Base de dados : ADOLEC Pesquisa : A05.810.453 [Categoria DeCS] Referências encontradas : 295 [refinar] Mostrando: 1 .. 10   no formato [Longo]

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Id: 501886 Autor: Ortiz-Neira, Clara L; Traubici, Jeffrey; Alan, Daneman; Moineddin, Rahim; Shuman, Cheryl; Weksberg, Rosanna; Epelman, Monica. Título: Sonographic assessment of renal growth in patients with Beckwith-Wiedemann syndrome: the Beckwith-Wiedemann syndrome renal nomogram. Fonte: Clinics;64(1):41-44, 2009. graf, tab. Resumo: BACKGROUND: Beckwith-Wiedemann syndrome is a disorder of somatic overgrowth. Evidence of kidney overgrowth is a diagnostic criterion that may be used to help identify those patients who are at the greatest risk of developing Wilms tumors. In such subjects, kidney size is typically larger than that of age-matched normal controls. OBJECTIVE: The purpose of our study was to generate a nomogram that could be used to measure renal dimensions in children with Beckwith-Wiedemann syndrome in a clinical setting. MATERIALS & METHODS: All of the Beckwith-Wiedemann syndrome patients followed at our institution from 1996 to 2004 were eligible for inclusion in our study. Renal length was measured with a curvilinear transducer and with the patient supine. Renal lengths were measured for both kidneys using real-time ultrasound for all patients. Their data were compared with those of age-matched controls reported in the 1984 study by Rosenbaum et al. RESULTS: Ninety-six children with Beckwith-Wiedemann syndrome were followed from 1996 to 2004. Forty-three of these patients met our criteria for inclusion in the study: 28 girls (65 percent) and 15 boys (35 percent). We identified a linear relationship between kidney length and patient age. No statistically significant differences in renal length were found between boys and girls (p=0.2153) or between the kidneys on either side of the body (p=0.9613). CONCLUSION: Our study provides a practical, simple renal growth chart that offers a reasonable, sensitive method for evaluating kidney size in children with Beckwith-Wiedemann syndrome.(AU). Responsável: BR1.1

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Id: 503899 Autor: Panuncio, Ana; Alba, Andrea; Bacigalupe, Claudia; Caorsi, Hena; Schwedt, Emma; Otatti, Gabriela; Saralegui, Patricia; Marino, Ana. Título: Nefropatía C1q en un paciente de 17 años: caso clínico / C1q nephropathy: report ofone case Fonte: Rev. méd. Chile;136(10):1307-1310, Oct. 2008. ilus, tab Resumo: Clq nephropathy (Clq N) is an infrequent disease and only about 100 cases have been reponed. It is defined by a pattern of immunofluorescense (IF) with dominant or co-dominant complement Clq with electrondense deposits in the mesangium, without clinical or serological features of Lupus Nephritis. The most common histopathological findings of ClqN are focal segmental glomerulosclerosis and Minimal Change Disease. We repon a 17 year-old male patient with an isolated selective proteinuría found in a routine study. He had normal renal function and uriñe culture was negative. Serum lipids, liver enzymes an complement were all normal. Serum antinuclear and anti-DNA antibodies, antineutrophil cytoplasmic antibodies (ANCA), HIV, Hepatitis B and C serology, were negative. Renal and abdominal ultrasonography was normal. The histopathological study revealed segmental glomerular sderosis, modérate increase of mesangial matrix, Bowmann capsule adhesions and fucsinophil deposits in mesangium. The IF was positive (dominant) for Clq (+++) and IgA, IgG, IgM, C3++, all of them with a granular mesangial distribution. Ultrastructural findings were pedicelar effacement and paramesangial electrondense deposits. Tubular reticular inclusions (TRI) were not found. Remission of proteinuría was reached after 18 months of treatment with enalapril and losartan. The patient remains with normal renal function. Clinical findings, negative serology for Lupus, light microscopy IFwith dominant positivity for Clq, absence of TRI and paramesangial electrondense deposits in electron microscopy lead us to the diagnosis of ClqN. A poor response to steroid therapy was described in ClqN. Thus it was worthwhile to differentiate it from lupus nephritis, that is responsive to steroids.(AU). Responsável: BR1.1

