||Kim, J. S; No, B. U; Lee, W. Y.|
||Brugian filariasis: 10-year follow-up study on the effectiveness of selective chemotherapy with diethylcarbamazine on Che Ju island, Republic of Korea|
||Bulletin of the World Health Organization (WHO);65(1):67-75, 1987. Tab.
||The results of a 10-year follow-up of Brugia malayi microfilarial (mf) carrier rates in seven villages on Che Ju island and adjacent islets are reported; four villages initially received large-scale selective treatment with diethylcarbamazine (DEC) and three served as untreated controls. Some 90 percent of the total population took part in the pre-treatment blood survey and 82 percent of the detected mf carriers completed a course of treatment with 72 mg DEC per kg body weight over a period of 24 days. In the DEC-treated villages 92 percent of the mf carriers were negative one year after the treatment; the mf rate fell from 18.2 percent to 3.3 percent, the median mf density (MfD-50) changed from 28.4 to 5.2 mf/20 mm3 blood, and the infectivity rate in Aedes Togoi fell from 5.5 percent to nil. Ten years later these parameters had risen only slightly to 4.1 percent, 5.7 mf/20 mm3 blood, and 0.3 percent, respectively. By contrast, in the untreated control villages none of these parameters changed significantly during the same period. Thus, selective DEC treatment of detected mf carriers is an excellent control measure for human filariasis as it is readily acceptable by the inhabitants and is cost-effective. Suitable intervals between treatments would be 8-10 years in areas where the mf prevalence rates is 10 percent or over, and 12-15 years where the prevalence is less than 10 percent|
||US1.1 - HQ Library|
||US1.1, WHO COLL|