Base de dados : MedCarib
Pesquisa : F02.463.425.097 [Categoria DeCS]
Referências encontradas : 6 [refinar]
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Fotocópia
Id: 11337
Autor: Wray, Samuel R; Melville, G. Norris; Grell, Gerald A. C; Egbe, Patrick C.
Título: Current concepts of abnormal motor disorder: an experimental model of attentional deficit disorder
Fonte: West Indian med. j;30(3):107-18, Sept. 1981.
Idioma: En.
Resumo: An attempt was made to indicate the neuropharmalogical relationship between Parkinson's disease, Huntington's chorea, tardive dyskinesia and Attentional Deficit Disorder. In the case of the latter, an experimental model has been prersented indicating cholinergic dysfunction in the nigro-striatal pathway. Postulates are proposed which will enable us to understand the many factors responsible for these clinical states. (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  2 / 6 MedCarib  
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Fotocópia
Id: 11258
Autor: Wray, Samuel R.
Título: Comparative analysis of drug-effects on differential avoidance behaviour
Fonte: West Indian med. j;28(2):111-5, June 1979.
Idioma: En.
Resumo: Levallorphan, a narcotic antagonist with psychotomimetic properties, was evaluated in rats trained on a discriminative and non-discriminative avoidance schedule. This compound induced essentially similar behavioural profiles in rats trained on the two avoidance schedules. It is suggested that similar central mechanisms may subserve avoidance response acquired using the two avoidance procedures (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  3 / 6 MedCarib  
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Fotocópia
Id: 11215
Autor: Wray, Samuel R.
Título: The absence of Levallorphan-induced post-depressant hyperactivity following stress-reduction
Fonte: West Indian med. j;26(2):59-65, June 1977.
Idioma: En.
Resumo: Following the administration of levallorphan(100 mg/kg) rats' well-established avoidance behaviour is severly depressed for 30 minutes. During this period, animals are almost incessantly shocked. During saline trials, rats receive relatively few shocks. It is postulated that the rate enhancement observed after the drug-induced depressant period is probably due to the excessive stress which animals undergo during the depressive phase. Following drug treatment, rats were kept out of operant during the depressive phase. No rate enhancement was observed throughout the 120-minute experimental period. Response rate enhancement seems to depend on the level of stress during the depressant phase of the drug (AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4


  4 / 6 MedCarib  
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Fotocópia
Id: 8733
Autor: Wray, Samuel R; Cowan, A.
Título: Correlation between animal and clinical findings with a psychotomimetic anticholinesterase
Fonte: Neuropharmacology;12(4):397-400, Apr. 1973.
Idioma: En.
Responsável: JM3.1 - Médical Library


  5 / 6 MedCarib  
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Fotocópia
Id: 8731
Autor: Wray, Samuel R.
Título: Possible catecholamine mediation of levallorphan-induced behavioural disruption in rats
Fonte: Psychopharmacologia;30(3):251-62, June 19 1973.
Idioma: En.
Responsável: JM3.1 - Médical Library


  6 / 6 MedCarib  
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Fotocópia
Id: 2310
Autor: Benjamin, L. C; Young, Ronald E; Young, Lauriann E.
Título: Hormonal variations influences learning - abstract
Fonte: WEST INDIAN MED. J;46(Suppl 2):22, Apr. 1997.
Idioma: En.
Conferência: Apresentado em: Commonwealth Caribbean Medical Research Council 42nd Scientific Meeting, St. Maarten, Apr. 16 - 19 1997.
Resumo: The study attempted to evaluate the influence of hormonal status (gender and oestrous cycle) on learning in male and female rats and to determine whether this difference was affected by dopamine agonists (cocaine and amphetamine). Rats were exposed to foot-shocks in a Y-maze. Exploratory and avoidance behaviours were tested on two trials, 24 hours following conditioning (Trial 1) and 2 weeks subsequently (Trial 2). Amphetamine (1mg/kg/ml) stimulated exploratory behaviour, whereas cocaine (1mg/kg/ml) had a depressant effect at Trial 1. Avoidance learning of a potentially dangerous environment was significantly less in oestrous than in diestrous and male rats. These results provide evidence that hormonal status influences learning. Cocaine and amphetamine given in a single low doses did not produce any significant effects on avoidance learning(AU)
Responsável: JM3.1 - Médical Library
JM3.1; R18.W4



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