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Id: 501781 Autor: Liern, Miguel; Maldonado, Laura; Jordán, Pablo; Vallejo, Graciela. Título: Eficacia del Enalapril en pacientes monorrenos con dieta normoproteica y sin ella / Efficacy of Enalapril in patients with single kidney and with or without normoprotein diet Fonte: Arch. argent. pediatr;106(5):416-421, oct. 2008. graf Resumo: El paciente monorreno, sin dieta normoproteica,puede presentar microalbuminuriaanormal con eventual desarrollo de glomerulosclerosis.Objetivo. Evaluar la eficacia del Enalapril parareducir la microalbuminuria patológica en pacientesmonorrenos con dieta normoproteica y sin ella.Población, material y métodos. Estudiamos 49 pacientesmonorrenos, edad (media) 11 años, eutróficos,con función renal normal y consentimiento médicoaprobado. Criterios de exclusión: uropatías,hipertensión arterial, enfermedades oncológicas, tratamientoscon drogas nefrotóxicas, proteinuriaortostática. La población se clasificó en dos grupos:Grupo A: con dieta normoproteica (0,8-1,2 g/kg/díapara sexo y edad). Grupo B: con dieta libre.A los pacientes con microalbuminuria anormal seles administró Enalapril (intervalo de dosis: 0,1 mg/kg/día a 0,3 mg/kg/día).Resultados. Grupo A: 21 pacientes, 2 con microalbuminuriapatológica. Aumento promedio del tamañorenal: 14% (DE 8 por ciento). Riesgo de presentarmicroalbuminuria patológica: 9 porc ciento.Grupo B: 28 pacientes, 11 con microalbuminuriaanormal. Riesgo de presentar microalbuminuriaanormal: 40 por ciento. Aumento promedio del tamaño renal:33,8 (DE 6,1 por ciento). RR: 4,125(IC 1-16) (p: 0,01).NND: 3. Media de microalbuminuria pre-Enalapril50,20 μg/minuto y post-Enalapril 11,5 μg/minuto.Dosis media de Enalapril: 0,2 mg/kg/día.Coeficiente de correlación entre microalbuminuriay aumento del tamaño renal: 0,75; y entre ingestaproteica y aumento del tamaño renal: 0,72.Tiempo (medio) de aparición de la microalbuminuriaanormal: 81 meses (DE 7 meses).Conclusión. El Enalapril junto con la dieta normoproteicaen pacientes monorrenos disminuyen elriesgo de desarrollar microalbuminuria anormal (AU). Responsável: AR94.1

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Id: 496812 Autor: Moscoso-Solorzano, G. T; Mastroianni-Kirsztajn, G; Ozaki, K. S; Araujo, S; Franco, M. F; Pacheco-Silva, A; Camara, N. O. S. Título: Are the current chronic allograft nephropathy grading systems sufficient to predict renal allograft survival?. Fonte: Braz. j. med. biol. res;41(10):896-903, Oct. 2008. tab. Projeto: CNPq; . Fundação Oswaldo Ramos. 300324/2004-9; 302011/2007-2. Resumo: A major problem in renal transplantation is identifying a grading system that can predict long-term graft survival. The present study determined the extent to which the two existing grading systems (Banff 97 and chronic allograft damage index, CADI) correlate with each other and with graft loss. A total of 161 transplant patient biopsies with chronic allograft nephropathy (CAN) were studied. The samples were coded and evaluated blindly by two pathologists using the two grading systems. Logistic regression analyses were used to evaluate the best predictor index for renal allograft loss. Patients with higher Banff 97 and CADI scores had higher rates of graft loss. Moreover, these measures also correlated with worse renal function and higher proteinuria levels at the time of CAN diagnosis. Logistic regression analyses showed that the use of angiotensin-converting enzyme inhibitor (ACEI), hepatitis C virus (HCV), tubular atrophy, and the use of mycophenolate mofetil (MMF) were associated with graft loss in the CADI, while the use of ACEI, HCV, moderate interstitial fibrosis and tubular atrophy and the use of MMF were associated in the Banff 97 index. Although Banff 97 and CADI analyze different parameters in different renal compartments, only some isolated parameters correlated with graft loss. This suggests that we need to review the CAN grading systems in order to devise a system that includes all parameters able to predict long-term graft survival, including chronic glomerulopathy, glomerular sclerosis, vascular changes, and severity of chronic interstitial fibrosis and tubular atrophy.(AU). Responsável: BR1.1

