rodgers Johnson, Pamela E. B; Mora, Carlos A; Asher, David M; Char, Gurendra; Gibbs, Clarence J; Gajdusek, D. Carlton.
Título: Pathological and immunological observations on tropical spastic paraparesis in patients from Jamaica
Fonte: Ann Neurol;23(suppl):S156-60, 1988.
Idioma: En.
Resumo: The neuropathological examination of the spinal cord of 2 Jamaican patients with classical tropical spastic paraparesis disclosed an intense chronic meningomyelitis with demyelination. In the 1 case in which serum and cerebrospnal fluid were available, antibodies to the human T-lymphotropic virus type 1 were found. (AU)
Responsável: JM3.1 - Médical Library
JM3.1; RC321.A42


  3 / 5 MedCarib  
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Fotocópia
Id: 8471
Autor: Teh, L. S; Lee, M. K; Wang, F; Manivasagar, M; Charles, P. J; Nicholson, George D; Hay, E. M; Isenberg, D. A; Amos, N; Williams, B. D.
Título: Antiribosomal P protien antibodies in different populations of patients with systemic lupus erythematosus
Fonte: Br J Rheumatol;32(8):663-5, Aug. 1993.
Idioma: En.
Resumo: We report a significantly increased prevalence of antribosomal P protein antibodies in Malaysian Chinese patients (38 percent) with SLE compared to white caucasian (13 percent) and Afro-Caribbean (20 percent) patients. The increase prevalence was not due to a generalized increase in autoantibody production because anti-dsDNA and anti-SSA antibodies were present in comparable frequencies in the three ethnic groups while anti-Sm and anti-SSB antibodies were rarely found in the Malaysian Chinese patients (AU)
Responsável: JM3.1 - Médical Library


  4 / 5 MedCarib  
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Fotocópia
Id: 5368
Autor: Barnes, K. C; Avjioglu, A; Marrugo, J; Naidu, Raana P; Caraballo, L. R; Schou, C; Levett, Paul N; Marsh, D. G.
Título: IgE antibodies to four mite allergens in atopics and non-atopics living in Barbados - abstract
Fonte: West Indian med. j;43(suppl.1):45, Apr. 1994.
Idioma: En.
Conferência: Apresentado em: Commonwealth Caribbean Medical Research Council 39th Scientific Meeting, Kingston, Apr. 21-3, 1994.
Resumo: The prevalence of specific IgE (RAST) to Blomia tropicalis (Bt) was evaluated for 64 individuals from four families residing in Barbados, with self-reported atopic asthma (AA) and/or self-reported allergic rhinitis (AR) or individuals with no reported atopic disease (NA). The presence of specific IgE antibodies that reacted with components of Chortoglyphus arcuatus (Ca), Dermatophagoides pteronyssinus (Dp) and Euroglyphus maynei (Em) was also evaluated; components from Ca, Dp and Em were separated by SDS-PAGE, transferred to nitrocellulose membranes and screened with sera from the 22 AAs, 17 ARs and 25 NAs. Total serum IgE was significantly higher in individuals with self-reported AA (logIgE = 977 ng/ml) than in individuals reporting no AA (logIgE = 323 ng/ml). There was a significant difference between the number of AAs who were Bt-positive according to RAST (68 percent) and the number of individuals without AA(p=0.002). IgE antibodies to Ch and Em were significantly higher in individuals with AA than in those without AA (p = 0.001 and p = 0.005, respectively), and there was a weak correlation between IgE antibodies to Dp and self-reported AA (p=0.05). A significant pattern of conversion of response to certain bands within families was observed (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


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Fotocópia
Id: 145
Autor: Justiz Vaillant, A; Anderson McFarlane, Norma; Smikle, Monica.
Título: Detection of red blood cell antibodies using bacterial antiglobulins: a new assay [abstract]
Fonte: West Indian med. j;50(Suppl 5):29-30, Nov. 2001.
Idioma: En.
Resumo: OBJECTIVE: To develop an agglutination technique using Staphylococcal protein A (SpA) and Steptococcalprotein G (SpG) to detect human red blood cell antibodies. METHODS: Blood samples were obtained from the National Transfusion Service of Jamaica. SpA, SpG, and anti-IgG, -C3d were commercial preparations. SpA and ApG were incubated with sensitized human red blood cells (RBC) to assess their RBC agglutinating capacity. The Ouchterlony technique was used to determine binding between the bacterial antigens and the IgG in human serum. Polyethyleneglycol (PEG) was used as an agglutination enhancer. Agglutination techniques for a large number of samples were developed, using 96 percent well polystyrene microplates and a microscope for visualizing the agglutination techniques to detect human anti-RBC IgG was compared with the traditional Coombs' test. Sensitivity and specificity were determined. RESULTS: SpA and SpG did not appear to cause agglutination of the red cells sensitized in vivo and in vitro. However, no precipitation bands were formed between human serum and the supernatant obtained after reaction of the sensitized RBC with SpA and SpG (Ouchterlony technique). These results indicated that indeed there was binding of SpA and SpG with the sensitized cells since they were not available for binding with human serum. In additon, SpA and SpG agglutinated the sensitized red blood cells in the presence of the PEG. When compared to the Coombs' test, the following results were obtained with new techniques. For the direct method, sensitivity was 93.8 percent and 95.1 percent for SpA and SpG respectively (n= 81), and specificity was 91.4 percent and 93.5 percent for SpA and SpG, respectivley (n= 93). For the indirect method, sensitivity was 96.3 percent and 97.5 percent for SPA and SpG, respectively (n= 81) and its specificity was 100 percent for both proteins (n= 85). CONCLUSION: Agglutination techniques using SpA and SpG constitute alternative and feasible tests for the detection of human red blood cell antibodies. (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4



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