||Nicholson, K. G; Tyrrell, D. A. J; Oxford, J. S; Wood, J; Schild, G. C; Potter, C. W; Jennings, R; Michaels, R. H; Appleyard, G.|
||Inefectivity and reactogenicity of reassortant cold-adapted influenza A/Korea/1/82 vaccines obtained from the USA and USSR|
||Bulletin of the World Health Organization (WHO);65(3):295-301, 1987. Tab.
||The safety and immunogenicity of two live influenza A virus vaccines strains, the CR 59 and 17/25/1 cold-adapted (ca) reassortants, were evaluated in 170 healthy young adult volunteers. The vaccines were produced by recombining A/Korea/1/82 (H3N2) wild-type virus with either A/Ann Arbor/6/60 (H2N2) or A/Leningrad/134/17/57 (H2N2) ca donors of attenuation. Both vaccines were well tolerated in volunteers. The 17/25/1 strain, prepared from A/Leningrad, infected at least 70 percent of seronegative volunteers after the first dose and 84 percent after the second; the CR 59 strain infected 62 percent and 72 percent of volunteers after first and second doses, respectively. Among the vaccinees who were intially seropositive, 17/25/1 infected 66 percent after one dose and 85 percent after two, while CR 59 infected 62 percent and 71 percent, respectively. Despite differences in temperature sensitivity, genetic composition, and serological reactivity to monoclonal antibodies, both vaccines behaved almost identically in animal models and man. We conclude that both donors of attenuation may be of great potential value|
||US1.1 - HQ Library|
||US1.1, WHO COLL|