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Id: 510305 Autor: Alves Júnior, José Miguel; Pantoja, Renata Kelly Sousa; Barros, Charlene Villacorta de; Braz, Marcelle Nobre. Título: Estudo clínico-patológico das glomerulopatias no Hospital de Clínicas Gaspar Vianna / Glomerular diseases clinicopathologic profile at Hospital de Clínicas Gaspar Vianna Fonte: Rev. para. med;22(1):39-47, Jan.-Mar. 2008. tab Resumo: Objetivo: estabelecer o perfil epidemiológico dos pacientes submetidos à biópsia renal na fundação.(AU).Objective: to establish the epidemiologic profile of Fundação Hospital de Clínicas Gaspar Vianna (FHCGV) patients submitted to renal biopsy and identify the most common kidney diseases biopsed and related clinical syndromes, formulating clinical and pathologic correlations. Methods: a retrospective study was undertaken of ali renal biopsy registries performed from 2002 to 2005 at Nephrology Service of FHCGV. Data were obtained from Kidney Biopsies Registry Book, which contained personal, clinical and histological data of 32 patients, of both sexes. Results: adults composed most part of the sample (94%) and 56% of ali patients were male. Only three subjects IInderwellt biopsies complicationsj. The most common clinical syndrome was nephritic syndrome (72%), followed by hematuria (25%). Focal segmental glomerulosclerosis (FSGS) (22%) and lupus nephritis (15%) were associated to nephrotic syndrome in most of cases. Conclusion: nephrotic syndrome and FSGS were the most frequent clinical and histological findings at FHCGV, respectively.(AU). Responsável: BR3.1

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Id: 18421276 Autor: Müssig K; Remer T; Haupt A; Gallwitz B; Fritsche A; Häring HU; Maser-Gluth C. Título: 11beta-hydroxysteroid dehydrogenase 2 activity is elevated in severe obesity and negatively associated with insulin sensitivity.. Fonte: Obesity (Silver Spring);16(6):1256-60, 2008 Jun. . Resumo: Alterations in glucocorticoid (GC) metabolism may contribute to the development of obesity and insulin resistance. We aimed to study the role of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in human adiposity, paying special attention to the association between altered GC metabolism and insulin sensitivity. In 24-h urine samples of 72 extremely obese (mean BMI 45.5 +/- 1.1 kg/m(2)), but otherwise healthy patients urinary free cortisol (UFF), urinary free cortisone (UFE), tetrahydrocortisol (THF), 5alpha-tetrahydrocortisol (5alpha-THF), and tetrahydrocortisone (THE) were quantified by radioimmunoassay. The sum of the three major tetrahydrometabolites is an estimate for daily GC secretion, and the sum of UFF and UFE represents potentially bioactive-free-GCs. Thirty healthy lean subjects (BMI 22.3 +/- 0.3 kg/m(2)) served as controls. In obese subjects, absolute daily GC secretion and the potentially bioactive-free-GCs were significantly (P < 0.005) higher than in lean controls (11.8 +/- 0.7 vs. 8.0 +/- 0.6 mg/d; and 171.8 +/- 11.2 vs. 117.6 +/- 9.2 mug/d, respectively). However, when these values were corrected for body surface area (BSA), significant differences were no longer detectable. While enzyme activity indices for 5alpha-reductase and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) were similar in lean and obese subjects, 11beta-HSD2 was markedly elevated in adiposity (3.7 +/- 0.2 vs. 2.1 +/- 0.1; P < 0.0001). This increase was accompanied by a significant reduction in UFF excretion corrected for BSA (16.5 +/- 1.2 vs. 21.7 +/- 2.0 mug/d/m(2); P = 0.0222). Besides, 11beta-HSD2 activity was significantly correlated with insulin sensitivity (P = 0.0262). When body size is accounted for, both adrenal GC secretion and potentially bioactive-free-GCs are indistinguishable between lean and extremely obese subjects. However in obesity, the kidney appears to intensify its supply of the direct substrate cortisone for extrarenal 11beta-HSD1, which may fuel visceral adiposity and insulin resistance.. Responsável: BR1.1

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Id: 18312644 Autor: Obajimi MO; Atalabi MO; Ogbole GI; Adeniji-Sofoluwe AT; Agunloye AM; Adekanmi AJ; Osuagwu YU; Olarinoye SA; Olusola-Bello MA; Ogunseyinde AO; Aken'Ova YA; Adewole IF. Título: Abdominal ultrasonography in HIV/AIDS patients in southwestern Nigeria.. Fonte: BMC Med Imaging;8:5, 2008. . Resumo: BACKGROUND: Though the major target of the HIV-virus is the immune system, the frequency of abdominal disorders in HIV/AIDS patients has been reported to be second only to pulmonary disease. These abdominal manifestations may be on the increase as the use of antiretroviral therapy has increased life expectancy and improved quality of life. Ultrasonography is an easy to perform, non invasive, inexpensive and safe imaging technique that is invaluable in Africa where AIDS is most prevalent and where sophisticated diagnostic tools are not readily available. Purpose: To describe the findings and evaluate the clinical utility of abdominal ultrasonography in HIV/AIDS patients in Ibadan, Nigeria METHODS: A Prospective evaluation of the abdominal ultrasonography of 391 HIV-positive patients as well as 391 age and sex-matched HIV-negative patients were carried out at the University College Hospital, Ibadan. RESULTS: Of the 391 cases studied, 260 (66.5%) were females; the mean age was 38.02 years, (range 15-66 years). The disease was most prevalent in the 4th decade with an incidence of 40.4%. Compared with the HIV-negative individuals, the HIV+ group of patients had a significantly higher proportion of splenomegaly (13.5% vs. 7.7%; p < 0.01), lymphadenopathy (2.0% vs. 1.3%; p < 0.70), and renal abnormalities (8.4% vs. 3.8%; p < 0.02). There were no differences in hepatic and pancreatic abnormalities between the HIV+ and HIV- groups. There were significantly fewer gallstones in the HIV+ group (1.4% vs. 5.1%; p < 0.01). CONCLUSION: AIDS is a multi-systemic disease and its demographic and clinical pattern remains the same globally. Ultrasonography is optimally suited for its clinical management especially in Africa. Its accuracy and sensitivity may be much improved with clinico-pathologic correlation which may not be readily available in developing countries; further studies may provide this much needed diagnostic algorithms.. Responsável: BR1.1

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Id: 18155544 Autor: Maya ID. Título: Hypertension and proteinuria in a 17-year-old at 19 weeks' gestation.. Fonte: Am J Kidney Dis;51(1):155-9, 2008 Jan. . Responsável: BR1.1

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Id: 474904 Autor: Donoso, Gilda; Lobo, Gabriel; Coll, Claudia; Arteaga, Paz; Pérez, Andrés; Jiménez, César; Bascuñan, Rodrigo; Pardo, Rodrigo. Título: Correlación entre cintigrama renal DMSA (CR) planar y tomográfico en 180º y 360º / Correlation between Tc99m-DMSA renal planar scintigraphy and tomography technique in 180 degrees and 360 degrees Fonte: Rev. med. nucl. Alasbimn j;9(36), Apr. 2007. ilus, tab Projeto: FONDEFF. D01 I 1035. Resumo: El C.R. planar es un examen habitual en la práctica clínica , cuya sensibilidad y especificidad han sido validadas en el estudio de infección urinaria en niños. El uso de técnica tomográfica es discutido , por lo que quisimos correlacionar los resultados obtenidos en el CR planar versus estudios tomográficos,considerando el planar nuestro gold estándar. 25 pacientes referidos por estudio de infección urinaria fueron estudiados con técnica planar habitual y el mismo día, tomografía en 180 º y en 360º. Se analizaron independientemente las imágenes planares de las tomográficas .Se realizó una tabla de correlación entre el CR planar y cada tomografía para evaluar las coincidencias (análisis Kappa). La mayor concordancia se observó entre el CR planar y la tomografía de 180º, índice kappa de 0.66, vs. 0.50 con la tomografía en 360º. Conclusión: Si se realiza tomografía renal ésta debe ser en 180º.(AU).Planar DMSA scintigraphy is a well established method for evaluating kidney in the urinary tract infection. There is no agreement of the utility of SPECT DMSA imaging. We compared the results of planar DMSA scintigraphy with tomography technique ( gold standard was planar DMSA). 25 children were evaluated with planar DMSA, 180º posterior and 360º full tomography in the same day. Images were interpreted independently in a blinded fashion. We made a correlation table and Kappa analysis were aplicated. The best concordancy were obtained between planar and 180º SPECT, with a Kappa index : 0.66 vs 0.50 with the 360º tomography. Conclusion: the 180º acquisition technique is preferable for kidney tomography.(AU). Responsável: CL1.1

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Id: 17469172 Autor: Pausova Z; Paus T; Abrahamowicz M; Almerigi J; Arbour N; Bernard M; Gaudet D; Hanzalek P; Hamet P; Evans AC; Kramer M; Laberge L; Leal SM; Leonard G; Lerner J; Lerner RM; Mathieu J; Perron M; Pike B; Pitiot A; Richer L; Séguin JR; Syme C; Toro R; Tremblay RE; Veillette S; Watkins K. Título: Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth Study.. Fonte: Hum Brain Mapp;28(6):502-18, 2007 Jun. . Resumo: The search for genes of complex traits is aided by the availability of multiple quantitative phenotypes collected in geographically isolated populations. Here we provide rationale for a large-scale study of gene-environment interactions influencing brain and behavior and cardiovascular and metabolic health in adolescence, namely the Saguenay Youth Study (SYS). The SYS is a retrospective study of long-term consequences of prenatal exposure to maternal cigarette smoking (PEMCS) in which multiple quantitative phenotypes are acquired over five sessions (telephone interview, home, hospital, laboratory, and school). To facilitate the search for genes that modify an individual's response to an in utero environment (i.e. PEMCS), the study is family-based (adolescent sibships) and is carried out in a relatively geographically isolated population of the Saguenay Lac-Saint-Jean (SLSJ) region in Quebec, Canada. DNA is acquired in both biological parents and in adolescent siblings. A genome-wide scan will be carried out with sib-pair linkage analyses, and fine mapping of identified loci will be done with family-based association analyses. Adolescent sibships (12-18 years of age; two or more siblings per family) are recruited in high schools throughout the SLSJ region; only children of French-Canadian origin are included. Based on a telephone interview, potential participants are classified as exposed or nonexposed prenatally to maternal cigarette smoking; the two groups are matched for the level of maternal education and the attended school. A total of 500 adolescent participants in each group will be recruited and phenotyped. The following types of datasets are collected in all adolescent participants: (1) magnetic resonance images of brain, abdominal fat, and kidneys, (2) standardized and computer-based neuropsychological tests, (3) hospital-based cardiovascular, body-composition and metabolic assessments, and (4) questionnaire-derived measures (e.g. life habits such as eating and physical activity; drug, alcohol use and delinquency; psychiatric symptoms; personality; home and school environment; academic and vocational attitudes). Parents complete a medical questionnaire, home-environment questionnaire, a handedness questionnaire, and a questionnaire about their current alcohol and drug use, depression, anxiety, and current and past antisocial behavior. To date, we have fully phenotyped a total of 408 adolescent participants. Here we provide the description of (AU). Responsável: BR1.1

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